The gamma-aminobutyric acid type B (GABA B) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens

Behavioral and Brain Functions

Volumn 8, Issue , 2012, Pages

  Fu, Zhenyu ^a,b   Yang, Hongfa ^a   Xiao, Yuqiang ^b   Zhao, Gang ^a   Huang, Haiyan ^a  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b DAQING OILFIELD CO LTD   (China)

Author keywords

Baclofen; Dopamine; Gaba receptor; Morphine; Nucleus accumbens; Sensitization

Indexed keywords

BACLOFEN; DOPAMINE; MORPHINE; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; NARCOTIC ANALGESIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOPAMINE RELEASE; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; LOCOMOTION; MALE; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; DISEASE MODEL; EXTRACELLULAR SPACE; METABOLISM; MORPHINE ADDICTION; MOTOR ACTIVITY; SPRAGUE DAWLEY RAT; WITHDRAWAL SYNDROME;

ANALGESICS, OPIOID; ANIMALS; BACLOFEN; DISEASE MODELS, ANIMAL; DOPAMINE; EXTRACELLULAR SPACE; GABA-B RECEPTOR AGONISTS; MALE; MICRODIALYSIS; MORPHINE; MORPHINE DEPENDENCE; MOTOR ACTIVITY; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84860502478     PISSN: None     EISSN: 17449081     Source Type: Journal    
DOI: 10.1186/1744-9081-8-20     Document Type: Article

References (53)

