-
1
-
-
40549102421
-
Assessment of the absorption, metabolism, and absolute bioavailability of maraviroc in healthy male subjects
-
ABEL, S.; RUSSELL, D.; WHITLOCK, L.A.; RIDGEWAY, C.E.; NEDDERMAN, A.N.R.; WALKER, D.K. Assessment of the absorption, metabolism, and absolute bioavailability of maraviroc in healthy male subjects. Br. J. Clin. Pharmacol., v.65, suppl.1, p.60-67, 2008.
-
(2008)
Br. J. Clin. Pharmacol
, vol.65
, Issue.SUPPL. 1
, pp. 60-67
-
-
Abel, S.1
Russell, D.2
Whitlock, L.A.3
Ridgeway, C.E.4
Nedderman, A.N.R.5
Walker, D.K.6
-
2
-
-
65949091785
-
Anti-HIV-1 Therapeutics: From FDA-approved drugs to hypothetical future targets
-
ADAMSON, C.S.; FREED, E.O. Anti-HIV-1 Therapeutics: from FDA-approved drugs to hypothetical future targets. Mol. Interv., v.9, p.70-74, 2009.
-
(2009)
Mol. Interv
, vol.9
, pp. 70-74
-
-
Adamson, C.S.1
Freed, E.O.2
-
3
-
-
33847035148
-
State of the art tools for computational site of metabolism predictions: Comparative analysis, mechanistically insights, and future applications
-
AFZELIUS, L.; ARNBY, C.H.; BROO, A.; CARLSSON, L.; ISAKSSON, C.; ULRIK JURVA, U.; KJELLANDER, B.; KOLMODIN, K.; NILSSON, K.; RAUBACHER, F.; WEIDOLF, L. State of the art tools for computational site of metabolism predictions: comparative analysis, mechanistically insights, and future applications. Drug Metab. Rev., v.39, p.61-86, 2007.
-
(2007)
Drug Metab. Rev
, vol.39
, pp. 61-86
-
-
Afzelius, L.1
Arnby, C.H.2
Broo, A.3
Carlsson, L.4
Isaksson, C.5
Ulrik Jurva, U.6
Kjellander, B.7
Kolmodin, K.8
Nilsson, K.9
Raubacher, F.10
Weidolf, L.11
-
4
-
-
0842327199
-
Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: Application to studies on the biotransformation of indinavir
-
ANARI, M.R.; SANCHEZ, R.I.; BAKHTIAR, R.; FRANKLIN, R.B.; BAILLIE, T.A. Integration of knowledge-based metabolic predictions with liquid chromatography data-dependent tandem mass spectrometry for drug metabolism studies: application to studies on the biotransformation of indinavir. Anal. Chem., v.76, p.823-832, 2004.
-
(2004)
Anal. Chem
, vol.76
, pp. 823-832
-
-
Anari, M.R.1
Sanchez, R.I.2
Bakhtiar, R.3
Franklin, R.B.4
Baillie, T.A.5
-
5
-
-
29944444269
-
Expression of cytochromes p450, conjugating enzymes and nuclear receptors in human hepatoma heparg cells
-
ANINAT, C.; PITON, A.; GLAISE, D.; LE CHARPENTIER, T.; LANGOUET, S.; MOREL, F.; Guguen-Guillouzo, C.; GUILLOUZO, A. Expression of cytochromes p450, conjugating enzymes and nuclear receptors in human hepatoma heparg cells. Drug Metab. Dispos., v.34, p.75-83, 2006.
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 75-83
-
-
Aninat, C.1
Piton, A.2
Glaise, D.3
le Charpentier, T.4
Langouet, S.5
Morel, F.6
Guguen-Guillouzo, C.7
Guillouzo, A.8
-
6
-
-
57349116037
-
Cunninghamella - A microbial model for drug metabolism studies - A review
-
ASHA S.; VIDYAVATHI, M. Cunninghamella - A microbial model for drug metabolism studies - A review. Biotechnol. Adv., v.27, p.16-29, 2009.
-
(2009)
Biotechnol. Adv
, vol.27
, pp. 16-29
-
-
Asha, S.1
Vidyavathi, M.2
-
7
-
-
0032608923
-
Microbial models for drug metabolism
-
AZERAD, R. Microbial models for drug metabolism. Adv. Biochem. Eng. Biotechnol., v.63, p.163-218, 1999.
-
(1999)
Adv. Biochem. Eng. Biotechnol
, vol.63
, pp. 163-218
-
-
Azerad, R.1
-
8
-
-
0028868234
-
Metabolites of L-735, 524, a potent HIV 1-protease inhibitor, in human urine
-
BALANI, S.K.; ARISON, B.H.; MATHAI, L.; KAUFFMAN, L.R.; MILLER, R.R.; STEARNS, R.A.; CHEN, I.W.; LIN, J.H. Metabolites of L-735, 524, a potent HIV 1-protease inhibitor, in human urine. Drug Metab. Dispos., v.23, p.266-270, 1995.
-
(1995)
Drug Metab. Dispos
, vol.23
, pp. 266-270
-
-
Balani, S.K.1
Arison, B.H.2
Mathai, L.3
Kauffman, L.R.4
Miller, R.R.5
Stearns, R.A.6
Chen, I.W.7
Lin, J.H.8
-
9
-
-
0027534661
-
Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: Potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)- 2,6-diaminopurine
-
BALZARINI, J.; HOLÝ, A.; JINDRICH, J.; NAESENS, L.; SNOECK, R.; SCHOLS, D.; DE CLERCQ, E. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)- 2,6-diaminopurine. Antimicrob. Agents Chemother., v.37, p.332-338, 1993.
-
(1993)
Antimicrob. Agents Chemother
, vol.37
, pp. 332-338
-
-
Balzarini, J.1
Holý, A.2
Jindrich, J.3
Naesens, L.4
Snoeck, R.5
Schols, D.6
de Clercq, E.7
-
10
-
-
0029566112
-
Kinetic properties of adenine nucleotide analogues against purified 5-phosphoribosyl-1- pyrophosphate synthetases from E. coli, rat liver and human erythrocytes
-
BALZARINI, J.; NAVE, J.F.; BECKER, M.A.; TATIBANA, M.; De Clerq, E. Kinetic properties of adenine nucleotide analogues against purified 5-phosphoribosyl-1- pyrophosphate synthetases from E. coli, rat liver and human erythrocytes. Nucleos. Nucleot. Nucl., v.14, p.1861-1871, 1995.
-
(1995)
Nucleos. Nucleot. Nucl
, vol.14
, pp. 1861-1871
-
-
Balzarini, J.1
Nave, J.F.2
Becker, M.A.3
Tatibana, M.4
de Clerq, E.5
-
11
-
-
0020596551
-
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
-
Barré-Sinoussi, F.; CHERMANN, J.C.; REY, F.; NUGEYRE, M.T.; CHAMARET, S.; GRUEST, J.; DAUGUET, C.; Axler-Blin, C.; Vézinet-Brun, F.; ROUZIOUX, C.; ROZENBAUM, W.; MONTAGNIER, L. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science, v.220, p.868-871, 1983.
-
(1983)
Science
, vol.220
, pp. 868-871
-
-
Barré-Sinoussi, F.1
Chermann, J.C.2
Rey, F.3
Nugeyre, M.T.4
Chamaret, S.5
Gruest, J.6
Dauguet, C.7
Axler-Blin, C.8
Vézinet-Brun, F.9
Rouzioux, C.10
Rozenbaum, W.11
Montagnier, L.12
-
12
-
-
79956101051
-
Determination of the cardioactive prototype LASSBio-294 and its metabolites in dog plasma by LC-MS/MS: Application for a pharmacokinetic study
-
in press, DOI: 10.1016/j. jpba.2011.02.031
-
BRAGA, R.C.; TORRES, A.C.B.; PERSIANO, C.B.; ALVES, R.O.; FRAGA, C.A.M.; BARREIRO, E.J.; DE OLIVEIRA, V. Determination of the cardioactive prototype LASSBio-294 and its metabolites in dog plasma by LC-MS/MS: Application for a pharmacokinetic study. J. Pharm. Biomed. Anal., in press, 2011, DOI: 10.1016/j. jpba.2011.02.031.
-
(2011)
J. Pharm. Biomed. Anal
-
-
Braga, R.C.1
Torres, A.C.B.2
Persiano, C.B.3
Alves, R.O.4
Fraga, C.A.M.5
Barreiro, E.J.6
de Oliveira, V.7
-
13
-
-
0029037417
-
Effect of fluconazole on pharmacokinetics of 2',3'-dideoxyinosine in persons seropositive for human immunodeficiency virus
-
BRUZZESE, V.L.; GILLUM, J.G.; ISRAEL, D.S.; JOHNSON, G.L.; KAPLOWITZ, L. G.; POLK, R.E. Effect of fluconazole on pharmacokinetics of 2',3'-dideoxyinosine in persons seropositive for human immunodeficiency virus. Antimicrob. Agents Chemother., v.39, p.1050-1053, 1995.
-
(1995)
Antimicrob. Agents Chemother
, vol.39
, pp. 1050-1053
-
-
Bruzzese, V.L.1
Gillum, J.G.2
Israel, D.S.3
Johnson, G.L.4
Kaplowitz, L.G.5
Polk, R.E.6
-
14
-
-
33745268491
-
Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms
-
BUMPUS, N.N.; KENT, U.M.; HOLLENBERG, P.F. Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms. J. Pharmacol. Exp. Ther., v.318, p.345-351, 2006.
-
(2006)
J. Pharmacol. Exp. Ther
, vol.318
, pp. 345-351
-
-
Bumpus, N.N.1
Kent, U.M.2
Hollenberg, P.F.3
-
15
-
-
52949112291
-
FDA and drug companies alike want ADME-tox testing performed earlier and earlier in a drug's life cycle
-
CANAVAN, N. FDA and drug companies alike want ADME-tox testing performed earlier and earlier in a drug's life cycle. Drug Discov. Dev., v.10, p.34-36, 2007.
-
(2007)
Drug Discov. Dev
, vol.10
, pp. 34-36
-
-
Canavan, N.1
-
16
-
-
77950857852
-
Microbial models of animal metabolism: Application to a study of the metabolism of LASSBio-873
-
CARNEIRO, E.O.; MENEGATTI, R.; FRAGA, C.A.M.; BARREIRO, E.J.; DE OLIVEIRA, V. Microbial models of animal metabolism: application to a study of the metabolism of LASSBio-873. Braz. J. Pharm. Sci., v.41, p.392-392, 2005.
