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Volumn 97, Issue 6, 2004, Pages 2190-2199

Acute ventilator-induced vascular permeability and cytokine responses in isolated and in situ mouse lungs

Author keywords

Interleukin 6; Knockout mice; Major intrinsic protein 2; Tumor necrosis factor ; Ventilator induced lung injury

Indexed keywords

CYTOKINE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 9244239218     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00324.2004     Document Type: Article
Times cited : (41)

References (54)
  • 2
    • 0026636670 scopus 로고
    • Tumor necrosis factor-α does not cause lung edema in rabbits
    • Bonsignore MR, Valenza F, and Spatafora M. Tumor necrosis factor-α does not cause lung edema in rabbits. J Appl Physiol 73: 173-178, 1992.
    • (1992) J Appl Physiol , vol.73 , pp. 173-178
    • Bonsignore, M.R.1    Valenza, F.2    Spatafora, M.3
  • 4
    • 0343893748 scopus 로고    scopus 로고
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and respiratory distress syndrome
    • Brower RG, Matthay MA, Morris A, Schoenfeld D, and Thompson BT. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and respiratory distress syndrome. N Engl J Med 342: 1301-1308, 2000.
    • (2000) N Engl J Med , vol.342 , pp. 1301-1308
    • Brower, R.G.1    Matthay, M.A.2    Morris, A.3    Schoenfeld, D.4    Thompson, B.T.5
  • 5
    • 0036258696 scopus 로고    scopus 로고
    • Ventilation with negative airway pressure induces a cytokine response in isolated mouse lung
    • Cheng KC, Zhang H, Lin CY, and Slutsky AS. Ventilation with negative airway pressure induces a cytokine response in isolated mouse lung. Anesth Analg 94: 1577-1582, 2002.
    • (2002) Anesth Analg , vol.94 , pp. 1577-1582
    • Cheng, K.C.1    Zhang, H.2    Lin, C.Y.3    Slutsky, A.S.4
  • 6
    • 0032794887 scopus 로고    scopus 로고
    • Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome
    • Chiumello D, Pristine G, and Slutsky AS. Mechanical ventilation affects local and systemic cytokines in an animal model of acute respiratory distress syndrome. Am J Respir Crit Care Med 160: 109-116, 1999.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 109-116
    • Chiumello, D.1    Pristine, G.2    Slutsky, A.S.3
  • 7
    • 0033781864 scopus 로고    scopus 로고
    • Invited review: Mechanisms of ventilator-induced lung injury: A perspective
    • Dos Santos CC and Slutsky AS. Invited review: Mechanisms of ventilator-induced lung injury: a perspective. J Appl Physiol 89: 1645-1655, 2000.
    • (2000) J Appl Physiol , vol.89 , pp. 1645-1655
    • Dos Santos, C.C.1    Slutsky, A.S.2
  • 8
    • 0034091146 scopus 로고    scopus 로고
    • Mechanotransduction, ventilator-induced lung injury and multiple organ dysfunction syndrome
    • Dos Santos CC and Slutsky AS. Mechanotransduction, ventilator-induced lung injury and multiple organ dysfunction syndrome. Intensive Care Med 26: 638-642, 2000.
    • (2000) Intensive Care Med , vol.26 , pp. 638-642
    • Dos Santos, C.C.1    Slutsky, A.S.2
  • 9
    • 0038808978 scopus 로고    scopus 로고
    • On the physiologic and clinical relevance of lung-borne cytokines during ventilator-induced lung injury
    • Dreyfuss D, Ricard JD, and Saumon G. On the physiologic and clinical relevance of lung-borne cytokines during ventilator-induced lung injury. Am J Respir Crit Care Med 167: 1467-1471, 2003.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 1467-1471
    • Dreyfuss, D.1    Ricard, J.D.2    Saumon, G.3
  • 10
    • 0031942649 scopus 로고    scopus 로고
    • Ventilator induced lung injury: Lessons from experimental studies
    • Dreyfuss D and Saumon G. Ventilator induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157: 294-323, 1998.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 294-323
    • Dreyfuss, D.1    Saumon, G.2
  • 11
    • 0026777746 scopus 로고
    • Spontaneous resolution of pulmonary edema caused by short periods of cyclic overinflation
    • Dreyfuss D, Soler P, and Saumon G. Spontaneous resolution of pulmonary edema caused by short periods of cyclic overinflation. J Appl Physiol 72: 2081-2089, 1992.
