Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 4, 2009, Pages 1778-1790

  Drel, Viktor R ^a   Xu, Weizheng ^b   Zhang, Jie ^b   Kador, Peter F ^c,d   Ali, Tayyeba K ^e   Shin, Jeho ^a   Julius, Ulrich ^f   Slusher, Barbara ^b   El Remessy, Azza B ^e   Obrosova, Irina G ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b MGI Pharma   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^e UNIVERSITY OF GEORGIA   (United States)

^f UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,5 ISOQUINOLINEDIOL; 10 (4 METHYL PIPERAZIN 1 YL METHYL) 2H 7 OXA 1,2 DIAZA BENZO[DE]ANTHRACEN 3 ONE; GLUCOSE; GPI 15427; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PALMITIC ACID; UNCLASSIFIED DRUG; 1,5-ISOQUINOLINEDIOL; ENZYME INHIBITOR; ORGANIC COMPOUND; QUINOLINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CELL CULTURE; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; DISEASE DURATION; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIUM CELL; ENZYME INHIBITION; GLIA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LENS EPITHELIUM; MALE; NICK END LABELING; NITROSATIVE STRESS; NONHUMAN; OPHTHALMOSCOPY; OXIDATIVE STRESS; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RETINA DISEASE; SLIT LAMP; STREPTOZOCIN DIABETES; TREATMENT DURATION; WESTERN BLOTTING; ANIMAL; CATTLE; CULTURE TECHNIQUE; DIABETIC RETINOPATHY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME IMMUNOASSAY; EPITHELIUM CELL; EXPERIMENTAL DIABETES MELLITUS; FLUORESCENCE MICROSCOPY; LENS; METABOLISM; RETINA; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; CATARACT; CATTLE; CELL CULTURE TECHNIQUES; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; LENS, CRYSTALLINE; MALE; MICROSCOPY, FLUORESCENCE; ORGANIC CHEMICALS; OXIDATIVE STRESS; PERICYTES; POLY(ADP-RIBOSE) POLYMERASES; QUINOLINES; RATS; RATS, WISTAR; RETINA;

EID: 64049094318     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-2191     Document Type: Article

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