-
(2005)
Braz. J. Pharm. Sci
, vol.41
, pp. 392
-
-
Carneiro, E.O.1
Menegatti, R.2
Fraga, C.A.M.3
Barreiro, E.J.4
de Oliveira, V.5
-
17
-
-
77954214021
-
Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294
-
CARNEIRO, E.O.; ANDRADE, C.H.; BRAGA, R.C.; TÔRRES, A.C.B., ALVES, R.O.; LIÃO, L.M.; FRAGA, C.A.M.; BARREIRO, E.J.; De Oliveira, V. Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294. Bioorg. Med. Chem. Lett., v.20, p.3734-3736, 2010.
-
(2010)
Bioorg. Med. Chem. Lett
, vol.20
, pp. 3734-3736
-
-
Carneiro, E.O.1
Andrade, C.H.2
Braga, R.C.3
Tôrres, A.C.B.4
Alves, R.O.5
Lião, L.M.6
Fraga, C.A.M.7
Barreiro, E.J.8
de Oliveira, V.9
-
18
-
-
0030755512
-
Identification of the metabolites of the HIV-1 reverse transcriptase inhibitor delavirdine in monkeys
-
CHANG, M.; SOOD, V.K.; KLOOSTERMAN, D.A.; HAUER, M.J.; FAGERNESS, P. E.; SANDERS, P.E.; VRBANAC, J.J. Identification of the metabolites of the HIV-1 reverse transcriptase inhibitor delavirdine in monkeys. Drug Metab. Dispos., v.25, p.814-827, 1997a.
-
(1997)
Drug Metab. Dispos
, vol.25
, pp. 814-827
-
-
Chang, M.1
Sood, V.K.2
Kloosterman, D.A.3
Hauer, M.J.4
Fagerness, P.E.5
Sanders, P.E.6
Vrbanac, J.J.7
-
19
-
-
0030854082
-
Metabolism of the HIV-1 Reverse transcriptase inhibitor delavirdine in mice
-
CHANG, M.; SOOD, V.K.; WILSON, G.J.; KLOOSTERMAN, D.A.; SANDERS, P.E.; HAUER, M.J.; ZHANG, W.; BRANSTETTER, D.G. Metabolism of the HIV-1 Reverse transcriptase inhibitor delavirdine in mice. Drug Metab. Dispos., v.25, p.828-839, 1997b.
-
(1997)
Drug Metab. Dispos
, vol.25
, pp. 828-839
-
-
Chang, M.1
Sood, V.K.2
Wilson, G.J.3
Kloosterman, D.A.4
Sanders, P.E.5
Hauer, M.J.6
Zhang, W.7
Branstetter, D.G.8
-
20
-
-
0031037656
-
Metabolism of the human immunodeficiency virus type 1 reverse transcriptase inhibitor delavirdine in rats
-
CHANG, M.; SOOD, V.K.; WILSON, G.J.; KLOOSTERMAN, D.A.; SANDERS, P. E.; HAUER, M.J.; FAGERNESS, P.E. Metabolism of the human immunodeficiency virus type 1 reverse transcriptase inhibitor delavirdine in rats. Drug Metab. Dispos., v.25, p.228-242, 1997c.
-
(1997)
Drug Metab. Dispos
, vol.25
, pp. 228-242
-
-
Chang, M.1
Sood, V.K.2
Wilson, G.J.3
Kloosterman, D.A.4
Sanders, P.E.5
Hauer, M.J.6
Fagerness, P.E.7
-
21
-
-
0030908131
-
Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes: Major role of CYP3A
-
CHIBA, M.; HENSLEIGH, M.; LIN, J.H. Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes: Major role of CYP3A. Biochem. Pharmacol., v.53, p.1187-1195, 1997.
-
(1997)
Biochem. Pharmacol
, vol.53
, pp. 1187-1195
-
-
Chiba, M.1
Hensleigh, M.2
Lin, J.H.3
-
22
-
-
0029872126
-
Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor
-
CHIBA, M.; HENSLEIGH, M.; NISHIME, J.A.; BALANI, S.K.; LIN, J.H. Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor. Drug Metab. Dispos., v.24, p.307-314, 1996.
-
(1996)
Drug Metab. Dispos
, vol.24
, pp. 307-314
-
-
Chiba, M.1
Hensleigh, M.2
Nishime, J.A.3
Balani, S.K.4
Lin, J.H.5
-
23
-
-
0034001402
-
Comparative in vitro metabolism of indinavir in primates - a unique stereoselective hydroxylation in monkey
-
CHIBA, M.; NISHIME, J.A.; NEWAY, W.; LIN, Y.; LIN, J.H. Comparative in vitro metabolism of indinavir in primates - a unique stereoselective hydroxylation in monkey. Xenobiotica, v.30, p.117-129, 2000.
-
(2000)
Xenobiotica
, vol.30
, pp. 117-129
-
-
Chiba, M.1
Nishime, J.A.2
Neway, W.3
Lin, Y.4
Lin, J.H.5
-
24
-
-
2942553781
-
Structure and function of HIV-1 integrase
-
CHIU, T.K.; DAVIES, D.R. Structure and function of HIV-1 integrase. Curr.Top. Med. Chem., v.4, p.965-77, 2004.
-
(2004)
Curr.Top. Med. Chem
, vol.4
, pp. 965-977
-
-
Chiu, T.K.1
Davies, D.R.2
-
25
-
-
41849127131
-
The spread, treatment, and prevention of HIV- 1: Evolution of a global pandemic
-
COHEN M.S.; HELLMANN, N.; LEVY, J.A.; DECOCK, K.; LANGE, J. The spread, treatment, and prevention of HIV- 1: evolution of a global pandemic. J. Clin. Invest., v.118, p.1244-1254, 2008.
-
(2008)
J. Clin. Invest
, vol.118
, pp. 1244-1254
-
-
Cohen, M.S.1
Hellmann, N.2
Levy, J.A.3
Decock, K.4
Lange, J.5
-
26
-
-
0035897707
-
Inter-species differences in drug properties
-
COLLINS, J.M. Inter-species differences in drug properties. Chem. Biol. Interact., v.134, p.237-242, 2001.
-
(2001)
Chem. Biol. Interact
, vol.134
, pp. 237-242
-
-
Collins, J.M.1
-
27
-
-
47949114939
-
Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
-
COOPER, D.A.; STEIGBIGEL, R.T.; GATELL, J.M.; ROCKSTROH, J.K.; KATLAMA, C.; YENI, P.; LAZZARIN, A.; CLOTET, B.; KUMAR, P.N.; ERON, J.E.; SCHECHTER, M.; MARKOWITZ, M.; LOUTFY, M.R.; LENNOX, J.L.; ZHAO, J.; CHEN, J.; RYAN, D.M.; RHODES, R.R.; KILLAR, J.A.; GILDE, L.R.; STROHMAIER, K.M.; MEIBOHM, A.R.; MILLER, M.D.; HAZUDA, D.J.; NESSLY, M.L.; DINUBILE, M.J.; ISAACS, R.D.; TEPPLER, H.; NGUYEN, B.Y. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N. Engl. J. Med., v.359, p.355-365, 2008.
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 355-365
-
-
Cooper, D.A.1
Steigbigel, R.T.2
Gatell, J.M.3
Rockstroh, J.K.4
Katlama, C.5
Yeni, P.6
Lazzarin, A.7
Clotet, B.8
Kumar, P.N.9
Eron, J.E.10
Schechter, M.11
Markowitz, M.12
Loutfy, M.R.13
Lennox, J.L.14
Zhao, J.15
Chen, J.16
Ryan, D.M.17
Rhodes, R.R.18
Killar, J.A.19
Gilde, L.R.20
Strohmaier, K.M.21
Meibohm, A.R.22
Miller, M.D.23
Hazuda, D.J.24
Nessly, M.L.25
Dinubile, M.J.26
Isaacs, R.D.27
Teppler, H.28
Nguyen, B.Y.29
more..
-
28
-
-
48849098904
-
Selection of filamentous fungi of the Beauveria genus able to metabolize quercetin like mammalian cells
-
COSTA, E.M.M.B.; PIMENTA, F.C.; LUZ, W.C.; De Oliveira V. Selection of filamentous fungi of the Beauveria genus able to metabolize quercetin like mammalian cells. Braz. J. Microbiol., v.39, p.405-408, 2008.
-
(2008)
Braz. J. Microbiol
, vol.39
, pp. 405-408
-
-
Costa, E.M.M.B.1
Pimenta, F.C.2
Luz, W.C.3
de Oliveira, V.4
-
29
-
-
0042858542
-
Evaluation of 3_-azido-3_-deoxythymidine, morphine and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: Specificity and influence of the UGT2B7*2 polymorphism
-
COURT, M.H.; KRISHNASWAMY, S.; HAO, Q.; DUAN, S.X.; PATTEN, C.J.; VON MOLTKE, L.L.; GREENBLATT, D.J. Evaluation of 3_-azido-3_-deoxythymidine, morphine and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism. Drug Metab. Dispos., v.31, p.1125-1133, 2003.
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 1125-1133
-
-
Court, M.H.1
Krishnaswamy, S.2
Hao, Q.3
Duan, S.X.4
Patten, C.J.5
von Moltke, L.L.6
Greenblatt, D.J.7
-
30
-
-
0025791020
-
Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys
-
CRETTON, E.M.; SCHINAZI, R.F.; MCCLURE, H.M.; ANDERSON, D.C.; SOMMADOSSI, J.P. Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys. Antimicrob. Agents Chemother., v.35, p.801-807, 1991.
-
(1991)
Antimicrob. Agents Chemother
, vol.35
, pp. 801-807
-
-
Cretton, E.M.1
Schinazi, R.F.2
McClure, H.M.3
Anderson, D.C.4
Sommadossi, J.P.5
-
31
-
-
0027321002
-
In vitro and in vivo disposition and metabolism of 3'-deoxy- 2',3'-didehydrothymidine
-
CRETTON, E.M.; ZHOU, Z.; KIDD, L.B.; MCCLURE, H.M.; KAUL, S.; HITCHCOCK, M.J.; SOMMADOSSI, J.P. In vitro and in vivo disposition and metabolism of 3'-deoxy- 2',3'-didehydrothymidine. Antimicrob. Agents Chemother., v.37, p.1816-1825, 1993.