    • (1992) J Appl Physiol , vol.72 , pp. 2081-2089
    • Dreyfuss, D.1    Soler, P.2    Saumon, G.3
  • 13
    • 0029900294 scopus 로고    scopus 로고
    • Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein
    • The Soluble TNF Receptor Sepsis Study Group [see comment]
    • Fisher CJJ, Agosti JM, Opal SM, Lowry SF, Balk RA, Sadoff JC, Abraham E, Schein RM, and Benjamin E. Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group [see comment]. N Engl J Med 334: 1697-1702, 1996.
    • (1996) N Engl J Med , vol.334 , pp. 1697-1702
    • Fisher, C.J.J.1    Agosti, J.M.2    Opal, S.M.3    Lowry, S.F.4    Balk, R.A.5    Sadoff, J.C.6    Abraham, E.7    Schein, R.M.8    Benjamin, E.9
  • 15
    • 0029283128 scopus 로고
    • Regulation of endothelial cell gap formation and paracellular permeability
    • Garcia JG and Schaphorst KL. Regulation of endothelial cell gap formation and paracellular permeability. J Investig Med 43: 117-126, 1995.
    • (1995) J Investig Med , vol.43 , pp. 117-126
    • Garcia, J.G.1    Schaphorst, K.L.2
  • 16
    • 0024582716 scopus 로고
    • Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury
    • Goldblum SE, Hennig B, Jay M, Yoneda K, and McClain CJ. Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury. Infect Immun 57: 1218-1226, 1989.
    • (1989) Infect Immun , vol.57 , pp. 1218-1226
    • Goldblum, S.E.1    Hennig, B.2    Jay, M.3    Yoneda, K.4    McClain, C.J.5
  • 17
    • 0030292571 scopus 로고    scopus 로고
    • Intra-alveolar macrophage-inflammatory peptide 2 induces rapid neutrophil localization in the lung
    • Gupta S, Feng L, Yoshimura T, Redick J, Fu SM, and Rose CE Jr. Intra-alveolar macrophage-inflammatory peptide 2 induces rapid neutrophil localization in the lung. Am J Respir Cell Mol Biol 15: 656-663, 1996.
    • (1996) Am J Respir Cell Mol Biol , vol.15 , pp. 656-663
    • Gupta, S.1    Feng, L.2    Yoshimura, T.3    Redick, J.4    Fu, S.M.5    Rose Jr., C.E.6
  • 18
    • 0030905548 scopus 로고    scopus 로고
    • Infections and the inflammatory response in acute respiratory distress syndrome
    • Headley AS, Tolley E, and Meduri GU. Infections and the inflammatory response in acute respiratory distress syndrome. Chest 111: 1306-1321, 1997.
    • (1997) Chest , vol.111 , pp. 1306-1321
    • Headley, A.S.1    Tolley, E.2    Meduri, G.U.3
  • 19
    • 0035076572 scopus 로고    scopus 로고
    • Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-κB and is blocked by steroids
    • Held HD, Boettcher S, Hamann L, and Uhlig S. Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-κB and is blocked by steroids. Am J Respir Crit Care Med 163: 711-716, 2001.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 711-716
    • Held, H.D.1    Boettcher, S.2    Hamann, L.3    Uhlig, S.4
  • 20
    • 0024396130 scopus 로고
    • Chest wall restriction limits high airway pressure-induced lung injury in young rabbits
    • Hernandez LA, Peevy KJ, Moise AA, and Parker JC. Chest wall restriction limits high airway pressure-induced lung injury in young rabbits. J Appl Physiol 66: 2364-2368, 1989.
