NF-κB is the transcription factor for FGF-2 that causes endothelial mesenchymal transformation in cornea

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 3, 2012, Pages 1530-1538

  Lee, Jeong Goo ^a   Kay, EunDuck P ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 1BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL FRACTIONATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CORNEA ENDOTHELIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; NONHUMAN; PIGMENT EPITHELIUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RABBIT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CHROMATIN; CYTOLOGY; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CHROMATIN; ENDOTHELIUM, CORNEAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROBLAST GROWTH FACTOR 2; HUMANS; I-KAPPA B KINASE; IMMUNOBLOTTING; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-1BETA; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; RABBITS; TNF RECEPTOR-ASSOCIATED FACTOR 6;

EID: 84860580606     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-9102     Document Type: Article

References (41)

1. Fuchs E. On keratoplasty. Z Augenheilkd. 1901;5:1-5.
2. Rodrigues MM, Waring GO, Laibson PR, Weinreb S. Endothelial alterations in congenital corneal dystrophies. Am J Ophthalmol. 1975;80:678-689.
3. Waring GO, Laibson PR, Rodrigues M. Clinical and pathologic alterations of Descemet's membrane: with emphasis on endothelial metaplasia. Surv Ophthalmol. 1974;18:325-331.
4. Jakobiec FA, Bhat P. Retrocorneal membranes: a comparative immunohistochemical analysis of keratocytic, endothelial, and epithelial origins. Am J Ophthalmol. 2010;150:230-242.
5. Lee JG, Kay EP. Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-kinase in response to fibroblast growth factor-2 stimulation. J Biol Chem. 2007;282:6444-6454.
6. Lee JG, Kay EP. Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008;49:189-196.
7. Lee JG, Kay EP. PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2. Invest Ophthalmol Vis Sci. 2011;52:417-426.
8. Ko MK, Kay EP. Regulatory role of FGF-2 on type I collagen expression during endothelial mesenchymal transformation. Invest Ophthalmol Vis Sci. 2005;46:4495-4503.
9. Lee JG, Kay EP. Cross-talk among Rho GTPases acting downstream of PI 3-kinase induces mesenchymal transformation of corneal endothelial cells mediated by FGF-2. Invest Ophthalmol Vis Sci. 2006;47:2358-2368.
10. Lee JG, Kay EP. FGF-2-induced wound healing in corneal endothelial cells requires Cdc42 activation and Rho inactivation through the phosphatidylinositol 3-kinase pathway. Invest Ophthalmol Vis Sci. 2006;47:1376-1386.
11. Lee JG, Kay EP. Common and distinct pathways for cellular activities in FGF-2 signaling induced by IL-1β in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2009;50:2067-2076.
12. Lee HT, Lee JG, Na M, Kay EP. FGF-2 induced by interleukin-1β through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells. J Biol Chem. 2004;279:32325-32332.
13. Song J-S, Lee JG, Kay EP. Induction of FGF-2 synthesis by IL-1β in aqueous humor through PI 3-kinase and p38 in rabbit corneal endothelium. Invest Ophthalmol Vis Sci. 2010;51:822-829.
14. Gabay C, Lamacchia C, Palmer G. IL-1 pathways in inflammation and human diseases. Nat Rev Rheumatol. 2010;6:232-241.
15. Dinarello CA. Blocking interleukin-1β in acute and chronic autoinflammatory diseases. J Int Med. 2011;269:16-28.
16. Dinarello CA. A clinical perspective of IL-1 as the gatekeeper of inflammation. Eur J Immunol. 2011;41:1203-1217.
17. Moore JE, McMullen TCB, Campbell IL, et al. The inflammatory milieu associated with conjunctivalized cornea and its alteration with IL-1 RA gene therapy. Invest Ophthalmol Vis Sci. 2002;43: 2905-2915.
18. McDermott AM, Redfern RL, Zhang B, Pei Y, Huang L, Proske RJ. Defensin expression by the cornea: multiple signaling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003;44:1859-1865.
