Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 10, 2012, Pages 3412-3417

  Ryabtsova, Oxana ^a   Jansen, Koen ^a   Van Goethem, Sebastiaan ^a   Joossens, Jurgen ^a   Cheng, Jonathan D ^b   Lambeir, Anne Marie ^a   De Meester, Ingrid ^a   Augustyns, Koen ^a   Van Der Veken, Pieter ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b FOX CHASE CANCER CENTER   (United States)

Author keywords

DPP IV, DPP4; FAP; Fibroblast activation protein ; PREP; Prolyl oligopeptidase; PT 100; Seprase; Talabostat; Val boroPro

Indexed keywords

DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE 9; DIPEPTIDYL PEPTIDASE II; DIPEPTIDYL PEPTIDASE IV; GLYCINE DERIVATIVE; NITRILE; PROLYL ENDOPEPTIDASE; PYRROLIDINE DERIVATIVE; SEPRASE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ACYLATION; GELATINASES; MEMBRANE PROTEINS; PYRROLIDINES; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84860472982     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.107     Document Type: Article

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