    • (1989) J Appl Physiol , vol.66 , pp. 2364-2368
    • Hernandez, L.A.1    Peevy, K.J.2    Moise, A.A.3    Parker, J.C.4
  • 21
    • 0032838053 scopus 로고    scopus 로고
    • Intratracheal anti-tumor necrosis factor-α antibody attenuates ventilator-induced lung injury in rabbits
    • Imai Y, Kawano T, Iwamoto S, Nakagawa S, Takata M, and Miyasaka K. Intratracheal anti-tumor necrosis factor-α antibody attenuates ventilator-induced lung injury in rabbits. J Appl Physiol 87: 510-515, 1999.
    • (1999) J Appl Physiol , vol.87 , pp. 510-515
    • Imai, Y.1    Kawano, T.2    Iwamoto, S.3    Nakagawa, S.4    Takata, M.5    Miyasaka, K.6
  • 22
    • 0031736846 scopus 로고    scopus 로고
    • Tumor necrosis factor-α in ischemic and reperfusion injury in rat lungs
    • Khimenko PL, Bagby GJ, Fuseler J, and Taylor AE. Tumor necrosis factor-α in ischemic and reperfusion injury in rat lungs. J Appl Physiol 85: 2005-2011, 1998.
    • (1998) J Appl Physiol , vol.85 , pp. 2005-2011
    • Khimenko, P.L.1    Bagby, G.J.2    Fuseler, J.3    Taylor, A.E.4
  • 23
    • 0034118223 scopus 로고    scopus 로고
    • A novel signaling mechanism between gas and blood compartments of the lung
    • Kuebler WM, Parthasarathi K, Wang PM, and Bhattacharya J. A novel signaling mechanism between gas and blood compartments of the lung. J Clin Invest 105: 905-913, 2000.
    • (2000) J Clin Invest , vol.105 , pp. 905-913
    • Kuebler, W.M.1    Parthasarathi, K.2    Wang, P.M.3    Bhattacharya, J.4
  • 24
    • 0034057929 scopus 로고    scopus 로고
    • Respiratory mechanics and maximal expiratory flow in the anesthetized mouse
    • Lai YL and Chou HC. Respiratory mechanics and maximal expiratory flow in the anesthetized mouse. J Appl Physiol 88: 939-943, 2000.
    • (2000) J Appl Physiol , vol.88 , pp. 939-943
    • Lai, Y.L.1    Chou, H.C.2
  • 25
    • 0028898380 scopus 로고
    • Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1β and IL-6 levels are consistent and efficient predictors of outcome over time
    • Meduri GU, Headley S, Kohler G, Stentz F, Tolley E, Umberger R, and Leeper K. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1β and IL-6 levels are consistent and efficient predictors of outcome over time. Chest 107: 1062-1073, 1995.
    • (1995) Chest , vol.107 , pp. 1062-1073
    • Meduri, G.U.1    Headley, S.2    Kohler, G.3    Stentz, F.4    Tolley, E.5    Umberger, R.6    Leeper, K.7
  • 26
    • 0034911996 scopus 로고    scopus 로고
    • Mechanical ventilation of isolated septic rat lungs: Effects on surfactant and inflammatory cytokines
    • Nakamura T, Malloy J, McCaig L, Yao LJ, Joseph M, Lewis J, and Veldhuizen R. Mechanical ventilation of isolated septic rat lungs: effects on surfactant and inflammatory cytokines. J Appl Physiol 91: 811-820, 2001.
