Endothelial mesenchymal transformation mediated by IL-1β-induced FGF-2 in corneal endothelial cells

Experimental Eye Research

Volumn 95, Issue 1, 2012, Pages 35-39

  Lee, Jeong Goo ^a   Ko, MinHee K ^a   Kay, EunDuck P ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Corneal endothelial cells; Endothelial mesenchymal transformation; FGF 2; IL 1 ; P27; PI 3 kinase; Retrocorneal fibrous membrane; Rho kinases; Type I collagen

Indexed keywords

COLLAGEN TYPE 1; FIBROBLAST GROWTH FACTOR 2; HEAT SHOCK PROTEIN 47; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR;

ACTIN FILAMENT; ARTICLE; CORNEA ENDOTHELIUM; CYTOKINE RELEASE; DESCEMET MEMBRANE; DESCEMET MEMBRANE ENDOTHELIAL KERATOPLASTY; ENDOTHELIUM CELL; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; HUMAN; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VISUAL IMPAIRMENT;

ACTIN CYTOSKELETON; ANIMALS; CELL SHAPE; COLLAGEN TYPE I; CORNEA; CORNEAL DISEASES; ENDOTHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROBLAST GROWTH FACTOR 2; FIBROSIS; HUMANS; INTERLEUKIN-1BETA; MITOSIS; PHOSPHATIDYLINOSITOL 3-KINASE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84856544096     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.08.003     Document Type: Article

References (42)

