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Volumn 7, Issue 4, 2012, Pages

Deletion of dicer in smooth muscle affects voiding pattern and reduces detrusor contractility and neuroeffector transmission

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL CAV1.2; CALCIUM CHANNEL L TYPE; CALPONIN; DESMIN; DICER; MICRORNA; MICRORNA 125B 5P; MICRORNA 145; MICRORNA 22; MICRORNA 27A; MYOCARDIN; RNA; TRANSGELIN; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; ADENOSINE TRIPHOSPHATE; CALCIUM BINDING PROTEIN; CALYCULIN A; CAV1.2 PROTEIN, MOUSE; DEAD BOX PROTEIN; DICER1 PROTEIN, MOUSE; OXAZOLE DERIVATIVE; RIBONUCLEASE III;

EID: 84860464993     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035882     Document Type: Article
Times cited : (28)

References (48)
  • 1
    • 79952241104 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors in the urinary tract
    • Andersson KE, (2011) Muscarinic acetylcholine receptors in the urinary tract. Handb Exp Pharmacol pp. 319-344.
    • (2011) Handb Exp Pharmacol , pp. 319-344
    • Andersson, K.E.1
  • 2
    • 77949490835 scopus 로고    scopus 로고
    • The physiological function of lower urinary tract smooth muscle
    • Fry CH, Meng E, Young JS, (2010) The physiological function of lower urinary tract smooth muscle. Auton Neurosci 154: 3-13.
    • (2010) Auton Neurosci , vol.154 , pp. 3-13
    • Fry, C.H.1    Meng, E.2    Young, J.S.3
  • 3
    • 0028965779 scopus 로고
    • The structural relations between nerve fibres and muscle cells in the urinary bladder of the rat
    • Gabella G, (1995) The structural relations between nerve fibres and muscle cells in the urinary bladder of the rat. J Neurocytol 24: 159-187.
    • (1995) J Neurocytol , vol.24 , pp. 159-187
    • Gabella, G.1
  • 4
    • 67650138614 scopus 로고    scopus 로고
    • Signaling processes for initiating smooth muscle contraction upon neural stimulation
    • Ding HL, Ryder JW, Stull JT, Kamm KE, (2009) Signaling processes for initiating smooth muscle contraction upon neural stimulation. J Biol Chem 284: 15541-15548.
    • (2009) J Biol Chem , vol.284 , pp. 15541-15548
    • Ding, H.L.1    Ryder, J.W.2    Stull, J.T.3    Kamm, K.E.4
  • 5
    • 0034662903 scopus 로고    scopus 로고
    • Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype
    • Matsui M, Motomura D, Karasawa H, Fujikawa T, Jiang J, et al. (2000) Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci U S A 97: 9579-9584.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9579-9584
    • Matsui, M.1    Motomura, D.2    Karasawa, H.3    Fujikawa, T.4    Jiang, J.5
  • 6
    • 15744394182 scopus 로고    scopus 로고
    • The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder
    • Ehlert FJ, Griffin MT, Abe DM, Vo TH, Taketo MM, et al. (2005) The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder. J Pharmacol Exp Ther 313: 368-378.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 368-378
    • Ehlert, F.J.1    Griffin, M.T.2    Abe, D.M.3    Vo, T.H.4    Taketo, M.M.5
  • 7
    • 32544436125 scopus 로고    scopus 로고
    • Purinoceptors as therapeutic targets for lower urinary tract dysfunction
    • Ford AP, Gever JR, Nunn PA, Zhong Y, Cefalu JS, et al. (2006) Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol 147 (Suppl 2): S132-143.
    • (2006) Br J Pharmacol , vol.147 , Issue.SUPPL. 2
    • Ford, A.P.1    Gever, J.R.2    Nunn, P.A.3    Zhong, Y.4    Cefalu, J.S.5
  • 8
    • 0020422949 scopus 로고
    • Atropine resistance of transmurally stimulated isolated human bladder muscle
    • Sjogren C, Andersson KE, Husted S, Mattiasson A, Moller-Madsen B, (1982) Atropine resistance of transmurally stimulated isolated human bladder muscle. J Urol 128: 1368-1371.
