Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide

EMBO Molecular Medicine

Volumn 4, Issue 5, 2012, Pages 412-423

  Dreymueller, Daniela ^a   Martin, Christian ^a   Kogel, Tanja ^a   Pruessmeyer, Jessica ^a   Hess, Franz M ^a   Horiuchi, Keisuke ^b   Uhlig, Stefan ^a   Ludwig, Andreas ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b KEIO UNIVERSITY   (Japan)

Author keywords

Inflammation; Metalloproteinase; Neutrophil recruitment; Oedema; Shedding

Indexed keywords

ADAM PROTEIN; ENDOTOXIN; FRACTALKINE; GW 280264X; INTERLEUKIN 6; INTERLEUKIN 8; JUNCTIONAL ADHESION MOLECULE A; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN ADAM17; PROTEIN INHIBITOR; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE RELEASE; EDEMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KNOCKOUT MOUSE; LEUKOCYTE; LUNG ENDOTHELIUM; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; UPREGULATION;

ADAM PROTEINS; ANIMALS; CELL ADHESION MOLECULES; CELLS, CULTURED; CHEMOKINE CX3CL1; ENDOTHELIAL CELLS; HUMANS; INFLAMMATION; INTERLEUKIN-6; LEUKOCYTES; LIPOPOLYSACCHARIDES; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PNEUMONIA; RECEPTORS, CELL SURFACE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84860524098     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201200217     Document Type: Article

References (45)

1. Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, et al (2004) The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J Immunol 172: 6362-6372.
2. Alm AS, Li K, Chen H, Wang D, Andersson R, Wang X (2010) Variation of lipopolysaccharide-induced acute lung injury in eight strains of mice. Respir Physiol Neurobiol 171: 157-164.
3. Armstrong L, Godinho SI, Uppington KM, Whittington HA, Millar AB (2006) Contribution of TNF-alpha converting enzyme and proteinase-3 to TNF-alpha processing in human alveolar macrophages. Am J Respir Cell Mol Biol 34: 219-225.
4. Bzowska M, Jura N, Lassak A, Black RA, Bereta J (2004) Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells. Eur J Biochem 271: 2808-2820.
5. Canault M, Peiretti F, Kopp F, Bonardo B, Bonzi MF, Coudeyre JC, Alessi MC, Juhan-Vague I, Nalbone G (2006) The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: possible contribution to elevated plasma levels of soluble TNF alpha receptors. Atherosclerosis 187: 82-91.
6. Canault M, Certel K, Schatzberg D, Wagner DD, Hynes RO (2010) The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation. PLoS One 5: e13433.
7. Cesaro A, Abakar-Mahamat A, Brest P, Lassalle S, Selva E, Filippi J, Hebuterne X, Hugot JP, Doglio A, Galland F, et al (2009) Differential expression and regulation of ADAM17 and TIMP3 in acute inflamed intestinal epithelia. Am J Physiol Gastrointest Liver Physiol 296: G1332-G1343.
8. Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, et al (2010) Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med 207: 1617-1624.
9. Dijkstra A, Postma DS, Noordhoek JA, Lodewijk ME, Kauffman HF, Ten Hacken NH, Timens W (2009) Expression of ADAMs ("a disintegrin and metalloprotease") in the human lung. Virchows Arch 454: 441-449.
10. Dreymueller D, Pruessmeyer J, Groth E, Ludwig A (2011) The role of ADAM-mediated shedding in vascular biology. Eur J Cell Biol DOI: 10.1016/j.ejcb.2011.09.003.
11. Gungor N, Pennings JL, Knaapen AM, Chiu RK, Peluso M, Godschalk RW, Van Schooten FJ (2010) Transcriptional profiling of the acute pulmonary inflammatory response induced by LPS: role of neutrophils. Respir Res 11: 24.
12. Haarmann A, Deiss A, Prochaska J, Foerch C, Weksler B, Romero I, Couraud PO, Stoll G, Rieckmann P, Buttmann M (2010) Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown. PLoS One 5: e13568.
13. Haczku A, Takeda K, Hamelmann E, Loader J, Joetham A, Redai I, Irvin CG, Lee JJ, Kikutani H, Conrad D, et al (2000) CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness. Am J Respir Crit Care Med 161: 952-960.
14. Horiuchi K, Kimura T, Miyamoto T, Takaishi H, Okada Y, Toyama Y, Blobel CP (2007) Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol 179: 2686-2689.
15. Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, et al (2003) The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 102: 1186-1195.
16. Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, et al (2009) Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases. Blood 113: 4799-4809.
17. Laukoetter MG, Nava P, Lee WY, Severson EA, Capaldo CT, Babbin BA, Williams IR, Koval M, Peatman E, Campbell JA, et al (2007) JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med 204: 3067-3076.
18. Li Y, Brazzell J, Herrera A, Walcheck B (2006) ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding. Blood 108: 2275-2279.
19. Long C, Wang Y, Herrera AH, Horiuchi K, Walcheck B (2009) In vivo role of leukocyte ADAM17 in the inflammatory and host responses during E. coli-mediated peritonitis. J Leukoc Biol 87: 1097-1101.
20. Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD (2005) Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules. Comb Chem High Throughput Screen 8: 161-171.
21. Matute-Bello G, Frevert CW, Martin TR (2008) Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 295: L379-L399.
22. Mazzon E, Cuzzocrea S (2007) Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation. Respir Res 8: 75.
23. Nonas S, Miller I, Kawkitinarong K, Chatchavalvanich S, Gorshkova I, Bochkov VN, Leitinger N, Natarajan V, Garcia JG, Birukov KG (2006) Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury. Am J Respir Crit Care Med 173: 1130-1138.
24. O'Grady NP, Preas HL, Pugin J, Fiuza C, Tropea M, Reda D, Banks SM, Suffredini AF (2001) Local inflammatory responses following bronchial endotoxin instillation in humans. Am J Respir Crit Care Med 163: 1591-1598.
25. Paulissen G, Rocks N, Gueders MM, Crahay C, Quesada-Calvo F, Bekaert S, Hacha J, El Hour M, Foidart JM Noel A, et al (2009) Role of ADAM and ADAMTS metalloproteinases in airway diseases. Respir Res 10: 127.
26. Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, Russell WE, Castner BJ, Johnson RS, Fitzner JN, et al (1998) An essential role for ectodomain shedding in mammalian development. Science 282: 1281-1284.
27. Ponnuchamy B, Khalil RA (2008) Role of ADAMs in endothelial cell permeability: cadherin shedding and leukocyte rolling. Circ Res 102: 1139-1142.
28. Pruessmeyer J, Ludwig A (2009) The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer. Semin Cell Dev Biol 20: 164-174.
29. Pruessmeyer J, Martin C, Hess FM, Schwarz N, Schmidt S, Kogel T, Hoettecke N, Schmidt B, Sechi A, Uhlig S, et al (2009) A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells. J Biol Chem 285: 555-564.
30. Pucci F, Venneri MA, Biziato D, Nonis A, Moi D, Sica A, Di Serio C, Naldini L, De Palma M (2009) A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships. Blood 114: 901-914.
31. Rabinowitz MH, Andrews RC, Becherer JD, Bickett DM, Bubacz DG, Conway JG, Cowan DJ, Gaul M, Glennon K, Lambert MH, et al (2001) Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). J Med Chem 44: 4252-4267.
32. Reiss K, Uhlig U, Uhlig S (2012) Models and mechanisms of acute lung injury caused by direct insults. Eur J Cell Biol DOI: 10.1016/j.ejcb.2011.11.004.
33. Schnyder-Candrian S, Quesniaux VF, Di Padova F, Maillet I, Noulin N, Couillin I, Moser R, Erard F, Vargaftig BB, Ryffel B, et al (2005) Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome. J Immunol 175: 262-269.
34. Schwarz N, Pruessmeyer J, Hess FM, Dreymueller D, Pantaler E, Koelsch A, Windoffer R, Voss M, Sarabi A, Weber C, et al (2010) Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1. Cell Mol Life Sci 67: 4233-4248.
35. Shimizu M, Hasegawa N, Nishimura T, Endo Y, Shiraishi Y, Yamasawa W, Koh H, Tasaka S, Shimada H, Nakano Y, et al (2009) Effects of TNF-alpha-converting enzyme inhibition on acute lung injury induced by endotoxin in the rat. Shock 32: 535-540.
36. Singh RJ, Mason JC, Lidington EA, Edwards DR, Nuttall RK, Khokha R, Knauper V, Murphy G, Gavrilovic J (2005) Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovasc Res 67: 39-49.
37. Smith S, Skerrett SJ, Chi EY, Jonas M, Mohler K, Wilson CB (1998) The locus of tumor necrosis factor-alpha action in lung inflammation. Am J Respir Cell Mol Biol 19: 881-891.
38. Song Y, Ao L, Raeburn CD, Calkins CM, Abraham E, Harken AH, Meng X (2001) A low level of TNF-alpha mediates hemorrhage-induced acute lung injury via p55 TNF receptor. Am J Physiol Lung Cell Mol Physiol 281: L677-L684.
39. Strieter RM, Kunkel SL (1994) Acute lung injury: the role of cytokines in the elicitation of neutrophils. J Investig Med 42: 640-651.
40. Trifilieff A, Walker C, Keller T, Kottirsch G, Neumann U (2002) Pharmacological profile of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in models of airway inflammation. Br J Pharmacol 135: 1655-1664.
41. Walcheck B, Herrera AH, St Hill C, Mattila PE, Whitney AR, Deleo FR (2006) ADAM17 activity during human neutrophil activation and apoptosis. Eur J Immunol 36: 968-976.
42. Ward PA (2003) Acute lung injury: how the lung inflammatory response works. Eur Respir J Suppl 44: 22s-23s.
43. Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, Lyman S, Hinoki A, Eguchi S, Guaiquil V, Horiuchi K, et al (2010) Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. Circ Res 106: 932-940.
44. Yoshikawa S, King JA, Lausch RN, Penton AM, Eyal FG, Parker JC (2004) Acute ventilator-induced vascular permeability and cytokine responses in isolated and in situ mouse lungs. J Appl Physiol 97: 2190-2199.
45. Zhang P, Summer WR, Bagby GJ, Nelson S (2000) Innate immunity and pulmonary host defense. Immunol Rev 173: 39-51.