1. McDaid J, Dallimore JE, Mackie AR, Napier TC. Changes in accumbal and pallidal pcreb and deltafosb in morphine-sensitized rats: correlations with receptor-evoked electrophysiological measures in the ventral pallidum. Neuropsychopharmacology 2006, 31:1212-1226. 1464405, 16123760.
2. Robinson TE, Berridge KC. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 1993, 18:247-291.
3. Fattore L, Spano MS, Deiana S, Melis V, Cossu G, Fadda P, Fratta W. An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives. Brain Res Rev 2007, 53:1-16. 10.1016/j.brainresrev.2006.05.003, 16839608.
4. Contet C, Filliol D, Matifas A, Kieffer BL. Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity. Neuropharmacology 2008, 54:475-486. 10.1016/j.neuropharm.2007.10.015, 18082850.
5. Narita M, Suzuki M, Kuzumaki N, Miyatake M, Suzuki T. Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine. Ann N Y Acad Sci 2008, 1141:96-104. 10.1196/annals.1441.032, 18991953.
6. Li JX, Zhang Q, Liang JH. Valproate prevents the induction, but not the expression of morphine sensitization in mice. Behav Brain Res 2004, 152:251-257. 10.1016/j.bbr.2003.10.006, 15196792.
7. Listos J, Talarek S, Poleszak E, Wrobel A, Fidecka S. Attenuating effect of adenosine receptor agonists on the development of behavioral sensitization induced by sporadic treatment with morphine. Pharmacol Biochem Behav 2011, 98:356-361. 10.1016/j.pbb.2011.01.019, 21295055.
8. Spanagel R, Sillaber I, Zieglgansberger W, Corrigall WA, Stewart J, Shaham Y. Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress. Psychopharmacology (Berl) 1998, 139:391-401.
9. Corominas-Roso M, Roncero C, Bruguera E, Casas M. the dopaminergic system and addictions. Rev Neurol 2007, 44:23-31.
10. Narita M, Funada M, Suzuki T. Regulations of opioid dependence by opioid receptor types. Pharmacol Ther 2001, 89:1-15. 10.1016/S0163-7258(00)00099-1, 11316510.
11. Spanagel R, Heilig M. Addiction and its brain science. Addiction 2005, 100:1813-1822. 10.1111/j.1360-0443.2005.01260.x, 16367982.
12. McClung CA, Ulery PG, Perrotti LI, Zachariou V, Berton O, Nestler EJ. Deltafosb: a molecular switch for long-term adaptation in the brain. Brain Res Mol Brain Res 2004, 132:146-154.
13. De Vries TJ, Shippenberg TS. Neural systems underlying opiate addiction. J Neurosci 2002, 22:3321-3325.
14. Willuhn I, Wanat MJ, Clark JJ, Phillips PE. Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse. Curr Top Behav Neurosci 2010, 3:29-71. 10.1007/7854_2009_27, 21161749.
15. Narita M, Kato H, Miyoshi K, Aoki T, Yajima Y, Suzuki T. Treatment for psychological dependence on morphine: usefulness of inhibiting nmda receptor and its associated protein kinase in the nucleus accumbens. Life Sci 2005, 77:2207-2220. 10.1016/j.lfs.2005.04.015, 15946694.
16. Dayan P. Dopamine, reinforcement learning, and addiction. Pharmacopsychiatry 2009, 42(Suppl 1):S56-S65.
17. Filip M, Frankowska M. Gaba(b) receptors in drug addiction. Pharmacol Rep 2008, 60:755-770.
18. Tyacke RJ, Lingford-Hughes A, Reed LJ, Nutt DJ. Gabab receptors in addiction and its treatment. Adv Pharmacol 2010, 58:373-396.
19. Van den Oever MC, Lubbers BR, Goriounova NA, Li KW, Van der Schors RC, Loos M, Riga D, Wiskerke J, Binnekade R, Stegeman M, Schoffelmeer AN, Mansvelder HD, Smit AB, De Vries TJ, Spijker S. Extracellular matrix plasticity and gabaergic inhibition of prefrontal cortex pyramidal cells facilitates relapse to heroin seeking. Neuropsychopharmacology 2010, 35:2120-2133. 10.1038/npp.2010.90, 3055295, 20592718.
20. Haney M, Hart CL, Foltin RW. Effects of baclofen on cocaine self-administration: opioid- and nonopioid-dependent volunteers. Neuropsychopharmacology 2006, 31:1814-1821. 10.1038/sj.npp.1300999, 16407903.
21. Paterson NE, Froestl W, Markou A. The gabab receptor agonists baclofen and cgp44532 decreased nicotine self-administration in the rat. Psychopharmacology (Berl) 2004, 172:179-186.
22. Knapp DJ, Overstreet DH, Breese GR. Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal. Alcohol Clin Exp Res 2007, 31:582-595. 2864137, 17374037.
23. Bartoletti M, Gubellini C, Ricci F, Gaiardi M. Baclofen blocks the development of sensitization to the locomotor stimulant effect of amphetamine. Behav Pharmacol 2005, 16:553-558. 10.1097/01.fbp.0000179279.98029.e9, 16170232.
24. Madhavan A, Bonci A, Whistler JL. Opioid-induced gaba potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area. J Neurosci 2010, 30:14029-14035. 10.1523/JNEUROSCI.3366-10.2010, 20962224.
25. Woodward RM, Polenzani L, Miledi R. Characterization of bicuculline/baclofen-insensitive (rho-like) gamma-aminobutyric acid receptors expressed in xenopus oocytes. Ii. Pharmacology of gamma-aminobutyric acida and gamma-aminobutyric acidb receptor agonists and antagonists. Mol Pharmacol 1993, 43:609-625.
26. Wei XL, Su RB, Wu N, Lu XQ, Zheng JQ, Li J. Agmatine inhibits morphine-induced locomotion sensitization and morphine-induced changes in striatal dopamine and metabolites in rats. Eur Neuropsychopharmacol 2007, 17:790-799. 10.1016/j.euroneuro.2007.04.001, 17604969.
27. Karasawa J, Kotani M, Kambe D, Chaki S. Ampa receptor mediates mglu 2/3 receptor antagonist-induced dopamine release in the rat nucleus accumbens shell. Neurochem Int 2010, 57:615-619. 10.1016/j.neuint.2010.07.011, 20674641.
28. Maccioni P, Bienkowski P, Carai MA, Gessa GL, Colombo G. Baclofen attenuates cue-induced reinstatement of alcohol-seeking behavior in sardinian alcohol-preferring (sp) rats. Drug Alcohol Depend 2008, 95:284-287. 10.1016/j.drugalcdep.2008.02.006, 18374518.
