Acamprosate suppresses the expression of morphine induced sensitization in rats but does not affect heroin self administration or relapse induced by heroin or stress

Psychopharmacology

Volumn 139, Issue 4, 1998, Pages 391-401

  Spanagel, Rainer ^a   Sillaber, Inge ^a   Zieglgänsberger, Walter ^a   Corrigall, William A ^b   Stewart, Jane ^c   Shaham, Yavin ^b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF TORONTO   (Canada)

^c and Applied Physiology   (Canada)

Author keywords

Acamprosate; Dopamine; Heroin self administration; Nucleus accumbens; Reinstatement; Relapse; Sensitization; Stress

Indexed keywords

ACAMPROSATE; DIAMORPHINE; MORPHINE;

ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG DEPENDENCE; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; RELAPSE; SENSITIZATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; DRUG INTERACTIONS; DRUG TOLERANCE; FOOD DEPRIVATION; HEROIN; HEROIN DEPENDENCE; MALE; MORPHINE; NARCOTICS; RATS; RATS, SPRAGUE-DAWLEY; RECURRENCE; SELF ADMINISTRATION; STRESS; TAURINE;

EID: 0031697417     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050730     Document Type: Article

References (63)

1. Acquas E, Di Chiara G (1992) Depression of mesolimbic dopamine transmission and sensitization to morphine during opiate abstinence. J Neurochem 58:1620-1625
2. B receptors in nucleus accumbens neurons. Alcohol Clin Exp Res 22:183-192
3. Boismare F, Daoust M, Moore N, Saligaut C, Lhuintre J, Chretien P, Durlach J (1984) A homotaurine derivate reduced the voluntary intake of ethanol by rats: are cerebral GABA receptors involved? Pharmacol Biochem Behav 21: 787-789
4. Bozarth MA, Wise RA (1981) Intracranial self-administration of morphine into the ventral tegmental area in rats. Life Sci 28: 551-555
5. Brady JV (1991) Animal models for assessing drugs of abuse. Neurosci Biobehav Rev 15:35-43
6. Childress AR, Ehrman R, Rohsenow DJ, Robbins SJ, O'Brien CP (1992) Classically conditioned factors in drug dependence. In: Lowinson JW, Luiz P, Millman RB, Langard G (eds) Substance abuse: a comprehensive textbook. Williams and Wilkins, Baltimore, pp 56-69
7. Collingridge GL, Singer W (1990) Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol Sci 1:290-296
8. Corrigall WA, Coen KM (1989) Nicotine maintains robust self-administration in rats on a limited access schedule. Psychopharmacology 99:473-478
9. Herz A (1997) Endogenous opioid systems and alcohol addiction. Psychopharmacology 129:99-111
10. Heyser CJ, Schulteis G, Koob GF (1997) Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm. Alcohol Clin Exp Res 21:784-792
11. Heyser CJ, Schulteis G, Durbin P, Koob GF (1998) Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology 18:125-133
12. Hölter SM, Landgraf R, Zieglgänsberger W, Spanagel R (1997) Time course of acamprosate action on operant ethanol self-administration after ethanol deprivation. Alcohol Clin Exp Res 21:862-869
13. Jeziorski M, White FJ, Wolf ME (1994) MK-801 prevents the development of behavioral sensitzation during repeated morphine administration. Synapse 16:137-147
14. Kalivas PW (1993) Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res Rev 18: 75-113
15. Kalivas PW, Stewart J (1991) Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Rev 16:223-244
16. Kosten TR, Rounsaville BJ, Kleber HD (1986) A 2.5 year follow up of depressions, life crises, and treatment effects on abstinence among opioid addicts. Arch Gen Psychiatry 43: 733-739
17. Landgraf R, Neumann I, Holsboer F, Pittman QJ (1995) Interleukin-1β stimulates both central and peripheral release of vasopressin andoxytocin in the rat. Eur J Neurosci 7:592-598
18. Legrand E, Naassila M, Durbin Ph. Daoust M (1997) Pharmacology of central acamprosate binding site. Alcohol Clin Exp Res 21:37A
19. Le Magnen J, Tran G, Durlach J, Martin C (1987) Dose-dependent suppression of the high alcohol intake of chronically intoxicated rats by Ca-acetyl homotaurinate. Alcohol 4:97-102
20. Levine AS, Hess S, Morley JL (1983) Alcohol and the opiate receptor. Alcohol Clin Exp Res 7: 83-84
21. Lhuintre J, Moore ND, Saligaut C, Boismare F, Daoust M, Chretien P, Tran G, Hillemand B (1985) Ability of calcium bis acetyl homotaurine, a gaba agonist, to prevent relapse in weaned alcoholics. Lancet 1:1014-1016
22. Littleton J (1995) Acamprosate in alcohol dependence: how does it work? Addiction 90: 1179-1188
23. Madamba SG, Schweitzer P, Zieglgänsberger W, Siggins GR (1996) Acamprosate (calcium acetylhomotaurinate) enhanced the N-methyl-D-aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro. Alcohol Clin Exp Res 20:651-658
24. Markou A, Weiss F, Gold LH, Caine B, Schulteis G, Koob GF (1993) Animals models of drug craving. Psychopharmacology 112:163-182
25. Marris RGM, Anderson E, Lynch G, Baudry M (1986) Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319:774-776
26. Nestler LJ (1996) Under siege: the brain on opiates. Neuron 16: 897-900
27. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer R, Rounsaville B (1992) Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Arch Gen Psychiatry 49:881-887
28. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic Press, San Diego, Calif.
29. Phillips AG, LePiane FG (1980) Reinforcing effects of morphine microinjections into the ventral tegmental area. Pharmacol Biochem Behav 12:965-968
