Glucose deprivation in tuberous sclerosis complex-related tumors

Cell and Bioscience

Volumn 1, Issue 1, 2011, Pages

  Jiang, Xiuyun ^a   Kenerson, Heidi L ^a   Yeung, Raymond S ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

2 deoxyglucose; Fatty acids; Glycolysis; Ketone bodies; Metabolism; Mtor; Rapamycin

Indexed keywords

MUS;

EID: 84860525972     PISSN: None     EISSN: 20453701     Source Type: Journal    
DOI: 10.1186/2045-3701-1-34     Document Type: Article

References (35)

1. Crino PB, Nathanson KL, Henske EP. The tuberous sclerosis complex. N Engl J Med 2006, 355:1345-1356. 10.1056/NEJMra055323, 17005952.
2. Platt FM, Hurst CD, Taylor CF, Gregory WM, Harnden P, et al. Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer. Clin Cancer Res 2009, 15:6008-6017. 10.1158/1078-0432.CCR-09-0898, 19789314.
3. Totoki Y, Tatsuno K, Yamamoto S, Arai Y, Hosoda F, et al. High-resolution characterization of a hepatocellular carcinoma genome. Nat Genet 2011, 43:464-469. 10.1038/ng.804, 21499249.
4. Chakraborty S, Mohiyuddin SM, Gopinath KS, Kumar A. Involvement of TSC genes and differential expression of other members of the mTOR signaling pathway in oral squamous cell carcinoma. BMC Cancer 2008, 8:163. 10.1186/1471-2407-8-163, 2430211, 18538015.
5. Kenerson H, Folpe AL, Takayama TK, Yeung RS. Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms. Hum Pathol 2007, 38:1361-1371. 10.1016/j.humpath.2007.01.028, 2722219, 17521703.
6. Pan CC, Chung MY, Ng KF, Liu CY, Wang JS, et al. Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma. J Pathol 2008, 214:387-393. 10.1002/path.2289, 18085521.
7. Huang J, Manning BD. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 2009, 37:217-222. 10.1042/BST0370217, 2778026, 19143635.
8. Kenerson HL, Aicher LD, True LD, Yeung RS. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res 2002, 62:5645-5650.
9. Kenerson H, Dundon TA, Yeung RS. Effects of rapamycin in the Eker rat model of tuberous sclerosis complex. Pediatr Res 2005, 57:67-75. 10.1203/01.PDR.0000147727.78571.07, 15557109.
10. Bissler JJ, McCormack FX, Young LR, Elwing JM, Chuck G, et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 2008, 358:140-151. 10.1056/NEJMoa063564, 18184959.
11. Krueger DA, Care MM, Holland K, Agricola K, Tudor C, et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med 2010, 363:1801-1811. 10.1056/NEJMoa1001671, 21047224.
12. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 2008, 7:11-20. 10.1016/j.cmet.2007.10.002, 18177721.
13. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033. 10.1126/science.1160809, 2849637, 19460998.
14. Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, et al. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 2004, 64:3892-3899. 10.1158/0008-5472.CAN-03-2904, 15172999.
15. Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA 2008, 105:18782-18787. 10.1073/pnas.0810199105, 2596212, 19033189.
16. El Mjiyad N, Caro-Maldonado A, Ramirez-Peinado S, Munoz-Pinedo C. Sugar-free approaches to cancer cell killing. Oncogene 2011, 30:253-264. 10.1038/onc.2010.466, 20972457.
17. Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590. 10.1016/S0092-8674(03)00929-2, 14651849.
18. Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, et al. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell 2010, 38:487-499. 10.1016/j.molcel.2010.05.007, 2896794, 20513425.
19. Duvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 2010, 39:171-183. 10.1016/j.molcel.2010.06.022, 2946786, 20670887.
20. Jiang X, Kenerson H, Aicher L, Miyaoka R, Eary J, et al. The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol 2008, 172:1748-1756. 10.2353/ajpath.2008.070958, 2408433, 18511518.
21. Young LR, Franz DN, Nagarkatte P, Fletcher CD, Wikenheiser-Brokamp KA, et al. Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis. Chest 2009, 136:926-933. 10.1378/chest.09-0336, 19349386.
22. Maher JC, Krishan A, Lampidis TJ. Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother Pharmacol 2004, 53:116-122. 10.1007/s00280-003-0724-7, 14605866.
23. Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, et al. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res 2005, 65:613-621.
24. Singh D, Banerji AK, Dwarakanath BS, Tripathi RP, Gupta JP, et al. Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme. Strahlenther Onkol 2005, 181:507-514. 10.1007/s00066-005-1320-z, 16044218.
25. Boling CL, Westman EC, Yancy WS. Carbohydrate-restricted diets for obesity and related diseases: an update. Curr Atheroscler Rep 2009, 11:462-469. 10.1007/s11883-009-0069-8, 19852888.
26. Cahill GF. Fuel metabolism in starvation. Annu Rev Nutr 2006, 26:1-22. 10.1146/annurev.nutr.26.061505.111258, 16848698.
27. Jin F, Wienecke R, Xiao GH, Maize JC, DeClue JE, et al. Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region. Proc Natl Acad Sci USA 1996, 93:9154-9159. 10.1073/pnas.93.17.9154, 38611, 8799170.
28. Jung CH, Ro SH, Cao J, Otto NM, Kim DH. mTOR regulation of autophagy. FEBS Lett 2010, 584:1287-1295. 10.1016/j.febslet.2010.01.017, 2846630, 20083114.
29. Seyfried BT, Kiebish M, Marsh J, Mukherjee P. Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet. J Cancer Res Ther 5 Suppl 2009, 1:S7-15.
30. Marsh J, Mukherjee P, Seyfried TN. Drug/diet synergy for managing malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic diet. Nutr Metab (Lond) 2008, 5:33.
31. Seyfried TN, Sanderson TM, El-Abbadi MM, McGowan R, Mukherjee P. Role of glucose and ketone bodies in the metabolic control of experimental brain cancer. Br J Cancer 2003, 89:1375-1382. 10.1038/sj.bjc.6601269, 2394295, 14520474.
32. Mavropoulos JC, Buschemeyer WC, Tewari AK, Rokhfeld D, Pollak M, et al. The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. Cancer Prev Res (Phila) 2009, 2:557-565.
33. Chu-Shore CJ, Thiele EA. Tumor growth in patients with tuberous sclerosis complex on the ketogenic diet. Brain Dev 2010, 32:318-322. 10.1016/j.braindev.2009.04.009, 19443154.
34. Fine EJ, Miller A, Quadros EV, Sequeira JM, Feinman RD. Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2. Cancer Cell Int 2009, 9:14. 10.1186/1475-2867-9-14, 2694762, 19480693.
35. Ricchi M, Odoardi MR, Carulli L, Anzivino C, Ballestri S, et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol 2009, 24:830-840. 10.1111/j.1440-1746.2008.05733.x, 19207680.