-
(1993)
Antimicrob. Agents Chemother
, vol.37
, pp. 1816-1825
-
-
Cretton, E.M.1
Zhou, Z.2
Kidd, L.B.3
McClure, H.M.4
Kaul, S.5
Hitchcock, M.J.6
Sommadossi, J.P.7
-
32
-
-
27444434892
-
MetaSite: Understanding metabolism in human cytochromes from the perspective of the chemist
-
CRUCIANI, G.; CAROSATI, E.; DEBOECK, B.; ETHIRAJULU, K.; MACKIE, C.; HOWE, T.; VIANELLO, R. MetaSite: Understanding metabolism in human cytochromes from the perspective of the chemist. J. Med. Chem., v.48, p.6970-6979, 2005.
-
(2005)
J. Med. Chem
, vol.48
, pp. 6970-6979
-
-
Cruciani, G.1
Carosati, E.2
Deboeck, B.3
Ethirajulu, K.4
Mackie, C.5
Howe, T.6
Vianello, R.7
-
33
-
-
0024027564
-
Predicting metabolic pathways by logic programming
-
DARVAS F. Predicting metabolic pathways by logic programming. J. Mol. Graph., v.6, p.80-86, 1988.
-
(1988)
J. Mol. Graph
, vol.6
, pp. 80-86
-
-
Darvas, F.1
-
35
-
-
2342451795
-
Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections
-
De Clercq, E. Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections. Expert Rev. Anti-Infect. Ther., v.1, p.21-43, 2003.
-
(2003)
Expert Rev. Anti-Infect. Ther
, vol.1
, pp. 21-43
-
-
de Clercq, E.1
-
36
-
-
17444411955
-
Cytochrome P450 in silico: An integrative modeling approach
-
DE GRAFF, C.; VERMEULEN, N.P.E.; FEENSTRA, K.A. Cytochrome P450 in silico: an integrative modeling approach. J. Med. Chem., v.48, p.2725-2755, 2005.
-
(2005)
J. Med. Chem
, vol.48
, pp. 2725-2755
-
-
de Graff, C.1
Vermeulen, N.P.E.2
Feenstra, K.A.3
-
37
-
-
0031820026
-
Metabolism of amprenavir in liver microsomes: Role of CYP3A4 inhibition for drug interactions
-
DECKER, C.J.; LAITINEN, L.M.; BRIDSON, G.W.; RAYBUCK, S.A.; TUNG, R.D.; CHATURVEDI, P.R. Metabolism of amprenavir in liver microsomes: role of CYP3A4 inhibition for drug interactions. J. Pharm. Sci., v.87, 803-807, 1998.
-
(1998)
J. Pharm. Sci
, vol.87
, pp. 803-807
-
-
Decker, C.J.1
Laitinen, L.M.2
Bridson, G.W.3
Raybuck, S.A.4
Tung, R.D.5
Chaturvedi, P.R.6
-
38
-
-
0030963109
-
Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans
-
DENISSEN, J.F.; GRABOWSKI, B.A.; JOHNSON, M.K.; BUKO, A.M.; KEMPF, D. J.; THOMAS, S.B.; SURBER, B.W. Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans. Drug Metab. Dispos., v.25, p.489-501, 1997.
-
(1997)
Drug Metab. Dispos
, vol.25
, pp. 489-501
-
-
Denissen, J.F.1
Grabowski, B.A.2
Johnson, M.K.3
Buko, A.M.4
Kempf, D.J.5
Thomas, S.B.6
Surber, B.W.7
-
39
-
-
77950866295
-
Preparation of new metabolites from lamivudine by filamentous fungi bioconversion
-
DIAS, L.E.S.; ANDRADE, C.H.; PAZINI, F.; DE OLIVEIRA, V. Preparation of new metabolites from lamivudine by filamentous fungi bioconversion. Braz. J. Pharm. Sci., v.41, p.133-133, 2005.
-
(2005)
Braz. J. Pharm. Sci
, vol.41
, pp. 133
-
-
Dias, L.E.S.1
Andrade, C.H.2
Pazini, F.3
de Oliveira, V.4
-
40
-
-
27644510382
-
Maraviroc (UK-427 857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
-
DORR, P.; WESTBY, M.; DOBBS, S.; GRIFFIN, P.; IRVINE, B.; MACARTNEY, M.; MORI, J.; RICKETT, G.; Smith-Burchnell, C.; NAPIER, C.; WEBSTER, R.; ARMOUR, D.; PRICE, D.; STAMMEN, B.; WOOD, A.; PERROS, M. Maraviroc (UK-427 857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob. Agents Chemother., v.49, p.4721-4732, 2005.
-
(2005)
Antimicrob. Agents Chemother
, vol.49
, pp. 4721-4732
-
-
Dorr, P.1
Westby, M.2
Dobbs, S.3
Griffin, P.4
Irvine, B.5
Macartney, M.6
Mori, J.7
Rickett, G.8
Smith-Burchnell, C.9
Napier, C.10
Webster, R.11
Armour, D.12
Price, D.13
Stammen, B.14
Wood, A.15
Perros, M.16
-
41
-
-
0036150281
-
CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro
-
EAGLINGS, V.A.; WILTSHIRE, H.; WHITCOMBE, I.W.A.; BACK, D.J. CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro. Xenobiotica, v.32, p.1-17, 2002.
-
(2002)
Xenobiotica
, vol.32
, pp. 1-17
-
-
Eaglings, V.A.1
Wiltshire, H.2
Whitcombe, I.W.A.3
Back, D.J.4
-
42
-
-
33344473208
-
A combined approach to drug metabolism and toxicity assessment
-
EKINS, S.; ANDREYEV, S.; RYABOV, A.; KIRILLOV, E.; RAKHMATULIN, E.A.; SOROKINA, S.; BUGRIM, A.; NIKOLSKAYA, T. A combined approach to drug metabolism and toxicity assessment. Drug Metab. Dispos., v.34, p.495-503, 2006.
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 495-503
-
-
Ekins, S.1
Andreyev, S.2
Ryabov, A.3
Kirillov, E.4
Rakhmatulin, E.A.5
Sorokina, S.6
Bugrim, A.7
Nikolskaya, T.8
-
43
-
-
0032727054
-
Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450
-
ERICKSON, D.A.; MATHER, G.; TRAGER, W.F.; LEVY, R.H.; KEIRNS, J.J. Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab. Dispos., v.27, p.1488-1495, 1999.
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 1488-1495
-
-
Erickson, D.A.1
Mather, G.2
Trager, W.F.3
Levy, R.H.4
Keirns, J.J.5
-
44
-
-
0030903443
-
Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89
-
FALETTO, M.B.; MILLER, W.H.; GARVEY, E.P.; St. CLAIRE, M.H.; DALUGE, S. M.; GOOD, S.S. Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89. Antimicrob. Agents Chemother., v.41, p.1099-1107, 1997.
-
(1997)
Antimicrob. Agents Chemother
, vol.41
, pp. 1099-1107
-
-
Faletto, M.B.1
Miller, W.H.2
Garvey, E.P.3
Claire St., M.H.4
Daluge, S.M.5
Good, S.S.6
-
45
-
-
0038639554
-
HIV and AIDS: 20 years of science
-
FAUCI, A.S. HIV and AIDS: 20 years of science. Nat. Med., v.9, p.839-843, 2003.
-
(2003)
Nat. Med
, vol.9
, pp. 839-843
-
-
Fauci, A.S.1
-
46
-
-
0004440808
-
Goals and analytical methodologies for protein disposition studies
-
In: FERRAIOLO, B.L.; MOHLER, M.A.; GLOFF, C.A, New York: Plenum Press
-
FERRAIOLO, B.L.; MOHLER, M.A.; GLOFF, C.A. Goals and analytical methodologies for protein disposition studies. In: FERRAIOLO, B.L.; MOHLER, M.A.; GLOFF, C.A. Protein pharmacokinetics and metabolism. New York: Plenum Press. 1992. p.1-21.
-
(1992)
Protein Pharmacokinetics and Metabolism
, pp. 1-21
-
-
Ferraiolo, B.L.1
Mohler, M.A.2
Gloff, C.A.3
-
47
-
-
0031024382
-
Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small intestinal cytochrome P450 3A4: Potential contribution to high first-pass metabolism
-
FITZSIMMONS, M.E.; COLLINS, J.M. Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small intestinal cytochrome P450 3A4: Potential contribution to high first-pass metabolism. Drug Metab. Dispos., v.25, p.256-266, 1997.
-
(1997)
Drug Metab. Dispos
, vol.25
, pp. 256-266
-
-
Fitzsimmons, M.E.1
Collins, J.M.2
-
48
-
-
0037569181
-
Enfuvirtide, a new drug for HIV infection
-
FLETCHER, C.V. Enfuvirtide, a new drug for HIV infection. Lancet, v.361, p.1577-78, 2003.
-
(2003)
Lancet
, vol.361
, pp. 1577-1578
-
-
Fletcher, C.V.1
-
49
-
-
84860394157
-
Avaliação do perfil metabólico da estavudina através do emprego da bioconversão e da modelagem molecular do citocromo P-450 CYP3A4
-
Dissertação de Mestrado. Faculdade de Farmácia. Universidade Federal de Goiás
-
FREITAS, L.M. Avaliação do perfil metabólico da estavudina através do emprego da bioconversão e da modelagem molecular do citocromo P-450 CYP3A4. Goiânia, 2009. 173 p. [Dissertação de Mestrado. Faculdade de Farmácia. Universidade Federal de Goiás].
-
(2009)
Goiânia
, pp. 173
-
-
Freitas, L.M.1
-
50
-
-
0022996630
-
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase
-
FURMAN, P.A.; FYFE, J.A.; St. CLAIR, M.H.; WEINHOLD, K.; RIDEOUT, J.L.; FREEMAN, G.A.; Nusinoff-Lehrman, S.; BOLOGNESI, D.P.; BRODER, S.; MITSUYA, H.; BARRY, D.W. Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc. Natl. Acad. Sci. USA, v.83, p.8333-8337, 1986.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 8333-8337
-
-
Furman, P.A.1
Fyfe, J.A.2
Clair St., M.H.3
Weinhold, K.4
Rideout, J.L.5
Freeman, G.A.6
Nusinoff-Lehrman, S.7
Bolognesi, D.P.8
Broder, S.9
Mitsuya, H.10
Barry, D.W.11
-
51
-
-
84860396854
-
-
In: ENCUENTRO REGIONAL BIOCATÁLISIS Y BIOTRANSFORMACIONES, 2., 2006, São Paulo. Resumos. São Paulo: Instituto de Química da Universidade de São Paulo
-
GOMES, T.C.F.; ANDRADE, C.H.; CIRILO, H.N.C.; RIOS, D.P.; DIAS, L.E.S.; PAZINI, F.; DE OLIVEIRA, V. Bioconversão de antiretrovirais por Cunninghamella echinulata ATCC 9244. In: ENCUENTRO REGIONAL BIOCATÁLISIS Y BIOTRANSFORMACIONES, 2., 2006, São Paulo. Resumos. São Paulo: Instituto de Química da Universidade de São Paulo, 2006. p.51-51.
