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Volumn 61, Issue 5, 2012, Pages 969-975

β-cell-specific gene repression: A mechanism to protect against inappropriate or maladjusted insulin secretion?

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLUCOKINASE; GLUCOSE; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 1; ORNITHINE OXOACID AMINOTRANSFERASE; PROTEIN HEXOKINASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SOMATOMEDIN BINDING PROTEIN 4; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG;

EID: 84860584838     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1564     Document Type: Review
Times cited : (68)

References (50)
  • 1
    • 0035122488 scopus 로고    scopus 로고
    • Endocrine pancreas plasticity under physiological and pathological conditions
    • Bernard-Kargar C, Ktorza A. Endocrine pancreas plasticity under physiological and pathological conditions. Diabetes 2001;50(Suppl. 1):S30-S35 (Pubitemid 32148212)
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Bernard-Kargar, C.1    Ktorza, A.2
  • 5
    • 78651472654 scopus 로고    scopus 로고
    • Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation
    • Thorrez L, Laudadio I, Van Deun K, et al. Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res 2011;21:95-105
    • (2011) Genome Res , vol.21 , pp. 95-105
    • Thorrez, L.1    Laudadio, I.2    Van Deun, K.3
  • 6
    • 77950450361 scopus 로고    scopus 로고
    • Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- Mice
    • Colsoul B, Schraenen A, Lemaire K, et al. Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci USA 2010;107:5208-5213
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5208-5213
    • Colsoul, B.1    Schraenen, A.2    Lemaire, K.3
  • 7
    • 79953760562 scopus 로고    scopus 로고
    • Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis
    • Lemaire K, Moura RF, Granvik M, et al. Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. PLoS ONE 2011;6:e18517
    • (2011) PLoS ONE , vol.6
    • Lemaire, K.1    Moura, R.F.2    Granvik, M.3
  • 8
    • 70349280000 scopus 로고    scopus 로고
    • Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
    • Lemaire K, Ravier MA, Schraenen A, et al. Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci USA 2009;106:14872-14877
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14872-14877
    • Lemaire, K.1    Ravier, M.A.2    Schraenen, A.3
  • 9
    • 46649115515 scopus 로고    scopus 로고
    • Using ribosomal protein genes as reference: A tale of caution
    • Thorrez L, Van Deun K, Tranchevent LC, et al. Using ribosomal protein genes as reference: a tale of caution. PLoS One 2008;3:e1854
    • (2008) PLoS One , vol.3
    • Thorrez, L.1    Van Deun, K.2    Tranchevent, L.C.3
  • 12
    • 79953749685 scopus 로고    scopus 로고
    • Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells
    • Jermendy A, Toschi E, Aye T, et al. Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells. Diabetologia 2011;54:594-604
    • (2011) Diabetologia , vol.54 , pp. 594-604
    • Jermendy, A.1    Toschi, E.2    Aye, T.3
  • 13
    • 0030810982 scopus 로고    scopus 로고
    • Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells
    • Schuit F, De Vos A, Farfari S, et al. Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem 1997;272:18572-18579
    • (1997) J Biol Chem , vol.272 , pp. 18572-18579
    • Schuit, F.1    De Vos, A.2    Farfari, S.3
  • 14
    • 77952966500 scopus 로고    scopus 로고
    • Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program
    • van Arensbergen J, García-Hurtado J, Moran I, et al. Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program. Genome Res 2010;20:722-732
    • (2010) Genome Res , vol.20 , pp. 722-732
    • Van Arensbergen, J.1    García-Hurtado, J.2    Moran, I.3
  • 15
    • 79960322580 scopus 로고    scopus 로고
    • miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1)
    • Pullen TJ, da Silva Xavier G, Kelsey G, Rutter GA. miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1). Mol Cell Biol 2011;31:3182-3194
    • (2011) Mol Cell Biol , vol.31 , pp. 3182-3194
    • Pullen, T.J.1    Da Silva Xavier, G.2    Kelsey, G.3    Rutter, G.A.4
  • 16
    • 0033553462 scopus 로고    scopus 로고
    • Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes
    • Jonas JC, Sharma A, Hasenkamp W, et al. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 1999;274:14112-14121
    • (1999) J Biol Chem , vol.274 , pp. 14112-14121
    • Jonas, J.C.1    Sharma, A.2    Hasenkamp, W.3
