Na +/H +-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis

International Journal of Molecular Medicine

Volumn 29, Issue 6, 2012, Pages 989-998

  Lupachyk, Sergey ^a   Stavniichuk, Roman ^a   Komissarenko, Julia I ^b   Drel, Viktor R ^a   Obrosov, Alexander A ^a   El Remessy, Azza B ^c   Pacher, Pal ^d   Obrosova, Irina G ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b BOGOMOLETS NATIONAL MEDICAL UNIVERSITY   (Ukraine)

^c UNIVERSITY OF GEORGIA   (United States)

^d NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Apoptosis; Cariporide; Diabetic cataract; Early diabetic retinopathy; Na + H + exchanger 1; Oxidative nitrative stress; Retinal endothelial cell; Retinal pericyte

Indexed keywords

3 NITROTYROSINE; BETA ACTIN; CARIPORIDE; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCEROPHOSPHATE; GLYCOLYTIC ENZYME; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; POLY(ADENOSINE DIPHOSPHATE RIBOSE); SODIUM PROTON EXCHANGE PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CATARACTOGENESIS; CELL PH; CONTROLLED STUDY; COW; DIABETES MELLITUS; DIABETIC RETINOPATHY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE; GLUCOSE BLOOD LEVEL; GLYCOLYSIS; HYPERGLYCEMIA; IN VITRO STUDY; LENS; MALE; NICK END LABELING; NITRATIVE STRESS; NONHUMAN; OPHTHALMOSCOPY; OXIDATIVE STRESS; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA; SLIT LAMP; STREPTOZOCIN DIABETES; UPREGULATION;

ALDEHYDES; ANIMALS; APOPTOSIS; BLOOD GLUCOSE; BLOTTING, WESTERN; CATARACT; CATTLE; DIABETES COMPLICATIONS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FASTING; GUANIDINES; IN SITU NICK-END LABELING; LENS, CRYSTALLINE; MALE; NITROSATION; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; RETINA; SODIUM-HYDROGEN ANTIPORTER; SULFONES; TYROSINE;

EID: 84860519937     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.933     Document Type: Article

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