Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 15076-15086

  Dogo Isonagie, Cajetan ^a   Lam, Son ^a,d   Gustchina, Elena ^b   Acharya, Priyamvada ^c   Yang, Yongping ^c   Shahzad ul Hussan, Syed ^a,c   Clore, G Marius ^b   Kwong, Peter D ^c   Bewley, Carole A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-HIV ACTIVITY; BIOCHEMICAL STUDIES; BROAD SPECTRUM; CHEMOKINE RECEPTORS; ENVELOPE PROTEINS; EXTRACELLULAR LOOPS; HIGH-RESOLUTION STRUCTURES; MICROMOLAR CONCENTRATION; SATURATION TRANSFER DIFFERENCE NMR; SMALL MOLECULES;

AMINO ACIDS; BINDING SITES; BIOMIMETICS;

PEPTIDES;

AMINO ACID; CCR5 ECL2 DERIVED PEPTIDE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYSTEINE; GLYCOPROTEIN GP 120; LYSINE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; ASSAY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; SECOND EXTRACELLULAR LOOP; VIRUS ENTRY; VIRUS INHIBITION; VIRUS STRAIN;

ANTI-HIV AGENTS; ANTIGENS, CD4; BIOMIMETIC MATERIALS; CELL LINE; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CCR5; RECEPTORS, CXCR5;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84860357305     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.332361     Document Type: Article

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