Attenuation of cocaine-seeking by GABAB receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons

Drug and Alcohol Dependence

Volumn 89, Issue 2-3, 2007, Pages 206-213

  Weerts, Elise M ^a   Froestl, Wolfgang ^b   Kaminski, Barbara J ^a   Griffiths, Roland R ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b AC IMMUNE SA   (Switzerland)

Author keywords

GABAB receptor agonist; Primates; Reinforcement; Reinstatement; Relapse; Self administration

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BACLOFEN; CGP 44532; COCAINE; SODIUM CHLORIDE; TIAGABINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; BABOON; COCAINE DEPENDENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVATION; DRUG EFFECT; DRUG INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; SELF INJECTION;

ANIMALS; APPETITIVE BEHAVIOR; BACLOFEN; COCAINE-RELATED DISORDERS; GABA AGONISTS; GABA ANTAGONISTS; MALE; MOTIVATION; NIPECOTIC ACIDS; PAPIO ANUBIS; RECEPTORS, GABA-B; SELF ADMINISTRATION;

PAPIO; PRIMATES;

EID: 34248598924     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2006.12.023     Document Type: Article

References (49)

1. Arroyo M., Markou A., Robbins T.W., and Everitt B.J. Acquisition, maintenance and reinstatement of intravenous cocaine self-administration under a second-order schedule of reinforcement in rats: effects of conditioned cues and continuous access to cocaine. Psychopharmacology (Berlin) 140 (1998) 331-344
2. Bardo M.T. Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Crit. Rev. Neurobiol. 12 (1998) 37-67
3. Brebner K., Childress A.R., and Roberts D.C. A potential role for GABA(B) agonists in the treatment of psychostimulant addiction. Alcohol 37 (2002) 478-484
4. Brebner K., Froestl W., Andrews M., Phelan R., and Roberts D.C. The GABA(B) agonist CGP 44532 decreases cocaine self-administration in rats: demonstration using a progressive ratio and a discrete trials procedure. Neuropharmacology 38 (1999) 1797-1804
5. Campbell U.C., Lac S.T., and Carroll M.E. Effects of baclofen on maintenance and reinstatement of intravenous cocaine self-administration in rats. Psychopharmacology (Berlin) 143 (1999) 209-214
6. Campbell U.C., Morgan A.D., and Carroll M.E. Sex differences in the effects of baclofen on the acquisition of intravenous cocaine self-administration in rats. Drug Alcohol Depend. 66 (2002) 61-69
7. Carroll M.E., and Comer S.D. Animal models of relapse. Exp. Clin. Psychopharmacol. 4 (1996) 11-18
8. Childress A.R., Franklin T., McElgin W., Acton P., and O'Brien C.P. GABAergics may Blunt Limbic Activation during Cue-induced Cocaine Craving (2000), College on the Problems of Drug Dependence, San Juan, Puerto Rico
9. Childress A.R., Mozley P.D., McElgin W., Fitzgerald J., Reivich M., and O'Brien C.P. Limbic activation during cue-induced cocaine craving. Am. J. Psychiatry 156 (1999) 11-18
10. Cousins M.S., Roberts D.C., and deWit H. GABA(B) receptor agonists for the treatment of drug addiction: a review of recent findings. Drug Alcohol Depend. 65 (2002) 209-220
11. Davis W.M., and Smith S.G. Role of conditioned reinforcers in the initiation, maintenance, and extinction of drug-seeking behavior. Pavlov. J. Biol. Sci. 11 (1976) 222-236
12. deWit H., and Stewart J. Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75 (1981) 134-143
13. Di Ciano P., and Everitt B.J. The GABA(B) receptor agonist baclofen attenuates cocaine- and heroin-seeking behavior by rats. Neuropsychopharmacology 28 (2003) 510-518
14. B receptor agonist, is hedonically neutral and reduces cocaine-induced enhancement of reward. Neuropharmacology 42 (2002) 626-632
15. Fadda P., Scherma M., Fresu A., Collu M., and Fratta W. Baclofen antagonizes nicotine-, cocaine- and morphine-induced dopamine release in the nucleus accumbens of rat. Synapse 50 (2003) 1-6
16. Franklin T., Kampman K., Ehrman R., O'Brien C., and Childress A.R. Impact of GABAergics in a Novel "Cue + Cocaine Challenge" Paradigm (2000), College on the Problems of Drug Dependence, San Juan, Puerto Rico
17. Froestl W., Mickel S.J., and Bittiger H. Potent GABAB agonists and antagonists. Curr. Opin. Ther. Patents 3 (1993) 561-567
18. B agonists. J. Med. Chem. 38 (1995) 3297-3312
19. Gasior M., Kaminski R., and Witkin J.M. Pharmacological modulation of GABA(B) receptors affects cocaine-induced seizures in mice. Psychopharmacology (Berlin) 174 (2004) 211-219
20. Gerber G.J., and Stretch R. Drug-induced reinstatement of extinguished self-administration behavior in monkeys. Pharmacol. Biochem. Behav. 3 (1975) 1055-1061
21. Goldberg S.R., Morse W.H., and Goldberg D.M. Behavior maintained under a second-order schedule by intramuscular injection of morphine or cocaine in rhesus monkeys. J. Pharmacol. Exp. Ther. 199 (1976) 278-286
22. Gonzalez G., Sevarino K., Sofuoglu M., Poling J., Oliveto A., Gonsai K., George T.P., and Kosten T.R. Tiagabine increases cocaine-free urines in cocaine-dependent methadone-treated patients: results of a randomized pilot study. Addiction 98 (2003) 1625-1632
