Characterization of the isomerization products of aspartate residues at two different sites in a monoclonal antibody

Pharmaceutical Research

Volumn 29, Issue 1, 2012, Pages 187-197

  Sreedhara, Alavattam ^a   Cordoba, Armando ^a   Zhu, Qing ^a   Kwong, Jeanne ^a   Liu, Jun ^a  

^a GENENTECH INC   (United States)

Author keywords

Aspartic acid; Higher order structure; Isomerization; Monoclonal antibodies; Shelf life

Indexed keywords

ASPARTIC ACID; BUFFER; IMIDE; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; CARBOXYPEPTIDASE B; IMMUNOGLOBULIN G; ISOASPARTIC ACID; PAPAIN; PEPTIDE FRAGMENT;

ANIMAL CELL; ANTIBODY STRUCTURE; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DEGRADATION KINETICS; FEMALE; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; INCUBATION TEMPERATURE; ION EXCHANGE CHROMATOGRAPHY; ISOMERIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE ANALYSIS; SHELF LIFE; STEADY STATE; STORAGE TEMPERATURE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CHO CELL; DRUG STABILITY; HAMSTER; HUMAN; ISOMERISM; METHODOLOGY; REVERSED PHASE LIQUID CHROMATOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ASPARTIC ACID; CARBOXYPEPTIDASE B; CHO CELLS; CHROMATOGRAPHY, ION EXCHANGE; CHROMATOGRAPHY, REVERSE-PHASE; COMPLEMENTARITY DETERMINING REGIONS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; DRUG STABILITY; HUMANS; IMMUNOGLOBULIN G; ISOASPARTIC ACID; ISOMERISM; MASS SPECTROMETRY; PAPAIN; PEPTIDE FRAGMENTS; PEPTIDE MAPPING;

EID: 84860567341     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0534-2     Document Type: Article

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