Pyrrolidides: Synthesis and structure-activity relationship as inhibitors of dipeptidyl peptidase IV

European Journal of Medicinal Chemistry

Volumn 32, Issue 4, 1997, Pages 301-309

  Augustyns, K J L ^b   Lambeir, A M ^a   Borloo, M ^b   De Meester, I ^a   Vedernikova, I ^b   Vanhoof, G ^a   Hendriks, D ^a   Scharpe S ^a   Haemers, A ^b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b NONE

Author keywords

Dipeptidyl peptidase IV; Protease inhibitor; Pyrrolidide; Serine protease

Indexed keywords

DIPEPTIDYL PEPTIDASE IV; ENZYME INHIBITOR; PYRROLIDINE DERIVATIVE;

ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; SEMINAL PLASMA; STRUCTURE ACTIVITY RELATION;

EID: 0030965178     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(97)89082-4     Document Type: Article

References (21)

1. 1 Yaron A, Naider F (1993) Crit Rev Biochem Mol Biol 28, 31-81
2. 2 Barrett AJ, Rawlings ND (1995) Arch Biochem Biophys 318, 247-250
3. 3 Tiruppathi C, Miyamoto Y, Ganapathy V, Roesel RA, Whitford GM, Leibach FH (1990) J Biol Chem 265, 1476-1483
4. 4 Frohman LA, Downs TR, Williams TC, Heimer EP, Pan YE, Felix AM (1986) J Clin Invest 78, 906-913
5. 5 Medeiros MS, Turner AJ (1994) Biochimie 76, 283-287
6. 6 Kieffer TJ, McIntosh CHS, and Pederson RA (1995) Endocrinology 136, 3585-3596
7. 7 Hoffmann T, Faust J, Neubert K, Ansorge S (1993) FEBS Lett 336, 61-64
8. 8 Fleisher B (1994) Immunol Today 15, 180-184
9. 9 Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C (1993) Science 241, 466-469
10. 10 Flentke GR, Munoz E, Huber BT, Plaut AG, Kettner CA, Bachovchin WW (1991) Proc Natl Acad Sci USA 88, 1556-1559
11. 11 Kelly TA, Adams J, Bachovchin WW et al (1993) J Am Chem Soc 115, 12637-12638
12. 12 Boduszek B, Oleksyszyn J, Kam CM, Selzler J, Smith RE, Powers JC (1994) J Med Chem 37, 3969-3976
13. 13 Lambeir AM, Borloo M, De Meester I et al (1996) Biochim Biophys Acta 1290, 76-82
14. 14 Demuth HU, Neumann U, Barth A (1989) J Enzyme Inhibit 2, 239-248
15. 15 Schön E, Born I, Demuth HU et al (1991) Biol Chem Hoppe-Seyler 372, 305-311
16. 16 Li J, Wilk E, Wilk, S (1995) Arch Biochem Biophys 323, 148-154
17. 17 Belokon YN, Bulychev AG, Pavlov VA et al (1988) J Chem Soc Perkin Trans I 2075-2083
18. 18 De Meester I, Vanhoof G, Lambeir AM , Scharpé S (1996) J Immunol Methods 189, 99-105
19. 19 Rahfeld J, Schutkowski M, Faust J, Neubert K, Barth A, Heins J (1991) Biol Chem Hoppe-Seyler 372, 313-318
20. 20 Brandt W, Lehman T, Thondorf I et al (1995) Int J Peptide Protein Res 46, 494-507
21. 21 Duke-Cohan JS, Morimoto C, Rocker JA, Schlossman S (1995) J Biol Chem 270, 14107-14114