-
(2006)
Bioconversão De Antiretrovirais Por Cunninghamella Echinulata ATCC 9244
, pp. 51
-
-
Gomes, T.C.F.1
Andrade, C.H.2
Cirilo, H.N.C.3
Rios, D.P.4
Dias, L.E.S.5
Pazini, F.6
de Oliveira, V.7
-
52
-
-
4644341747
-
Human hepatocytes in primary culture: The choice to investigate drug metabolism in man
-
Gomez-Lechon, M.J.; DONATO, M.T.; CASTELL, J.V.; JOVER, R. Human hepatocytes in primary culture: the choice to investigate drug metabolism in man. Curr. Drug Metab., v.5, p.443-462, 2004.
-
(2004)
Curr. Drug Metab
, vol.5
, pp. 443-462
-
-
Gomez-Lechon, M.J.1
Donato, M.T.2
Castell, J.V.3
Jover, R.4
-
53
-
-
0342732426
-
1592U89 succinate-preclinical toxicological and disposition studies and preliminary clinical pharmacokinetics
-
GOOD, S.S.; DALUGE, S.M.; CHING, S.V.; AYERS, M.M.; MAHONY, W.B.; FALETTO, M.B.; DOMIN, B.A.; OWENS, B.S.; DORNSIFE, R.E., MCDOWELL, J.A.; LAFON, S.W.; SYMONDS, W.T. 1592U89 succinate-preclinical toxicological and disposition studies and preliminary clinical pharmacokinetics. Antiviral Res., v.26, p.A229, 1995.
-
(1995)
Antiviral Res
, vol.26
-
-
Good, S.S.1
Daluge, S.M.2
Ching, S.V.3
Ayers, M.M.4
Mahony, W.B.5
Faletto, M.B.6
Domin, B.A.7
Owens, B.S.8
Dornsife, R.E.9
McDowell, J.A.10
Lafon, S.W.11
Symonds, W.T.12
-
54
-
-
34147136222
-
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK- 0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
-
GRINSZTEJN, B.; NGUYEN, B.Y.; KATLAMA, C.; GATELL, J.M.; LAZZARIN, A.; VITTECOQ, D.; GONZALEZ, C.J.; CHEN, J.; HARVEY, C.M.; ISAACS, R.D. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK- 0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet, v.369, p.1261-1269, 2007.
-
(2007)
Lancet
, vol.369
, pp. 1261-1269
-
-
Grinsztejn, B.1
Nguyen, B.Y.2
Katlama, C.3
Gatell, J.M.4
Lazzarin, A.5
Vittecoq, D.6
Gonzalez, C.J.7
Chen, J.8
Harvey, C.M.9
Isaacs, R.D.10
-
55
-
-
33645050104
-
Cytochrome P450s and other enzymes in drug metabolism and toxicity
-
GUENGERICH, F.P. Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS Journal, v.8, p.E101-E111, 2006.
-
(2006)
AAPS Journal
, vol.8
-
-
Guengerich, F.P.1
-
56
-
-
33747122666
-
Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society--USA panel
-
HAMMER, S.M.; SAAG, M.S.; SCHECHTER, M.; MONTANER, J.S.; SCHOOLEY, R.T.; JACOBSEN, D.M.; THOMPSON, M.A.; CARPENTER, C.C.; FISCHL, M.A.; GAZZARD, B.G.; GATELL, J.M.; HIRSCH, M.S.; KATZENSTEIN, D.A.; RICHMAN, D.D.; VELLA, S.; YENI, P.G.; VOLBERDING, P.A. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society--USA panel. JAMA, v.296, p.827-843, 2006.
-
(2006)
JAMA
, vol.296
, pp. 827-843
-
-
Hammer, S.M.1
Saag, M.S.2
Schechter, M.3
Montaner, J.S.4
Schooley, R.T.5
Jacobsen, D.M.6
Thompson, M.A.7
Carpenter, C.C.8
Fischl, M.A.9
Gazzard, B.G.10
Gatell, J.M.11
Hirsch, M.S.12
Katzenstein, D.A.13
Richman, D.D.14
Vella, S.15
Yeni, P.G.16
Volberding, P.A.17
-
57
-
-
0035150854
-
Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: Potential drug interactions with bupropion
-
HESSE, L.M.; VON MOLTKE, L.L.; SHADER, R.I.; GREENBLATT, D.J. Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion. Drug Metab. Dispos., v.29, p.100-102, 2001.
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 100-102
-
-
Hesse, L.M.1
von Moltke, L.L.2
Shader, R.I.3
Greenblatt, D.J.4
-
58
-
-
9444245372
-
Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19
-
HIRANI, V N.; RAUCY, J.L.; LASKER, J.M. Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19. Drug Metab. Dispos., v.32, p.1462-1467, 2004.
-
(2004)
Drug Metab. Dispos
, vol.32
, pp. 1462-1467
-
-
Hirani, V.N.1
Raucy, J.L.2
Lasker, J.M.3
-
59
-
-
33947482804
-
Monomethanesulfonates of 1-(2-deoxy-b-D-threo-pentofuranosyl)thymine
-
HORWITZ, J.P.; CHUA, J.; NOEL, M. Nucleosides V. Monomethanesulfonates of 1-(2-deoxy-b-D-threo-pentofuranosyl)thymine. J. Org. Chem., v.29, 2076-2078, 1964.
-
(1964)
J. Org. Chem
, vol.29
, pp. 2076-2078
-
-
Horwitz, J.P.1
Chua, J.2
Noel, M.3
Nucleosides, V.4
-
60
-
-
51649088021
-
Maraviroc: In vitro assessment of drug-drug interaction potential
-
HYLAND, R.; DICKINS, M.; COLLINS, C.; JONES H.; JONES, B. Maraviroc: in vitro assessment of drug-drug interaction potential. Br. J. Clin. Pharmacol., v.66, suppl.4, p.498-507, 2008.
-
(2008)
Br. J. Clin. Pharmacol., V.66, Suppl
, vol.4
, pp. 498-507
-
-
Hyland, R.1
Dickins, M.2
Collins, C.3
Jones, H.4
Jones, B.5
-
61
-
-
38349182976
-
Lack of a pharmacokinetic effect of raltegravir on midazolam: In vitro/ in vivo correlation
-
IWAMOTO, M.; KASSAHUN, K.; TROYER, M.D.; HANLEY, W.D.; LU, P.; RHOTON, A.; PETRY, A.S.; GHOSH, K.; MANGIN, E.; DENOIA, E.P.; WENNING, L.A.; STONE, J.A.; GOTTESDIENER, K.M.; WAGNER, J.A. Lack of a pharmacokinetic effect of raltegravir on midazolam: in vitro/ in vivo correlation. J. Clin. Pharmacol., v.48, p.209-214, 2008.
-
(2008)
J. Clin. Pharmacol
, vol.48
, pp. 209-214
-
-
Iwamoto, M.1
Kassahun, K.2
Troyer, M.D.3
Hanley, W.D.4
Lu, P.5
Rhoton, A.6
Petry, A.S.7
Ghosh, K.8
Mangin, E.9
Denoia, E.P.10
Wenning, L.A.11
Stone, J.A.12
Gottesdiener, K.M.13
Wagner, J.A.14
-
62
-
-
0031818475
-
The pharmacokinetics of iamivudine in patients with impaired hepatic function
-
JOHNSON, M.A.; HORAK, J.; BREUEL, P. The pharmacokinetics of iamivudine in patients with impaired hepatic function. Eur. J. Clin. Pharmacol., v.54, p.363-366, 1998.
-
(1998)
Eur. J. Clin. Pharmacol
, vol.54
, pp. 363-366
-
-
Johnson, M.A.1
Horak, J.2
Breuel, P.3
-
63
-
-
34548065793
-
Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme
-
KASSAHUN, K.; MCINTOSH, I.; CUI, D.; HRENIUK, D.; MERSCHMAN, S.; LASSETER, K.; AZROLAN, N.; IWAMOTO, M.; WAGNER J.A.; WENNING, L.A. Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme. Drug Metab. Dispos., v.35, p.1657-1663, 2007.
-
(2007)
Drug Metab. Dispos
, vol.35
, pp. 1657-1663
-
-
Kassahun, K.1
McIntosh, I.2
Cui, D.3
Hreniuk, D.4
Merschman, S.5
Lasseter, K.6
Azrolan, N.7
Iwamoto, M.8
Wagner, J.A.9
Wenning, L.A.10
-
64
-
-
0027229341
-
Absorption, disposition, and metabolism of [14C]didanosine in the beagle dog
-
KAUL, S.; SHYU, W.C.; SHUKLA, U.A.; DANDEKAR, K.A.; BARBHAIYA, R.H. Absorption, disposition, and metabolism of [14C]didanosine in the beagle dog. Drug Metab. Dispos., v.21, p.447-453, 1993.
-
(1993)
Drug Metab. Dispos
, vol.21
, pp. 447-453
-
-
Kaul, S.1
Shyu, W.C.2
Shukla, U.A.3
Dandekar, K.A.4
Barbhaiya, R.H.5
-
65
-
-
0033866253
-
Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease
-
KHALIQ, Y.; GALLICANO, K.; SEGUIN, I.; FYKE, K.; CARIGNAN, G.; BULMAN, D.; BADLEY, A.; CAMERON, D.W. Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease. Br. J. Clin. Pharmacol., v.50, p.108-115, 2000.
-
(2000)
Br. J. Clin. Pharmacol
, vol.50
, pp. 108-115
-
-
Khaliq, Y.1
Gallicano, K.2
Seguin, I.3
Fyke, K.4
Carignan, G.5
Bulman, D.6
Badley, A.7
Cameron, D.W.8
-
66
-
-
0028534521
-
META A program for the evaluation of metabolic transformation of chemicals
-
KLOPMAN, G.; DIMAYUGA, M.; TALAFOUS, J. META A program for the evaluation of metabolic transformation of chemicals. J. Chem. Inf. Comput. Sci., v.34, p.1320-1325, 1994.
