The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice

Environmental Research

Volumn 115, Issue , 2012, Pages 1-10

  Cassee, Flemming R ^a   Campbell, Arezoo ^b   Boere, A John F ^a   McLean, Steven G ^c   Duffin, Rodger ^d   Krystek, Petra ^e   Gosens, Ilse ^a   Miller, Mark R ^c  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e PHILIPS RESEARCH LABORATORIES   (Germany)

Author keywords

Atherosclerosis; Cerium oxide; Diesel exhaust; Inhalation; Nanomaterial; Neuroinflammation

Indexed keywords

CERIUM OXIDE; CYTOKINE; DIESEL FUEL; NANOPARTICLE;

CERIUM; CHEMICAL POLLUTANT; DIESEL; EXHAUST EMISSION; HEALTH IMPACT; HEMATOLOGY; NANOTECHNOLOGY; PARTICLE SIZE; PATHOLOGY; POLLUTION EFFECT; PROTEIN; RODENT; SURFACE AREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; BRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXHAUST GAS; FEMALE; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXIC INHALATION;

ANIMALS; ATHEROSCLEROSIS; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; BRAIN; CERIUM; FEMALE; HEMATOCRIT; HEMOGLOBINS; IMMUNOHISTOCHEMISTRY; INHALATION EXPOSURE; LUNG; MALE; MICE; MICE, KNOCKOUT; NANOPARTICLES; PARTICLE SIZE; PARTICULATE MATTER; RANDOM ALLOCATION; VEHICLE EMISSIONS;

MUS;

EID: 84860341257     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2012.03.004     Document Type: Article

References (49)