    • (1982) J Urol , vol.128 , pp. 1368-1371
    • Sjogren, C.1    Andersson, K.E.2    Husted, S.3    Mattiasson, A.4    Moller-Madsen, B.5
  • 9
    • 0027751526 scopus 로고
    • Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis
    • Palea S, Artibani W, Ostardo E, Trist DG, Pietra C, (1993) Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis. J Urol 150: 2007-2012.
    • (1993) J Urol , vol.150 , pp. 2007-2012
    • Palea, S.1    Artibani, W.2    Ostardo, E.3    Trist, D.G.4    Pietra, C.5
  • 10
    • 0035197684 scopus 로고    scopus 로고
    • Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles
    • Yoshida M, Homma Y, Inadome A, Yono M, Seshita H, et al. (2001) Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles. Exp Gerontol 36: 99-109.
    • (2001) Exp Gerontol , vol.36 , pp. 99-109
    • Yoshida, M.1    Homma, Y.2    Inadome, A.3    Yono, M.4    Seshita, H.5
  • 11
    • 9144270691 scopus 로고    scopus 로고
    • A pancreatic islet-specific microRNA regulates insulin secretion
    • Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, et al. (2004) A pancreatic islet-specific microRNA regulates insulin secretion. Nature 432: 226-230.
    • (2004) Nature , vol.432 , pp. 226-230
    • Poy, M.N.1    Eliasson, L.2    Krutzfeldt, J.3    Kuwajima, S.4    Ma, X.5
  • 13
    • 77953780835 scopus 로고    scopus 로고
    • MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    • Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, et al. (2010) MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science 328: 1566-1569.
    • (2010) Science , vol.328 , pp. 1566-1569
    • Najafi-Shoushtari, S.H.1    Kristo, F.2    Li, Y.3    Shioda, T.4    Cohen, D.E.5
  • 14
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, et al. (2010) Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327: 198-201.
    • (2010) Science , vol.327 , pp. 198-201
    • Lanford, R.E.1    Hildebrandt-Eriksen, E.S.2    Petri, A.3    Persson, R.4    Lindow, M.5
  • 15
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel DP, (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 16
    • 68449097267 scopus 로고    scopus 로고
    • miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
    • Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, et al. (2009) miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 460: 705-710.
    • (2009) Nature , vol.460 , pp. 705-710
    • Cordes, K.R.1    Sheehy, N.T.2    White, M.P.3    Berry, E.C.4    Morton, S.U.5
  • 17
    • 70349213385 scopus 로고    scopus 로고
    • Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
    • Boettger T, Beetz N, Kostin S, Schneider J, Kruger M, et al. (2009) Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest 119: 2634-2647.
    • (2009) J Clin Invest , vol.119 , pp. 2634-2647
    • Boettger, T.1    Beetz, N.2    Kostin, S.3    Schneider, J.4    Kruger, M.5
  • 18
    • 70349125875 scopus 로고    scopus 로고
    • MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury
    • Xin M, Small EM, Sutherland LB, Qi X, McAnally J, et al. (2009) MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev 23: 2166-2178.
    • (2009) Genes Dev , vol.23 , pp. 2166-2178
    • Xin, M.1    Small, E.M.2    Sutherland, L.B.3    Qi, X.4    McAnally, J.5
  • 19
    • 68049083397 scopus 로고    scopus 로고
    • MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation
    • Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, et al. (2009) MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ Res 105: 158-166.
    • (2009) Circ Res , vol.105 , pp. 158-166
    • Cheng, Y.1    Liu, X.2    Yang, J.3    Lin, Y.4    Xu, D.Z.5
  • 20
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis BN, Hilyard AC, Lagna G, Hata A, (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454: 56-61.
