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Volumn 11, Issue SUPPL.1, 2011, Pages

Outcome of treatment of chronic myeloid leukemia with second-generation tyrosine kinase inhibitors after imatinib failure

Author keywords

CML; Imatinib; Tyrosine kinase inhibitors

Indexed keywords

ALPHA INTERFERON; BOSUTINIB; CYTARABINE; DASATINIB; HOMOHARRINGTONINE; IMATINIB; NILOTINIB; PEGINTERFERON ALPHA; PONATINIB;

EID: 84860571418     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.1016/j.clml.2011.02.009     Document Type: Conference Paper
Times cited : (10)

References (105)
  • 1
    • 0032999728 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia: Update on biology and treatment
    • Faderl S, Kantarjian HM, Talpaz M. Chronic myelogenous leukemia: update on biology and treatment. Oncology 1999; 2:169-810.
    • (1999) Oncology , vol.2 , pp. 169-810
    • Faderl, S.1    Kantarjian, H.M.2    Talpaz, M.3
  • 2
    • 34447544253 scopus 로고    scopus 로고
    • BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukemia
    • Schiffer CA. BCR-ABL tyrosine kinase inhibitors for chronic myelogenous leukemia. N Engl J Med 2007; 357:258-65.
    • (2007) N Engl J Med , vol.357 , pp. 258-265
    • Schiffer, C.A.1
  • 3
    • 77957067159 scopus 로고    scopus 로고
    • Dasatinib in the treatment of imatinib refractory chronic myeloid leukemia
    • Ramchandren R, Schiffer CA. Dasatinib in the treatment of imatinib refractory chronic myeloid leukemia. Biologics: Targets & Therapy 2009; 3:205-14.
    • (2009) Biologics: Targets & Therapy , vol.3 , pp. 205-214
    • Ramchandren, R.1    Schiffer, C.A.2
  • 4
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers CL. Chronic myeloid leukemia. N Engl J Med 1999; 340:1330-40.
    • (1999) N Engl J Med , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 5
    • 0027296354 scopus 로고
    • Role of p21 RAS in p210 BCR-ABL transformation of murine myeloid cells
    • Mandanas RA, Leibowitz DS, Gharehbaghi K, et al. Role of p21 RAS in p210 BCR-ABL transformation of murine myeloid cells. Blood 1993; 82:1838-47.
    • (1993) Blood , vol.82 , pp. 1838-1847
    • Mandanas, R.A.1    Leibowitz, D.S.2    Gharehbaghi, K.3
  • 6
    • 0027998224 scopus 로고
    • Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-on-cogene Raf-1
    • Okuda K, Matulonis U, Salgia R, et al. Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-on-cogene Raf-1. Exp Hematol 1994; 22:1111-17.
    • (1994) Exp Hematol , vol.22 , pp. 1111-1117
    • Okuda, K.1    Matulonis, U.2    Salgia, R.3
  • 7
    • 0029589929 scopus 로고
    • The BCR-ABL leukemia oncogene activates Jun kinase and requires Jun for transformation
    • Raitano AB, Halper JR, Hambuch TM, et al. The BCR-ABL leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc Natl Acad Sci USA 1995; 92:11746-50.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11746-11750
    • Raitano, A.B.1    Halper, J.R.2    Hambuch, T.M.3
  • 8
    • 0026788001 scopus 로고
    • Dominant negative MYC blocks transformation by ABL oncogenes
    • Sawyers CL, Callahan W, Witte ON. Dominant negative MYC blocks transformation by ABL oncogenes. Cell 1992; 70:901-10.
    • (1992) Cell , vol.70 , pp. 901-910
    • Sawyers, C.L.1    Callahan, W.2    Witte, O.N.3
  • 9
    • 0029810923 scopus 로고    scopus 로고
    • Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
    • Shuai K, Halpern J, Ten Hoeve J, et al. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene 1996; 13:247-54.
    • (1996) Oncogene , vol.13 , pp. 247-254
    • Shuai, K.1    Halpern, J.2    Ten Hoeve, J.3
  • 10
    • 0029863169 scopus 로고    scopus 로고
    • Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by BCR/ABL
    • Carlesso N, Frank DA, Griffin JD. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by BCR/ABL. J Exp Med 1996; 183:811-20.
    • (1996) J Exp Med , vol.183 , pp. 811-820
    • Carlesso, N.1    Frank, D.A.2    Griffin, J.D.3
  • 11
    • 0000506439 scopus 로고    scopus 로고
    • P210 and P190 (BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
    • Ilaria FL Jr, Van Etten RA. P210 and P190 (BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem 1996; 271:31704-10.
    • (1996) J Biol Chem , vol.271 , pp. 31704-31710
    • Ilaria Jr., F.L.1    Van Etten, R.A.2
  • 12
    • 67749135477 scopus 로고    scopus 로고
    • New dosing schedules of dasatinib for CML and adverse event management
    • Wong SF. New dosing schedules of dasatinib for CML and adverse event management. J Hematol Oncol 2009; 2:10-18.
    • (2009) J Hematol Oncol , vol.2 , pp. 10-18
    • Wong, S.F.1
  • 13
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344:1031-37.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 14
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006; 354:2542-51.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 15
    • 10744220743 scopus 로고    scopus 로고
    • Approval summary: Imatinib mesylate capsules for treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase
    • Johnson JR, Bross P, Cohen M, et al. Approval summary: imatinib mesylate capsules for treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Clin Cancer Res 2003; 9:1972-79.
