Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 1, 2008, Pages 189-196

  Lee, Jeong Goo ^a   Kay, Eunduck P ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b DOHENY EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; EYE PROTEIN; FIBROBLAST GROWTH FACTOR 2; PROTEIN CUL1; PROTEIN KPC1; PROTEIN KPC2; PROTEIN SCF SKP2; S PHASE KINASE ASSOCIATED PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; SERINE; THREONINE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CULLIN; CYSTEINE PROTEINASE INHIBITOR; DNA; LEPTOMYCIN B; LEUPEPTIN; UBIQUITIN PROTEIN LIGASE; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA EPITHELIUM; CYTOPLASM; DNA SYNTHESIS; IMMUNOPRECIPITATION; NONHUMAN; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RABBIT; UBIQUITINATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL NUCLEUS; CORNEA ENDOTHELIUM; DNA REPLICATION; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; CULLIN PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYSTEINE PROTEINASE INHIBITORS; CYTOPLASM; DNA; DNA REPLICATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIUM, CORNEAL; FATTY ACIDS, UNSATURATED; FIBROBLAST GROWTH FACTOR 2; IMMUNOPRECIPITATION; LEUPEPTINS; PHOSPHORYLATION; RABBITS; S-PHASE KINASE-ASSOCIATED PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 39549092672     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-0855     Document Type: Article

References (33)

1. Hengst L, Dulic V, Slingerland JM, Lees E, Reed SI. A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc Natl Acad Sci USA. 1994;91:5291-5295.
2. Pagano M, Tam SW, Theodoras AM, et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995;269:682-685.
3. Kip1 accumulation during the cell cycle. Science. 1996;271:1861-1864.
4. Shirane M, Harumiya Y, Ishida N, et al. Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing. J Biol Chem. 1999;274:13886-13893.
5. 1-phase progression. Genes Dev. 1999;13:1501-1512.
6. Lee HT, Kay EP. Regulatory role of PI 3-kinase on expression of Cdk4 and p27, nuclear localization of Cdk4, and phosphorylation of p27 in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2003;44:1521-1528.
7. Ishida N, Kitagawa M, Hatakeyama S, Nakayama K. Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J Biol Chem. 2000;275:25146-25154.
8. Liang J, Zubovitz J, Petrocelli T, et al. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med. 2002;8:1153-1160.
9. Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem. 2002;277:28706-28713.
10. Boehm M, Yoshimoto T, Crook MF, et al. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J. 2002;21:3390-3401.
11. Lee JG, Kay EP. Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-Kinase in response to fibroblast growth factor-2 stimulation. J Biol Chem. 2007;282:6444-6454.
12. Carrano AC, Eytan E, Hershko A, Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol. 1999;1:193-199.
13. Ohta T, Michel JJ, Schottelius AJ, Xiong Y. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell. 1999;3:535-541.
14. Nakayama KI, Nakayama K. Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol. 2005;16:323-333.
15. Sitry D, Seeliger MA, Ko TK, et al. Three different binding sites of Cks1 are required for p27-ubiquitin ligation. J Biol Chem. 2002; 277:42233-42240.
16. Hao B, Zheng N, Schulman BA, et al. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell. 2005;20:9-19.
17. Kamura T, Hara T, Matsumoto M, et al. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol. 2004;6:1229-1235.
18. Kay EP, Smith RE, Nimni ME. Basement membrane collagen synthesis by rabbit corneal endothelial cells in culture: evidence for an alpha chain derived from a larger biosynthetic precursor. J Biol Chem. 1982;257:7116-7121.
19. Kay EP, Gu X, Ninomiya Y, Smith RE. Corneal endothelial modulation: a factor released by leukocytes induces basic fibroblast growth factor that modulates cell shape and collagen. Invest Ophthalmol Vis Sci. 1993;34:663-672.
20. Meriin AB, Gabai VL, Yaglom J, Shifrin VI, Sherman MY. Proteasome inhibitors activate stress kinases and induce Hsp72: diverse effects on apoptosis. J Biol Chem. 1998;273:6373-6379.
21. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
22. Rodier G, Montagnoli A, Di Marcotullio L, et al. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 2001;20:6672-6682.
23. Ishida N, Hara T, Kamura T, et al. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export. J Biol Chem. 2002;277:14355-14358.
24. Kotake Y, Nakayama K, Ishida N, Nakayama KI. Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation. J Biol Chem. 2005; 280:1095-1102.
25. Kip1 antisense-induced proliferative activity of rat corneal endothelial cells. Invest Ophthalmol Vis Sci. 2004;45:1763-1770.
26. KIP1 in the proliferation of the developing corneal endothelium. Invest Ophthalmol Vis Sci. 2004;45:2163-2167.
27. Senoo T, Joyce NC. Cell cycle kinetics in corneal endothelium from old and young donors. Invest Ophthalmol Vis Sci. 2000;41: 660-667.
28. Joyce NC. Proliferative capacity of the corneal endothelium. Prog Retin Eye Res. 2003;22:359-389.
29. Brown SI, Kitano S. Pathogenesis of the retrocorneal membrane. Arch Ophthalmol. 1966;75:518-525.
30. Kay EP, Cheung CC, Jester JV, Nimni ME, Smith RE. Type I collagen and fibronectin synthesis by retrocorneal fibrous membrane. Invest Ophthalmol Vis Sci. 1982;22:200-212.
31. Leung EW, Rife L, Smith RE, Kay EP. Extracellular matrix components in retrocorneal fibrous membrane in comparison to corneal endothelium and Descemet's membrane. Mol Vis. 2000;6:15-23.
32. Kay EP, Gu X, Smith RE. Corneal endothelial modulation: bFGF as direct mediator and corneal endothelium modulation factor as inducer. Invest Ophthalmol Vis Sci. 1994;35:2427-2435.
33. Lee HT, Lee JG, Na M, Kay EP. FGF-2 induced by interleukin-1 beta through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells. J Biol Chem. 2004;279:32325-32332.