Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Wang, Lihong ^a,b   Liu, Liping ^a   Shi, Yan ^a   Cao, Hanwei ^a   Chaturvedi, Rupesh ^c   Calcutt, M Wade ^d   Hu, Tianhui ^b   Ren, Xiubao ^e   Wilson, Keith T ^c,d,f   Polk, D Brent ^g   Yan, Fang ^a,e  

^a MONROE CARELL JR CHILDREN S HOSPITAL AT VANDERBILT   (United States)

^b XIAMEN UNIVERSITY   (China)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e TIANJIN MEDICAL UNIVERSITY   (China)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; APOPTOSIS INDUCING FACTOR; BERBERINE; CASPASE; CASPASE INHIBITOR; CATHEPSIN B; CYCLOHEXIMIDE; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL FATE; CELL IMMORTALIZATION; CELL NUCLEUS; COLON MUCOSA; COLON TUMOR; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME RELEASE; GENE MUTATION; INTESTINE EPITHELIUM CELL; LYSOSOME; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN SECRETION; PROTEIN TRANSPORT; TUMOR CELL; ACTIVE TRANSPORT; ANIMAL; EPITHELIUM CELL; HUMAN; METABOLISM; PATHOLOGY; SECRETION; TUMOR CELL LINE;

BACTERIA (MICROORGANISMS);

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS INDUCING FACTOR; BERBERINE; CASPASES; CATHEPSIN B; CELL DEATH; CELL LINE, TUMOR; CELL NUCLEUS; COLONIC NEOPLASMS; EPITHELIAL CELLS; HUMANS; L-LACTATE DEHYDROGENASE; MICE; MITOCHONDRIA; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES;

EID: 84860521181     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036418     Document Type: Article

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