1. Arnaud E., Touriol C., Boutonnet C., Gensac M.C., Vagner S., Prats H., Prats A.C. Anew 34-kilodalton isoform of human fibroblast growth factor 2 is cap dependently synthesized by using a non-AUG start codon and behaves as a survival factor. Mol. Cell Biol. 1999, 19:505-514.
2. Banitt M.R., Chopra V. Descemet's stripping with automated endothelial keratoplasty and glaucoma. Curr. Opin. Ophthalmol. 2010, 21:144-149.
3. Bikfalvi A., Klein S., Pintucci G., Rifkin D.B. Biological roles of fibroblast growth factor-2. Endocr. Rev. 1997, 18:26-45.
4. Kip1 and regulates cell cycle progression. EMBO J. 2002, 21:3390-3401.
5. Chen S., Gardner D.G. Suppression of WEE1 and stimulation of CDC25A correlates with endothelin-dependent proliferation of rat aortic smooth muscle cells. J.Biol. Chem. 2004, 279:13755-13763.
6. Cronauer M.V., Stadlmann S., Klocker H., Abendstein B., Eder I.E., Rogatsch H., Zeimet A.G., Marth C., Offner F.A. Basic fibroblast growth factor synthesis by human peritoneal mesothelial cells: induction by interleukin-1. Am. J. Pathol. 1999, 155:1977-1984.
7. Dailey L., Ambrosetti D., Mansukhani A., Basilico C. Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev. 2005, 16:233-247.
8. Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 2009, 27:519-550.
9. Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature 2002, 420:629-635.
10. Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J.Biol. Chem. 2002, 277:28706-28713.
11. Hynes N.C., Dey J.H. Potential for targeting the fibroblast growth factor receptors in breast cancer. Cancer Res. 2010, 70:5199-5202.
12. Jakobiec F.A., Bhat P. Retrocorneal membranes: a comparative immunohistochemical analysis of keratocytic, endothelial, and epithelial origins. Am. J. Ophthalmol. 2010, 150:230-242.
13. Johnson D.E., Williams L.T. Structural and functional diversity in the FGF receptor multigene family. Adv. Cancer Res. 1993, 60:1-41.
14. Joyce N.C. Proliferative capacity of the corneal endothelium. Prog. Retin. Eye Res. 2003, 22:359-389.
15. Kay E.D., Cheung C.-C., Jester J.V., Nimni M.E., Smith R.E. Type I collagen and fibronectin synthesis by retrocorneal fibrous membrane. Invest. Ophthalmol. Vis. Sci. 1982, 22:200-212.
16. Kay E.P., Nimni M.E., Smith R.E. Stability of collagen phenotype in morphologically modulated rabbit corneal endothelial cells. Invest. Ophthalmol. Vis. Sci. 1984, 25:495-501.
17. Kay E.P., Nimni M.E., Smith R.E. Modulation of endothelial cell morphology and collagen synthesis by polymorphonuclear leukocytes. Invest. Ophthalmol. Vis. Sci. 1984, 25:502-512.
18. Kay E.P., Gu X., Ninomiya Y., Smith R.E. Corneal endothelial modulation: a factor released by leukocytes induces basic fibroblast growth factor thatmodulates cell shape and collagen. Invest. Ophthalmol. Vis. Sci. 1993, 34:663-672.
19. Kimura K., Teranishi S., Nishida T. Interleukin-1β-induced disruption of barrier function in cultured human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 2009, 50:597-603.
20. Ko M.K., Kay E.P. Subcellular localization of procollagen I and prolyl 4-hydroxylase in corneal endothelial cells. Exp. Cell Res. 2001, 264:363-371.
21. Ko M.K., Kay E.P. Regulatory role of FGF-2 on type I collagen expression during endothelial mesenchymal transformation. Invest. Ophthalmol. Vis. Sci. 2005, 46:4495-4503.
22. Lee H.T., Kay E.P. FGF-2 induced reorganization and disruption of actin cytoskeleton through PI 3-kinase, Rho, and Cdc42 in corneal endothelial cells. Mol. Vis. 2003, 9:624-634.
23. Lee H.T., Lee J.G., Na M., Kay E.P. FGF-2 induced by interleukin-1β through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells. J.Biol. Chem. 2004, 279:32325-32332.
24. Lee J.G., Kay E.P. Cross-talk among Rho GTPases acting downstream of PI 3-kinase induces mesenchymal transformation of corneal endothelial cells mediated by FGF-2. Invest. Ophthalmol. Vis. Sci. 2006, 47:2358-2368.
25. Lee J.G., Kay E.P. FGF-2-induced wound healing in corneal endothelial cells requires Cdc42 activation and Rho inactivation through the phosphatidylinositol 3-kinase pathway. Invest. Ophthalmol. Vis. Sci. 2006, 47:1376-1386.
26. Lee J.G., Kay E.P. Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-kinase in response to fibroblast growth factor-2 stimulation. J.Biol. Chem. 2007, 282:6444-6454.
27. Lee J.G., Kay E.P. Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells. Invest. Ophthalmol. Vis. Sci. 2008, 49:189-196.
28. Lee J.G., Kay E.P. Common and distinct pathways for cellular activities in FGF-2 signaling induced by IL-1β in corneal endothelial cells. Invest. Ophthalmol. Vis. Sci. 2009, 50:2067-2076.
29. Lee J.G., Kay E.P. PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS andThr187 by Cdc25A/Cdk2. Invest. Ophthalmol. Vis. Sci. 2011, 52:417-426.
30. Liang J., Zubovitz J., Petrocelli T., Kotchetkov R., Connor M.K., Han K., Lee J.H., Ciarallo S., Catzavelos C., Beniston R., Franssen E., Slingerland J.M. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat. Med. 2002, 8:1153-1160.
31. Kip1. Mol. Cell. Biol. 2009, 29:547-558.
32. Nickel W. Unconventional secretion: an extracellular trap for export of fibroblast growth factor 2. J. Cell Sci. 2007, 120:2295-2299.
33. Ornitz D.M., Itoh N. Fibroblast growth factors. Genome Biol. 2001, 2:3005.1-3005.12.
34. Pagano M., Tam S.W., Theodoras A.M., Beer-Romero P., Del Sal G., Chau V., Yew P.R., Draetta G.F., Rolfe M. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 1995, 269:682-685.
35. Prats H., Kaghad M., Prats A.C., Klagsbrun M., Lelias J.M., Liauzun P., Chalon P., Tauber J.P., Amalric F., Smith J.A., Caput D. High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons. Proc. Natl. Acad. Sci. U.S.A. 1989, 86:1836-1840.
36. Price M.O., Price F.W. Descemet's stripping endothelial keratoplasty. Curr. Opin. Ophthalmol. 2007, 18:290-294.
37. 1-phase progression. Genes Dev. 1999, 13:1501-1512.
38. Song J.-S., Lee J.G., Kay E.P. Induction of FGF-2 synthesis by IL-1β in aqueous humor through PI 3-kinase p38 in rabbit corneal endothelium. Invest. Ophthalmol. Vis. Sci. 2010, 51:822-829.
39. Turner N., Grose R. Fibroblast growth factor signalling: from development to cancer. Nat. Rev. Cancer 2010, 10:116-129.
40. Waring G.O. Posterior collagenous layer of the cornea. Ultrastructural classification of abnormal collagenous tissue posterior to Descemet's membrane in 30 cases. Arch. Ophthalmol. 1982, 100:122-134.
41. Young A.L., Tam P.M.K., Lau T.T.Y., Cheng L.L., Rao S.K., Lam P.T.H. Case of post Descemet stripping endothelial keratoplasty retrocorneal fibrous membrane. Clin. Experiment. Ophthalmol. 2009, 37:418-425.
42. Kip1 in the proliferation of the developing corneal endothelium. Invest. Ophthalmol. Vis. Sci. 2004, 45:2163-2167.