Extension of the liquid chromatography/quantitative structure-property relationship method to assess the lipophilicity of neutral, acidic, basic and amphotheric drugs

Journal of Chromatography A

Volumn 1240, Issue , 2012, Pages 113-122

  Pallicer, Juan M ^a   Calvet, Carme ^b   Port, Adriana ^b   Rosés, Martí ^a   Ràfols, Clara ^a   Bosch, Elisabeth ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b ESTEVE   (Spain)

Author keywords

Drugs; HPLC; Lipophilicity; Polarity model; QSPR model; UHPLC

Indexed keywords

DRUGS; HPLC; LIPOPHILICITY; QSPR MODEL; UHPLC;

ALCOHOLS; CHROMATOGRAPHIC ANALYSIS;

CHROMATOGRAPHY;

ATENOLOL; ATORVASTATIN; CARBAMAZEPINE; CELECOXIB; CHLORPROMAZINE; CLOFAZIMINE; CLOPIDOGREL; DILTIAZEM; DRUG; DULOXETINE; ETIRACETAM; FLUFENAMIC ACID; FLUOXETINE; FLURBIPROFEN; GLIMEPIRIDE; INDOMETACIN; KETOROLAC; LORATADINE; MEBENDAZOLE; MICONAZOLE; MILNACIPRAN; NAPROXEN; OMEPRAZOLE; PANTOPRAZOLE; QUETIAPINE; RANITIDINE; RIMONABANT; ROSIGLITAZONE; ROSUVASTATIN; UNINDEXED DRUG;

ACID BASE BALANCE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; INTERNAL CONSISTENCY; LIPOPHILICITY; PARTICLE SIZE; PARTITION COEFFICIENT; PKA; POTENTIOMETRY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE PROPERTY RELATION; REFERENCE VALUE; TIME SERIES ANALYSIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

1-OCTANOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LINEAR MODELS; METHANOL; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860487095     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.03.089     Document Type: Article

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