-
1
-
-
33644851751
-
Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism
-
Anderson CL, Delisle BP, Anson BD, Kilby JA, Will ML, Tester DJ, Gong Q, Zhou Z, Ackerman MJ, and January CT (2006) Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation 113:365-373.
-
(2006)
Circulation
, vol.113
, pp. 365-373
-
-
Anderson, C.L.1
Delisle, B.P.2
Anson, B.D.3
Kilby, J.A.4
Will, M.L.5
Tester, D.J.6
Gong, Q.7
Zhou, Z.8
Ackerman, M.J.9
January, C.T.10
-
3
-
-
66149125148
-
PKA phosphorylation of HERG protein regulates the rate of channel synthesis
-
Chen J, Sroubek J, Krishnan Y, Li Y, Bian J, and McDonald TV (2009) PKA phosphorylation of HERG protein regulates the rate of channel synthesis. Am J Physiol Heart Circ Physiol 296:H1244-H1254.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.296
-
-
Chen, J.1
Sroubek, J.2
Krishnan, Y.3
Li, Y.4
Bian, J.5
McDonald, T.V.6
-
4
-
-
0024298706
-
70K heat shock related proteins stimulate protein translocation into microsomes
-
Chirico WJ, Waters MG, and Blobel G (1988) 70K heat shock related proteins stimulate protein translocation into microsomes. Nature 332:805-810.
-
(1988)
Nature
, vol.332
, pp. 805-810
-
-
Chirico, W.J.1
Waters, M.G.2
Blobel, G.3
-
5
-
-
34249731333
-
Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits
-
Cockerill SL, Tobin AB, Torrecilla I, Willars GB, Standen NB, and Mitcheson JS (2007) Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits. J Physiol 581:479-493.
-
(2007)
J Physiol
, vol.581
, pp. 479-493
-
-
Cockerill, S.L.1
Tobin, A.B.2
Torrecilla, I.3
Willars, G.B.4
Standen, N.B.5
Mitcheson, J.S.6
-
6
-
-
0025097866
-
Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells
-
Cotecchia S, Kobilka BK, Daniel KW, Nolan RD, Lapetina EY, Caron MG, Lefkowitz RJ, and Regan JW (1990) Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. J Biol Chem 265:63-69. (Pubitemid 20032308)
-
(1990)
Journal of Biological Chemistry
, vol.265
, Issue.1
, pp. 63-69
-
-
Cotecchia, S.1
Kobilka, B.K.2
Daniel, K.W.3
Nolan, R.D.4
Lapetina, E.Y.5
Caron, M.G.6
Lefkowitz, R.J.7
Regan, J.W.8
-
7
-
-
0035907235
-
Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2
-
Cui J, Kagan A, Qin D, Mathew J, Melman YF, and McDonald TV (2001) Analysis of the cyclic nucleotide binding domain of the HERG potassium channel and interactions with KCNE2. J Biol Chem 276:17244-17251.
-
(2001)
J Biol Chem
, vol.276
, pp. 17244-17251
-
-
Cui, J.1
Kagan, A.2
Qin, D.3
Mathew, J.4
Melman, Y.F.5
McDonald, T.V.6
-
8
-
-
0034212628
-
Cyclic AMP regulates the HERG K(+) channel by dual pathways
-
Cui J, Melman Y, Palma E, Fishman GI, and McDonald TV (2000) Cyclic AMP regulates the HERG K(+) channel by dual pathways. Curr Biol 10:671-674.
-
(2000)
Curr Biol
, vol.10
, pp. 671-674
-
-
Cui, J.1
Melman, Y.2
Palma, E.3
Fishman, G.I.4
McDonald, T.V.5
-
9
-
-
0028914969
-
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
-
Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, and Keating MT (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80:795-803.
-
(1995)
Cell
, vol.80
, pp. 795-803
-
-
Curran, M.E.1
Splawski, I.2
Timothy, K.W.3
Vincent, G.M.4
Green, E.D.5
Keating, M.T.6
-
10
-
-
59149089973
-
Small GTPase determinants for the Golgi processing and plasmalemmal expression of human ether-a-go-go related (hERG) K+ channels
-
Delisle BP, Underkofler HA, Moungey BM, Slind JK, Kilby JA, Best JM, Foell JD, Balijepalli RC, Kamp TJ, and January CT (2009) Small GTPase determinants for the Golgi processing and plasmalemmal expression of human ether-a-go-go related (hERG) K+ channels. J Biol Chem 284:2844-2853.
