miR than meets the eye

Genes and Development

Volumn 25, Issue 16, 2011, Pages 1663-1667

  Sage, Julien ^a   Ventura, Andrea ^b  

^a STANFORD UNIVERSITY   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cancer; MicroRNA; Mir 17 92; Rb; Retina; Retinoblastoma

Indexed keywords

CYCLIN DEPENDENT KINASE; MICRORNA; MIR 17 92; MYC PROTEIN; PROTEIN P107; PROTEIN P130; PROTEIN P21; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; COLON CANCER; GENE AMPLIFICATION; GENE DELETION; GENE DOSAGE; GENE MUTATION; GENE OVEREXPRESSION; GENE REGULATORY NETWORK; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; LARGE CELL LYMPHOMA; MEDULLOBLASTOMA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA DEVELOPMENT; RETINOBLASTOMA; UPREGULATION;

ANIMALS; FEMALE; HUMANS; MALE; MICRORNAS; MUTATION; PREGNANCY; RETINOBLASTOMA; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION;

MUS;

EID: 84860400268     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.17454011     Document Type: Article

References (42)

1. Aslanian A, Iaquinta PJ, Verona R, Lees JA. 2004. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev 18: 1413-1422.
2. Bartel DP. 2009. MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
3. Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA. 2009. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci 106: 14932-14936.
4. Binne UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG Jr, Naar AM, Dyson NJ. 2007. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol 9: 225-232.
5. Burkhart DL, Wirt SE, Zmoos AF, Kareta MS, Sage J. 2010. Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genet 6: e1001003. doi: 10.1371/journal.pgen.1001003.
6. Chen D, Livne-Bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R. 2004. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell 5: 539-551.
7. Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, Bremner R. 2009. Division and apoptosis of E2f-deficient retinal progenitors. Nature 462: 925-929.
8. Chinnam M, Goodrich DW. 2011. RB1, development, and cancer. Curr Top Dev Biol 94: 129-169.
9. Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. 1996. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev 10: 1633-1644.
10. Conkrite K, Sundby M, Mukai S, Thomson JM, Mu D, Hammond SM, MacPherson D. 2011. miR-17;92 cooperates with RB pathway mutations to promote retinoblastoma. Genes Dev (this issue). doi: 10.1101/gad.17027411.
11. Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT, et al. 2006. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet 38: 1060-1065.
12. Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA. 2006. Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol 4: 14. doi: 10.1186/ 1741-7007-4-14.
13. Fontana L, Fiori ME, Albini S, Cifaldi L, Giovinazzi S, Forloni M, Boldrini R, Donfrancesco A, Federici V, Giacomini P, et al. 2008. Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS ONE 3: e2236. doi: 10.1371/journal.pone.0002236.
14. Fugaro MN, Kiupel M, Montiani-Ferreira F, Hawkins JF, Janovitz EB. 2005. Retinoblastoma in the eye of a llama (Llama glama). Vet Ophthalmol 8: 287-290.
15. He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, et al. 2005. A microRNA polycistron as a potential human oncogene. Nature 435: 828-833.
16. Hiyama H, Iavarone A, Reeves SA. 1998. Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F. Oncogene 16: 1513-1523.
17. Ivanovska I, Ball AS, Diaz RL, Magnus JF, Kibukawa M, Schelter JM, Kobayashi SV, Lim L, Burchard J, Jackson AL, et al. 2008. MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol 28: 2167-2174.
18. Jiang Z, Deng T, Jones R, Li H, Herschkowitz JI, Liu JC, Weigman VJ, Tsao MS, Lane TF, Perou CM, et al. 2010. Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status. J Clin Invest 120: 3296-3309.