    • (2003) Clin Cancer Res , vol.9 , pp. 1972-1979
    • Johnson, J.R.1    Bross, P.2    Cohen, M.3
  • 16
    • 43449118108 scopus 로고    scopus 로고
    • Front-line treatment of Philadelphia positive chronic myeloid leukemia with imatinib and interferon-alpha: 5-year outcome
    • Palandri F, Iacobucci I, Castagnetti F, et al. Front-line treatment of Philadelphia positive chronic myeloid leukemia with imatinib and interferon-alpha: 5-year outcome. Haematologica 2008; 93:770-4.
    • (2008) Haematologica , vol.93 , pp. 770-774
    • Palandri, F.1    Iacobucci, I.2    Castagnetti, F.3
  • 17
    • 84860595231 scopus 로고    scopus 로고
    • East Hanover, NJ: Novartis Pharmaceuticals Corporation
    • Gleevec ®[package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2007.
    • (2007) Gleevec ®[Package Insert]
  • 18
    • 67349179696 scopus 로고    scopus 로고
    • Treatment selection after imatinib resistance in chronic myeloid leukemia
    • Jabbour E, Cortes J, Kantarjian H. Treatment selection after imatinib resistance in chronic myeloid leukemia. Targ Oncol 2009; 4:3-10.
    • (2009) Targ Oncol , vol.4 , pp. 3-10
    • Jabbour, E.1    Cortes, J.2    Kantarjian, H.3
  • 19
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Bradford S, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003; 349:1423-32.
    • (2003) N Engl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Bradford, S.3
  • 20
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic phase chronic myeloid leukemia. N Engl J Med 2003; 348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 21
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien S, et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355:2408-17.
    • (2006) N Engl J Med , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.3
  • 22
    • 77949767505 scopus 로고    scopus 로고
    • International randomized study of interferon vs. STI571 (IRIS) 8-year follow up: Sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib
    • Abstr 1126
    • Deininger M, O'Brien SG, Guilhot F, et al. International randomized study of interferon vs. STI571 (IRIS) 8-year follow up: sustained survival and low risk for progression or events in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib. Blood 2009; 114 (abstr):1126.
    • (2009) Blood , vol.114
    • Deininger, M.1    O'Brien, S.G.2    Guilhot, F.3
  • 23
    • 33747154547 scopus 로고    scopus 로고
    • Evolving concepts in the management of chronic myeloid leukemia: Recommendations from an expert panel on behalf of the European Leukemia Net
    • Baccarani M, Saglio G, Goldman J, et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European Leukemia Net. Blood 2006; 108:1809-20.
    • (2006) Blood , vol.108 , pp. 1809-1820
    • Baccarani, M.1    Saglio, G.2    Goldman, J.3
  • 24
    • 33748133844 scopus 로고    scopus 로고
    • Survival advantage from imatinib compared with the combination interferon-A plus cytarabine in chronic-phase chronic my-elogenous leukemia: Historical comparison between two phase 3 trials
    • Roy L, Guilhot J, Krahnke T, et al. Survival advantage from imatinib compared with the combination interferon-a plus cytarabine in chronic-phase chronic my-elogenous leukemia: historical comparison between two phase 3 trials. Blood 2006; 108:1478-84.
    • (2006) Blood , vol.108 , pp. 1478-1484
    • Roy, L.1    Guilhot, J.2    Krahnke, T.3
  • 25
    • 33748696341 scopus 로고    scopus 로고
    • Survival benefit with imatinib mesylate versus interferon-a-based regimens in newly diagnosed chronic-phase chronic my-elogenous leukemia
    • Kantarjian H, Talpaz M, O'Brien S, et al. Survival benefit with imatinib mesylate versus interferon-a-based regimens in newly diagnosed chronic-phase chronic my-elogenous leukemia. Blood 2006; 108:1835-40.
    • (2006) Blood , vol.108 , pp. 1835-1840
    • Kantarjian, H.1    Talpaz, M.2    O'Brien, S.3
  • 26
    • 58149396984 scopus 로고    scopus 로고
    • European Leukemia Net criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor
    • Marin D, Milojkovic D, Olavarria E, et al. European Leukemia Net criteria for failure or suboptimal response reliably identify patients with CML in early chronic phase treated with imatinib whose eventual outcome is poor. Blood 2008; 112:4437-44.
    • (2008) Blood , vol.112 , pp. 4437-4444
    • Marin, D.1    Milojkovic, D.2    Olavarria, E.3
  • 27
    • 68549098145 scopus 로고    scopus 로고
    • Significance of suboptimal response to imatinib, as defined by the European Leukemia Net, in the long-term outcome of patients with early chronic myeloid leukemia in chronic phase
    • Alvarado Y, Kantarjian H, O'Brien S, et al. Significance of suboptimal response to imatinib, as defined by the European Leukemia Net, in the long-term outcome of patients with early chronic myeloid leukemia in chronic phase. Cancer 2009; 115:3709-18.
    • (2009) Cancer , vol.115 , pp. 3709-3718
    • Alvarado, Y.1    Kantarjian, H.2    O'Brien, S.3
  • 28
    • 10744229080 scopus 로고    scopus 로고
    • Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Bradford S, et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. NEngl J Med 2003; 349:1423-32.
    • (2003) NEngl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Bradford, S.3
  • 29
    • 37549072095 scopus 로고    scopus 로고
    • National Comprehensive Cancer network [Web site] Accessed: May 23, 2010
    • NCCN Clinical Practice Guidelines in Oncology: chronic myelogenous leukemia. National Comprehensive Cancer network [Web site]. Available at: http://www.nc-cn.org/professionals/physician-gls/PDF/cml.pdf. Accessed: May 23, 2010.
    • NCCN Clinical Practice Guidelines in Oncology: Chronic Myelogenous Leukemia
  • 30
    • 77749288978 scopus 로고    scopus 로고
    • Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance
    • Bixby D, Talpaz M. Mechanisms of resistance to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies to overcome resistance. Hematology Am Soc of Hematology Educ Program 2009:46176.