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 21
    • 34250172419 scopus 로고    scopus 로고
    • MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation
    • Ji R, Cheng Y, Yue J, Yang J, Liu X, et al. (2007) MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ Res 100: 1579-1588.
    • (2007) Circ Res , vol.100 , pp. 1579-1588
    • Ji, R.1    Cheng, Y.2    Yue, J.3    Yang, J.4    Liu, X.5
  • 22
    • 61949252089 scopus 로고    scopus 로고
    • A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia
    • Liu X, Cheng Y, Zhang S, Lin Y, Yang J, et al. (2009) A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res 104: 476-487.
    • (2009) Circ Res , vol.104 , pp. 476-487
    • Liu, X.1    Cheng, Y.2    Zhang, S.3    Lin, Y.4    Yang, J.5
  • 23
    • 79957655520 scopus 로고    scopus 로고
    • Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury?
    • Albinsson S, Sessa WC, (2010) Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury? Physiol Genomics. 43: 529-33.
    • (2010) Physiol Genomics , vol.43 , pp. 529-533
    • Albinsson, S.1    Sessa, W.C.2
  • 24
    • 79955038937 scopus 로고    scopus 로고
    • MicroRNAs dynamically remodel gastrointestinal smooth muscle cells
    • Park C, Yan W, Ward SM, Hwang SJ, Wu Q, et al. (2011) MicroRNAs dynamically remodel gastrointestinal smooth muscle cells. PLoS One 6: e18628.
    • (2011) PLoS One , vol.6
    • Park, C.1    Yan, W.2    Ward, S.M.3    Hwang, S.J.4    Wu, Q.5
  • 25
    • 72549100392 scopus 로고    scopus 로고
    • MicroRNAs and cancer: current state and future perspectives in urologic oncology
    • Schaefer A, Jung M, Kristiansen G, Lein M, Schrader M, et al. (2010) MicroRNAs and cancer: current state and future perspectives in urologic oncology. Urol Oncol 28: 4-13.
    • (2010) Urol Oncol , vol.28 , pp. 4-13
    • Schaefer, A.1    Jung, M.2    Kristiansen, G.3    Lein, M.4    Schrader, M.5
  • 26
    • 79955547741 scopus 로고    scopus 로고
    • Smooth Muscle miRNAs Are Critical for Post-Natal Regulation of Blood Pressure and Vascular Function
    • Albinsson S, Skoura A, Yu J, Dilorenzo A, Fernandez-Hernando C, et al. (2011) Smooth Muscle miRNAs Are Critical for Post-Natal Regulation of Blood Pressure and Vascular Function. PLoS One 6: e18869.
    • (2011) PLoS One , vol.6
    • Albinsson, S.1    Skoura, A.2    Yu, J.3    Dilorenzo, A.4    Fernandez-Hernando, C.5
  • 27
    • 36049028276 scopus 로고    scopus 로고
    • Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
    • Gevaert T, Vriens J, Segal A, Everaerts W, Roskams T, et al. (2007) Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest 117: 3453-3462.
    • (2007) J Clin Invest , vol.117 , pp. 3453-3462
    • Gevaert, T.1    Vriens, J.2    Segal, A.3    Everaerts, W.4    Roskams, T.5
  • 28
    • 79551494259 scopus 로고    scopus 로고
    • Biomechanical properties and innervation of the female caveolin-1-deficient detrusor
    • Sadegh MK, Ekman M, Rippe C, Sundler F, Wierup N, et al. (2011) Biomechanical properties and innervation of the female caveolin-1-deficient detrusor. Br J Pharmacol 162: 1156-1170.
    • (2011) Br J Pharmacol , vol.162 , pp. 1156-1170
    • Sadegh, M.K.1    Ekman, M.2    Rippe, C.3    Sundler, F.4    Wierup, N.5
  • 29
    • 77951205835 scopus 로고    scopus 로고
    • Human urinary bladder smooth muscle is dependent on membrane cholesterol for cholinergic activation
    • Shakirova Y, Mori M, Ekman M, Erjefalt J, Uvelius B, et al. (2010) Human urinary bladder smooth muscle is dependent on membrane cholesterol for cholinergic activation. Eur J Pharmacol 634: 142-148.