19. Knottenbelt DC, Hetzel U, Roberts V. 2007. Primary intraocular primitive neuroectodermal tumor (retinoblastoma) causing unilateral blindness in a gelding. Vet Oph thalmol 10: 348-356.
20. Lee WH, Murphree AL, Benedict WF. 1984. Expression and amplification of the N-myc gene in primary retinoblastoma. Nature 309: 458-460.
21. Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T. 1996. Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev 10: 1621-1632.
22. Levine AJ. 2009. The common mechanisms of transformation by the small DNA tumor viruses: the inactivation of tumor suppressor gene products: p53. Virology 384: 285-293.
23. MacPherson D. 2008. Insights from mouse models into human retinoblastoma. Cell Div 3: 9. doi: 10.1186/1747-1028-3-9.
24. MacPherson D, Sage J, Kim T, Ho D, McLaughlin ME, Jacks T. 2004. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev 18: 1681-1694.
25. MacPherson D, Conkrite K, Tam M, Mukai S, Mu D, Jacks T. 2007. Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J 26: 784-794.
26. Mavrakis KJ, Wolfe AL, Oricchio E, Palomero T, de Keersmaecker K, McJunkin K, Zuber J, James T, Khan AA, Leslie CS, et al. 2010. Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lympho-blastic leukaemia. Nat Cell Biol 12: 372-379.
27. Mestdagh P, Bostrom AK, Impens F, Fredlund E, Van Peer G, De Antonellis P, von Stedingk K, Ghesquiere B, Schulte S, Dews M, et al. 2010. The miR-17-92 microRNA cluster regulates multiple components of the TGF-b pathway in neuroblas-toma. Mol Cell 40: 762-773.
28. Mu P, Han YC, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, D'Andrea A, Sander C, Ventura A. 2009. Genetic dissection of the miR-17;92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev 23: 2806-2811.
29. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. 2005. c-Myc-regulated microRNAs modulate E2F1 expres sion. Nature 435: 839-843.
30. Olive V, Bennett MJ, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li QJ, Lowe SW, Hannon GJ, He L. 2009. miR-19 is a key oncogenic component of mir-17-92. Genes Dev 23: 2839-2849.
31. Olive V, Jiang I, He L. 2010. mir-17-92, a cluster of miRNAs in the midst of the cancer network. Int J Biochem Cell Biol 42: 1348-1354.
32. Ota A, Tagawa H, Karnan S, Tsuzuki S, Karpas A, Kira S, Yoshida Y, Seto M. 2004. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res 64: 3087-3095.
33. Schaffer BE, Park KS, Yiu G, Conklin JF, Lin C, Burkhart DL, Karnezis AN, Sweet-Cordero EA, Sage J. 2010. Loss of p130 accelerates tumor development in a mouse model for human small-cell lung carcinoma. Cancer Res 70: 3877-3883.
34. Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, Chen CJ, Hildesheim A, Sugden B, Ahlquist P. 2008. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Proc Natl Acad Sci 105: 5874-5878.
35. Syed NA, Nork TM, Poulsen GL, Riis RC, George C, Albert DM. 1997. Retinoblastoma in a dog. Arch Ophthalmol 115: 758-763.
36. Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P. 2007. An E2F/miR-20a autoregulatory feedback loop. J Biol Chem 282: 2135-2143.
37. Uziel T, Karginov FV, Xie S, Parker JS, Wang YD, Gajjar A, He L, Ellison D, Gilbertson RJ, Hannon G, et al. 2009. The miR-17;92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci 106: 2812-2817.
38. Ventura A, Jacks T. 2009. MicroRNAs and cancer: short RNAs go a long way. Cell 136: 586-591.
39. Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, et al. 2008. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132: 875-886.
40. Wirt SE, Adler AS, Gebala V, Weimann JM, Schaffer BE, Saddic LA, Viatour P, Vogel H, Chang HY, Meissner A, et al. 2010. G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol 191: 809-825.
41. Woods K, Thomson JM, Hammond SM. 2007. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors. J Biol Chem 282: 2130-2134.
42. Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA. 2004. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet 36: 351-360.