-
(2009)
J Biol Chem
, vol.284
, pp. 2844-2853
-
-
Delisle, B.P.1
Underkofler, H.A.2
Moungey, B.M.3
Slind, J.K.4
Kilby, J.A.5
Best, J.M.6
Foell, J.D.7
Balijepalli, R.C.8
Kamp, T.J.9
January, C.T.10
-
11
-
-
0029876322
-
Cardiac sympathetic nerve function in congestive heart failure
-
Eisenhofer G, Friberg P, Rundqvist B, Quyyumi AA, Lambert G, Kaye DM, Kopin IJ, Goldstein DS, and Esler MD (1996) Cardiac sympathetic nerve function in congestive heart failure. Circulation 93:1667-1676.
-
(1996)
Circulation
, vol.93
, pp. 1667-1676
-
-
Eisenhofer, G.1
Friberg, P.2
Rundqvist, B.3
Quyyumi, A.A.4
Lambert, G.5
Kaye, D.M.6
Kopin, I.J.7
Goldstein, D.S.8
Esler, M.D.9
-
12
-
-
0034502477
-
Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome
-
Ficker E, Dennis AT, Obejero-Paz CA, Castaldo P, Taglialatela M, and Brown AM (2000) Retention in the endoplasmic reticulum as a mechanism of dominant-negative current suppression in human long QT syndrome. J Mol Cell Cardiol 32:2327-2337.
-
(2000)
J Mol Cell Cardiol
, vol.32
, pp. 2327-2337
-
-
Ficker, E.1
Dennis, A.T.2
Obejero-Paz, C.A.3
Castaldo, P.4
Taglialatela, M.5
Brown, A.M.6
-
13
-
-
2442464375
-
Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG
-
Ficker E, Dennis AT, Wang L, and Brown AM (2003) Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ Res 92:e87-100.
-
(2003)
Circ Res
, vol.92
-
-
Ficker, E.1
Dennis, A.T.2
Wang, L.3
Brown, A.M.4
-
14
-
-
21444453337
-
Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway
-
Gong Q, Keeney DR, Molinari M, and Zhou Z (2005) Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway. J Biol Chem 280:19419-19425.
-
(2005)
J Biol Chem
, vol.280
, pp. 19419-19425
-
-
Gong, Q.1
Keeney, D.R.2
Molinari, M.3
Zhou, Z.4
-
15
-
-
34248583575
-
Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes
-
Guo J, Massaeli H, Li W, Xu J, Luo T, Shaw J, Kirshenbaum LA, and Zhang S (2007) Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes. J Pharmacol Exp Ther 321:911-920.
-
(2007)
J Pharmacol Exp Ther
, vol.321
, pp. 911-920
-
-
Guo, J.1
Massaeli, H.2
Li, W.3
Xu, J.4
Luo, T.5
Shaw, J.6
Kirshenbaum, L.A.7
Zhang, S.8
-
16
-
-
0034141614
-
Protein kinase C enhances the rapidly activating delayed rectifier potassium current, IKr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes
-
Heath BM and Terrar DA (2000) Protein kinase C enhances the rapidly activating delayed rectifier potassium current, IKr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes. J Physiol 522:391-402.
-
(2000)
J Physiol
, vol.522
, pp. 391-402
-
-
Heath, B.M.1
Terrar, D.A.2
-
17
-
-
0037090803
-
14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity
-
Kagan A, Melman YF, Krumerman A, and McDonald TV (2002) 14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity. EMBO J 21:1889-1898.
-
(2002)
EMBO J
, vol.21
, pp. 1889-1898
-
-
Kagan, A.1
Melman, Y.F.2
Krumerman, A.3
McDonald, T.V.4
-
18
-
-
0034646627
-
The dominant negative LQT2 mutation A561V reduces wild-type HERG expression
-
Kagan A, Yu Z, Fishman GI, and McDonald TV (2000) The dominant negative LQT2 mutation A561V reduces wild-type HERG expression. J Biol Chem 275:11241-11248.
-
(2000)
J Biol Chem
, vol.275
, pp. 11241-11248
-
-
Kagan, A.1
Yu, Z.2
Fishman, G.I.3
McDonald, T.V.4
-
20
-
-
0032566546
-
HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways
-
Kiehn J, Karle C, Thomas D, Yao X, Brachmann J, and Kübler W (1998) HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways. J Biol Chem 273:25285-25291.