    • (2009) Hematology Am Soc of Hematology Educ Program , pp. 46176
    • Bixby, D.1    Talpaz, M.2
  • 31
    • 67349233062 scopus 로고    scopus 로고
    • Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia
    • Hochhaus A, O'Brien SG, Guilhot F, et al. Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia. Leukemia 2009; 23:1054-61.
    • (2009) Leukemia , vol.23 , pp. 1054-1061
    • Hochhaus, A.1    O'Brien, S.G.2    Guilhot, F.3
  • 33
    • 39049127041 scopus 로고    scopus 로고
    • Overcoming kinase resistance in chronic myeloid leukemia
    • Lee F, Fandi A, Voi M. Overcoming kinase resistance in chronic myeloid leukemia. Int J Biochem Cell Biol 2008;40:334-43.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 334-343
    • Lee, F.1    Fandi, A.2    Voi, M.3
  • 34
    • 0034665713 scopus 로고    scopus 로고
    • Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase
    • Schindler T, Bornmann W, Pellicena P, et al. Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase. Science 2000; 289:1938-42.
    • (2000) Science , vol.289 , pp. 1938-1942
    • Schindler, T.1    Bornmann, W.2    Pellicena, P.3
  • 35
    • 10744232328 scopus 로고    scopus 로고
    • Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
    • Branford S, Rudzki Z, Walsh S, et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003; 102:276-83.
    • (2003) Blood , vol.102 , pp. 276-283
    • Branford, S.1    Rudzki, Z.2    Walsh, S.3
  • 36
    • 33750077276 scopus 로고    scopus 로고
    • Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate
    • Jabbour E, Kantarjian H, Jones D, et al. Frequency and clinical significance of BCR-ABL mutations in patients with chronic myeloid leukemia treated with imatinib mesylate. Leukemia 2006; 20:1767-73.
    • (2006) Leukemia , vol.20 , pp. 1767-1773
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3
  • 37
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A, Kreil S, Corbin AS, et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 16:2190-96.
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3
  • 38
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of BCR-ABL inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant ABL kinase domain mutants
    • O'Hare T, Walters DK, Stoffregen EP, et al. In vitro activity of BCR-ABL inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant ABL kinase domain mutants. Cancer Res 2005; 65:4500-05.
    • (2005) Cancer Res , vol.65 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3
  • 39
    • 79959308232 scopus 로고    scopus 로고
    • Loss of response to imatinib: Mechanisms and management
    • Shah NP. Loss of response to imatinib: mechanisms and management. Hematology Am Soc Hematol Educ Program 2005:183-7.
    • (2005) Hematology Am Soc Hematol Educ Program , pp. 183-187
    • Shah, N.P.1
  • 40
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005; 105:2640-53.
    • (2005) Blood , vol.105 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 41
    • 0034210577 scopus 로고    scopus 로고
    • Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines
    • Weisberg E, Griffin JD. Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines. Blood 2000; 95:3498-3505.
    • (2000) Blood , vol.95 , pp. 3498-3505
    • Weisberg, E.1    Griffin, J.D.2
  • 42
    • 0034161460 scopus 로고    scopus 로고
    • Induction of resistance to the Abelson inhibitor STI571 in human leukemia cells through gene amplification
    • le Coutre P, Tassi E, Varella-Garcia M, et al. Induction of resistance to the Abelson inhibitor STI571 in human leukemia cells through gene amplification. Blood 2000; 95:1758-66.
    • (2000) Blood , vol.95 , pp. 1758-1766
    • Le Coutre, P.1    Tassi, E.2    Varella-Garcia, M.3
  • 43
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance
    • Mahon FX, Deininger MW, Schultheis B, et al. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance. Blood 2000; 96:1070-79.
    • (2000) Blood , vol.96 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.2    Schultheis, B.3
  • 44
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293: 876-80.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 45
    • 17744421180 scopus 로고    scopus 로고
    • Reversal of P-glycoprotein mediated multidrug resistance by a newly synthesized 1, 4-benzothiaxipine derivative, JTV-519
    • Che XF, Nakajima Y, Sumizawa T, et al. Reversal of P-glycoprotein mediated multidrug resistance by a newly synthesized 1, 4-benzothiaxipine derivative, JTV-519. Cancer Lett 2002; 187:111-19.
    • (2002) Cancer Lett , vol.187 , pp. 111-119
    • Che, X.F.1    Nakajima, Y.2    Sumizawa, T.3
  • 46
    • 0041878883 scopus 로고    scopus 로고
    • Anti-proliferative effect of the ABL tyrosine kinase inhibitor STI571 on the P-glycoprotein positive K562/ADM cell line
    • Kotaki M, Motoji T, Takanashi M, et al. Anti-proliferative effect of the ABL tyrosine kinase inhibitor STI571 on the P-glycoprotein positive K562/ADM cell line. Cancer Lett 2003; 199:61-68.
    • (2003) Cancer Lett , vol.199 , pp. 61-68
    • Kotaki, M.1    Motoji, T.2    Takanashi, M.3
  • 47
    • 20444482337 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines
    • Rumpold H, Wolf AM, Gruenewald K, et al. RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines. Exp Hematol 2005; 33:767-75.
    • (2005) Exp Hematol , vol.33 , pp. 767-775
    • Rumpold, H.1    Wolf, A.M.2    Gruenewald, K.3
  • 48
    • 9444282642 scopus 로고    scopus 로고
    • Active transport of imatinib into and out of cells: Implications for drug resistance
    • Thomas J, Wang L, Clark RE, et al. Active transport of imatinib into and out of cells: implications for drug resistance. Blood 2004; 104:3739-45.