    • (2001) J Appl Physiol , vol.91 , pp. 811-820
    • Nakamura, T.1    Malloy, J.2    McCaig, L.3    Yao, L.J.4    Joseph, M.5    Lewis, J.6    Veldhuizen, R.7
  • 27
    • 0028959783 scopus 로고
    • Effect of IL-1 blockade on inflammatory manifestations of acute ventilator-induced lung injury in a rabbit model
    • Narimanbekov IO and Rozycki HJ. Effect of IL-1 blockade on inflammatory manifestations of acute ventilator-induced lung injury in a rabbit model. Exp Lung Res 21: 239-254, 1995.
    • (1995) Exp Lung Res , vol.21 , pp. 239-254
    • Narimanbekov, I.O.1    Rozycki, H.J.2
  • 29
    • 0031898295 scopus 로고    scopus 로고
    • Gadolinium prevents high airway pressure induced permeability increases in isolated rat lungs
    • Parker JC, Ivey C, and Tucker A. Gadolinium prevents high airway pressure induced permeability increases in isolated rat lungs. J Appl Physiol 84: 1113-1118, 1998.
    • (1998) J Appl Physiol , vol.84 , pp. 1113-1118
    • Parker, J.C.1    Ivey, C.2    Tucker, A.3
  • 30
    • 0031456255 scopus 로고    scopus 로고
    • Isoproterenol attenuates high vascular pressure induced permeability increases in isolated rat lungs
    • Parker JC and Ivey CL. Isoproterenol attenuates high vascular pressure induced permeability increases in isolated rat lungs. J Appl Physiol 83: 1962-1967, 1998.
    • (1998) J Appl Physiol , vol.83 , pp. 1962-1967
    • Parker, J.C.1    Ivey, C.L.2
  • 31
    • 0031738599 scopus 로고    scopus 로고
    • Phosphotyrosine phosphatase and tyrosine inhibition modulate airway pressure induced lung injury
    • Parker JC, Ivey CL, and Tucker A. Phosphotyrosine phosphatase and tyrosine inhibition modulate airway pressure induced lung injury. J Appl Physiol 85: 1753-1761, 1998.
    • (1998) J Appl Physiol , vol.85 , pp. 1753-1761
    • Parker, J.C.1    Ivey, C.L.2    Tucker, A.3
  • 32
    • 4243977630 scopus 로고    scopus 로고
    • Vascular segmental permeability after high peak inflation pressure (PIP) injury in isolated rat lungs
    • Parker JC, Stevens T, and Martin SL. Vascular segmental permeability after high peak inflation pressure (PIP) injury in isolated rat lungs (Abstract). FASEB J 14: A605, 2000.
    • (2000) FASEB J , vol.14
    • Parker, J.C.1    Stevens, T.2    Martin, S.L.3
  • 34
    • 0021702385 scopus 로고
    • Increased microvascular permeability in dog lungs due to high peak airway pressures
    • Parker JC, Townsley MI, Rippe B, Taylor AE, and Thigpen J. Increased microvascular permeability in dog lungs due to high peak airway pressures. J Appl Physiol 57: 1809-1816, 1984.
    • (1984) J Appl Physiol , vol.57 , pp. 1809-1816
    • Parker, J.C.1    Townsley, M.I.2    Rippe, B.3    Taylor, A.E.4    Thigpen, J.5
  • 36
    • 0032778978 scopus 로고    scopus 로고
    • Stretch-induced mitogen-activated protein kinase activation and interleukin-8 production in type II alveolar cells
    • Quinn D, Tager A, Joseph PM, Bonventre JV, Force T, and Hales CA. Stretch-induced mitogen-activated protein kinase activation and interleukin-8 production in type II alveolar cells. Chest 116: 89-90, 1999.
    • (1999) Chest , vol.116 , pp. 89-90
    • Quinn, D.1    Tager, A.2    Joseph, P.M.3    Bonventre, J.V.4    Force, T.5    Hales, C.A.6
  • 37
    • 0036021802 scopus 로고    scopus 로고
    • Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury
    • Quinn DA, Moufarrej RK, Volokhov A, and Hales CA. Interactions of lung stretch, hyperoxia, and MIP-2 production in ventilator-induced lung injury. J Appl Physiol 93: 517-525, 2002.
