Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121)

Journal of Medicinal Chemistry

Volumn 51, Issue 4, 2008, Pages 875-896

  Bonfanti, Jean François ^a   Meyer, Christophe ^a   Doublet, Frédéric ^a   Fortin, Jérôme ^a   Müller, Philippe ^a   Queguiner, Laurence ^a   Gevers, Tom ^b   Janssens, Peggy ^b   Szel, Heidi ^b   Willebrords, Rudy ^b   Timmerman, Philip ^b   Wuyts, Koen ^b   Van Remoortere, Pieter ^c   Janssens, Frans ^b   Wigerinck, Piet ^c   Andries, Koen ^b  

^a JOHNSON AND JOHNSON   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c TIBOTEC BVBA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[1 (2 AMINOETHYL) 4 PIPERIDINYL]AMINO] 4 METHYL 1H BENZIMIDAZOL 1 YL]METHYL] 6 METHYL 3 PYRIDINOL; ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; PALIZIVUMAB; RIBAVIRIN; TCM 353121; TMC 353121; UNCLASSIFIED DRUG; VP 146373;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SCREENING; MOLECULAR MODEL; NONHUMAN; PROTEIN CONFORMATION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VIRUS INFECTION;

ANIMALS; ANTIVIRAL AGENTS; BENZIMIDAZOLES; BINDING SITES; DRUG RESISTANCE, VIRAL; MALE; MODELS, MOLECULAR; MORPHOLINES; MUTATION; PROTEIN BINDING; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY SYNCYTIAL VIRUSES; SIGMODONTINAE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL FUSION PROTEINS; VIRUS INTERNALIZATION;

EID: 39749188747     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701284j     Document Type: Article

References (15)