Respiratory syncytial virus fusion inhibitors. Part 7: Structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 16, 2009, Pages 4857-4862

  Sin, Ny ^a   Venables, Brian L ^a   Combrink, Keith D ^a   Gulgeze, H Belgin ^a   Yu, Kuo Long ^a   Civiello, Rita L ^a   Thuring, Jan ^a   Wang, X Alan ^a   Yang, Zheng ^a   Zadjura, Lisa ^a   Marino, Anthony ^a   Kadow, Kathleen F ^a   Cianci, Christopher W ^a   Clarke, Junius ^a   Genovesi, Eugene V ^a   Medina, Ivette ^a   Lamb, Lucinda ^a   Krystal, Mark ^a   Meanwell, Nicholas A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Benzimidazoleisatin oximes; Isatin oximes; Respiratory syncytial virus; RSV; RSV fusion inhibitors

Indexed keywords

1 CYCLOPROPYL 1,3 DIHYDRO 3 [[1 (4 HYDROXYBUTYL) 1H BENZIMIDAZOL 2 YL]METHYL] 2H IMIDAZO[4,5 C]PYRIDIN 2 ONE; BENZIMIDAZOLE; BENZIMIDAZOLE 2 ONE DERIVATIVE; ISATIN DERIVATIVE; OXIME DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DRUG STABILITY; IN VIVO STUDY; LIPOPHILICITY; LIVER METABOLISM; LIVER MICROSOME; MOUSE; NONHUMAN; RAT; REACTION OPTIMIZATION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; BENZIMIDAZOLES; CACO-2 CELLS; CELL LINE, TUMOR; HUMANS; ISATIN; MICE; MICE, INBRED BALB C; MICROSOMES, LIVER; OXIMES; RATS; RESPIRATORY SYNCYTIAL VIRUSES; STRUCTURE-ACTIVITY RELATIONSHIP;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

EID: 67651102834     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.030     Document Type: Article

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