Lipophilicity assessment of basic drugs (logPo/w determination) by a chromatographic method

Journal of Chromatography A

Volumn 1218, Issue 37, 2011, Pages 6356-6368

  Pallicer, Juan M ^a   Sales, Joaquim ^a   Rosés, Martí ^a   Ràfols, Clara ^a   Bosch, Elisabeth ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

HPLC; Hydrophobicity of basic drugs; LogPo w of basic drugs; Polarity model; QSPR model

Indexed keywords

BASIC DRUGS; BIOACTIVE COMPOUNDS; CHEMICAL NATURE; CHROMATOGRAPHIC METHODS; DIFFERENT STRUCTURE; GOOD CORRELATIONS; HIGH PH; HPLC; LIPOPHILICITY; MOBILE PHASIS; PARTITION COEFFICIENT; POLARITY MODEL; QSPR MODEL; STATIONARY PHASIS;

ALCOHOLS; ALKALINITY; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HYDROPHOBICITY; RATING;

CHEMICAL COMPOUNDS;

ACEBUTOLOL; ALPRENOLOL; AMITRIPTYLINE; ATENOLOL; ATROPINE; BUPIVACAINE; CHLORPROMAZINE; CLONIDINE; CYPROHEPTADINE; DIPHENHYDRAMINE; EPHEDRINE; FLURBIPROFEN; IMIPRAMINE; ISONIAZID; KETOPROFEN; LIDOCAINE; MAPROTILINE; MEPIVACAINE; METOPROLOL; NADOLOL; NORTRIPTYLINE; OXPRENOLOL; PENBUTOLOL; PILOCARPINE; PROCAINAMIDE; PROPRANOLOL; QUININE; TRAZODONE; TRIMETHOPRIM; UNINDEXED DRUG;

ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG STRUCTURE; HYDROPHOBICITY; LIPOPHILICITY; PARTITION COEFFICIENT; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

1-OCTANOL; ACETONITRILES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LINEAR MODELS; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 80051871295     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.07.002     Document Type: Article

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