-
4
-
-
0025273418
-
Targets and strategies for the antiviral chemotherapy of AIDS
-
E. De Clercq: Targets and strategies for the antiviral chemotherapy of AIDS. Trends Pharmacol. Sci. 11, 198-205 (1990).
-
(1990)
Trends Pharmacol. Sci.
, vol.11
, pp. 198-205
-
-
De Clercq, E.1
-
5
-
-
0023268502
-
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex: A double-blind, placebo-controlled trial
-
M. A. Fischl, D. D. Richman, M. H. Grieco, M. S. Gottlieb, P. A. Volberding, O. L. Laskin, J. M. Leedom, J. E. Groopman, D. Mildvan, R. T. Schooley, G. G. Jackson, D. T. Durack, D. King, and The AZT Collaborative Working Group: The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex: a double-blind, placebo-controlled trial. N. Engl. J. Med. 317, 185-191 (1987).
-
(1987)
N. Engl. J. Med.
, vol.317
, pp. 185-191
-
-
Fischl, M.A.1
Richman, D.D.2
Grieco, M.H.3
Gottlieb, M.S.4
Volberding, P.A.5
Laskin, O.L.6
Leedom, J.M.7
Groopman, J.E.8
Mildvan, D.9
Schooley, R.T.10
Jackson, G.G.11
Durack, D.T.12
King, D.13
-
6
-
-
0024436217
-
Clinical pharmacology of 3′-azido-2′,3′-dideoxythymidine (zidovudine) and related dideoxynucleosides
-
R. Yarchoan, H. Mitsuya, C. E. Myers, and S. Broder: Clinical pharmacology of 3′-azido-2′,3′-dideoxythymidine (zidovudine) and related dideoxynucleosides. N. Engl. J. Med. 321, 726-738 (1989).
-
(1989)
N. Engl. J. Med.
, vol.321
, pp. 726-738
-
-
Yarchoan, R.1
Mitsuya, H.2
Myers, C.E.3
Broder, S.4
-
7
-
-
0024349612
-
In vivo activity against HIV and favorable toxicity profile of 2′,3′-dideoxyinosine
-
R. Yarchoan, H. Mitsuya, R. V. Thomas, J. M. Pluda, N. R. Hartman, C.-F. Perno, K. S. Marczyk, J. P. Allain, D. G. Johns, and S. Broder: In vivo activity against HIV and favorable toxicity profile of 2′,3′-dideoxyinosine. Science (Washington, DC) 245, 412-417 (1989).
-
(1989)
Science (Washington, DC)
, vol.245
, pp. 412-417
-
-
Yarchoan, R.1
Mitsuya, H.2
Thomas, R.V.3
Pluda, J.M.4
Hartman, N.R.5
Perno, C.-F.6
Marczyk, K.S.7
Allain, J.P.8
Johns, D.G.9
Broder, S.10
-
8
-
-
0025263835
-
2′,3′-Dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex: A phase I trial
-
J. S. Lambert, M. Seidlin, R. C. Reichman, C. S. Plank, M. Laverty, G. D. Morse, C. Knupp, C. McLaren, C. Pettinelli, F. T. Valentine, and R. Dolin: 2′,3′-Dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex: a phase I trial. N. Engl. J. Med. 322, 1333-1340 (1990).
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 1333-1340
-
-
Lambert, J.S.1
Seidlin, M.2
Reichman, R.C.3
Plank, C.S.4
Laverty, M.5
Morse, G.D.6
Knupp, C.7
McLaren, C.8
Pettinelli, C.9
Valentine, F.T.10
Dolin, R.11
-
9
-
-
0025232288
-
Once-daily administration of 2′, 3′-dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. Results of a phase I trial
-
T. P. Cooley, L. M. Kunches, C. A. Saunders, J. K. Ritter, C. J. Perkins, C. McLaren, R. P. McCaffrey, and H. A. Liebman: Once-daily administration of 2′, 3′-dideoxyinosine (ddI) in patients with the acquired immunodeficiency syndrome or AIDS-related complex. Results of a phase I trial. N. Engl. J. Med. 322, 1340-1345 (1990).