-
(1998)
J Biol Chem
, vol.273
, pp. 25285-25291
-
-
Kiehn, J.1
Karle, C.2
Thomas, D.3
Yao, X.4
Brachmann, J.5
Kübler, W.6
-
21
-
-
0242637601
-
What is the role of beta-adrenergic signaling in heart failure?
-
Lohse MJ, Engelhardt S, and Eschenhagen T (2003) What is the role of beta-adrenergic signaling in heart failure? Circ Res 93:896-906.
-
(2003)
Circ Res
, vol.93
, pp. 896-906
-
-
Lohse, M.J.1
Engelhardt, S.2
Eschenhagen, T.3
-
22
-
-
0030872366
-
A minK-HERG complex regulates the cardiac potassium current IKr
-
McDonald TV, Yu Z, Ming Z, Palma E, Meyers MB, Wang KW, Goldstein SA, and Fishman GI (1997) A minK-HERG complex regulates the cardiac potassium current IKr. Nature 388:289-292.
-
(1997)
Nature
, vol.388
, pp. 289-292
-
-
McDonald, T.V.1
Yu, Z.2
Ming, Z.3
Palma, E.4
Meyers, M.B.5
Wang, K.W.6
Goldstein, S.A.7
Fishman, G.I.8
-
23
-
-
0033559258
-
The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis
-
Meacham GC, Lu Z, King S, Sorscher E, Tousson A, and Cyr DM (1999) The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. EMBO J 18:1492-1505. (Pubitemid 29127063)
-
(1999)
EMBO Journal
, vol.18
, Issue.6
, pp. 1492-1505
-
-
Meacham, G.C.1
Lu, Z.2
King, S.3
Sorscher, E.4
Tousson, A.5
Cyr, D.M.6
-
24
-
-
13444304228
-
Protein kinase C in cardiac disease and as a potential therapeutic target
-
Murphy S and Frishman WH (2005) Protein kinase C in cardiac disease and as a potential therapeutic target. Cardiol Rev 13:3-12.
-
(2005)
Cardiol Rev
, vol.13
, pp. 3-12
-
-
Murphy, S.1
Frishman, W.H.2
-
25
-
-
0036110488
-
Heterogeneous expression of voltage-gated potassium channels in the heart: Roles in normal excitation and arrhythmias
-
Nerbonne JM and Guo W (2002) Heterogeneous expression of voltage-gated potassium channels in the heart: roles in normal excitation and arrhythmias. J Cardiovasc Electrophysiol 13:406-409.
-
(2002)
J Cardiovasc Electrophysiol
, vol.13
, pp. 406-409
-
-
Nerbonne, J.M.1
Guo, W.2
-
26
-
-
33645529873
-
Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload
-
O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, et al. (2006) Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest 116:1005-1015.
-
(2006)
J Clin Invest
, vol.116
, pp. 1005-1015
-
-
O'Connell, T.D.1
Swigart, P.M.2
Rodrigo, M.C.3
Ishizaka, S.4
Joho, S.5
Turnbull, L.6
Tecott, L.H.7
Baker, A.J.8
Foster, E.9
Grossman, W.10
-
27
-
-
0028341881
-
Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes
-
Pucéat M, Hilal-Dandan R, Strulovici B, Brunton LL, and Brown JH (1994) Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes. J Biol Chem 269:16938-16944.
-
(1994)
J Biol Chem
, vol.269
, pp. 16938-16944
-
-
Pucéat, M.1
Hilal-Dandan, R.2
Strulovici, B.3
Brunton, L.L.4
Brown, J.H.5
-
28
-
-
33644872508
-
Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control
-
Qian SB, Princiotta MF, Bennink JR, and Yewdell JW (2006) Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control. J Biol Chem 281:392-400.
-
(2006)
J Biol Chem
, vol.281
, pp. 392-400
-
-
Qian, S.B.1
Princiotta, M.F.2
Bennink, J.R.3
Yewdell, J.W.4
-
29
-
-
0037050009
-
Seven-transmembrane-spanning receptors and heart function
-
Rockman HA, Koch WJ, and Lefkowitz RJ (2002) Seven-transmembrane-spanning receptors and heart function. Nature 415:206-212.