23. Haney M., Hart C.L., and Foltin R.W. Effects of baclofen on cocaine self-administration: opioid- and non-opioid-dependent volunteers. Neuropsychopharmacology 31 (2006) 1814-1821
24. Johanson C.E. Behavior maintained under fixed-interval and second-order schedules of cocaine or pentobarbital in rhesus monkeys. J. Pharmacol. Exp. Ther. 221 (1982) 384-393
25. Katz J.L. A comparison of responding maintained under second-order schedules of intramuscular cocaine injection or food presentation in squirrel monkeys. J. Exp. Anal. Behav. 32 (1979) 419-431
26. Lile J.A., Stoops W.W., Glaser P.E., Hays L.R., and Rush C.R. Acute administration of the GABA reuptake inhibitor tiagabine does not alter the effects of oral cocaine in humans. Drug Alcohol Depend. 76 (2004) 81-91
27. Ling W., Shoptaw S., and Majewska D. Baclofen as a cocaine anti-craving medication: a preliminary clinical study. Neuropsychopharmacology 18 (1998) 403-404 (letter)
28. Lukas S.E., Griffiths R.R., Bradford L.D., Brady J.V., and Daley L. A tethering system for intravenous and intragastric drug administration in the baboon. Pharmacol. Biochem. Behav. 17 (1982) 823-829
29. Markou A., Arroyo M., and Everitt B.J. Effects of contingent and non-contingent cocaine on drug-seeking behavior measured using a second-order schedule of cocaine reinforcement in rats. Neuropsychopharmacology 20 (1999) 542-555
30. Markou A., Weiss F., Gold L.H., Caine S.B., Schulteis G., and Koob G.F. Animal models of drug craving. Psychopharmacology 112 (1993) 163-182
31. Norman A.B., Norman M.K., Hall J.F., and Tsibulsky V.L. Priming threshold: a novel quantitative measure of the reinstatement of cocaine self-administration. Brain Res. 831 (1999) 165-174
32. Roberts D.C., and Andrews M.M. Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure. Psychopharmacology (Berlin) 131 (1997) 271-277
33. Roberts D.C., Andrews M.M., and Vickers G.J. Baclofen attenuates the reinforcing effects of cocaine in rats. Neuropsychopharmacology 15 (1996) 417-423
34. Schindler C.W., Panlilio L.V., and Goldberg S.R. Second-order schedules of drug self-administration in animals. Psychopharmacology (Berlin) 163 (2002) 327-344
35. Self D.W., and Nestler E.J. Relapse to drug-seeking: neural and molecular mechanisms. Drug Alcohol Depend. 51 (1998) 49-60
36. Shoaib M., Swanner L.S., Beyer C.E., Goldberg S.R., and Schindler C.W. The GABAB agonist baclofen modifies cocaine self-administration in rats. Behav. Pharmacol. 9 (1998) 195-206
37. Shoptaw S., Yang X., Rotheram-Fuller E.J., Hsieh Y.C., Kintaudi P.C., Charuvastra V.C., and Ling W. Randomized placebo-controlled trial of baclofen for cocaine dependence: preliminary effects for individuals with chronic patterns of cocaine use. J. Clin. Psychiatry 64 (2003) 1440-1448
38. Sidman M. Tactics of Scientific Research (1960), Basic Books, New York
39. Slikker Jr. W., Brocco M.J., and Killam Jr. K.F. Reinstatement of responding maintained by cocaine or thiamylal. J. Pharmacol. Exp. Ther. 228 (1984) 43-52
40. Sofuoglu M., and Kosten T.R. Novel approaches to the treatment of cocaine addiction. CNS Drugs 19 (2005) 13-25
41. Sofuoglu M., and Kosten T.R. Emerging pharmacological strategies in the fight against cocaine addiction. Expert Opin. Emerg. Drugs 11 (2006) 91-98
42. Sofuoglu M., Poling J., Mitchell E., and Kosten T.R. Tiagabine affects the subjective responses to cocaine in humans. Pharmacol. Biochem. Behav. 82 (2005) 569-573
43. Spealman R.D., Barrett-Larimore R.L., Rowlett J.K., Platt D.M., and Khroyan T.V. Pharmacological and environmental determinants of relapse to cocaine-seeking behavior. Pharmacol. Biochem. Behav. 64 (1999) 327-336
44. Stafford D., and Glowa J.R. Effects of Intravenous Baclofen Pretreatment on Food- and Cocaine-maintained Responding in Rhesus Monkeys (2000), College on the Problems of Drug Dependence, San Juan, Puerto Rico
45. Suzdak P.D., and Jansen J.A. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia 36 (1995) 612-626
46. Weerts E.M., Froestl W., and Griffiths R.R. Effects of GABAergic modulators on food and cocaine self-administration in baboons. Drug Alcohol Depend. 80 (2005) 369-376
47. Weerts E.M., and Griffiths R.R. Cocaine, caffeine and CGS15943 reinstate extinguished cocaine-taking behavior in baboons. Soc. Neurosci. Abstracts 25 (1999) 305
48. Weerts E.M., and Griffiths R.R. The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboons. Psychopharmacology (Berlin) 168 (2003) 155-163
49. Winhusen T.M., Somoza E.C., Harrer J.M., Mezinskis J.P., Montgomery M.A., Goldsmith R.J., Coleman F.S., Bloch D.A., Leiderman D.B., Singal B.M., Berger P., and Elkashef A. A placebo-controlled screening trial of tiagabine, sertraline and donepezil as cocaine dependence treatments. Addiction 100 Suppl. 1 (2005) 68-77