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 1340-1345
-
-
Cooley, T.P.1
Kunches, L.M.2
Saunders, C.A.3
Ritter, J.K.4
Perkins, C.J.5
McLaren, C.6
McCaffrey, R.P.7
Liebman, H.A.8
-
10
-
-
0023837875
-
Phase I studies of 2′-3′dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT)
-
R. Yarchoan, R. V. Thomas, J.-P. Allain, N. McAtee, R. Dubinsky, H. Mitsuya, T. J. Lawley, B. Safai, C. E. Myers, C. F. Perno, R. W. Klecker, R. J. Wills, M. A. Fischl, M. C. McNeely, J. M. Pluda, M. Leuther, J. M. Collins, and S. Broder: Phase I studies of 2′-3′dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT). Lancet 1, 76-81 (1988).
-
(1988)
Lancet
, vol.1
, pp. 76-81
-
-
Yarchoan, R.1
Thomas, R.V.2
Allain, J.-P.3
McAtee, N.4
Dubinsky, R.5
Mitsuya, H.6
Lawley, T.J.7
Safai, B.8
Myers, C.E.9
Perno, C.F.10
Klecker, R.W.11
Wills, R.J.12
Fischl, M.A.13
McNeely, M.C.14
Pluda, J.M.15
Leuther, M.16
Collins, J.M.17
Broder, S.18
-
11
-
-
0029086438
-
Antiretroviral activity of stavudine (2′,3′-didehydro-3′-deoxythymidine, d4T)
-
S. A. Riddler, R. E. Anderson, and J. W. Mellors: Antiretroviral activity of stavudine (2′,3′-didehydro-3′-deoxythymidine, d4T). Antiviral Res. 27, 189-203 (1995).
-
(1995)
Antiviral Res.
, vol.27
, pp. 189-203
-
-
Riddler, S.A.1
Anderson, R.E.2
Mellors, J.W.3
-
12
-
-
0025866982
-
Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2′-deoxy-3′-thiacytidine (BCH-189), a novel heterocylic nucleoside analog
-
H. Soudeyns, X.-J. Yao, Q. Gao, B. Belleau, J.-L. Kraus, N. Nguyen-ba, B. Spira, and M. A. Wainberg: Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2′-deoxy-3′-thiacytidine (BCH-189), a novel heterocylic nucleoside analog. Antimicrob. Agents Chemother. 35, 1386-1390 (1991).
-
(1991)
Antimicrob. Agents Chemother.
, vol.35
, pp. 1386-1390
-
-
Soudeyns, H.1
Yao, X.-J.2
Gao, Q.3
Belleau, B.4
Kraus, J.-L.5
Nguyen-ba, N.6
Spira, B.7
Wainberg, M.A.8
-
13
-
-
0026507919
-
(-)-2′-Deoxy-3′-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro
-
J. A. V. Coates, N. Cammack, H. J. Jenkinson, A. J. Jowett, M. I. Jowett, B. A. Pearson, C. R. Penn, P. L. Rouse, K. C. Viner, and J. M. Cameron. (-)-2′-Deoxy-3′-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro. Antimicrob. Agents Chemother. 36, 733-739 (1992).
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 733-739
-
-
Coates, J.A.V.1
Cammack, N.2
Jenkinson, H.J.3
Jowett, A.J.4
Jowett, M.I.5
Pearson, B.A.6
Penn, C.R.7
Rouse, P.L.8
Viner, K.C.9
Cameron, J.M.10
-
14
-
-
0023266214
-
The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex: A double-blind, placebo-controlled trial
-
D. D. Richman, M. A. Fischl, M. H. Grieco, M. S. Gottlieb, P. A. Volberding, O. L. Laskin, J. M. Leedom, J. E. Groopman, D. Mildvan, M. S. Hirsch, G. G. Jackson, D. T. Durack, S. Nusinoff-Lehrman., and The AZT Collaborative Working Group: The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex: A double-blind, placebo-controlled trial. N. Engl. J. Med. 317, 192-197 (1987).
-
(1987)
N. Engl. J. Med.
, vol.317
, pp. 192-197
-
-
Richman, D.D.1
Fischl, M.A.2
Grieco, M.H.3
Gottlieb, M.S.4
Volberding, P.A.5
Laskin, O.L.6
Leedom, J.M.7
Groopman, J.E.8
Mildvan, D.9
Hirsch, M.S.10
Jackson, G.G.11
Durack, D.T.12
Nusinoff-Lehrman, S.13
-
15
-
-
0024406638
-
Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type I reverse transcriptase and DNA polymerase gamma
-
H. König, E. Behr, J. Löwer, and R. Kurth: Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type I reverse transcriptase and DNA polymerase gamma. Antimicrob. Agents Chemother. 33, 2109-2114 (1989).