    • (2004) Blood , vol.104 , pp. 3739-3745
    • Thomas, J.1    Wang, L.2    Clark, R.E.3
  • 49
    • 33745085275 scopus 로고    scopus 로고
    • OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): Reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
    • White DL, Saunders VA, Dang P, et al. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. Blood 2006; 108:697-704.
    • (2006) Blood , vol.108 , pp. 697-704
    • White, D.L.1    Saunders, V.A.2    Dang, P.3
  • 50
    • 68549084355 scopus 로고    scopus 로고
    • CML patients with low OCT-1 activity achieve better molecular responses on high dose imatinib than on standard dose. Those with high OCT-1 activity have excellent responses on either dose: A TOPS correlative study
    • Abstr 3187
    • White DL, Saunders VA, Dang P, et al. CML patients with low OCT-1 activity achieve better molecular responses on high dose imatinib than on standard dose. Those with high OCT-1 activity have excellent responses on either dose: a TOPS correlative study. Blood 2008; 112 (abstr):3187.
    • (2008) Blood , vol.112
    • White, D.L.1    Saunders, V.A.2    Dang, P.3
  • 51
    • 38349193809 scopus 로고    scopus 로고
    • Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia
    • Wang L, Giannoudis A, Lane S, et al. Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. Clin Pharmacol Ther 2008; 83:258-64.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 258-264
    • Wang, L.1    Giannoudis, A.2    Lane, S.3
  • 52
    • 0034684075 scopus 로고    scopus 로고
    • Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL (+) leukemic cells to the ABL inhibitor STI571
    • Gambacorti-Passerini C, Barni R, le Coutre P, et al. Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL (+) leukemic cells to the ABL inhibitor STI571. JNatl Cancer Inst 2000; 92:1641-50.
    • (2000) JNatl Cancer Inst , vol.92 , pp. 1641-1650
    • Gambacorti-Passerini, C.1    Barni, R.2    Le Coutre, P.3
  • 53
    • 0042305479 scopus 로고    scopus 로고
    • Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients
    • Gambacorti-Passerini C, Zucchetti M, Russo D, et al. Alpha1 acid glycoprotein binds to imatinib (STI571) and substantially alters its pharmacokinetics in chronic myeloid leukemia patients. Clin Cancer Res 2003; 9:625-32.
    • (2003) Clin Cancer Res , vol.9 , pp. 625-632
    • Gambacorti-Passerini, C.1    Zucchetti, M.2    Russo, D.3
  • 54
    • 33746881712 scopus 로고    scopus 로고
    • Population pharmacokinetics of imatinib and the role of alpha-acid glycoprotein
    • Widmer N, Decosterd LA, Csajka C, et al. Population pharmacokinetics of imatinib and the role of alpha-acid glycoprotein. Br J Clin Pharmacol 2006; 62:97-112.
    • (2006) Br J Clin Pharmacol , vol.62 , pp. 97-112
    • Widmer, N.1    Decosterd, L.A.2    Csajka, C.3
  • 55
    • 77952467377 scopus 로고    scopus 로고
    • Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib
    • Marin D, Bazeos A, Mahon FX, et al. Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib.J Clin Oncol 2010; 28:2381-88.
    • (2010) J Clin Oncol , vol.28 , pp. 2381-2388
    • Marin, D.1    Bazeos, A.2    Mahon, F.X.3
  • 56
    • 34249782019 scopus 로고    scopus 로고
    • Treatment interruptions and on-adher-ence with imatinib and associated healthcare costs: A retrospective analysis among managed care patients with chronic myelogenous leukaemia
    • Darkow T, Henk HJ, Thomas SK, et al. Treatment interruptions and on-adher-ence with imatinib and associated healthcare costs: a retrospective analysis among managed care patients with chronic myelogenous leukaemia. Pharmacoeconomics 2007; 25:481-96.
    • (2007) Pharmacoeconomics , vol.25 , pp. 481-496
    • Darkow, T.1    Henk, H.J.2    Thomas, S.K.3
  • 57
    • 67049087117 scopus 로고    scopus 로고
    • Prevalence determinants and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: The ADAGIO study
    • Noens L, van Lierde MA, De Bock R, et al. Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: The ADAGIO study. Blood 2009; 113:5401-11.
    • (2009) Blood , vol.113 , pp. 5401-5411
    • Noens, L.1    Van Lierde, M.A.2    De Bock, R.3
  • 58
    • 60049092698 scopus 로고    scopus 로고
    • Efficacy of imatinib dose escalation in patients with chronic myeloid leukemia in chronic phase
    • Kantarjian HM, Larson RA, Guilhot F, et al. Efficacy of imatinib dose escalation in patients with chronic myeloid leukemia in chronic phase. Cancer 2009; 115:551-60.
    • (2009) Cancer , vol.115 , pp. 551-560
    • Kantarjian, H.M.1    Larson, R.A.2    Guilhot, F.3
  • 59
    • 64049099666 scopus 로고    scopus 로고
    • Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia post cytogenetic failure on standard-dose imatinib therapy
    • Jabbour E, Kantarjian H, O'Brien S, et al. Imatinib mesylate dose escalation is associated with durable responses in patients with chronic myeloid leukemia post cytogenetic failure on standard-dose imatinib therapy. Blood 2008; 113:2154-60.
    • (2008) Blood , vol.113 , pp. 2154-2160
    • Jabbour, E.1    Kantarjian, H.2    O'Brien, S.3
  • 60
    • 74249106495 scopus 로고    scopus 로고
    • Princeton NJ: [package insert]
    • Sprycel® (dasatinib), Princeton NJ: [package insert]. 2007.
    • (2007) Sprycel® (Dasatinib)
  • 61
    • 38949134552 scopus 로고    scopus 로고
    • Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate
    • Brave M, Goodman V, Kaminskas E, et al. Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. Clin Cancer Res 2008; 14:352-59.