-
(1994)
J. Chem. Inf. Comput. Sci
, vol.34
, pp. 1320-1325
-
-
Klopman, G.1
Dimayuga, M.2
Talafous, J.3
-
67
-
-
0038408563
-
Spectroscopic identification of AZT derivative obtained from biotransformation of AZT by Stenotrophomonas maltophilia
-
KRUSZEWSKA, H.; CHMIELOWIEC, U.; BEDNAREK, E.; Witowska-Jarosz, J.; DOBROWOLSKI, J.C.; MISICKA, A. Spectroscopic identification of AZT derivative obtained from biotransformation of AZT by Stenotrophomonas maltophilia. J. Mol. Struct., v.651-653, p.645-650, 2003.
-
(2003)
J. Mol. Struct
, vol.651-653
, pp. 645-650
-
-
Kruszewska, H.1
Chmielowiec, U.2
Bednarek, E.3
Witowska-Jarosz, J.4
Dobrowolski, J.C.5
Misicka, A.6
-
68
-
-
0032811807
-
Potent Inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction
-
KUMAR, G.N.; DYKSTRA, J.; ROBERTS, E.M.; JAYANTI, V.K.; HICKMAN, D.; UCHIC, J.; YAO, Y.; SURBER, B.; THOMAS, S.; GRANNEMAN, G.R. Potent Inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: a positive drug-drug interaction. Drug Metab. Dispos., v.27, p.902-908, 1999.
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 902-908
-
-
Kumar, G.N.1
Dykstra, J.2
Roberts, E.M.3
Jayanti, V.K.4
Hickman, D.5
Uchic, J.6
Yao, Y.7
Surber, B.8
Thomas, S.9
Granneman, G.R.10
-
69
-
-
0030430035
-
Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes
-
KUMAR, G.N.; RODRIGUES, A.D.; BUKO, A.M.; DENISSEN, J.F. Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. J. Pharmacol. Exp. Ther., v.277, p.423-431, 1996.
-
(1996)
J. Pharmacol. Exp. Ther
, vol.277
, pp. 423-431
-
-
Kumar, G.N.1
Rodrigues, A.D.2
Buko, A.M.3
Denissen, J.F.4
-
70
-
-
0034885012
-
Role of drug metabolism in drug discovery and development
-
KUMAR, G.N.; SURAPANENI, S. Role of drug metabolism in drug discovery and development. Med. Res. Rev., v.21, p.397-411, 2001.
-
(2001)
Med. Res. Rev
, vol.21
, pp. 397-411
-
-
Kumar, G.N.1
Surapaneni, S.2
-
71
-
-
34347354196
-
Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
-
LAZZARIN, A.; CAMPBELL, T.; CLOTET, B.; JOHNSON, M.; KATLAMA, C.; MOLL, A.; TOWNER, W.; TROTTIER, B.; PEETERS, M.; VINGERHOETS, J.; DE SMEDT, G.; BAETEN, B.; BEETS, G.; SINHA, R.; WOODFALL, B. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, v.370, p.39-48, 2007.
-
(2007)
Lancet
, vol.370
, pp. 39-48
-
-
Lazzarin, A.1
Campbell, T.2
Clotet, B.3
Johnson, M.4
Katlama, C.5
Moll, A.6
Towner, W.7
Trottier, B.8
Peeters, M.9
Vingerhoets, J.10
de Smedt, G.11
Baeten, B.12
Beets, G.13
Sinha, R.14
Woodfall, B.15
-
72
-
-
33644919674
-
Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line
-
LE VEE, M.; JIGOREL, E.; GLAISE, D.; GRIPON, P.; Guguen-Guillouzo, C.; FARDEL, O. Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line. Eur. J. Pharm. Sci., v.28, p.109-117, 2006.
-
(2006)
Eur. J. Pharm. Sci
, vol.28
, pp. 109-117
-
-
le Vee, M.1
Jigorel, E.2
Glaise, D.3
Gripon, P.4
Guguen-Guillouzo, C.5
Fardel, O.6
-
73
-
-
8444233186
-
-
New York: Marcel Dekker, Inc
-
LEE, J.S.; OBACH, R.S.; FISHER, M.B. Drug metabolizing enzymes. Cytochrome P450 and other enzymes in drug discovery and development. New York: Marcel Dekker, Inc., 2003. 587 p.
-
(2003)
Drug Metabolizing Enzymes. Cytochrome P450 and Other Enzymes In Drug Discovery and Development
, pp. 587
-
-
Lee, J.S.1
Obach, R.S.2
Fisher, M.B.3
-
74
-
-
0030726508
-
Preclinical evaluation of drug-drug interaction potential: Present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction
-
LI, A.P.; MAUREL, P.; Gomez-Lechon, M.J.; CHENG, L.C.; Jurima-Romet, M. Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction. Chem. Biol. Interact., v.107, p.5-16, 1997.
-
(1997)
Chem. Biol. Interact
, vol.107
, pp. 5-16
-
-
Li, A.P.1
Maurel, P.2
Gomez-Lechon, M.J.3
Cheng, L.C.4
Jurima-Romet, M.5
-
75
-
-
0032871057
-
Transport, metabolism and elimination mechanisms of anti-HIV agents
-
LI, X.; CHAN, W.K. Transport, metabolism and elimination mechanisms of anti-HIV agents. Adv. Drug Delivery Rev., v.39, p.81-103, 1999.
-
(1999)
Adv. Drug Delivery Rev
, vol.39
, pp. 81-103
-
-
Li, X.1
Chan, W.K.2
-
76
-
-
0344765487
-
Characterization of the selectivity and mechanism of human cytochrome P450 Inhibition by the human immunodeficiency virus-protease inhibitor nelfinavir mesylate
-
LILLIBRIDGE, J.H.; LIANG, B.H.; KERR, B.M.; WEBBER, S.; QUART, B.; SHETTY, B.V.; LEE, C.A. Characterization of the selectivity and mechanism of human cytochrome P450 Inhibition by the human immunodeficiency virus-protease inhibitor nelfinavir mesylate. Drug Metab. Dispos., v.26, p.609-616, 1998.
-
(1998)
Drug Metab. Dispos
, vol.26
, pp. 609-616
-
-
Lillibridge, J.H.1
Liang, B.H.2
Kerr, B.M.3
Webber, S.4
Quart, B.5
Shetty, B.V.6
Lee, C.A.7
-
77
-
-
0029974065
-
Species differences in the pharmacokinetics and metabolism of indinavir, a potent HIV protease inhibitor
-
LIN, J.H.; CHIBA, M.; BALANI, S.K.; CHEN, I. W.; KWEI, G.Y.; VASTAG, K.J.; NISHIME, J.A. Species differences in the pharmacokinetics and metabolism of indinavir, a potent HIV protease inhibitor. Drug Metab. Dispos., v.24, p.1111-1120, 1996.
-
(1996)
Drug Metab. Dispos
, vol.24
, pp. 1111-1120
-
-
Lin, J.H.1
Chiba, M.2
Balani, S.K.3
Chen, I.W.4
Kwei, G.Y.5
Vastag, K.J.6
Nishime, J.A.7
-
78
-
-
8544224973
-
The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
-
MACKENZIE, P.I.; OWENS, I.S.; BURCHELL, B.; BOCK, K.W.; BAIROCH, A.; BÉLANGER, A.; Fournel-Gigleux, S.; GREEN, M.; HUM, D.W.; IYANAGI, T.; LANCET, D.; LOUISOT, P.; MAGDALOU, J.; CHOWDHURY, J.R.; RITTER, J.K.; SCHACHTER, H.; TEPHLY, T.R.; TIPTON, K.F.; NEBERT, D.W. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenet., v.7, p.255-269, 1997.
-
(1997)
Pharmacogenet
, vol.7
, pp. 255-269
-
-
Mackenzie, P.I.1
Owens, I.S.2
Burchell, B.3
Bock, K.W.4
Bairoch, A.5
Bélanger, A.6
Fournel-Gigleux, S.7
Green, M.8
Hum, D.W.9
Iyanagi, T.10
Lancet, D.11
Louisot, P.12
Magdalou, J.13
Chowdhury, J.R.14
Ritter, J.K.15
Schachter, H.16
Tephly, T.R.17
Tipton, K.F.18
Nebert, D.W.19
-
79
-
-
34347327010
-
Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
-
MADRUGA, J.V.; CAHN, P.; GRINSZTEJN, B.; HAUBRICH, R.; LALEZARI, J.; MILLS, A.; PIALOUX, G.; WILKIN, T.; PEETERS, M.; VINGERHOETS, J.; DE SMEDT, G.; LEOPOLD, L.; TREFIGLIO, R.; WOODFALL, B. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, v.370, p.29-38, 2007.
-
(2007)
Lancet
, vol.370
, pp. 29-38
-
-
Madruga, J.V.1
Cahn, P.2
Grinsztejn, B.3
Haubrich, R.4
Lalezari, J.5
Mills, A.6
Pialoux, G.7
Wilkin, T.8
Peeters, M.9
Vingerhoets, J.10
de Smedt, G.11
Leopold, L.12
Trefiglio, R.13
Woodfall, B.14
-
80
-
-
1642391068
-
Enfuvirtide: The first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes
-
MATTHEWS, T.; SALGO, M.; GREENBERG, M.; CHUNG, J.; DEMASI, R.; BOLOGNESI, D. Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes. Nat. Rev. Drug Discov., v.3, p.215-225, 2004.
-
(2004)
Nat. Rev. Drug Discov
, vol.3
, pp. 215-225
-
-
Matthews, T.1
Salgo, M.2
Greenberg, M.3
Chung, J.4
Demasi, R.5
Bolognesi, D.6
-
81
-
-
0032585875
-
Pharmacokinetics of [14C]Abacavir, a human immunodeficiency Virus Type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: A mass balance study
-
MCDOWELL, J.A.; CHITTICK, G.E.; RAVITCH, J.R.; POLK, R.E.; KERKERING, T.M.; STEIN, D.S. Pharmacokinetics of [14C]Abacavir, a human immunodeficiency Virus Type 1 (HIV-1) reverse transcriptase inhibitor, administered in a single oral dose to HIV-1-infected adults: a mass balance study. Antimicrob. Agents Chemother., v.43, p.2855-2861, 1999.