    • (2010) Eur J Pharmacol , vol.634 , pp. 142-148
    • Shakirova, Y.1    Mori, M.2    Ekman, M.3    Erjefalt, J.4    Uvelius, B.5
  • 30
    • 77953183812 scopus 로고    scopus 로고
    • A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
    • Cheloufi S, Dos Santos CO, Chong MM, Hannon GJ, (2010) A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465: 584-589.
    • (2010) Nature , vol.465 , pp. 584-589
    • Cheloufi, S.1    Dos Santos, C.O.2    Chong, M.M.3    Hannon, G.J.4
  • 31
    • 77953897182 scopus 로고    scopus 로고
    • A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity
    • Cifuentes D, Xue H, Taylor DW, Patnode H, Mishima Y, et al. (2010) A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science 328: 1694-1698.
    • (2010) Science , vol.328 , pp. 1694-1698
    • Cifuentes, D.1    Xue, H.2    Taylor, D.W.3    Patnode, H.4    Mishima, Y.5
  • 33
    • 9144257346 scopus 로고    scopus 로고
    • An essential role of Cav1.2 L-type calcium channel for urinary bladder function
    • Wegener JW, Schulla V, Lee TS, Koller A, Feil S, et al. (2004) An essential role of Cav1.2 L-type calcium channel for urinary bladder function. FASEB J 18: 1159-1161.
    • (2004) FASEB J , vol.18 , pp. 1159-1161
    • Wegener, J.W.1    Schulla, V.2    Lee, T.S.3    Koller, A.4    Feil, S.5
  • 34
    • 79957832166 scopus 로고    scopus 로고
    • Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation
    • Ronkainen JJ, Hanninen SL, Korhonen T, Koivumaki JT, Skoumal R, et al. (2011) Ca2+-calmodulin-dependent protein kinase II represses cardiac transcription of the L-type calcium channel alpha(1C)-subunit gene (Cacna1c) by DREAM translocation. J Physiol 589: 2669-2686.
    • (2011) J Physiol , vol.589 , pp. 2669-2686
    • Ronkainen, J.J.1    Hanninen, S.L.2    Korhonen, T.3    Koivumaki, J.T.4    Skoumal, R.5
  • 35
    • 77956640976 scopus 로고    scopus 로고
    • Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice
    • Xu L, Lai D, Cheng J, Lim HJ, Keskanokwong T, et al. (2010) Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice. Circ Res 107: 398-407.
    • (2010) Circ Res , vol.107 , pp. 398-407
    • Xu, L.1    Lai, D.2    Cheng, J.3    Lim, H.J.4    Keskanokwong, T.5
  • 38
    • 0036346950 scopus 로고    scopus 로고
    • Altered mechanical properties in smooth muscle of mice with a mutated calponin locus
    • Fujishige A, Takahashi K, Tsuchiya T, (2002) Altered mechanical properties in smooth muscle of mice with a mutated calponin locus. Zoolog Sci 19: 167-174.
    • (2002) Zoolog Sci , vol.19 , pp. 167-174
    • Fujishige, A.1    Takahashi, K.2    Tsuchiya, T.3
  • 39
    • 55949127002 scopus 로고    scopus 로고
    • Role of desmin in active force transmission and maintenance of structure during growth of urinary bladder
    • Scott RS, Li Z, Paulin D, Uvelius B, Small JV, et al. (2008) Role of desmin in active force transmission and maintenance of structure during growth of urinary bladder. Am J Physiol Cell Physiol 295: C324-331.
    • (2008) Am J Physiol Cell Physiol , vol.295
    • Scott, R.S.1    Li, Z.2    Paulin, D.3    Uvelius, B.4    Small, J.V.5
  • 40
    • 2442708970 scopus 로고    scopus 로고
    • Signal transduction underlying carbachol-induced contraction of human urinary bladder
    • Schneider T, Fetscher C, Krege S, Michel MC, (2004) Signal transduction underlying carbachol-induced contraction of human urinary bladder. J Pharmacol Exp Ther 309: 1148-1153.