    • (2008) Clin Cancer Res , vol.14 , pp. 352-359
    • Brave, M.1    Goodman, V.2    Kaminskas, E.3
  • 62
    • 54949154484 scopus 로고    scopus 로고
    • Dasatinib 2-year efficacy in patients with chronic-phase chronic myelogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C)
    • Abstr 7009
    • Mauro MJ, Baccarani F, Cervantes JH, et al. Dasatinib 2-year efficacy in patients with chronic-phase chronic myelogenous leukemia (CML-CP) with resistance or intolerance to imatinib (START-C). J Clin Oncol 2009; 26: (abstr) 7009.
    • (2009) J Clin Oncol , vol.26
    • Mauro, M.J.1    Baccarani, F.2    Cervantes, J.H.3
  • 63
    • 34848876293 scopus 로고    scopus 로고
    • Dasatinib 50 mg or 70 mg BID compared to 100 mg or 140 mg QD in patients with CML in chronic phase (CP) who are resistant or intolerant to imatinib: One-year results of CA180034
    • ABSTR 7004
    • Shah NP, Kim DW, Kantarjian HM, et al. Dasatinib 50 mg or 70 mg BID compared to 100 mg or 140 mg QD in patients with CML in chronic phase (CP) who are resistant or intolerant to imatinib: One-year results of CA180034. J Clin Oncol 2007 25 ((abstr 7004):18S.
    • (2007) J Clin Oncol , vol.25
    • Shah, N.P.1    Kim, D.W.2    Kantarjian, H.M.3
  • 64
    • 73949105873 scopus 로고    scopus 로고
    • Dasatinib treatment of chronic-phase chronic myeloid leukemia: Analysis of responses according to preexisting BCR-ABL mutations
    • Muller MC, Cortes JE, Kim DW, et al. Dasatinib treatment of chronic-phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations. Blood 2009; 114:4944-53.
    • (2009) Blood , vol.114 , pp. 4944-4953
    • Muller, M.C.1    Cortes, J.E.2    Kim, D.W.3
  • 65
    • 70249141675 scopus 로고    scopus 로고
    • Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: The START-A trial
    • Apperley JF, Cortes JE, Kim DW, et al. Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START-A trial. J Clin Oncol 2009; 27:3472-79.
    • (2009) J Clin Oncol , vol.27 , pp. 3472-3479
    • Apperley, J.F.1    Cortes, J.E.2    Kim, D.W.3
  • 66
    • 67650607999 scopus 로고    scopus 로고
    • Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up
    • Kantarjian H, Cortes J, Kim DW, et al. Phase 3 study of dasatinib 140 mg once daily versus 70 mg twice daily in patients with chronic myeloid leukemia in accelerated phase resistant or intolerant to imatinib: 15-month median follow-up. Blood 2009; 113:6322-29.
    • (2009) Blood , vol.113 , pp. 6322-6329
    • Kantarjian, H.1    Cortes, J.2    Kim, D.W.3
  • 67
    • 34548523623 scopus 로고    scopus 로고
    • Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure
    • Quintas-Cardama A, Kantarjian H, O'Brien S, et al. Pleural effusion in patients with chronic myelogenous leukemia treated with dasatinib after imatinib failure. J Clin Oncol 2007; 25:3908-14.
    • (2007) J Clin Oncol , vol.25 , pp. 3908-3914
    • Quintas-Cardama, A.1    Kantarjian, H.2    O'Brien, S.3
  • 68
    • 67651089848 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia
    • Quintas-Cardama A, Han X, Kantarjian H, Cortes J. Tyrosine kinase inhibitor-induced platelet dysfunction in patients with chronic myeloid leukemia. Blood 2009; 114:261-63.
    • (2009) Blood , vol.114 , pp. 261-263
    • Quintas-Cardama, A.1    Han, X.2    Kantarjian, H.3    Cortes, J.4
  • 69
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006; 354:2542-51.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 71
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005; 105:2640-53.
    • (2005) Blood , vol.105 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 72
    • 74849136196 scopus 로고    scopus 로고
    • Nilotinib in chronic myeloid leukemia patients in accelerated phase (CML-AP) with imatinib resistance or intolerance: 24-month follow-up results of a phase 2 study
    • abstr 0631
    • Hochhaus A, Giles F, Apperley J, et al. Nilotinib in chronic myeloid leukemia patients in accelerated phase (CML-AP) with imatinib resistance or intolerance: 24-month follow-up results of a phase 2 study. Haematologica 2009; 94 (suppl 2; abstr 0631):256.
    • (2009) Haematologica , vol.94 , Issue.SUPPL. 2 , pp. 256
    • Hochhaus, A.1    Giles, F.2    Apperley, J.3
  • 73
    • 57749172532 scopus 로고    scopus 로고
    • Incidence of grade 3/4 adverse events in imatinib resistant/intolerant chronic phase CML (CP-CML): A comparison of nilotinib and dasatinib
    • Abstr 17501
    • Carpiuc KT, Stephens JM, Liou SY, et al. Incidence of grade 3/4 adverse events in imatinib resistant/intolerant chronic phase CML (CP-CML): A comparison of nilotinib and dasatinib.J Clin Oncol 2007; 25 (abstr): 17501.
    • (2007) J Clin Oncol , vol.25
    • Carpiuc, K.T.1    Stephens, J.M.2    Liou, S.Y.3
  • 74
    • 84860555159 scopus 로고    scopus 로고
    • Nilotinib is associated with minimal cross intolerance to imatinib in patients with imatinib-intolerant chronic myelogenous leukemia (CML) in chronic phase (CP)
    • Abstr 7039
    • Jabbour E, le Coutre P, Baccarani M, et al. Nilotinib is associated with minimal cross intolerance to imatinib in patients with imatinib-intolerant chronic myelogenous leukemia (CML) in chronic phase (CP). Blood 2009; 25 (abstr) 7039.