-
(1999)
Antimicrob. Agents Chemother
, vol.43
, pp. 2855-2861
-
-
McDowell, J.A.1
Chittick, G.E.2
Ravitch, J.R.3
Polk, R.E.4
Kerkering, T.M.5
Stein, D.S.6
-
82
-
-
77249134151
-
Twenty-six years of anti- HIV drug discovery: Where do we stand and where do we go?
-
MEHELLOU, W.; DE CLERCQ, E. Twenty-six years of anti- HIV drug discovery: where do we stand and where do we go? J. Med. Chem., v.53, p.521-538, 2010.
-
(2010)
J. Med. Chem
, vol.53
, pp. 521-538
-
-
Mehellou, W.1
de Clercq, E.2
-
83
-
-
0031050615
-
Isolated perfused liver as a tool to study the disposition of peptides, liver first-pass effects, and cell-specific drug delivery
-
MEIJER, D.K.F.; SWART, P.J. Isolated perfused liver as a tool to study the disposition of peptides, liver first-pass effects, and cell-specific drug delivery. J. Controlled Release, v.46, p.139-156, 1997.
-
(1997)
J. Controlled Release
, vol.46
, pp. 139-156
-
-
Meijer, D.K.F.1
Swart, P.J.2
-
85
-
-
0026441170
-
Phosphorylation of 9-(2-phosphonomethoxyethyl) adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP (dAMP) kinase from L1210 cells
-
MERTA, A.; VOTRUBA, I.; JINDRICH, J.; HOLÝ, A.; CIHLÁR, T.; ROSENBERG, I.; OTMAR, M.; HERVE, T.Y. Phosphorylation of 9-(2-phosphonomethoxyethyl) adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP (dAMP) kinase from L1210 cells. Biochem. Pharmacol., v.44, p.2067-2077, 1992.
-
(1992)
Biochem. Pharmacol
, vol.44
, pp. 2067-2077
-
-
Merta, A.1
Votruba, I.2
Jindrich, J.3
Holý, A.4
Cihlár, T.5
Rosenberg, I.6
Otmar, M.7
Herve, T.Y.8
-
86
-
-
0001707601
-
3'-Azido-3'-deoxythymidine (BW A509U): An antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy associated virus in vitro
-
MITSUYA, H.; WEINHOLD, K.J.; FURMAN, P.A.; ST CLAIR, M.H.; LEHRMAN, S.N.; GALLO, R.C.; BOLOGNESI, D.; BARRY, D.W.; BRODER, S. 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy associated virus in vitro. Proc. Natl. Acad. Sci. USA, v.82, p.7096-7100, 1985.
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 7096-7100
-
-
Mitsuya, H.1
Weinhold, K.J.2
Furman, P.A.3
Clair St., M.H.4
Lehrman, S.N.5
Gallo, R.C.6
Bolognesi, D.7
Barry, D.W.8
Broder, S.9
-
87
-
-
52949113498
-
PK/DB: Database for pharmacokinetic properties and predictive in silico ADME models
-
MODA, T.L.; TORRES, L.G.; CARRARA, A.E.; ANDRICOPULO, A.D. PK/DB: database for pharmacokinetic properties and predictive in silico ADME models. Bioinformatics, v.24, p.2270-2271, 2008.
-
(2008)
Bioinformatics
, vol.24
, pp. 2270-2271
-
-
Moda, T.L.1
Torres, L.G.2
Carrara, A.E.3
Andricopulo, A.D.4
-
88
-
-
0036335573
-
Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans
-
MOULY, S.; LOWN, K.S.; KORNHAUSER, D.; JOSEPH, J.L.; FISKE, W.D.; BENEDEK, I.H.; WATKINS, P.B. Hepatic but not intestinal CYP3A4 displays dose-dependent induction by efavirenz in humans. Clin. Pharmacol. Therap., v.72, p.1-9, 2002.
-
(2002)
Clin. Pharmacol. Therap
, vol.72
, pp. 1-9
-
-
Mouly, S.1
Lown, K.S.2
Kornhauser, D.3
Joseph, J.L.4
Fiske, W.D.5
Benedek, I.H.6
Watkins, P.B.7
-
89
-
-
0032589627
-
Identification and characterization of efavirenz metabolites by LC/MS and high field NMR. Species differences in the metabolism of efavirenz
-
MUTLIB, A.E.; CHEN, H.; NEMETH, G.A.; MARWALDER, J.A.; SEITZ, S.P.; GAN, L.S.; CHRIST, D.D. Identification and characterization of efavirenz metabolites by LC/MS and high field NMR. Species differences in the metabolism of efavirenz. Drug Metab. Dispos., v.27, p.1319-1333, 1999.
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 1319-1333
-
-
Mutlib, A.E.1
Chen, H.2
Nemeth, G.A.3
Marwalder, J.A.4
Seitz, S.P.5
Gan, L.S.6
Christ, D.D.7
-
90
-
-
0037403950
-
Utility of hepatocytes in predicting drug metabolism: Comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro
-
NARITOMI, Y.; TERASHITA, S.; KAGAYAMA, A.; SUGIYAMA, Y. Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro. Drug Metab. Dispos., v.31, p.580-588, 2003.
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 580-588
-
-
Naritomi, Y.1
Terashita, S.2
Kagayama, A.3
Sugiyama, Y.4
-
91
-
-
0028146656
-
Enzymatic phosphorylation and pyrophosphorylation of 2',3'-dideoxyadenosine-5'- monophosphate, a key metabolite in the pathway for activation of the anti-HIV (human immunodeficiency virus) agent 2',3'-dideoxyinosine
-
NAVÉ, J.F.; ESCHBACH, A.; Wolff-Kugel, D.; HALAZY, S.; BALZARINI, J. Enzymatic phosphorylation and pyrophosphorylation of 2',3'-dideoxyadenosine-5'- monophosphate, a key metabolite in the pathway for activation of the anti-HIV (human immunodeficiency virus) agent 2',3'-dideoxyinosine. Biochem. Pharmacol., v.48, p.1105-1112, 1994.
-
(1994)
Biochem. Pharmacol
, vol.48
, pp. 1105-1112
-
-
Navé, J.F.1
Eschbach, A.2
Wolff-Kugel, D.3
Halazy, S.4
Balzarini, J.5
-
92
-
-
84860403271
-
Aplicação da bioconversão da zidovudina por Cunninghamella echinulata ATCC 9244 na síntese de derivados funcionalizados por carboidratos
-
Dissertação de Mestrado. Faculdade de Farmácia. Universidade Federal de Goiás
-
NUNES, E.S. Aplicação da bioconversão da zidovudina por Cunninghamella echinulata ATCC 9244 na síntese de derivados funcionalizados por carboidratos. Goiânia, 2008. 146 p. [Dissertação de Mestrado. Faculdade de Farmácia. Universidade Federal de Goiás].
-
(2008)
Goiânia
, pp. 146
-
-
Nunes, E.S.1
-
93
-
-
0033616138
-
Forty years of cytochrome P450
-
OMURA, T. Forty years of cytochrome P450. Biochem. Biophys. Res. Commun., v.266, p.690-698, 1999.
-
(1999)
Biochem. Biophys. Res. Commun
, vol.266
, pp. 690-698
-
-
Omura, T.1
-
94
-
-
84860407297
-
Preparação de metabólitos fase I e II do derivado N-fenilpiperazínico (LASSBio-581) via bioconversão por Cunninghamella echinulata ATCC 9244 e Mortierella isabelina NRRL 1757
-
PAZINI, F.; DE OLIVEIRA, V.; MENEGATTI, R.; FIGUEIRA, A.P.; FRAGA, C.A.M.; BARREIRO, E.J. Preparação de metabólitos fase I e II do derivado N-fenilpiperazínico (LASSBio-581) via bioconversão por Cunninghamella echinulata ATCC 9244 e Mortierella isabelina NRRL 1757. Rev. Eletr. Farm., v.2, supl.2, p.157-160, 2005.
-
(2005)
Rev. Eletr. Farm., V.2, Supl
, vol.2
, pp. 157-160
-
-
Pazini, F.1
de Oliveira, V.2
Menegatti, R.3
Figueira, A.P.4
Fraga, C.A.M.5
Barreiro, E.J.6
-
95
-
-
77950866707
-
Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581
-
PAZINI, F.; MENEGATTI, R.; SABINO, J.R.; ANDRADE, C.H.; NEVES, G.; RATES, S. M.K.; NOËL, F.; FRAGA, C.A.M.; BARREIRO, E.J.; DE OLIVEIRA, V. Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581. Bioorg. Med. Chem. Lett., v.20, p.2888-2891, 2010.
-
(2010)
Bioorg. Med. Chem. Lett
, vol.20
, pp. 2888-2891
-
-
Pazini, F.1
Menegatti, R.2
Sabino, J.R.3
Andrade, C.H.4
Neves, G.5
Rates, S.M.K.6
Noël, F.7
Fraga, C.A.M.8
Barreiro, E.J.9
de Oliveira, V.10
-
96
-
-
15244345304
-
Prediction of drug metabolism and interactions on the basis of in vitro investigations
-
PELKONEN, O.; TURPEINEN, M.; UUSITALO, J.; RAUTIO, A.; RAUNIO, H. Prediction of drug metabolism and interactions on the basis of in vitro investigations. Basic Clin. Pharmacol. Toxicol., v.96, p.167-175, 2005.
-
(2005)
Basic Clin. Pharmacol. Toxicol
, vol.96
, pp. 167-175
-
-
Pelkonen, O.1
Turpeinen, M.2
Uusitalo, J.3
Rautio, A.4
Raunio, H.5
-
97
-
-
48349104816
-
CCR5 antagonists for the treatment of HIV infection and AIDS
-
PERROS, M. CCR5 antagonists for the treatment of HIV infection and AIDS. Adv. Antiviral Drug Design, v.5, p.185-212, 2007.
-
(2007)
Adv. Antiviral Drug Design
, vol.5
, pp. 185-212
-
-
Perros, M.1
-
98
-
-
84890779944
-
Drug metabolism: Significance and challenges
-
In: XIE, W. (Ed.), New York: John Wiley & Sons, Inc, Chap.1
-
PRAKASH, C.; VAZ, A.D.N. Drug metabolism: significance and challenges. In: XIE, W. (Ed.). Nuclear receptors in drug metabolism. New York: John Wiley & Sons, Inc. 2009. Chap.1, p.1-41.