-
(1989)
Antimicrob. Agents Chemother.
, vol.33
, pp. 2109-2114
-
-
König, H.1
Behr, E.2
Löwer, J.3
Kurth, R.4
-
16
-
-
0024310253
-
Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
-
B. A. Larder and S. D. Kemp: Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science (Washington, DC) 246, 1155-1158 (1989).
-
(1989)
Science (Washington, DC)
, vol.246
, pp. 1155-1158
-
-
Larder, B.A.1
Kemp, S.D.2
-
17
-
-
0024508058
-
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy
-
B. A. Larder, G. Darby, and D. D. Richman: HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science (Washington, DC) 243, 1731-1734 (1989).
-
(1989)
Science (Washington, DC)
, vol.243
, pp. 1731-1734
-
-
Larder, B.A.1
Darby, G.2
Richman, D.D.3
-
18
-
-
0026565278
-
Fifth mutation in a human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
-
P. Kellam, C. A. B. Boucher, and B. A. Larder: Fifth mutation in a human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. Proc. Natl. Acad. Sci. USA 89, 1934-1938 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 1934-1938
-
-
Kellam, P.1
Boucher, C.A.B.2
Larder, B.A.3
-
19
-
-
0025950055
-
Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase
-
M. H. St. Clair, J. L. Martin, G. Tudor-Williams, M. C. Bach, C. L. Vavro, D. M. King, P. Kellam, S. D. Kemp, and B. A. Larder: Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. Science (Washington, DC) 253, 1557-1559 (1991).
-
(1991)
Science (Washington, DC)
, vol.253
, pp. 1557-1559
-
-
St. Clair, M.H.1
Martin, J.L.2
Tudor-Williams, G.3
Bach, M.C.4
Vavro, C.L.5
King, D.M.6
Kellam, P.7
Kemp, S.D.8
Larder, B.A.9
-
20
-
-
0029024089
-
Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC)
-
R. Schuurman, M. Nijhuis, R. van Leeuwen, P. Schipper, D. de Jong, P. Collis, S. A. Danner, J. Mulder, C. Loveday, C. Christopherson, S. Kwok, J. Sninsky, and C. A. B. Boucher: Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC). J. Infect. Dis. 17, 1411-1419 (1995).
-
(1995)
J. Infect. Dis.
, vol.17
, pp. 1411-1419
-
-
Schuurman, R.1
Nijhuis, M.2
Van Leeuwen, R.3
Schipper, P.4
De Jong, D.5
Collis, P.6
Danner, S.A.7
Mulder, J.8
Loveday, C.9
Christopherson, C.10
Kwok, S.11
Sninsky, J.12
Boucher, C.A.B.13
-
21
-
-
0027178052
-
U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication
-
T. J. Dueweke, S. M. Poppe, D. L. Romero, S. M. Swaney, A. G. So, K. M. Downey, I. W. Althaus, F. Reusser, M. Busso, L. Resnick, D. Mayers, J. Lane, P. A. Aristoff, R. C. Thomas, and W. G. Tarpley: U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob. Agents Chemother. 37, 1127-1131 (1993).
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1127-1131
-
-
Dueweke, T.J.1
Poppe, S.M.2
Romero, D.L.3
Swaney, S.M.4
So, A.G.5
Downey, K.M.6
Althaus, I.W.7
Reusser, F.8
Busso, M.9
Resnick, L.10
Mayers, D.11
Lane, J.12
Aristoff, P.A.13
Thomas, R.C.14
Tarpley, W.G.15
-
22
-
-
0027278282
-
Bis(heteroaryl)piperazine (BHAP): Reverse transcriptase inhibitors: Structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3-[(1-methylethyl)amino]- pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate
-
D. L. Romero, R. A. Morge, M. J. Genin, C. Biles, M. Busso, L. Resnick, I. W. Althaus, F. Reusser, R. C. Thomas, and W. G. Tarpley. Bis(heteroaryl)piperazine (BHAP): reverse transcriptase inhibitors: Structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3-[(1-methylethyl)amino]- pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate. J. Med. Chem. 36, 1505-1508 (1993).