    • (2009) Blood , vol.25
    • Jabbour, E.1    Le Coutre, P.2    Baccarani, M.3
  • 75
    • 65649108082 scopus 로고    scopus 로고
    • Efficacy and safety of bosutinib (SKI-606) in patients with chronic phase (CP) Ph+ chronic myelogenous leukemia (CML) with resistance or intolerance to imatinib
    • Abstr 1098
    • Cortes J, Kantarjian HM, Kim DW, et al. Efficacy and safety of bosutinib (SKI-606) in patients with chronic phase (CP) Ph+ chronic myelogenous leukemia (CML) with resistance or intolerance to imatinib. Blood 2008; 112 (abstr): 1098.
    • (2008) Blood , vol.112
    • Cortes, J.1    Kantarjian, H.M.2    Kim, D.W.3
  • 76
    • 77949674913 scopus 로고    scopus 로고
    • A phase 1 trial of oral AP24534 inpatients with refractory chronic myeloid leukemia and other hematologic malignancies: First results of safety and clinical activity against T315I and resistant mutations
    • Abstr 643
    • Cortes J, Talpaz M, Deininger M, et al. A phase 1 trial of oral AP24534 inpatients with refractory chronic myeloid leukemia and other hematologic malignancies: first results of safety and clinical activity against T315I and resistant mutations. Blood 2009; 114 (abstr): 643.
    • (2009) Blood , vol.114
    • Cortes, J.1    Talpaz, M.2    Deininger, M.3
  • 77
    • 77957089790 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in chronic myeloid leukemia (CML) patients who are resistant or intolerant to two or more tyrosine kinase inhibitors-results of a multicenter phase 2/3 study
    • Abstr 861
    • Cortes-Franco J, Raghunadharao D, Parikh P, et al. Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in chronic myeloid leukemia (CML) patients who are resistant or intolerant to two or more tyrosine kinase inhibitors-results of a multicenter phase 2/3 study. Blood 2009; 114 (abstr): 861.
    • (2009) Blood , vol.114
    • Cortes-Franco, J.1    Raghunadharao, D.2    Parikh, P.3
  • 78
    • 77950394312 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in imatinib-resistant chronic myeloid leukemia (CML) patients who harbor the BCR-ABL T315I mutation-results of an ongoing multicenter phase 2/3 study
    • Abstr 644
    • Cortes-Franco J, Khoury HJ, Emmanuel F, et al. Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in imatinib-resistant chronic myeloid leukemia (CML) patients who harbor the BCR-ABL T315I mutation-results of an ongoing multicenter phase 2/3 study. Blood 2009; 114 (abstr): 644.
    • (2009) Blood , vol.114
    • Cortes-Franco, J.1    Khoury, H.J.2    Emmanuel, F.3
  • 79
    • 84860559238 scopus 로고    scopus 로고
    • Subcutaneous omacetaxine (OM) treatment of chronic phase (cp) chronic myeloid leukemia (CML) patients following multiple tyrosine kinase inhibitor (TKI) Failure
    • December 4-7, 2010; Orlando, Florida. Abstract 2290
    • Cortes JE, Wetzler M, Lipton J, et al. Subcutaneous omacetaxine (OM) treatment of chronic phase (cp) chronic myeloid leukemia (CML) patients following multiple tyrosine kinase inhibitor (TKI) Failure. Program and abstracts of the 52nd American Society of Hematology Annual Meeting and Exposition; December 4-7, 2010; Orlando, Florida. Abstract 2290.
    • Program and Abstracts of the 52nd American Society of Hematology Annual Meeting and Exposition
    • Cortes, J.E.1    Wetzler, M.2    Lipton, J.3
  • 80
    • 68549097002 scopus 로고    scopus 로고
    • International randomized study of interferon versus STI571 (IRIS) 7-Year follow-up: Sustained survival low rate of transformation and increased rate of major molecular response (MMR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (IM) [abstract]
    • Abstr 186
    • O'Brien SG, Guilhot F, Goldman JM, et al. International randomized study of interferon versus STI571 (IRIS) 7-Year follow-up: sustained survival, low rate of transformation and increased rate of major molecular response (MMR) in patients (pts) with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) treated with imatinib (IM) [abstract]. Blood 2008; 112 (suppl; abstr): 186.
    • (2008) Blood , vol.112 , Issue.SUPPL.
    • O'Brien, S.G.1    Guilhot, F.2    Goldman, J.M.3
  • 81
    • 70149105272 scopus 로고    scopus 로고
    • Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia resistant to imatinib at a dose of 400 to 600 milligrams daily: Two-year follow-up of a randomized phase 2 study (START-R)
    • Kantarjian H, Pasquinin R, Levy V, et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia resistant to imatinib at a dose of 400 to 600 milligrams daily: two-year follow-up of a randomized phase 2 study (START-R). Cancer 2009 115: 4136-47.
    • (2009) Cancer , vol.115 , pp. 4136-4147
    • Kantarjian, H.1    Pasquinin, R.2    Levy, V.3
  • 82
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H, Giles F, Wunderle L, et al. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006; 354:2542-51.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 83
    • 33947280081 scopus 로고    scopus 로고
    • Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
    • Hochhaus A, Kantarjian HM, Baccarani M, et al. Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2007; 109: 2303-9.
    • (2007) Blood , vol.109 , pp. 2303-2309
    • Hochhaus, A.1    Kantarjian, H.M.2    Baccarani, M.3
  • 84
    • 37049003546 scopus 로고    scopus 로고
    • Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors
    • Cortes J, Jabbour E, Kantarjian H, et al. Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. Blood 2007; 110:4005-11.