    • (2002) J Appl Physiol , vol.93 , pp. 517-525
    • Quinn, D.A.1    Moufarrej, R.K.2    Volokhov, A.3    Hales, C.A.4
  • 38
    • 9244245678 scopus 로고    scopus 로고
    • Release of the chemokine MIP-2 but not the cytokines TNF-α and IL-1β during high volume mechanical ventilation of ex vivo rat lungs
    • Ricard JD, Dreyfuss D, and Saumon G. Release of the chemokine MIP-2 but not the cytokines TNF-α and IL-1β during high volume mechanical ventilation of ex vivo rat lungs (Abstract). Am J Respir Crit Care Med 161: A211, 2000.
    • (2000) Am J Respir Crit Care Med , vol.161
    • Ricard, J.D.1    Dreyfuss, D.2    Saumon, G.3
  • 39
    • 0035029679 scopus 로고    scopus 로고
    • Production of inflammatory cytokines in ventilator-induced lung injury: A reappraisal
    • Ricard JD, Dreyfuss D, and Saumon G. Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal. Am J Respir Crit Care Med 163: 1176-1180, 2001.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 1176-1180
    • Ricard, J.D.1    Dreyfuss, D.2    Saumon, G.3
  • 42
    • 0031255581 scopus 로고    scopus 로고
    • Thrombin-mediated focal adhesion plaque reorganization in endothelium: Role of protein phosphorylation
    • Schaphorst KL, Pavalko FM, Patterson CE, and Garcia JG. Thrombin-mediated focal adhesion plaque reorganization in endothelium: role of protein phosphorylation. Am J Respir Cell Mol Biol 17: 443-455, 1997.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 443-455
    • Schaphorst, K.L.1    Pavalko, F.M.2    Patterson, C.E.3    Garcia, J.G.4
  • 43
    • 0036220794 scopus 로고    scopus 로고
    • MV causes lung inflammation and systemic immune depression. A balance of fire and ice
    • Suter PM. MV causes lung inflammation and systemic immune depression. A balance of fire and ice. Intensive Care Med 28: 383-385, 2002.
    • (2002) Intensive Care Med , vol.28 , pp. 383-385
    • Suter, P.M.1
  • 44
    • 0033060932 scopus 로고    scopus 로고
    • Differential lung mechanics are genetically determined in inbred murine strains
    • Tankersley CG, Rabold R, and Mitzner W. Differential lung mechanics are genetically determined in inbred murine strains. J Appl Physiol 86: 1764-1769, 1999.
    • (1999) J Appl Physiol , vol.86 , pp. 1764-1769
    • Tankersley, C.G.1    Rabold, R.2    Mitzner, W.3
  • 45
    • 0030981335 scopus 로고    scopus 로고
    • Injurious ventilatory strategies increase cytokines and c-fos mRNA expression in an isolated rat lung model
    • Tremblay L, Valenza F, Ribeiro SP, Li J, and Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos mRNA expression in an isolated rat lung model. J Clin Invest 99: 944-952, 1997.
    • (1997) J Clin Invest , vol.99 , pp. 944-952
    • Tremblay, L.1    Valenza, F.2    Ribeiro, S.P.3    Li, J.4    Slutsky, A.S.5
  • 46
    • 0031737722 scopus 로고    scopus 로고
    • Ventilator-induced injury: From barotrauma to biotrauma
    • Tremblay LN and Slutsky AS. Ventilator-induced injury: from barotrauma to biotrauma. Proc Assoc Am Physicians 110: 482-488, 1998.