-
(2002)
Nature
, vol.415
, pp. 206-212
-
-
Rockman, H.A.1
Koch, W.J.2
Lefkowitz, R.J.3
-
30
-
-
1442306232
-
Drug-induced prolongation of the QT interval
-
Roden DM (2004) Drug-induced prolongation of the QT interval. N Engl J Med 350:1013-1022.
-
(2004)
N Engl J Med
, vol.350
, pp. 1013-1022
-
-
Roden, D.M.1
-
31
-
-
0026709274
-
Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy
-
Sadoshima J, Jahn L, Takahashi T, Kulik TJ, and Izumo S (1992) Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem 267:10551-10560.
-
(1992)
J Biol Chem
, vol.267
, pp. 10551-10560
-
-
Sadoshima, J.1
Jahn, L.2
Takahashi, T.3
Kulik, T.J.4
Izumo, S.5
-
32
-
-
0029002969
-
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
-
Sanguinetti MC, Jiang C, Curran ME, and Keating MT (1995) A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 81:299-307.
-
(1995)
Cell
, vol.81
, pp. 299-307
-
-
Sanguinetti, M.C.1
Jiang, C.2
Curran, M.E.3
Keating, M.T.4
-
33
-
-
0034643336
-
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
-
Schubert U, Antón LC, Gibbs J, Norbury CC, Yewdell JW, and Bennink JR (2000) Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature 404:770-774.
-
(2000)
Nature
, vol.404
, pp. 770-774
-
-
Schubert, U.1
Antón, L.C.2
Gibbs, J.3
Norbury, C.C.4
Yewdell, J.W.5
Bennink, J.R.6
-
34
-
-
0036017520
-
Diabetes, heart rate, and mortality
-
Singh N (2002) Diabetes, heart rate, and mortality. J Cardiovasc Pharmacol Ther 7:117-129.
-
(2002)
J Cardiovasc Pharmacol Ther
, vol.7
, pp. 117-129
-
-
Singh, N.1
-
35
-
-
0242711529
-
Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): Molecular mechanisms and restoration of intracellular protein processing
-
Thomas D, Kiehn J, Katus HA, and Karle CA (2003a) Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing. Cardiovasc Res 60:235-241.
-
(2003)
Cardiovasc Res
, vol.60
, pp. 235-241
-
-
Thomas, D.1
Kiehn, J.2
Katus, H.A.3
Karle, C.A.4
-
36
-
-
0033600758
-
Deletion of protein kinase a phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase a
-
Thomas D, Zhang W, Karle CA, Kathöfer S, Schöls W, Kübler W, and Kiehn J (1999) Deletion of protein kinase A phosphorylation sites in the HERG potassium channel inhibits activation shift by protein kinase A. J Biol Chem 274:27457-27462. (Pubitemid 129527787)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.39
, pp. 27457-27462
-
-
Thomas, D.1
Zhang, W.2
Karle, C.A.3
Kathofer, S.4
Schols, W.5
Kubler, W.6
Kiehn, J.7
-
37
-
-
0038771923
-
Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein
-
Thomas D, Zhang W, Wu K, Wimmer AB, Gut B, Wendt-Nordahl G, Kathöfer S, Kreye VA, Katus HA, Schoels W, et al. (2003b) Regulation of HERG potassium channel activation by protein kinase C independent of direct phosphorylation of the channel protein. Cardiovasc Res 59:14-26.
-
(2003)
Cardiovasc Res
, vol.59
, pp. 14-26
-
-
Thomas, D.1
Zhang, W.2
Wu, K.3
Wimmer, A.B.4
Gut, B.5
Wendt-Nordahl, G.6
Kathöfer, S.7
Kreye, V.A.8
Katus, H.A.9
Schoels, W.10
-
38
-
-
0032979720
-
Electrophysiological remodeling in hypertrophy and heart failure
-
Tomaselli GF and Marbán E (1999) Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res 42:270-283.
-
(1999)
Cardiovasc Res
, vol.42
, pp. 270-283
-
-
Tomaselli, G.F.1
Marbán, E.2
-
39
-
-
0027497584
-
1-adrenergic receptors in the failing human heart
-
Ungerer M, Böhm M, Elce JS, Erdmann E, and Lohse MJ (1993) Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation 87:454-463. (Pubitemid 23040915)
-
(1993)
Circulation
, vol.87
, Issue.2
, pp. 454-463
-
-
Ungerer, M.1
Bohm, M.2
Elce, J.S.3
Erdmann, E.4
Lohse, M.J.5
|