    • (2007) Blood , vol.110 , pp. 4005-4011
    • Cortes, J.1    Jabbour, E.2    Kantarjian, H.3
  • 85
    • 47249123747 scopus 로고    scopus 로고
    • Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy
    • Jabbour E, Kantarjian H, Jones D, et al. Characteristics and outcomes of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy. Blood 2008; 112:53-5.
    • (2008) Blood , vol.112 , pp. 53-55
    • Jabbour, E.1    Kantarjian, H.2    Jones, D.3
  • 86
    • 70349245253 scopus 로고    scopus 로고
    • Long-term outcome of patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations
    • Jabbour E, Jones D, Kantarjian HM, et al. Long-term outcome of patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations. Blood 2009; 114:2037-43.
    • (2009) Blood , vol.114 , pp. 2037-2043
    • Jabbour, E.1    Jones, D.2    Kantarjian, H.M.3
  • 87
    • 34548825177 scopus 로고    scopus 로고
    • Presence or the emergence of a F317L BCR-ABL mutation may be associated with resistance to dasatinib in Philadelphia chromosome-positive leukemia
    • Soverini S, Martinelli G, Colarossi S, et al. Presence or the emergence of a F317L BCR-ABL mutation may be associated with resistance to dasatinib in Philadelphia chromosome-positive leukemia. Blood 2006; 24:51-52.
    • (2006) Blood , vol.24 , pp. 51-52
    • Soverini, S.1    Martinelli, G.2    Colarossi, S.3
  • 88
    • 58149380741 scopus 로고    scopus 로고
    • Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors
    • Jabbour E, Kantarjian HM, Jones D, et al. Characteristics and outcome of chronic myeloid leukemia patients with F317L BCR-ABL kinase domain mutation after therapy with tyrosine kinase inhibitors. Blood 2008 112 (suppl B):4839-42.
    • (2008) Blood , vol.112 , Issue.SUPPL. B , pp. 4839-4842
    • Jabbour, E.1    Kantarjian, H.M.2    Jones, D.3
  • 89
    • 73949105873 scopus 로고    scopus 로고
    • Dasatinib treatment of chronic phase chronic myeloid leukemia: Analysis of responses according to pre-existing BCR-ABL mutations
    • Müller MC, Cortes JE, Kim D-W, et al. Dasatinib treatment of chronic phase chronic myeloid leukemia: analysis of responses according to pre-existing BCR-ABL mutations. Blood; 2009; 114:4544-53.
    • (2009) Blood , vol.114 , pp. 4544-4553
    • Müller, M.C.1    Cortes, J.E.2    Kim, D.-W.3
  • 90
    • 77949674913 scopus 로고    scopus 로고
    • A Phase 1 trial oforal AP24534 inpatients with refractory chronic myeloid leukemia and other hematologic malignancies: First results of safety and clinical activity against T315I and resistant mutations
    • Abstr 643
    • Cortes J, Talpaz M, Deininger M, et al. A Phase 1 trial oforal AP24534 inpatients with refractory chronic myeloid leukemia and other hematologic malignancies: first results of safety and clinical activity against T315I and resistant mutations. Blood 2009; 114 (abstr): 643.
    • (2009) Blood , vol.114
    • Cortes, J.1    Talpaz, M.2    Deininger, M.3
  • 91
    • 77950394312 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in imatinib-resistant chronic myeloid leukemia (CML) patients who harbor the Bcr-AblT315I mutation-results of an ongoing multicenter phase 2/3 study
    • Abstr 644
    • Cortes-Franco J, Khoury HJ, Nicolini FE, et al. Safety and efficacy of subcutaneous-administered omacetaxine mepesuccinate in imatinib-resistant chronic myeloid leukemia (CML) patients who harbor the Bcr-AblT315I mutation-results of an ongoing multicenter phase 2/3 study. Blood 2009; 114 (abstr): 644.
    • (2009) Blood , vol.114
    • Cortes-Franco, J.1    Khoury, H.J.2    Nicolini, F.E.3
  • 92
    • 77957071416 scopus 로고    scopus 로고
    • Prognostic factors for progression-free survival in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in chronic phase (CML-CP) treated with nilotinib based on 24 month data
    • Kantarjian HM, Jabbour E, Giles FJ, et al. Prognostic factors for progression-free survival in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in chronic phase (CML-CP) treated with nilotinib based on 24 month data. Blood 2009; 113 (suppl D):3298.
    • (2009) Blood , vol.113 , Issue.SUPPL. D , pp. 3298
    • Kantarjian, H.M.1    Jabbour, E.2    Giles, F.J.3
  • 93
    • 77957060891 scopus 로고    scopus 로고
    • Predictive factors for response and outcome in patients (pts) treated with second generation tyrosine kinase inhibitors (2-TKI) for chronic myeloid leukemia in chronic phase (CML-CP) post imatinib failure
    • Abstr 509
    • Jabbour E, Kantarjian H, O'Brien S, et al. Predictive factors for response and outcome in patients (pts) treated with second generation tyrosine kinase inhibitors (2-TKI) for chronic myeloid leukemia in chronic phase (CML-CP) post imatinib failure. Blood 2009; 114 (abstr 509):210.
    • (2009) Blood , vol.114 , pp. 210
    • Jabbour, E.1    Kantarjian, H.2    O'Brien, S.3
  • 94
    • 70350124429 scopus 로고    scopus 로고
    • Pleural effusions in patients treated with dasatinib: Results from two institutions, risk factors and management
    • Lipton JH, Sriharsha L, Bogomilsky S, et al. Pleural effusions in patients treated with dasatinib: results from two institutions, risk factors and management. J Clin Oncol 2007; 25: 680s
    • (2007) J Clin Oncol , vol.25
    • Lipton, J.H.1    Sriharsha, L.2    Bogomilsky, S.3
  • 95
    • 77954799488 scopus 로고    scopus 로고
    • Update on imatinib-resistant chronic myeloid leukemia patients in chronic phase (CML-CP) on nilotinib therapy at 24 months: Clinical response safety and long-term outcomes
    • Abstr 1129
    • Kantarjian H, Giles F, Bhalla K, et al. Update on imatinib-resistant chronic myeloid leukemia patients in chronic phase (CML-CP) on nilotinib therapy at 24 months: clinical response, safety, and long-term outcomes. Blood 2009;114 (abstr): 1129.