19. Djalilan AR, Nagineni CN, Mahesh SP, Smith JA, Nussenblatt RB, Hooks JJ. Inhibition of inflammatory cytokine production in human corneal cells by dexamethasone, but not cyclosporin. Cornea. 2006;25:709-714.
20. Jung YD, Liu W, Reinmuth N, et al. Vascular endothelial growth factor is upregulated by interleukin-1β in human vascular smooth muscle cells via the p38 mitogen-activated protein kinase pathway. Angiogenesis. 2001;4:155-162.
21. Im H-J, Li X, Muddasani P, et al. Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes. J Cell Physiol. 2008;215:452-463.
22. Watari K, Nakao S, Fotovati A, et al. Role of macrophages in inflammatory lymphangiogenesis: enhanced production of vascular endothelial growth factor C and D through NF-κB activation. Biochem Biophys Res Commun. 2008;377:826-831.
23. Cronauer MV, Stadlmann S, Klocker H, et al. Basic fibroblast growth factor synthesis by human peritoneal mesothelial cells: induction by interleukin-1. Am J Pathol. 1999;155:1977-1984.
24. Sobue T, Zhang X, Florkiewicz RZ, Hurley MM. Interleukin-1 regulates FGF-2 mRNA and localization of FGF-2 protein in human osteoblasts. Biochem Biophys Res Commun. 2001;286: 33-40.
25. Hayashi T, Matsuoka K, Saitoh M, Takeda S, Kimura M. Influence of α-tumor necrosis factor and β-interleukin-1 on production of angiogenetic factors and thymidine phosphorylase activity in immortalized human decidual fibroblasts in vitro. J Obstet Gynaecol Res. 2006;32:15-22.
26. Cahill CM, Rogers J. Interleukin (IL) 1β induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IκB kinase α pathway targeting activator protein-1. J Biol Chem. 2008; 283:25900-25912.
27. Yamazaki K, Gohda J, Kanayama A, et al. Two mechanically and temporally distinct NF-κB activation pathways in IL-1 signaling. Sci Signal. 2009;2:ra66.
28. Neumann D, Lienenklaus S, Rosati O, Martin MU. IL-1-induced phosphorylation of PKB/AKT depends on the presence of IRAK-1. Eur J Immunol. 2002;32:3689-3698.
29. Eda H, Burnette BL, Shimada H, Hope HR, Monahan JB. Interleukin-1β-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor-associated kinase-4. Cell Biol Int. 2011;35:355-358.
30. Chen LF, Greene WC. Shaping the nuclear action of NFκB. Nat Rev Mol Cell Biol. 2004;5:392-401.
31. Kim HJ, Hawke N, Baldwin AS. NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ. 2006;13:738-747.
32. Hayden MS, Ghosh S. Shared principles in NF-κB signaling. Cell. 2008;132:344-362.
33. Kay EP, Smith RE, Nimni ME. Basement membrane collagen synthesis by rabbit corneal endothelial cells in culture. Evidence for an alpha chain derived from a larger biosynthetic precursor. J Biol Chem. 1982;257:7116-7121.
34. Lee JG, Song J-S, Smith RE, Kay EP. Human corneal endothelial cells employ phosphorylation of p27Kip1 at both Ser10 and Thr187 sites for FGF-2-mediated cell proliferation via PI 3-kinase. Invest Ophthalmol Vis Sci. 2011;52:8216 - 8223.
35. Sonoda S, Spee C, Barron E, Ryan SJ, Kannan R, Hinton DR. A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nat Protoc. 2009;4:662-673.
36. Senoo T, Joyce NC. Cell cycle kinetics in corneal endothelium from old and young donors. Invest Ophthalmol Vis Sci. 2000;41:660-667.
37. Joyce NC. Proliferative capacity of corneal endothelial cells. Exp Eye Res. 2012;95:16-23.
38. Lee JG, Ko M, Kay EP. Endothelial mesenchymal transformation mediated by IL-1β- induced FGF-2 in corneal endothelial cells. Exp Eye Res. 2012;95:35-39.
39. Reddy SAG, Huang JH, Liao WS-L. Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NF-κB and AP-1 activation. J Biol Chem. 1997;272:29167-29173.
40. Marmiroli S, Bavelloni A, Faenza I, et al. Phosphatidylinositol 3-kinase is recruited to a specific site in the activated IL-1 receptor 1. FEBS Lett. 1998;438:49-54.
41. Wang KZQ, Wara-Aswapati N, Boch JA, et al. TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src. J Cell Sci. 2006;119:1579-1591.