30. Pierce RC, Bell K, Duffy P, Kalivas PW (1996) Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization. J Neurosci 16:1550-1560
31. Pierce RC, Reeder DC, Hicks J, Morgan ZR, Kalivas PW (1998) Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine. Neuroscience (in press)
32. Popik P, Danysz W (1997) Inhibition of reinforcing effects of morphine and motivational aspects of naloxone-precipitated opioid withdrawal by an N-methyl-D-aspartate receptor antagonist, memantine. J Pharmacol Exp Ther 280:854-865
33. Putzke J, Spanagel R, Tölle TR, Zieglgänsberger W (1996) The anti-craving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal. Eur J Pharmacol 317:39-48
34. Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Rev 18:247-291
35. Sass H, Soyka M, Mann K, Zieglgänsberger W (1996) Relapse prevention by acamprosate: results from a placebo controlled study in alcohol dependence. Arch Gen Psychiatry 53:673-680
36. Sesack SR, Pickel VM (1990) In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are on apposition to each other. Brain Res 527:83-91
37. Shaham Y (1996) Effect of stress on opioid seeking behavior: evidence from studies with rats. Ann Behav Med 18: 255-263
38. Shaham Y, Stewart J (1995) Stress reinstates heroin self-administration behavior in drug-free animals: an effect mimicking heroin, not withdrawal. Psychopharmacology 119:334-341
39. Shaham Y, Stewart J (1996) Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re exposure to heroin in rats. Psychopharmacology 125:385-391
40. Shaham Y, Rajabi H, Stewart J (1996) Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin priming, and withdrawal. J Neurosci 16:1957-1963
41. Shaham Y, Funk D, Erb S, Brown T, Walker CD, Stewart J (1997) Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats. J Neurosci 17:2605-2614
42. Sinclair JD, Senter RJ (1967) Increased preference for ethanol in rats following alcohol deprivation. Psychonom Sci 8:11-16
43. Spanagel R (1995) Modulation of drug-induced sensitization processes by endogenous opioid systems. Behav Brain Res 70: 37-19
44. Spanagel R, Kirschke C (1997) The effects of anticraving compounds on conditioned opiate withdrawal in the rat. Pharmacopsychiatry 30:21
45. Spanagel R. Zieglgänsberger W (1997) Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci 18:54-59
46. Spanagel R, Almeida OFX, Shippenberg TS (1993) Long lasting changes in morphine-induced mesolimbic dopamine release after chronic morphine exposure. Synapse 14:243-245
47. Spanagel R, Hölter S, Allingham K, Landgraf R, Zieglgänsberger W (1996) Acamprosate and alcohol: I. effects of alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 305: 39-44
48. Stewart J, Badiani A (1993) Tolerance and sensitization to the behavioral effects of drugs. Behav Pharmacol 4:289-312
49. Stewart J, de Wit H (1987) Reinstatement of drug-taking behavior as a method of assessing incentive motivational properties of drugs. In: Bozarth MA (ed) Methods of assessing the reinforcing properties of abused drugs. Springer, New York, pp 211-227
50. Stewart J, Vezina P (1988) A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior. Brain Res 457:287-294
51. Tabakoff B, Hoffman PL (1996) Alcohol addiction: an enigma among us. Neuron 16:909-912
52. Terenius L (1996) Alcohol addiction (alcoholism) and the opioid system. Alcohol 13:31-34
53. Tran-Nguyen LT, Fuchs RA, Coffey GP, O'Dell LE, Baker DA, Neisewander JL (1998) Time-dependent changes in cocaine-seeking behavior and dopamine overflow in the amygdala during cocaine withdrawal. Neuropsychopharmacology (in press)
54. Tzschentke TM, Schmidt WJ (1996) Procedural examination of behavioural sensitization to morphine: lack of blockade by MK-801, occurence of sensitized sniffing, and evidence for cross-sensitization between morphine and MK-801. Behav Pharmacol 7:169-184
55. Ulm RR, Volpicelli JR, Volpicelli LA (1995) Opiates and alcohol self-administration in animals. J Clin Psychiatry 56:5-14
56. Vaccarino FJ, Bloom FE, Koob GF (1985) Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat. Psychopharmacology 86:37-12
57. Vezina P, Kalivas PW, Stewart J (1987) Sensitization occurs to the locomotor effects of morphine and the specific μ-opioid receptor agonist. DAGO, administered repeatedly to the ventral tegmental area but not to the nucleus accumbens. Brain Res 417:51-58
58. Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP (1992) Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 49:876-880
59. Whitworth AB, Fischer F, Lesch OM, Nimmerrichter A, Oberbauer H, Platz T, Potgieter A, Walter H, Fleischhacker WW (1996) Comparison of acamprosate and placebo in long-term treatment of alcohol dependence. Lancet 347:1438-1442
60. Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469-492
61. Wolf ME, Jeziorski M (1994) Coadministration of Mk-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization. Brain Res 613:291-294
62. Zeise ML, Kasparov S, Capogna M, Zieglgänsberger W (1993) Acamprosate (calciumacetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: possible involvement of excitatory amino acid receptors. Eur J Pharmacol 231:47-52
63. Zieglgänsberger W, Hauser C, Wetzel C, Putzke J, Siggins GR, Spanagel R (1996) Actions of acamprosate on neurons of the central nervous system. In: Soyka M (ed) Acamprosate. Springer, Heidelberg, pp 65-70