-
(1993)
J. Med. Chem.
, vol.36
, pp. 1505-1508
-
-
Romero, D.L.1
Morge, R.A.2
Genin, M.J.3
Biles, C.4
Busso, M.5
Resnick, L.6
Althaus, I.W.7
Reusser, F.8
Thomas, R.C.9
Tarpley, W.G.10
-
23
-
-
33644757144
-
Correlation of proton and nitrogen-15 chemical shifts by multiple quantum NMR
-
A. Bax, R. H. Griffey, and B. L. Hawkins: Correlation of proton and nitrogen-15 chemical shifts by multiple quantum NMR. J. Magn. Reson. 55, 301-315 (1983).
-
(1983)
J. Magn. Reson.
, vol.55
, pp. 301-315
-
-
Bax, A.1
Griffey, R.H.2
Hawkins, B.L.3
-
24
-
-
0345311216
-
Proton and carbon-13 assignments from sensitivity-enhanced detection of heteronuclear multiple-bond connectivity by 2D multiple quantum NMR
-
A. Bax and M. F. Summers: Proton and carbon-13 assignments from sensitivity-enhanced detection of heteronuclear multiple-bond connectivity by 2D multiple quantum NMR. J. Am. Chem. Soc. 108, 2093-2094 (1986).
-
(1986)
J. Am. Chem. Soc.
, vol.108
, pp. 2093-2094
-
-
Bax, A.1
Summers, M.F.2
-
25
-
-
13444269041
-
Computer-optimized decoupling scheme for wideband applications and low-level operation
-
A. J. Shaka, P. B. Barker, and R. Freeman: Computer-optimized decoupling scheme for wideband applications and low-level operation. J. Magn. Reson. 64, 547-552 (1985).
-
(1985)
J. Magn. Reson.
, vol.64
, pp. 547-552
-
-
Shaka, A.J.1
Barker, P.B.2
Freeman, R.3
-
26
-
-
84989037493
-
Distortionless enhancement of NMR signals by polarization transfer
-
D. M. Doddrell, D. T. Pegg, and M. R. Bendall: Distortionless enhancement of NMR signals by polarization transfer. J. Magn. Reson. 64, 547-552 (1985).
-
(1985)
J. Magn. Reson.
, vol.64
, pp. 547-552
-
-
Doddrell, D.M.1
Pegg, D.T.2
Bendall, M.R.3
-
27
-
-
0031037656
-
Metabolism of the reverse transcriptase inhibitor delavirdine in rats
-
M. Chang, V. K. Sood, G. J. Wilson, D. A. Kloosterman, P. E. Sanders, M. J. Hauer, and P. E. Fagerness: Metabolism of the reverse transcriptase inhibitor delavirdine in rats. Drug Metab. Dispos. 25, 228-242 (1997).
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 228-242
-
-
Chang, M.1
Sood, V.K.2
Wilson, G.J.3
Kloosterman, D.A.4
Sanders, P.E.5
Hauer, M.J.6
Fagerness, P.E.7
-
28
-
-
0343575017
-
Metabolism of the reverse transcriptase inhibitor delavirdine: Identification of novel N-acetylglucosamine and pyridinol sulfate conjugates
-
(Abstract), Seattle
-
V. K. Sood, D. A. Kloosterman, P. E. Sanders, M. J. Hauer, J. J. Vrbanac, and M. Chang: Metabolism of the reverse transcriptase inhibitor delavirdine: Identification of novel N-acetylglucosamine and pyridinol sulfate conjugates. Presented at "Fourth International Meeting of the International Society for the Study of Xenobiotics," (Abstract), Seattle, 1995.
-
(1995)
Fourth International Meeting of the International Society for the Study of Xenobiotics
-
-
Sood, V.K.1
Kloosterman, D.A.2
Sanders, P.E.3
Hauer, M.J.4
Vrbanac, J.J.5
Chang, M.6
-
29
-
-
0343086852
-
Mechanism of delavirdine-induced pseudopregnancy in mice
-
(Abstract), San Diego
-
V. K. Sood, W. Zhang, D. G. Branstetter, and M. Chang. Mechanism of delavirdine-induced pseudopregnancy in mice. Presented at "Seventh North American Meeting of the International Society for the Study of Xenobiotics," (Abstract), San Diego, 1996.
-
(1996)
Seventh North American Meeting of the International Society for the Study of Xenobiotics
-
-
Sood, V.K.1
Zhang, W.2
Branstetter, D.G.3
Chang, M.4
|