Human urinary bladder smooth muscle is dependent on membrane cholesterol for cholinergic activation

European Journal of Pharmacology

Volumn 634, Issue 1-3, 2010, Pages 142-148

  Shakirova, Yulia ^a   Mori, Michiko ^a   Ekman, Mari ^a   Erjefält, Jonas ^a   Uvelius, Bengt ^b   Swärd, Karl ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Caveolae; Caveolin 1; Detrusor; Human; Incontinence; Muscarinic receptor

Indexed keywords

CARBACHOL; CAVEOLIN 1; CHOLESTEROL; METHYL BETA CYCLODEXTRIN; MUSCARINIC M3 RECEPTOR; PHOSPHOLIPASE C BETA1; CHOLINERGIC RECEPTOR STIMULATING AGENT; MUSCARINIC AGENT;

ADULT; AGED; ARTICLE; BLADDER; CAVEOLA; CELL MEMBRANE; CHOLINERGIC STIMULATION; CLINICAL ARTICLE; DEPOLARIZATION; DESORPTION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPID RAFT; MALE; MUSCLE CONTRACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; URINARY BLADDER SMOOTH MUSCLE; ANIMAL; C57BL MOUSE; CHOLINERGIC NERVE; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; ELECTROSTIMULATION; IN VITRO STUDY; METABOLISM; MIDDLE AGED; MOUSE; PHYSIOLOGY; PROCEDURES; RAT; SMOOTH MUSCLE FIBER; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CHOLESTEROL; CHOLINERGIC AGENTS; CHOLINERGIC FIBERS; ELECTRIC STIMULATION; FEMALE; HUMANS; MALE; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MIDDLE AGED; MUSCARINIC AGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; URINARY BLADDER; IN VITRO TECHNIQUES;

EID: 77951205835     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.02.017     Document Type: Article

References (36)