1. Araujo J.A., Barajas B., Kleinman M., Wang X., Bennett B.J., Gong K.W., Navab M., Harkema J., Sioutas C., Lusis A.J., Nel A.E. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ. Res. 2008, 102:589-596.
2. Araujo J.A., Nel A.E. Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress. Part. Fibre Toxicol. 2009, 6:24.
3. Bai N., Kido T., Suzuki H., Yang G., Kavanagh T.J., Kaufman J.D., Rosenfeld M.E., van Breemen C., Eeden S.F. Changes in atherosclerotic plaques induced by inhalation of diesel exhaust. Atherosclerosis 2011, 216:299-306.
4. Brook R.D. Cardiovascular effects of air pollution. Clin. Sci. (Lond.) 2008, 115:175-187.
5. Calderón-Garcidueňas L., Solt A., Henríquez-Roldán C., Torres-Jardón R., Nuse B., Herritt L., Villarreal-Calderón R., Osnaya N., Stone I., García R., Brooks D.M., González-Maciel A., Reynoso-Robles R., Delgado-Chávez R., Reed W. Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood brain barrier, ultrafine particulate deposition, and accumulation of amyloid Β-42 and α-synuclein in children and young adults. Toxicol. Pathol. 2008, 36:289-310.
6. Campbell A. Inflammation, neurodegenerative diseases and environmental exposures. Ann. N. Y. Acad. Sci. 2004, 1035:117-132.
7. Campbell A., Araujo J.A., Li H., Sioutas C., Kleinman M. Particulate matter induced enhancement of inflammatory markers in the brains of apolipoprotein E knockout mice. J. Nanosci. Nanotechnol. 2009, 9:5099-5104.
8. Campen M.J., Lund A.K., Knuckles T.L., Conklin D.J., Bishop B., Young D., Seilkop S., Seagrave J., Reed M.D., McDonald J.D. Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE-/- mice. Toxicol. Appl. Pharmacol. 2010, 242:310-317.
9. Cassee F.R., Boere A.J., Fokkens P.H., Leseman D.L., Sioutas C., Kooter I.M., Dormans J.A. Inhalation of concentrated particulate matter produces pulmonary inflammation and systemic biological effects in compromised rats. J. Toxicol. Environ. Health Part A 2005, 68:773-796.
10. Cassee F.R., Van Balen E.C., Singh C., Green D., Muijser H., Weinstein J., Dreher K. Exposure, health and ecological effects review of engineered nanoscale cerium and cerium oxide associated with its use as a fuel additive. Crit. Rev Toxicol. 2010, 41:213-229.
11. Dockery D.W., Pope C.A., Xu X., Spengler J.D., Ware J.H., Fay M.E., Ferris B.G., Speizer F.E. An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med. 1993, 329:1753-1759.
12. Farraj A.K., Boykin E., Ledbetter A., Andrews D., Gavett S.H. Increased lung resistance after diesel particulate and ozone co-exposure not associated with enhanced lung inflammation in allergic mice. Inhal. Toxicol. 2010, 22:33-41.
13. Fox J.G., Barthold S.W., Davisson M.T., Newcomer C.E., Quimby F.W., Smith A.L. The Mouse in Biomedical Research Second Edition Diseases. American College of Laboratory Animal Medicine 2007, Elsevier, Amsterdam.
14. Gerlofs-Nijland M., Berlo D., Cassee F.R., Schins R., Wang K., Campbell A. Effect of subchronic exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Part. Fibre Toxicol. 2010, 7:12.
15. Gerlofs-Nijland M.E., Totlandsdal A.I., Kilinç E., Miller M.R., Boere A.J.F., Fokkens P.H.B., et al. Pulmonary and cardiovascular effects of traffic-related particulate matter: 4-week exposure of rats to roadside and diesel engine exhaust particles. Inhal. Toxicol. 2010, 22:1162-1173.
16. Hadoke P., Wainwright C.L., Wadsworth R.M., Butler K., Giddings M.J. Characterization of the morphological and functional alterations in rabbit subclavian artery subjected to balloon angioplasty. Coron. Artery Dis. 1995, 6:403-415.
17. Hardas S.S., Butterfield D.A., Sultana R., Tseng M.T., Dan M., Florence R.L., Unrine J.M., Graham U.M., Wu P., Grulke E.A., Yokel R.A. Brain distribution and toxicological evaluation of a systemically delivered engineered nanoscale ceria. Toxicol. Sci. 2010, 116:562-576.
18. Hassing C., Twickler M., Brunekreef B., Cassee F., Doevendans P., Kastelein J., Cramer M.J. Particulate air pollution, coronary heart disease and individual risk assessment: a general overview. Eur. J. Cardiovasc. Prev. Rehabil. 2009, 16:10-15.
19. Hiramatsu K., Saito Y., Sakakibara K., Azuma A., Takizawa H., Sugawara I. The effects of inhalation of diesel exhaust on murine mycobacterial infection. Exp. Lung Res. 2005, 31:405-415.
20. Ichinose T., Takano H., Sadakane K., Yanagisawa R., Yoshikawa T., Sagai M., Shibamoto T. Mouse strain differences in eosinophilic airway inflammation caused by intratracheal instillation of mite allergen and diesel exhaust particles. J. Appl. Toxicol. 2004, 24:69-76.
21. Jackson C.L. Defining and defending murine models of plaque rupture. Arterioscler. Thromb. Vasc. Biol. 2007, 27:973-977.
22. Jackson C.L., Bennett M.R., Biessen E.A., Johnson J.L., Krams R. Assessment of unstable atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 2007, 27:714-720.
23. Johnson J.L., Jackson C.L. Atherosclerotic plaque rupture in the apolipoprotein Eknockout mouse. Atherosclerosis 2001, 154:399-406.