  • 17
    • 34548513528 scopus 로고    scopus 로고
    • Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats
    • DOI 10.1007/s00125-007-0749-2
    • Laybutt DR, Hawkins YC, Lock J, et al. Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia 2007;50:2117-2125 (Pubitemid 47373842)
    • (2007) Diabetologia , vol.50 , Issue.10 , pp. 2117-2125
    • Laybutt, D.R.1    Hawkins, Y.C.2    Lock, J.3    Lebet, J.4    Sharma, A.5    Bonner-Weir, S.6    Weir, G.C.7
  • 19
    • 0025334163 scopus 로고
    • Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes
    • Matschinsky FM. Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes 1990;39:647-652 (Pubitemid 20218960)
    • (1990) Diabetes , vol.39 , Issue.6 , pp. 647-652
    • Matschinsky, F.M.1
  • 22
    • 52249114681 scopus 로고    scopus 로고
    • The islet beta-cell: Fuel responsive and vulnerable
    • Nolan CJ, Prentki M. The islet beta-cell: fuel responsive and vulnerable. Trends Endocrinol Metab 2008;19:285-291
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 285-291
    • Nolan, C.J.1    Prentki, M.2
  • 23
    • 12044255619 scopus 로고
    • Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing
    • Sekine N, Cirulli V, Regazzi R, et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem 1994;269:4895-4902
    • (1994) J Biol Chem , vol.269 , pp. 4895-4902
    • Sekine, N.1    Cirulli, V.2    Regazzi, R.3
  • 24
    • 0035140273 scopus 로고    scopus 로고
    • Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas
    • Zhao C, Wilson MC, Schuit F, Halestrap AP, Rutter GA. Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas. Diabetes 2001;50:361-366 (Pubitemid 32127293)
    • (2001) Diabetes , vol.50 , Issue.2 , pp. 361-366
    • Zhao, C.1    Wilson, M.C.2    Schuit, F.3    Halestrap, A.P.4    Rutter, G.A.5
  • 25
    • 0033431775 scopus 로고    scopus 로고
    • Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells
    • Ishihara H, Wang H, Drewes LR, Wollheim CB. Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells. J Clin Invest 1999;104:1621-1629 (Pubitemid 30002374)
    • (1999) Journal of Clinical Investigation , vol.104 , Issue.11 , pp. 1621-1629
    • Ishihara, H.1    Wang, H.2    Drewes, L.R.3    Wollheim, C.B.4
  • 26
    • 0037221769 scopus 로고    scopus 로고
    • Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release
    • DOI 10.2337/diabetes.52.1.199
    • Otonkoski T, Kaminen N, Ustinov J, et al. Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release. Diabetes 2003;52:199-204 (Pubitemid 36042127)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 199-204
    • Otonkoski, T.1    Kaminen, N.2    Ustinov, J.3    Lapatto, R.4    Meissner, T.5    Mayatepek, E.6    Kere, J.7    Sipila, I.8
  • 28
    • 80052839471 scopus 로고    scopus 로고
    • A low-oxygenated subpopulation of pancreatic islets constitutes a functional reserve of endocrine cells
    • Olsson R, Carlsson PO. A low-oxygenated subpopulation of pancreatic islets constitutes a functional reserve of endocrine cells. Diabetes 2011;60:2068-2075
    • (2011) Diabetes , vol.60 , pp. 2068-2075
    • Olsson, R.1    Carlsson, P.O.2
  • 29
    • 0039829851 scopus 로고
    • Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells
    • Schuit FC, In't Veld PA, Pipeleers DG. Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci USA 1988;85:3865-3869
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3865-3869
    • Schuit, F.C.1    In't Veld, P.A.2    Pipeleers, D.G.3
  • 30
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • DOI 10.1016/0891-5849(96)02051-5
    • Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 1996;20:463-466 (Pubitemid 26077870)
    • (1996) Free Radical Biology and Medicine , vol.20 , Issue.3 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 31
    • 78751513443 scopus 로고    scopus 로고
    • Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells
    • Elsner M, Gehrmann W, Lenzen S. Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells. Diabetes 2011;60:200-208
    • (2011) Diabetes , vol.60 , pp. 200-208
    • Elsner, M.1    Gehrmann, W.2    Lenzen, S.3
  • 32
    • 33748329472 scopus 로고    scopus 로고
    • Metallothionein and catalase sensitize to diabetes in nonobese diabetic mice: Reactive oxygen species may have a protective role in pancreatic beta-cells
    • Li X, Chen H, Epstein PN. Metallothionein and catalase sensitize to diabetes in nonobese diabetic mice: reactive oxygen species may have a protective role in pancreatic beta-cells. Diabetes 2006;55:1592-1604
