Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters

Nucleic Acids Research

Volumn 38, Issue 15, 2010, Pages 5242-5259

  Watts, Jonathan K ^a   Yu, Dongbo ^a   Charisse, Klaus ^b   Montaillier, Christophe ^c   Potier, Pierre ^c   Manoharan, Muthiah ^b   Corey, David R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b ALNYLAM PHARMACEUTICALS   (United States)

^c Parc Scientifique de Luminy   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENE RNA; COMPLEMENTARY RNA; DOUBLE STRANDED RNA; LOCKED NUCLEIC ACID; MESSENGER RNA; PROGESTERONE RECEPTOR; PYRIMIDINE; RNA POLYMERASE II; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; OLIGONUCLEOTIDE; UNTRANSLATED RNA;

ARTICLE; CELL STRAIN MCF 7; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE SILENCING; IC 50; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROMOTER REGION; BIOSYNTHESIS; CHEMISTRY; GENETICS; HUMAN; METABOLISM; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

CELL LINE, TUMOR; GENE SILENCING; HUMANS; OLIGONUCLEOTIDES; PROMOTER REGIONS, GENETIC; RECEPTORS, PROGESTERONE; RNA POLYMERASE II; RNA, ANTISENSE; RNA, DOUBLE-STRANDED; RNA, UNTRANSLATED; TRANSCRIPTIONAL ACTIVATION;

EID: 77956107879     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq258     Document Type: Article

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