24. Johnson J., Carson K., Williams H., Karanam S., Newby A., Angelini G., George S., Jackson C. Plaque rupture after short periods of fat feeding in the apolipoprotein E-knockout mouse: model characterization and effects of pravastatin treatment. Circulation 2005, 111:1422-1430.
25. Kobayashi T. Exposure to diesel exhaust aggravates nasal allergic reaction in guinea pigs. Am. J. Respir. Crit. Care Med. 2000, 162:352-356.
26. Lahiri D.K., Ge Y. Electrophoretic mobility shift assay for the detection of specific DNA-protein complex in nuclear extracts from the cultured cells and frozen autopsy human brain tissue. Brain Res. Brain Res. Protoc. 2000, 5:257-265.
27. Logothetidis S., Patsalas P., Charitidis C. Enhanced catalytic activity of nanostructured cerium oxide films. Mater. Sci. Eng., C 2003, 23:803-806.
28. Ma J.Y., Zhao H., Mercer R.R., Barger M., Rao M., Meighan T., Schwegler-Berry D., Castranova V., Ma J.K. Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats. Nanotoxicology 2011, 5:312-325.
29. Maricq M. Chemical characterization of particulate emissions from diesel engines. J. Aerosol. Sci. 2007, 38:1079-1118.
30. Methia N., Andre P., Hafezi-Moghadam A., Economopoulos M., Thomas K.L., Wagner D.D. ApoE deficiency compromises the blood brain barrier especially after injury. Mol. Med. 2001, 7:810-815.
31. Mills N.L., Tornqvist H., Gonzalez M.C., Vink E., Robinson S.D., Soderberg S., Boon N.A., Donaldson K., Sandström T., Blomberg A., Newby D.E. Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N. Engl. J. Med. 2007, 357:1075-1082.
32. Miyabara Y., Ichinose T., Takano H., Sagai M. Diesel exhaust inhalation enhances airway hyperresponsiveness in mice. Int. Arch. Allergy Immunol. 1998, 116:124-131.
33. OECD, 2007. http://www.oecd.org/document/47/0,3746,en_2649_37015404_41197295_1_1_1_1,00.html.
34. Park B., Donaldson K., Duffin R., Tran L., Kelly F., Mudway I., Morin J.P., Guest R., Jenkinson P., Samaras Z., Giannouli M., Kouridis H., Martin P. Hazard and risk assessment of a nanoparticulate cerium oxide-based diesel fuel additive - a case study. Inhal. Toxicol. 2008, 20:547-566.
35. Pope C.A., Hansen M.L., Long R.W., Nielsen K.R., Eatough N.L., Wilson W.E., Eatough D.J. Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. Environ. Health Perspect. 2004, 112:339-345.
36. Rosenfeld M.E., Polinsky P., Virmani R., Kauser K., Rubanyi G., Schwartz S.M. Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse. Arterioscler. Thromb. Vasc. Biol. 2000, 20:2587-2592.
37. Rosenfeld M.E., Averill M.M., Bennett B.J., Schwartz S.M. Progression and disruption of advanced atherosclerotic plaques in murine models. Curr. Drug Targets 2008, 9:210-216.
38. Sajith, V., Sobhan, C.B., Peterson, G.P. 2010. Experimental investigations on the effects of cerium oxide nanoparticle fuel additives on biodiesel. Advance Mechanical Engineering Volume 2010(1). Article ID 581407. pp. 1-6.
39. Selvan Arul Mozhi, Anand V., Udayakumar, M.R.B. Effects of cerium oxide nanoparticle addition in diesel and diesel-biodiesel-ethanol blends on the performance and emission characteristics of a CI engine. J. Eng. Appl. Sci. 2009, 4:1-6.
40. Sun Q., Yue P., Kirk R.I., Wang A., Moatti D., Jin X., Lu B., Schecter A.D., Lippmann M., Gordon T., Chen L.C., Rajagopalan S. Ambient air particulate matter exposure and tissue factor expression in atherosclerosis. Inhal. Toxicol. 2008, 20:127-137.
41. Sun Q., Hong X., Wold L.E. Cardiovascular effects of ambient particulate air pollution exposure. Circulation 2010, 121:2755-2765.
42. Sunil V.R., Patel K.J., Mainelis G., Turpin B.J., Ridgely S., Laumbach R.J., Kipen H.M., Nazarenko Y., Veleeparambil M., Gow A.J., Laskin J.D., Laskin D.L. Pulmonary effects of inhaled diesel exhaust in aged mice. Toxicol. Appl. Pharmacol. 2009, 241:283-293.
43. Tilleux S., Hermans E. Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J. Neurosci. Res 2007, 85:2059-2070.
44. Ulrich A., Wichser A. Analysis of additive metals in fuel and emission aerosols of diesel vehicles with and without particle traps. Anal. Bioanal. Chem. 2003, 377:71-81.
45. Van Berlo D., Albrecht C., Knaapen A.M., Cassee F.R., Gerlofs-Nijland M.E., Kooter I.M., Palomero-Gallagher N., Bidmon H.J., van Schooten F.J., Krutmann J., Schins R.P. Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Arch. Toxicol. 2010, 84:553-562.
46. Wakefield G., Wu X., Gardener M., Park B., Anderson S. Envirox™ fuel-borne catalyst: developing and launching a nano-fuel additive. Tech. Anal. Strat. Manag. 2008, 20:127-136.
47. Woutersen R.A., van Garderen-Hoetmer A., Bruijntjes J.P., Zwart A., Feron V.J. Nasal tumours in rats after severe injury to the nasal mucosa and prolonged exposure to 10ppm formaldehyde. J. Appl. Toxicol. 1994, 9:39-46.
48. Yatera K., Hsieh J., Hogg J.C., Tranfield E., Suzuki H., Shih C.H., Behzad A.R., Vincent R., van Eeden S.F. Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques. Am. J. Physiol. 2008, 294:H944-H953.
49. Ying Z., Kampfrath T., Thurston G., Farrar B., Lippmann M., Wang A., Sun Q., Chen L.C., Rajagopalan S. Ambient particulates alter vascular function through induction of reactive oxygen and nitrogen species. Toxicol. Sci. 2009, 111:80-88.