    • (2006) Diabetes , vol.55 , pp. 1592-1604
    • Li, X.1    Chen, H.2    Epstein, P.N.3
  • 33
    • 20144364947 scopus 로고    scopus 로고
    • Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells
    • DOI 10.1074/jbc.M411869200
    • Martens GA, Cai Y, Hinke S, Stangé G, Van de Casteele M, Pipeleers D. Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. J Biol Chem 2005;280:20389-20396 (Pubitemid 40776738)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.21 , pp. 20389-20396
    • Martens, G.A.1    Cai, Y.2    Hinke, S.3    Stange, G.4    Van De, C.M.5    Pipeleers, D.6
  • 34
    • 70349569257 scopus 로고    scopus 로고
    • Hepatic glutamate metabolism: A tale of 2 hepatocytes
    • Brosnan ME, Brosnan JT. Hepatic glutamate metabolism: a tale of 2 hepatocytes. Am J Clin Nutr 2009;90:857S-861S
    • (2009) Am J Clin Nutr , vol.90
    • Brosnan, M.E.1    Brosnan, J.T.2
  • 35
    • 0346250004 scopus 로고
    • Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy
    • Ramesh V, McClatchey AI, Ramesh N, et al. Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy. Proc Natl Acad Sci USA 1988;85:3777-3780
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3777-3780
    • Ramesh, V.1    McClatchey, A.I.2    Ramesh, N.3
  • 37
    • 67650675165 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2)
    • Liu Z, Habener JF. Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2). Diabetologia 2009;52:1589-1598
    • (2009) Diabetologia , vol.52 , pp. 1589-1598
    • Liu, Z.1    Habener, J.F.2
  • 38
    • 79960907300 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival
    • Liu Z, Stanojevic V, Avadhani S, Yano T, Habener JF. Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival. Diabetologia 2011;54:2067-2076
    • (2011) Diabetologia , vol.54 , pp. 2067-2076
    • Liu, Z.1    Stanojevic, V.2    Avadhani, S.3    Yano, T.4    Habener, J.F.5
  • 39
    • 0025354160 scopus 로고
    • Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis
    • Welsh M, Claesson-Welsh L, Hallberg A, et al. Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis. Proc Natl Acad Sci USA 1990;87:5807-5811
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5807-5811
    • Welsh, M.1    Claesson-Welsh, L.2    Hallberg, A.3
  • 40
    • 80054991835 scopus 로고    scopus 로고
    • PDGF signalling controls age-dependent proliferation in pancreatic b-cells
    • Chen H, Gu X, Liu Y, et al. PDGF signalling controls age-dependent proliferation in pancreatic b-cells. Nature 2011;478:349-355
    • (2011) Nature , vol.478 , pp. 349-355
    • Chen, H.1    Gu, X.2    Liu, Y.3
  • 41
    • 43049104176 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo
    • DOI 10.1210/me.2007-0536
    • Ning Y, Schuller AG, Conover CA, Pintar JE. Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo. Mol Endocrinol 2008;22:1213-1225 (Pubitemid 351629620)
    • (2008) Molecular Endocrinology , vol.22 , Issue.5 , pp. 1213-1225
    • Ning, Y.1    Schuller, A.G.P.2    Conover, C.A.3    Pintar, J.E.4
  • 42
    • 65249157082 scopus 로고    scopus 로고
    • RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer
    • Cho HJ, Baek KE, Park SM, et al. RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer. Clin Cancer Res 2009;15:2612-2619
    • (2009) Clin Cancer Res , vol.15 , pp. 2612-2619
    • Cho, H.J.1    Baek, K.E.2    Park, S.M.3
  • 45
    • 66449119468 scopus 로고    scopus 로고
    • Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function
    • Lin HM, Lee JH, Yadav H, et al. Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function. J Biol Chem 2009;284:12246-12257
    • (2009) J Biol Chem , vol.284 , pp. 12246-12257
    • Lin, H.M.1    Lee, J.H.2    Yadav, H.3
  • 46
    • 0028859374 scopus 로고
    • Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression
    • De Vos A, Heimberg H, Quartier E, et al. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest 1995;96:2489-2495
    • (1995) J Clin Invest , vol.96 , pp. 2489-2495
    • De Vos, A.1    Heimberg, H.2    Quartier, E.3
  • 48
    • 68349146403 scopus 로고    scopus 로고
    • Expression of MafA in pancreatic progenitors is detrimental for pancreatic development
    • Nishimura W, Bonner-Weir S, Sharma A. Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev Biol 2009;333:108-120
    • (2009) Dev Biol , vol.333 , pp. 108-120
    • Nishimura, W.1    Bonner-Weir, S.2    Sharma, A.3


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