-
(2009)
Nuclear Receptors In Drug Metabolism
, pp. 1-41
-
-
Prakash, C.1
Vaz, A.D.N.2
-
99
-
-
34347347164
-
Pharmacokinetics of emtricitabine, tenofovir, and GS- 9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavirboosted GS-9137
-
RAMANATHAN, S.; SHEN, G.; CHENG, A.; KEARNEY, B.P. Pharmacokinetics of emtricitabine, tenofovir, and GS- 9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavirboosted GS-9137. J. Acquir. Immune Defic. Syndr., v.45, p.274-279, 2007a.
-
(2007)
J. Acquir. Immune Defic. Syndr
, vol.45
, pp. 274-279
-
-
Ramanathan, S.1
Shen, G.2
Cheng, A.3
Kearney, B.P.4
-
100
-
-
84860407662
-
-
In: INTERNATIONAL WORKSHOP ON CLINICAL PHARMACOLOGY OF HIV THERAPY, 8., Budapest, Hungary, Abstract. Budapest
-
RAMANATHAN, S.; WRIGHT, M.; WEST, S.; KEARNEY, B.P. Pharmacokinetics, metabolism and excretion of ritonavir-boosted GS-9137 (elvitegravir). In: INTERNATIONAL WORKSHOP ON CLINICAL PHARMACOLOGY OF HIV THERAPY, 8., Budapest, Hungary, 2007. Abstract. Budapest: 2007b. p.30-31.
-
(2007)
Pharmacokinetics, Metabolism and Excretion of Ritonavir-boosted GS-9137 (elvitegravir)
, vol.2007
, pp. 30-31
-
-
Ramanathan, S.1
Wright, M.2
West, S.3
Kearney, B.P.4
-
101
-
-
84860422195
-
-
In: CONFERENCE ON RETROVIRUSES AND OPPORTUNISTIC INFECTIONS, 5., 1998, Chicago, Ill. Abstract. Chicago: Foundation for Retrovirology and Human Health
-
RAVITCH, J.R.; BRYANT, B.J.; REESE, M.J.; BOEHLERT, C.C.; WALSH, J.S.; MCDOWELL, J.P.; SADLER, B.M. CNS penetration of the anti-retroviral 1592 in human and animal models. In: CONFERENCE ON RETROVIRUSES AND OPPORTUNISTIC INFECTIONS, 5., 1998, Chicago, Ill. Abstract. Chicago: Foundation for Retrovirology and Human Health, 1998. p.199-199.
-
(1998)
CNS Penetration of the Anti-retroviral 1592 In Human and Animal Models
, pp. 199
-
-
Ravitch, J.R.1
Bryant, B.J.2
Reese, M.J.3
Boehlert, C.C.4
Walsh, J.S.5
McDowell, J.P.6
Sadler, B.M.7
-
102
-
-
0032770872
-
Disposition and biotransformation of the antiretroviral drug nevirapine in humans
-
RISKA, P.; LAMSON, M.; MCGREGOR, T.; SABO, J.; HATTOX, S.; PAV, J.; KEIRNS, J. Disposition and biotransformation of the antiretroviral drug nevirapine in humans. Drug Metab. Dispos., v.27, p.895-901, 1999a.
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 895-901
-
-
Riska, P.1
Lamson, M.2
McGregor, T.3
Sabo, J.4
Hattox, S.5
Pav, J.6
Keirns, J.7
-
103
-
-
0032701771
-
Biotransformation of Nevirapine, a Non-nucleoside HIV-1 Reverse Transcriptase Inhibitor, In Mice, Rats, Rabbits, Dogs, Monkeys, and Chimpanzees
-
RISKA, P.S.; JOSEPH, D.P.; DINALLO, R.M.; DAVIDSON, W.C.; KEIRNS, J.J.; HATTOX, S.E. Biotransformation of nevirapine, a non-nucleoside HIV-1 reverse transcriptase inhibitor, in mice, rats, rabbits, dogs, monkeys, and chimpanzees. Drug Metab. Dispos., v.27, p.1434-1447, 1999b.
-
(1999)
Drug Metab. Dispos
, vol.27
, pp. 1434-1447
-
-
Riska, P.S.1
Joseph, D.P.2
Dinallo, R.M.3
Davidson, W.C.4
Keirns, J.J.5
Hattox, S.E.6
-
104
-
-
17644414659
-
Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects
-
Rodriguez-Novoa, S.; BARREIRO, P.; RENDÓN, A.; Jiménez-Nacher, I.; González-Lahoz, J.; SORIANO, V. Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects. Clin. Infect. Dis., v.40, p.1358-1361, 2005.
-
(2005)
Clin. Infect. Dis
, vol.40
, pp. 1358-1361
-
-
Rodriguez-Novoa, S.1
Barreiro, P.2
Rendón, A.3
Jiménez-Nacher, I.4
González-Lahoz, J.5
Soriano, V.6
-
105
-
-
0025338874
-
Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys
-
SCHINAZI, R.F.; BOUDINOT, F.D.; DOSHI, K.J.; MCCLURE, H.M. Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rhesus monkeys. Antimicrob. Agents Chemother., v.34, p.1214-1219, 1990.
-
(1990)
Antimicrob. Agents Chemother
, vol.34
, pp. 1214-1219
-
-
Schinazi, R.F.1
Boudinot, F.D.2
Doshi, K.J.3
McClure, H.M.4
-
106
-
-
0016250297
-
Microbial models of mammalian metabolism, aromatic hydroxylation
-
SMITH, R.V.; ROSAZZA, J.P. Microbial models of mammalian metabolism, aromatic hydroxylation. Arch. Biochem. Biophys., v.161, p.551-558, 1974.
-
(1974)
Arch. Biochem. Biophys
, vol.161
, pp. 551-558
-
-
Smith, R.V.1
Rosazza, J.P.2
-
107
-
-
0016839144
-
Microbial models of mammalian metabolism
-
SMITH, R.V.; ROSAZZA, J.P. Microbial models of mammalian metabolism. J. Pharm. Sci., v.11, p.1737-1758, 1975.
-
(1975)
J. Pharm. Sci
, vol.11
, pp. 1737-1758
-
-
Smith, R.V.1
Rosazza, J.P.2
-
108
-
-
47949120697
-
Raltegravir with optimized background therapy for resistant HIV-1 infection
-
STEIGBIGEL, R.T.; COOPER, D.A.; KUMAR, P.N.; ERON, J.E.; SCHECHTER, M.; MARKOWITZ, M.; LOUTFY, M.R.; LENNOX, J.L.; GATELL, J.M.; ROCKSTROH, J.K.; KATLAMA, C.; YENI, P.; LAZZARIN, A.; CLOTET, B.; ZHAO, J.; CHEN, J.; RYAN, D.M.; RHODES, R.R.; KILLAR, J.A.; GILDE, L.R.; STROHMAIER, K.M.; MEIBOHM, A.R.; MILLER, M.D.; HAZUDA, D.J.; NESSLY, M.L.; DINUBILE, M.J.; ISAACS, R.D.; NGUYEN, B.Y.; TEPPLER, H. Raltegravir with optimized background therapy for resistant HIV-1 infection. N. Engl. J. Med., v.359, p.339-354, 2008.
-
(2008)
N. Engl. J. Med
, vol.359
, pp. 339-354
-
-
Steigbigel, R.T.1
Cooper, D.A.2
Kumar, P.N.3
Eron, J.E.4
Schechter, M.5
Markowitz, M.6
Loutfy, M.R.7
Lennox, J.L.8
Gatell, J.M.9
Rockstroh, J.K.10
Katlama, C.11
Yeni, P.12
Lazzarin, A.13
Clotet, B.14
Zhao, J.15
Chen, J.16
Ryan, D.M.17
Rhodes, R.R.18
Killar, J.A.19
Gilde, L.R.20
Strohmaier, K.M.21
Meibohm, A.R.22
Miller, M.D.23
Hazuda, D.J.24
Nessly, M.L.25
Dinubile, M.J.26
Isaacs, R.D.27
Nguyen, B.Y.28
Teppler, H.29
more..
-
109
-
-
45949107967
-
Computational prediction of drug binding and rationalisation of selectivity towards cytochromes P450
-
STJERNSCHANTZ, E.; VERMEULEN, N.P.E.; OOSTENBRINK C. Computational prediction of drug binding and rationalisation of selectivity towards cytochromes P450. Expert Opin. Drug Metab. Toxicol., v. 4, p.513-527, 2008.
-
(2008)
Expert Opin. Drug Metab. Toxicol
, vol.4
, pp. 513-527
-
-
Stjernschantz, E.1
Vermeulen, N.P.E.2
Oostenbrink, C.3
-
110
-
-
23044488827
-
Predicting drug metabolism - an evaluation of the expert system METEOR
-
TESTA, B.; BALMAT, A.L.; LONG, A.; JUDSON, P.N. Predicting drug metabolism - an evaluation of the expert system METEOR. Chem. Biodivers., v.2, p.872-885, 2005.
-
(2005)
Chem. Biodivers
, vol.2
, pp. 872-885
-
-
Testa, B.1
Balmat, A.L.2
Long, A.3
Judson, P.N.4
-
111
-
-
0031808472
-
Glucuronidation of 3'-azido-3'- deoxythymidine (zidovudine) by human liver microsomes: Relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid
-
TRAPNELL, C.B.; KLECKER, R.W.; Jamis-Dow, C.; COLLINS, J.M. Glucuronidation of 3'-azido-3'- deoxythymidine (zidovudine) by human liver microsomes: relevance to clinical pharmacokinetic interactions with atovaquone, fluconazole, methadone, and valproic acid. Antimicrob. Agents Chemother., v.42, p.1592-1596, 1998.
-
(1998)
Antimicrob. Agents Chemother
, vol.42
, pp. 1592-1596
-
-
Trapnell, C.B.1
Klecker, R.W.2
Jamis-Dow, C.3
Collins, J.M.4
-
112
-
-
0037371251
-
Oxidative metabolism of amprenavir in the human liver. effect of the CYP3A maturation
-
TRÉLUYER, J.M.; BOWERS, G.; CAZALI, N.; SONNIER, M.; REY, E.; PONS, G.; CRESTEIL, T. Oxidative metabolism of amprenavir in the human liver. effect of the CYP3A maturation. Drug Metab. Dispos., v.31, p.275-281, 2003.
