3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective α1- adrenoceptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 1, 2006, Pages 150-153

  Pittalà, Valeria ^a   Romeo, Giuseppe ^a   Salerno, Loredana ^a   Siracusa, Maria Angela ^a   Modica, Maria ^a   Materia, Luisa ^a   Mereghetti, Ilario ^b   Cagnotto, Alfredo ^b   Mennini, Tiziana ^b   Marucci, Gabriella ^c   Angeli, Piero ^c   Russo, Filippo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c UNIVERSITY OF CAMERINO   (Italy)

Author keywords

1 Adrenoceptor subtypes; 1 Adrenoceptor antagonists; 1H Pyrrolo 2,3 d pyrimidine 2,4(3H,7H) dione; Arylpiperazine

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 3 [2 [4 (2 CHLOROPHENYL) 1 PIPERAZINYL]ETHYL] 6 (4 METHYLPHENYL) 1H PYRROLO[2,3 D]PYRIMIDINE 2,4(3H,7H) DIONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; PYRIMIDINE DERIVATIVE; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIGAND BINDING;

CHLORINE; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; PIPERAZINES; PROTEIN BINDING; PYRIMIDINONES; PYRROLES; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; TIME FACTORS;

EID: 27744494611     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.09.027     Document Type: Article

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