Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 16, 2007, Pages 4592-4598

  Wang, Xiangdong Alan ^a   Cianci, Christopher W ^a   Yu, Kuo Long ^a   Combrink, Keith D ^a   Thuring, Jan W ^a   Zhang, Yi ^a   Civiello, Rita L ^a   Kadow, Kathleen F ^a   Roach, Julia ^a   Li, Zhufang ^a   Langley, David R ^a   Krystal, Mark ^a   Meanwell, Nicholas A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

5 Aminomethyl analogue; Asp200; Binding pocket; Resistant virus; Retained activity; RSV fusion inhibitor; Substitution of the benzimidazole

Indexed keywords

ANTIVIRUS AGENT; BENZIMIDAZOL 2 ONE; BENZIMIDAZOLE; BMS 433771; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG IDENTIFICATION; DRUG SYNTHESIS; NONHUMAN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; RESPIRATORY SYNCYTIAL VIRUSES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

EID: 34447310013     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.102     Document Type: Article

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