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 1148-1153
    • Schneider, T.1    Fetscher, C.2    Krege, S.3    Michel, M.C.4
  • 41
    • 0031898438 scopus 로고    scopus 로고
    • L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells
    • Gollasch M, Haase H, Ried C, Lindschau C, Morano I, et al. (1998) L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells. FASEB J 12: 593-601.
    • (1998) FASEB J , vol.12 , pp. 593-601
    • Gollasch, M.1    Haase, H.2    Ried, C.3    Lindschau, C.4    Morano, I.5
  • 42
    • 0030722259 scopus 로고    scopus 로고
    • Long-term regulation of contractility and calcium current in smooth muscle
    • Gomez M, Sward K, (1997) Long-term regulation of contractility and calcium current in smooth muscle. Am J Physiol 273: C1714-1720.
    • (1997) Am J Physiol , vol.273
    • Gomez, M.1    Sward, K.2
  • 43
    • 4143074790 scopus 로고    scopus 로고
    • L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism
    • Wamhoff BR, Bowles DK, McDonald OG, Sinha S, Somlyo AP, et al. (2004) L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Circ Res 95: 406-414.
    • (2004) Circ Res , vol.95 , pp. 406-414
    • Wamhoff, B.R.1    Bowles, D.K.2    McDonald, O.G.3    Sinha, S.4    Somlyo, A.P.5
  • 44
    • 77957822445 scopus 로고    scopus 로고
    • Distinct effects of voltage- and store-dependent calcium influx on stretch-induced differentiation and growth in vascular smooth muscle
    • Ren J, Albinsson S, Hellstrand P, (2010) Distinct effects of voltage- and store-dependent calcium influx on stretch-induced differentiation and growth in vascular smooth muscle. J Biol Chem 285: 31829-31839.
    • (2010) J Biol Chem , vol.285 , pp. 31829-31839
    • Ren, J.1    Albinsson, S.2    Hellstrand, P.3
  • 45
    • 84860444584 scopus 로고    scopus 로고
    • Ca2+/calmodulin-dependent protein kinase II Function in Vascular Remodeling
    • Singer HA, (2011) Ca2+/calmodulin-dependent protein kinase II Function in Vascular Remodeling. J Physiol.
    • (2011) J Physiol
    • Singer, H.A.1
  • 46
    • 77957033832 scopus 로고    scopus 로고
    • Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries
    • Narayanan D, Xi Q, Pfeffer LM, Jaggar JH, (2010) Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries. Circ Res 107: 631-641.
    • (2010) Circ Res , vol.107 , pp. 631-641
    • Narayanan, D.1    Xi, Q.2    Pfeffer, L.M.3    Jaggar, J.H.4
  • 47
    • 58149379604 scopus 로고    scopus 로고
    • MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons
    • Aschrafi A, Schwechter AD, Mameza MG, Natera-Naranjo O, Gioio AE, et al. (2008) MicroRNA-338 regulates local cytochrome c oxidase IV mRNA levels and oxidative phosphorylation in the axons of sympathetic neurons. J Neurosci 28: 12581-12590.
    • (2008) J Neurosci , vol.28 , pp. 12581-12590
    • Aschrafi, A.1    Schwechter, A.D.2    Mameza, M.G.3    Natera-Naranjo, O.4    Gioio, A.E.5
  • 48
    • 70350772348 scopus 로고    scopus 로고
    • MicroRNAs potentiate neural development
    • Fineberg SK, Kosik KS, Davidson BL, (2009) MicroRNAs potentiate neural development. Neuron 64: 303-309.
    • (2009) Neuron , vol.64 , pp. 303-309
    • Fineberg, S.K.1    Kosik, K.S.2    Davidson, B.L.3


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