1. Bergdahl A., Swärd K. Caveolae-associated signalling in smooth muscle. Can. J. Physiol. Pharmacol. 2004, 82:289-299.
2. 2 muscarinic receptor contributes to contraction of the denervated rat urinary bladder. Am. J. Physiol. 1998, 275:R1654-R1660.
3. Cohen A.W., Hnasko R., Schubert W., Lisanti M.P. Role of caveolae and caveolins in health and disease. Physiol. Rev. 2004, 84:1341-1379.
4. Cristofaro V., Peters C.A., Yalla S.V., Sullivan M.P. Smooth muscle caveolae differentially regulate specific agonist induced bladder contractions. Neurourol. Urodyn. 2007, 26:71-80.
5. Darblade B., Caillaud D., Poirot M., Fouque M., Thiers J.C., Rami J., Bayard F., Arnal J.F. Alteration of plasmalemmal caveolae mimics endothelial dysfunction observed in atheromatous rabbit aorta. Cardiovasc. Res. 2001, 50:566-576.
6. Drab M., Verkade P., Elger M., Kasper M., Lohn M., Lauterbach B., Menne J., Lindschau C., Mende F., Luft F.C., Schedl A., Haller H., Kurzchalia T.V. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 2001, 293:2449-2452.
7. Dreja K., Voldstedlund M., Vinten J., Tranum-Jensen J., Hellstrand P., Swärd K. Cholesterol depletion disrupts caveolae and differentially impairs agonist-induced arterial contraction. Arterioscler. Thromb. Vasc. Biol. 2002, 22:1267-1272.
8. 2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder. J. Pharmacol. Exp. Ther. 2005, 313:368-378.
9. El-Yazbi A.F., Cho W.J., Schulz R., Daniel E.E. Calcium extrusion by plasma membrane calcium pump is impaired in caveolin-1 knockout mouse small intestine. Eur. J. Pharmacol. 2008, 591:80-87.
10. Feron O., Smith T.W., Michel T., Kelly R.A. Dynamic targeting of the agonist-stimulated M2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J. Biol. Chem. 1997, 272:17744-17748.
11. Gabella G., Uvelius B. Urinary bladder of rat: fine structure of normal and hypertrophic musculature. Cell Tissue Res. 1990, 262:67-79.
12. Gosens R., Stelmack G.L., Dueck G., Mutawe M.M., Hinton M., McNeill K.D., Paulson A., Dakshinamurti S., Gerthoffer W.T., Thliveris J.A., Unruh H., Zaagsma J., Halayko A.J. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am. J. Physiol. Lung. Cell. Mol. Physiol. 2007, 293:1406-1418.
13. Hegde S.S. Muscarinic receptors in the bladder: from basic research to therapeutics. Br. J. Pharmacol. 2006, 147(2):S80-S87.
14. Hill M.M., Bastiani M., Luetterforst R., Kirkham M., Kirkham A., Nixon S.J., Walser P., Abankwa D., Oorschot V.M., Martin S., Hancock J.F., Parton R.G. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell 2008, 132:113-124.
15. Iino S., Nojyo Y. Muscarinic M(2) acetylcholine receptor distribution in the guinea-pig gastrointestinal tract. Neuroscience 2006, 138:549-559.
16. Jositsch G., Papadakis T., Haberberger R.V., Wolff M., Wess J., Kummer W. Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice. Naunyn Schmiedebergs Arch. Pharmacol. 2009, 379:389-395.
17. Kilsdonk E.P., Yancey P.G., Stoudt G.W., Bangerter F.W., Johnson W.J., Phillips M.C., Rothblat G.H. Cellular cholesterol efflux mediated by cyclodextrins. J. Biol. Chem. 1995, 270:17250-17256.
18. Lai H.H., Boone T.B., Yang G., Smith C.P., Kiss S., Thompson T.C., Somogyi G.T. Loss of caveolin-1 expression is associated with disruption of muscarinic cholinergic activities in the urinary bladder. Neurochem. Int. 2004, 45:1185-1193.
19. Lai H.H., Boone T.B., Thompson T.C., Smith C.P., Somogyi G.T. Using caveolin-1 knockout mouse to study impaired detrusor contractility and disrupted muscarinic activity in the aging bladder. Urology 2007, 69:407-411.
20. Levy R., Muller N. Urinary incontinence: economic burden and new choices in pharmaceutical treatment. Adv. Ther. 2006, 23:556-573.
21. 3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J. Neurosci. 2002, 22:10627-10632.
22. Michel M.C., Wieland T., Tsujimoto G. How reliable are G-protein-coupled receptor antibodies?. Naunyn Schmiedebergs Arch. Pharmacol. 2009, 379:385-388.
23. Milsom I., Stewart W., Thüroff J. The prevalence of overactive bladder. Am. J. Manag. Care 2000, 6:565-573.
24. Pradidarcheep W., Labruyere W.T., Dabhoiwala N.F., Lamers W.H. Lack of specificity of commercially available antisera: better specifications needed. J. Histochem. Cytochem. 2008, 56:1099-1111.
25. Pradidarcheep W., Stallen J., Labruyere W.T., Dabhoiwala N.F., Michel M.C., Lamers W.H. Lack of specificity of commercially available antisera against muscarinergic and adrenergic receptors. Naunyn Schmiedebergs Arch. Pharmacol. 2009, 379:397-402.
26. Razani B., Engelman J.A., Wang X.B., Schubert W., Zhang X.L., Marks C.B., Macaluso F., Russell R.G., Li M., Pestell R.G., Di Vizio D., Hou H., Kneitz B., Lagaud G., Christ G.J., Edelmann W., Lisanti M.P. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J. Biol. Chem. 2001, 276:38121-38138.
27. Rothberg K.G., Heuser J.E., Donzell W.C., Ying Y.S., Glenney J.R., Anderson R.G. Caveolin, a protein component of caveolae membrane coats. Cell 1992, 68:673-682.
28. Shakirova Y., Bonnevier J., Albinsson S., Adner M., Rippe B., Broman J., Arner A., Swärd K. Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1. Am. J. Physiol. Cell Physiol. 2006, 291:1326-1335.
29. Simons K., Toomre D. Lipid rafts and signal transduction. Nat.Rev. Mol. Cell. Biol. 2000, 1:31-39.
30. Somara S., Gilmont R.R., Martens J.R., Bitar K.N. Ectopic expression of caveolin-1 restores physiological contractile response of aged colonic smooth muscle. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 293:240-249.
31. Wang P., Luthin G.R., Ruggieri M.R. Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins. J. Pharmacol. Exp. Ther. 1995, 273:959-966.
32. Woodman S.E., Cheung M.W., Tarr M., North A.C., Schubert W., Lagaud G., Marks C.B., Russell R.G., Hassan G.S., Factor S.M., Christ G.J., Lisanti M.P. Urogenital alterations in aged male caveolin-1 knockout mice. J. Urol. 2004, 17:1950-1957.
33. Wuest M., Hecht J., Christ T., Braeter M., Schoeberl C., Hakenberg O.W., Wirth M.P., Ravens U. Pharmacodynamics of propiverine and three of its main metabolites on detrusor contraction. Br. J. Pharmacol. 2005, 145:608-619.
34. Wuest M., Hiller N., Braeter M., Hakenberg O.W., Wirth M.P., Ravens U. Contribution of Ca2+ influx to carbachol-induced detrusor contraction is different in human urinary bladder compared to pig and mouse. Eur. J. Pharmacol. 2007, 565:180-189.
35. Wuest M., Eichhorn B., Grimm M.O., Wirth M.P., Ravens U., Kaumann A.J. Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man. J. Pharmacol. Exp. Ther. 2009, 328:213-222.
36. Zhao Y.Y., Liu Y., Stan R.V., Fan L., Gu Y., Dalton N., Chu P.H., Peterson K., Ross J., Chien K.R. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc. Natl. Acad. Sci. U S A. 2002, 99:11375-11380.