MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency

Retrovirology

Volumn 9, Issue , 2012, Pages

  Grupping, Katrijn ^a   Selhorst, Philippe ^a   Michiels, Johan ^a   Vereecken, Katleen ^a   Heyndrickx, Leo ^a   Kessler, Pascal ^b   Vanham, Guido ^a,c   Martin, Loïc ^b   Ariën, Kevin K ^a  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

CD4 binding site; Entry efficiency; Entry inhibitors; HIV 1; Resistance

Indexed keywords

COLONY STIMULATING FACTOR 1; EPITOPE; GLYCOPROTEIN GP 120; PROTEIN; PROTEIN MINICD4; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CROSS RESISTANCE; ENVELOPE GENE; GENE MUTATION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IC 50; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BINDING; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; VIROGENESIS; VIRUS ENTRY; VIRUS ENVELOPE; VIRUS INFECTIVITY; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS RESISTANCE; VIRUS TITRATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; BINDING SITES; DRUG RESISTANCE, VIRAL; EPITOPES; HEK293 CELLS; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; PEPTIDES; PHENYLALANINE; PROTEIN CONFORMATION; VIRUS ATTACHMENT; VIRUS INTERNALIZATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84860342068     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-9-36     Document Type: Article

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