29. Weerts EM, Froestl W, Kaminski BJ, Griffiths RR. Attenuation of cocaine-seeking by gaba b receptor agonists baclofen and cgp44532 but not the gaba reuptake inhibitor tiagabine in baboons. Drug Alcohol Depend 2007, 89:206-213. 10.1016/j.drugalcdep.2006.12.023, 1933605, 17234367.
30. Fattore L, Spano MS, Cossu G, Scherma M, Fratta W, Fadda P. Baclofen prevents drug-induced reinstatement of extinguished nicotine-seeking behaviour and nicotine place preference in rodents. Eur Neuropsychopharmacol 2009, 19:487-498. 10.1016/j.euroneuro.2009.01.007, 19250803.
31. Le Foll B, Wertheim CE, Goldberg SR. Effects of baclofen on conditioned rewarding and discriminative stimulus effects of nicotine in rats. Neurosci Lett 2008, 443:236-240. 10.1016/j.neulet.2008.07.074, 2679513, 18682277.
32. Bartoletti M, Colantoni A, De Luca V, Gaiardi M. Single and repeated baclofen treatment attenuates the discriminative stimulus effects of morphine in rats. Pharmacol Biochem Behav 2010, 97:279-283. 10.1016/j.pbb.2010.08.011, 20807548.
33. Spano MS, Fattore L, Fratta W, Fadda P. The gabab receptor agonist baclofen prevents heroin-induced reinstatement of heroin-seeking behavior in rats. Neuropharmacology 2007, 52:1555-1562. 10.1016/j.neuropharm.2007.02.012, 17451755.
34. Xi ZX, Stein EA. Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release. J Pharmacol Exp Ther 1999, 290:1369-1374.
35. Fadda P, Scherma M, Fresu A, Collu M, Fratta W. Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat. Synapse 2003, 50:1-6. 10.1002/syn.10238, 12872287.
36. Bexis S, Ong J, White J. Attenuation of morphine withdrawal signs by the gaba(b) receptor agonist baclofen. Life Sci 2001, 70:395-401. 10.1016/S0024-3205(01)01485-0, 11798009.
37. Diaz SL, Barros VG, Antonelli MC, Rubio MC, Balerio GN. Morphine withdrawal syndrome and its prevention with baclofen: autoradiographic study of mu-opioid receptors in prepubertal male and female mice. Synapse 2006, 60:132-140. 10.1002/syn.20279, 16715492.
38. Woo SH, Kim HS, Yun JS, Lee MK, Oh KW, Seong YH, Oh SK, Jang CG. Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity. Pharmacol Res 2001, 43:335-340. 10.1006/phrs.2000.0789, 11352538.
39. Bartoletti M, Ricci F, Gaiardi M. A gaba(b) agonist reverses the behavioral sensitization to morphine in rats. Psychopharmacology (Berl) 2007, 192:79-85.
40. Leite-Morris KA, Fukudome EY, Shoeb MH, Kaplan GB. Gaba(b) receptor activation in the ventral tegmental area inhibits the acquisition and expression of opiate-induced motor sensitization. J Pharmacol Exp Ther 2004, 308:667-678.
41. Smith MA, Greene-Naples JL, Lyle MA, Iordanou JC, Felder JN. The effects of repeated opioid administration on locomotor activity: I. Opposing actions of mu and kappa receptors. J Pharmacol Exp Ther 2009, 330:468-475. 10.1124/jpet.108.150011, 2713083, 19403853.
42. Chefer VI, Shippenberg TS. Augmentation of morphine-induced sensitization but reduction in morphine tolerance and reward in delta-opioid receptor knockout mice. Neuropsychopharmacology 2009, 34:887-898. 10.1038/npp.2008.128, 2639630, 18704097.
43. Zarrindast MR, Heidari-Darvishani A, Rezayof A, Fathi-Azarbaijani F, Jafari-Sabet M, Hajizadeh-Moghaddam A. Morphine-induced sensitization in mice: changes in locomotor activity by prior scheduled exposure to gabaa receptor agents. Behav Pharmacol 2007, 18:303-310. 10.1097/FBP.0b013e3282186baa, 17551323.
44. Li JX, Zhao WL, Liang JH. Effects of carbamazepine on morphine-induced behavioral sensitization in mice. Brain Res 2004, 1019:77-83. 10.1016/j.brainres.2004.05.082, 15306241.
45. Yui K, Goto K, Ikemoto S, Ishiguro T, Angrist B, Duncan GE, Sheitman BB, Lieberman JA, Bracha SH, Ali SF. Neurobiological basis of relapse prediction in stimulant-induced psychosis and schizophrenia: the role of sensitization. Mol Psychiatry 1999, 4:512-523. 10.1038/sj.mp.4000575, 10578232.
46. Kalivas PW, Pierce RC, Cornish J, Sorg BA. A role for sensitization in craving and relapse in cocaine addiction. J Psychopharmacol 1998, 12:49-53. 10.1177/026988119801200107, 9584968.
47. Phillips AG, Di Ciano P. Behavioral sensitization is induced by intravenous self-administration of cocaine by rats. Psychopharmacology (Berl) 1996, 124:279-281.
48. Piazza PV, Deminiere JM, le Moal M, Simon H. Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration. Brain Res 1990, 514:22-26. 10.1016/0006-8993(90)90431-A, 2357527.
49. Covington HE, Miczek KA. Repeated social-defeat stress, cocaine or morphine. Effects on behavioral sensitization and intravenous cocaine self-administration " binges" . Psychopharmacology (Berl) 2001, 158:388-398.
50. Powell KR, Holtzman SG. Parametric evaluation of the development of sensitization to the effects of morphine on locomotor activity. Drug Alcohol Depend 2001, 62:83-90. 10.1016/S0376-8716(00)00167-8, 11173171.
51. Nestler EJ. Historical review: molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol Sci 2004, 25:210-218. 10.1016/j.tips.2004.02.005, 15063085.
52. Pierce RC, Kumaresan V. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?. Neurosci Biobehav Rev 2006, 30:215-238. 10.1016/j.neubiorev.2005.04.016, 16099045.
53. Pinto A, Jankowski M, Sesack SR. Projections from the paraventricular nucleus of the thalamus to the rat prefrontal cortex and nucleus accumbens shell: ultrastructural characteristics and spatial relationships with dopamine afferents. J Comp Neurol 2003, 459:142-155. 10.1002/cne.10596, 12640666.