    • (2009) Blood , vol.114
    • Kantarjian, H.1    Giles, F.2    Bhalla, K.3
  • 96
    • 75749105885 scopus 로고    scopus 로고
    • Phase III, randomized, open-label study of daily imatinib mesylate 400 mg versus 800 mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: Tyrosine kinase inhibitor optimization and selectivity study
    • Cortes JE, Baccarani M, Guilhot F, et al. Phase III, randomized, open-label study of daily imatinib mesylate 400 mg versus 800 mg in patients with newly diagnosed, previously untreated chronic myeloid leukemia in chronic phase using molecular end points: tyrosine kinase inhibitor optimization and selectivity study J Clin Oncol 2010; 28:424-30.
    • (2010) J Clin Oncol , vol.28 , pp. 424-430
    • Cortes, J.E.1    Baccarani, M.2    Guilhot, F.3
  • 97
    • 70449334476 scopus 로고    scopus 로고
    • Randomized comparison of imatinib versus imatinib combination therapies in newly diagnosed chronic myeloid leukaemia (CML) patients in chronic phase (CP): First results of the phase III (SPIRIT) trial from the French CML group (FI LMC)
    • Abstr 183
    • Guilhot F. Randomized comparison of imatinib versus imatinib combination therapies in newly diagnosed chronic myeloid leukaemia (CML) patients in chronic phase (CP): first results of the phase III (SPIRIT) trial from the French CML group (FI LMC). Blood 2008;112-(abstr):183
    • (2008) Blood , vol.112
    • Guilhot, F.1
  • 98
    • 75749090051 scopus 로고    scopus 로고
    • Niltonib as front-line therapy for patients with chronic myeloid lekemia in early chronic phase
    • Cortes JE, Jones D, O'Brien et al. Niltonib as front-line therapy for patients with chronic myeloid lekemia in early chronic phase. J Clin Oncol 2010; 28:392-7.
    • (2010) J Clin Oncol , vol.28 , pp. 392-397
    • Cortes, J.E.1    Jones, D.2    O'Brien3
  • 99
    • 79953320397 scopus 로고    scopus 로고
    • Excellent outcomes at 3 years with Nilotinib 800 mg daily in early chronic phase Ph (+) chronic myeloid leukemia (CML): Results of a phase 2 GIMEMA CML WP clinical trial
    • Abstr 359
    • Rosti G, Castagnetti F, Gugliotta G. Excellent outcomes at 3 years with Nilotinib 800 mg daily in early chronic phase, Ph (+) chronic myeloid leukemia (CML): results of a phase 2 GIMEMA CML WP clinical trial. Blood 2010; 116 (abstr): 359.
    • (2010) Blood , vol.116
    • Rosti, G.1    Castagnetti, F.2    Gugliotta, G.3
  • 100
    • 84860580062 scopus 로고    scopus 로고
    • ENESTnd update: Continued superiority of nilotinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP)
    • Abstr 207
    • Hughes TP, Hochhaus A, Saglio G, et al. ENESTnd update: Continued superiority of nilotinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP). BloodYEAR; XXX (abstr):207
    • BloodYEAR , vol.30
    • Hughes, T.P.1    Hochhaus, A.2    Saglio, G.3
  • 101
    • 75749129911 scopus 로고    scopus 로고
    • Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia
    • Cortes JE, Jones D, O'Brien S, et al. Results of dasatinib therapy in patients with early chronic-phase chronic myeloid leukemia. J Clin Oncol 2010; 28:398-404.
    • (2010) J Clin Oncol , vol.28 , pp. 398-404
    • Cortes, J.E.1    Jones, D.2    O'Brien, S.3
  • 102
    • 77953725855 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
    • Kantarjian H, Shah NP, Hochhaus A, et al. Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010;362:2260-70.
    • (2010) N Engl J Med , vol.362 , pp. 2260-2270
    • Kantarjian, H.1    Shah, N.P.2    Hochhaus, A.3
  • 103
    • 84860580063 scopus 로고    scopus 로고
    • Dasatinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) in the DASISION trial: 18-month follow-up
    • December 4-7, 2010; Orlando, Florida. Abstract 206
    • Shah N, Kantarjian HM, Hochhaus A, et al. Dasatinib versus imatinib in patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) in the DASISION trial: 18-month follow-up. Program and abstracts of the 52nd American Society of Hematology Annual Meeting and Exposition; December 4-7, 2010; Orlando, Florida. Abstract 206.
    • Program and Abstracts of the 52nd American Society of Hematology Annual Meeting and Exposition
    • Shah, N.1    Kantarjian, H.M.2    Hochhaus, A.3
  • 104
    • 79952787880 scopus 로고    scopus 로고
    • A randomized phase II trial of dasatinib 100 Mg vs imatinib 400 mg in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): TheS0325 Intergroup Trial
    • Abstr
    • Radich JP, Kopecky KJ, Kamel-Reid S, et al. A randomized phase II trial of dasatinib 100 Mg vs imatinib 400 mg in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP): theS0325 Intergroup Trial. Blood 2010; 116 (abstr);LBA-6.
    • (2010) Blood , vol.116
    • Radich, J.P.1    Kopecky, K.J.2    Kamel-Reid, S.3


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