    • (1998) Proc Assoc Am Physicians , vol.110 , pp. 482-488
    • Tremblay, L.N.1    Slutsky, A.S.2
  • 47
    • 0032739397 scopus 로고    scopus 로고
    • Different ventilation strategies affect lung function but do not increase tumor necrosis factor-α and prostacyclin production in lavaged rat lungs in vivo
    • Verbrugge SJ, Uhlig S, Neggers SJ, Martin C, Held HD, Haitsma JJ, and Lachmann B. Different ventilation strategies affect lung function but do not increase tumor necrosis factor-α and prostacyclin production in lavaged rat lungs in vivo. Anesthesiology 91: 1834-1843, 1999.
    • (1999) Anesthesiology , vol.91 , pp. 1834-1843
    • Verbrugge, S.J.1    Uhlig, S.2    Neggers, S.J.3    Martin, C.4    Held, H.D.5    Haitsma, J.J.6    Lachmann, B.7
  • 48
    • 0037308350 scopus 로고    scopus 로고
    • Response of alveolar cells to mechanical stress
    • Vlahakis NE and Hubmayr RD. Response of alveolar cells to mechanical stress. Curr Opin Crit Care 9: 2-8, 2003.
    • (2003) Curr Opin Crit Care , vol.9 , pp. 2-8
    • Vlahakis, N.E.1    Hubmayr, R.D.2
  • 50
    • 0034604129 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome
    • Ware LB and Matthay MA. The acute respiratory distress syndrome. N Engl J Med 342: 1334-1349, 2000.
    • (2000) N Engl J Med , vol.342 , pp. 1334-1349
    • Ware, L.B.1    Matthay, M.A.2
  • 51
    • 0033635734 scopus 로고    scopus 로고
    • Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function
    • Wrigge H, Zinserling J, Stuber F, von Spiegel T, Hering R, Wetegrove S, Hoeft A, and Putensen C. Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function. Anesthesiology 93: 1413-1417, 2000.
    • (2000) Anesthesiology , vol.93 , pp. 1413-1417
    • Wrigge, H.1    Zinserling, J.2    Stuber, F.3    Von Spiegel, T.4    Hering, R.5    Wetegrove, S.6    Hoeft, A.7    Putensen, C.8
  • 52
    • 0033209860 scopus 로고    scopus 로고
    • Tumor necrosis factor-α mediates lipopolysaccharide-induced macrophage inflammatory protein-2 release from alveolar epithelial cells. Autoregulation in host defense
    • Xavier AM, Isowa N, Cai L, Dziak E, Opas M, McRitchie DI, Slutsky AS, Keshavjee SH, and Liu M. Tumor necrosis factor-α mediates lipopolysaccharide-induced macrophage inflammatory protein-2 release from alveolar epithelial cells. Autoregulation in host defense. Am J Respir Cell Mol Biol 21: 510-520, 1999.
    • (1999) Am J Respir Cell Mol Biol , vol.21 , pp. 510-520
    • Xavier, A.M.1    Isowa, N.2    Cai, L.3    Dziak, E.4    Opas, M.5    McRitchie, D.I.6    Slutsky, A.S.7    Keshavjee, S.H.8    Liu, M.9
  • 53
    • 4243846578 scopus 로고    scopus 로고
    • i in venular capillaries of rat lung
    • i in venular capillaries of rat lung (Abstract). FASEB J 11: A134, 1997.
    • (1997) FASEB J , vol.11
    • Ying, X.1    Bhattacharya, J.2
  • 54
    • 1242351834 scopus 로고    scopus 로고
    • Time and pressure dependence of transvascular Clara cell protein, albumin, and IgG transport during ventilator-induced lung injury in mice
    • Yoshikawa S, King JA, Reynolds SD, Stripp BR, and Parker JC. Time and pressure dependence of transvascular Clara cell protein, albumin, and IgG transport during ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 286: L604-L612, 2004.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286
    • Yoshikawa, S.1    King, J.A.2    Reynolds, S.D.3    Stripp, B.R.4    Parker, J.C.5


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