-
(2003)
Drug Metab. Dispos
, vol.31
, pp. 275-281
-
-
Tréluyer, J.M.1
Bowers, G.2
Cazali, N.3
Sonnier, M.4
Rey, E.5
Pons, G.6
Cresteil, T.7
-
113
-
-
63849203115
-
-
UNAIDS/WORLD HEALTH ORGANIZATION, Geneva: Joint United Nations Programme on HIV/AIDS
-
UNAIDS/WORLD HEALTH ORGANIZATION. Report on the global HIV/AIDS epidemic 2008. August 2008. Geneva: Joint United Nations Programme on HIV/AIDS, p.1-356, 2008.
-
(2008)
Report On the Global HIV/AIDS Epidemic 2008. August 2008
, pp. 1-356
-
-
-
114
-
-
0029591968
-
Metabolism of zidovudine
-
VEAL, G.J.; BACK, D.J. Metabolism of zidovudine. Gen. Pharmacol., v.26, p.1469-1475, 1995.
-
(1995)
Gen. Pharmacol
, vol.26
, pp. 1469-1475
-
-
Veal, G.J.1
Back, D.J.2
-
115
-
-
67149101031
-
The global fight against HIV/AIDS, tuberculosis, and malaria: Current status and future perspectives
-
VITORIA, M.; GRANICH, R.; GILKS, C.F.; GUNNEBERG, C.; HOSSEINI, M.; WERE, W.; RAVIGLIONE, M.; DE COCK, K.M. The global fight against HIV/AIDS, tuberculosis, and malaria: current status and future perspectives. Am. J. Clin. Pathol., v.131, p.844-848, 2009.
-
(2009)
Am. J. Clin. Pathol
, vol.131
, pp. 844-848
-
-
Vitoria, M.1
Granich, R.2
Gilks, C.F.3
Gunneberg, C.4
Hosseini, M.5
Were, W.6
Raviglione, M.7
de Cock, K.M.8
-
116
-
-
0031819080
-
Metabolism of delavirdine, a human immunodeficiency virus type-1 reverse transcriptase inhibitor, by microsomal cytochrome P450 in humans, rats, and other species: Probable involvement of CYP2D6 and CYP3A
-
VOORMAN, R.L.; MAIO, S.M.; HAUER, M.J.; SANDERS, P.E.; PAYNE, N.A.; ACKLAND, M.J. Metabolism of delavirdine, a human immunodeficiency virus type-1 reverse transcriptase inhibitor, by microsomal cytochrome P450 in humans, rats, and other species: probable involvement of CYP2D6 and CYP3A. Drug Metab. Dispos., v.26, p.631-639, 1998a.
-
(1998)
Drug Metab. Dispos
, vol.26
, pp. 631-639
-
-
Voorman, R.L.1
Maio, S.M.2
Hauer, M.J.3
Sanders, P.E.4
Payne, N.A.5
Ackland, M.J.6
-
117
-
-
0032454713
-
Delavirdine: Evidence for mechanism-based inactivation of human cytochrome P450 3A
-
VOORMAN, R.L.; MAIO, S.M.; PAYNE, N.A.; ZHAO, Z.; KOEPLINGER, K.A.; WANG, X. Delavirdine: evidence for mechanism-based inactivation of human cytochrome P450 3A. J. Pharmacol. Exp. Ther., v.287, p.381-388, 1998b.
-
(1998)
J. Pharmacol. Exp. Ther
, vol.287
, pp. 381-388
-
-
Voorman, R.L.1
Maio, S.M.2
Payne, N.A.3
Zhao, Z.4
Koeplinger, K.A.5
Wang, X.6
-
118
-
-
0035155252
-
Interaction of delavirdine with human liver microsomal cytochrome P450: Inhibition of CYP2C9, CYP2C19, and CYP2D6
-
VOORMAN, R.L.; PAYNE, N.A.; WIENKERS, L.C.; HAUER, M.J.; SANDERS, P.E. Interaction of delavirdine with human liver microsomal cytochrome P450: inhibition of CYP2C9, CYP2C19, and CYP2D6. Drug Metab. Dispos., v.29, p.41-47, 2001.
-
(2001)
Drug Metab. Dispos
, vol.29
, pp. 41-47
-
-
Voorman, R.L.1
Payne, N.A.2
Wienkers, L.C.3
Hauer, M.J.4
Sanders, P.E.5
-
119
-
-
15344350690
-
Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV
-
WALKER, D.K.; ABEL, S.; COMBY, P.; MUIRHEAD, G.J.; NEDDERMAN, A.N.; SMITH, D.A. Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV. Drug Metab Dispos., v.33, p.587-595, 2005.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 587-595
-
-
Walker, D.K.1
Abel, S.2
Comby, P.3
Muirhead, G.J.4
Nedderman, A.N.5
Smith, D.A.6
-
120
-
-
0038002981
-
The cytochrome P4502B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism. Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity
-
WARD, B.A.; GORSKI, J.C.; JONES, D.R.; HALL, S.D.; FLOCKHART, D.A.; DESTA, Z. The cytochrome P4502B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism. Implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J. Pharmacol. Exp. Ther., v.306, p.287-300, 2003.
-
(2003)
J. Pharmacol. Exp. Ther
, vol.306
, pp. 287-300
-
-
Ward, B.A.1
Gorski, J.C.2
Jones, D.R.3
Hall, S.D.4
Flockhart, D.A.5
Desta, Z.6
-
121
-
-
28544434492
-
CCR5 antagonists: Host-targeted antivirals for the treatment of HIV infection
-
WESTBY, M.; VAN DER RYST, E. CCR5 antagonists: host-targeted antivirals for the treatment of HIV infection. Antiviral Chem. Chemother., v.16, p.339-354, 2005.
-
(2005)
Antiviral Chem. Chemother
, vol.16
, pp. 339-354
-
-
Westby, M.1
van der Ryst, E.2
-
122
-
-
0005524728
-
-
In: INTERNATIONAL ISSX MEETING, 5., Cairns, Australia, 1998. Abstracts. Cairns: International Society for the Study of Xenobiotics
-
WU, E.; SANDOVAL, T.; ZHANG, K.; GRETTENBERGER, H.; HEE, B.; LEE, C.; WEBBER, S.; SHETTY, B. Cytochrome P450 isoforms involved in the metabolism of nelfinavir mesylate, an HIV-1 protease inhibitor. In: INTERNATIONAL ISSX MEETING, 5., Cairns, Australia, 1998. Abstracts. Cairns: International Society for the Study of Xenobiotics, 1998. p.110-110.
-
(1998)
Cytochrome P450 Isoforms Involved In the Metabolism of Nelfinavir Mesylate, An HIV-1 Protease Inhibitor
, pp. 110
-
-
Wu, E.1
Sandoval, T.2
Zhang, K.3
Grettenberger, H.4
Hee, B.5
Lee, C.6
Webber, S.7
Shetty, B.8
-
123
-
-
0035009420
-
Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology
-
YOSHITOMI, S.; IKEMOTO, K.; TAKAHASHI, J.; MIKI, H.; NAMBA, M.; ASAHI, S. Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology. Toxicol. In Vitro, v.15, p.245-256, 2001.
-
(2001)
Toxicol. In Vitro
, vol.15
, pp. 245-256
-
-
Yoshitomi, S.1
Ikemoto, K.2
Takahashi, J.3
Miki, H.4
Namba, M.5
Asahi, S.6
-
124
-
-
0033374014
-
Identification of in vitro metabolites of indinavir by "intelligent automated LC-MS/ MS" (INTAMS) utilizing triple quadrupole tandem mass spectrometry
-
YU, X.; CUI, D.; DAVIS, M.R. Identification of in vitro metabolites of indinavir by "intelligent automated LC-MS/ MS" (INTAMS) utilizing triple quadrupole tandem mass spectrometry J. Am. Soc. Mass Spectrom., v.10, p.175-183, 1999.
-
(1999)
J. Am. Soc. Mass Spectrom
, vol.10
, pp. 175-183
-
-
Yu, X.1
Cui, D.2
Davis, M.R.3
-
125
-
-
0005563913
-
-
In: INTERNATIONAL ISSX MEETING, 5., Cairns, Australia, 1998. Abstracts. Cairns: International Society for the Study of Xenobiotics
-
ZHANG, K.; KERR, B.; HEE, B.; TALAAT, R.; MOGER, L.; SHETTY, B.; WEBBER, S. Biotransformation of nelfinavir, a potent HIV protease inhibitor, in healthy human subjects. In: INTERNATIONAL ISSX MEETING, 5., Cairns, Australia, 1998. Abstracts. Cairns: International Society for the Study of Xenobiotics, 1998. p.112-112.
-
(1998)
Biotransformation of Nelfinavir, a Potent HIV Protease Inhibitor, In Healthy Human Subjects
, pp. 112
-
-
Zhang, K.1
Kerr, B.2
Hee, B.3
Talaat, R.4
Moger, L.5
Shetty, B.6
Webber, S.7
-
126
-
-
0035086498
-
Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: Structural identification, levels in plasma, and antiviral activities
-
ZHANG, K.E.; WU, E.; PATICK, A.K.; KERR, B.; ZORBAS, M.; LANKFORD, A.; KOBAYASHI, T.; MAEDA, Y.; SHETTY, B.; WEBBER, S. Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities. Antimicrob. Agents Chemother., v.45, p.1086-1093, 2001.
-
(2001)
Antimicrob. Agents Chemother
, vol.45
, pp. 1086-1093
-
-
Zhang, K.E.1
Wu, E.2
Patick, A.K.3
Kerr, B.4
Zorbas, M.5
Lankford, A.6
Kobayashi, T.7
Maeda, Y.8
Shetty, B.9
Webber, S.10
-
127
-
-
33646787431
-
Application of biocatalysis to drug metabolism: Preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA receptor potentiator using actinoplanes missouriensis
-
ZMIJEWSKI, M.; GILLESPIE, T.A.; JACKSON, D.A.; SCHMIDT, D.F.; YI, P.; KULANTHAIVEL, P. Application of biocatalysis to drug metabolism: preparation of mammalian metabolites of a biaryl-bis-sulfonamide AMPA receptor potentiator using actinoplanes missouriensis. Drug Metab. Dispos., v.34, p.925-931, 2006.
-
(2006)
Drug Metab. Dispos
, vol.34
, pp. 925-931
-
-
Zmijewski, M.1
Gillespie, T.A.2
Jackson, D.A.3
Schmidt, D.F.4
Yi, P.5
Kulanthaivel, P.6
|