Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein

Journal of Medicinal Chemistry

Volumn 53, Issue 18, 2010, Pages 6572-6583

  Tsai, Ting Yueh ^a   Yeh, Teng Kuang ^a   Chen, Xin ^a   Hsu, Tsu ^a   Jao, Yu Chen ^a   Huang, Chih Hsiang ^a   Song, Jen Shin ^a   Huang, Yu Chen ^a   Chien, Chia Hui ^a   Chiu, Jing Huai ^a   Yen, Shih Chieh ^a   Tang, Hung Kuan ^a   Chao, Yu Sheng ^a   Jiaang, Weir Torn ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 [2 (5 CHLORO 1,3 DIHYDROISOINDOL 2 YL) 2 OXOETHYL] 5 OXOPYRROLIDINE 2 CARBONYL] 4 FLUOROPYRROLIDINE 2 CARBONITRILE; 1 [[4 [2 (1,3 DIHYDRO 2H ISOINDOL 2 YL) 2 OXOETHYL] 5 OXOPYRROLIDIN 2 YL]CARBONYL] 4 FLUOROPYRROLIDINE 2 CARBONITRILE; 1 [[4 [2 (1,3 DIHYDRO 2H ISOINDOL 2 YL) 2 OXOETHYL] 5 OXOPYRROLIDIN 2 YL]CARBONYL] 4,4 DIFLUOROPYRROLIDINE 2 CARBONITRILE; 4 CARBOXYMETHYLPYROGLUTAMIC ACID DIAMIDE DERIVATIVE; CYSTEINE PROTEINASE; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE II; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IX; DIPEPTIDYL PEPTIDASE VIII; FIBROBLAST ACTIVATION PROTEIN INHIBITOR; PEPTIDE HYDROLASE INHIBITOR; PROLINE IMINOPEPTIDASE; UNCLASSIFIED DRUG; AMIDE; DIPEPTIDASE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DPP8 PROTEIN, HUMAN; DPP9 PROTEIN, HUMAN; GELATINASE; MEMBRANE PROTEIN; PYROGLUTAMIC ACID; SEPRASE; SERINE PROTEINASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; IC 50; MOUSE; NONHUMAN; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; HUMAN; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDES; ANIMALS; ANTIGENS, CD26; DIPEPTIDASES; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; GELATINASES; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PYRROLIDONECARBOXYLIC ACID; SERINE ENDOPEPTIDASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; DIPEPTIDYL-PEPTIDASE IV INHIBITORS;

EID: 77956717491     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1002556     Document Type: Article

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