Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 14-21

  Awadallah, Fadi M ^a   El Eraky, Wafaa I ^b   Saleh, Dalia O ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

1 Adrenergic receptor; Molecular modeling; Phthalazine; Piperazine; Vasorelaxant

Indexed keywords

3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL] N' (PHTHALZIN 1 YL)PROPANEHYDRAZIDE; ADRENALIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; HYDRALAZINE; PHTHALAZINE DERIVATIVE; PRAZOSIN; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; RAT; REACTION ANALYSIS; THORACIC AORTA; VASODILATATION;

ANIMALS; AORTA, THORACIC; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHTHALAZINES; RATS; RATS, WISTAR; VASODILATION;

EID: 84860331828     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.02.051     Document Type: Article

References (25)

1. A.E. Kümmerle, J.M. Raimundo, C.M. Leal, G.S. daSilva, T.L. Balliano, M.A. Pereira, C.A. de Simone, R.T. Sudo, G. Zapata-Sudo, C.A.M. Fraga, and E.J. Barreiro Eur. J. Med. Chem. 44 2009 4004 4009
2. A.D. Lopez, C.D. Mathers, M. Ezzati, D.T. Jamison, and C.J. Murray Lancet 367 2006 1747 1757
3. G.S. Stokes J. Clin. Hypertens. 6 2004 192 197
4. H. Marona, N. Szkaradek, A. Rapacz, B. Filipek, M. Dybata, A. Siwek, M. Cegta, and E. Szneler Bioorg. Med. Chem. 17 2009 1345 1352
5. R. Barbaro, L. Betti, M. Botta, F. Corelli, G. Giannaccini, L. Maccari, F. Manetti, G. Strappaghetti, and F. Corsano J. Med. Chem. 44 2001 2118 2132
6. D. Bylund, D. Eikenberg, J. Heieble, S. Langer, R. Lefkowiskitz, K. Minneman, P. Molinoff, R. Rufolo, and U. Trendelenburg Pharmacol. Rev. 46 1994 121 136
7. C. Forray, J. Bard, J. Wetzel, G. Chiu, E. Shapiro, R. Tang, H. Lepor, P. Hartig, R. Weinshbank, and T. Brancheck Mol. Pharmacol. 45 1994 703 708
8. M.A. Patane, A.L. Scott, T.P. Broten, R.S.L. Chang, R.W. Ransom, J. DiSalvo, C. Forray, and M.G. Bock J. Med. Chem. 41 1998 1206 1210
9. J. Handzlik, D. Maciag, M. Kubacka, S. Mogliski, B. Filipek, K. Stadnicka, and K. Kiec- Kononowicz Bioorg. Med. Chem. 16 2008 5982 5998
10. V. Alabaster, S. Campbell, J. Danilewicz, C. Greengrass, and R.M. Plews J. Med. Chem. 30 1987 999 1003
11. H. Lepor Prostate 1990 75 84 Suppl. 3
12. H. Nagano, M. Takagi, N. Kubodera, I. Matsunaga, H. Nabata, Y. Ohba, K. Sakai, S. Hata, Y. Uchida, Eur. Pat. 89065, 1983, Chugai Pharmaceutical Co., Ltd., Japan; Chem. Abstr. 100 (1983) p. 6547.
13. T. Elworthy, A. Ford, G. Bantle, and D. Morgans J. Med. Chem. 40 1997 2674 2687
14. S.M. Abou-Seri, K. Abouzid, and D.A. Abou El Ella Eur. J. Med. Chem. 46 2011 647 658
15. Hydralazine, through: http://www.drugs.com/pro/hydralazine.html.
16. L. Betti, M. Botta, F. Corelli, M. Floridi, P. Fossa, G. Giannaccini, F. Manetti, G. Strappaghetti, and S. Corasno Bioorg. Med. Chem. Lett. 12 2002 437 440
17. M.A. Ismail, M.N. Aboul-Enein, K.A. Abouzid, and R.A. Serya Bioorg. Med. Chem. 14 2006 898 910
18. Y. Chen, and W. Hua Spectrochimica Acta 56 2000 1045 1049
19. D. J. Nelson, US 7,220,858 B2 (2007).
20. A.S. Girgis, N.S.M. Ismail, and H. Farag Eur. J. Med. Chem. 46 2011 2397 2407
21. A.S. Girgis, N.S.M. Ismail, H. Farag, W.I. El-Eraky, D.O. Saleh, S.R. Tala, and A.R. Katritzky Eur. J. Med. Chem. 45 2010 4229 4238
22. A.S. Girgis, N. Mishriky, A.M. Farag, W.I. El-Eraky, and H. Farag Eur. J. Med. Chem. 43 2008 1818 1827
23. A.S. Girgis, A. Kalmouch, and M. Ellithey Bioorg. Med. Chem. 14 2006 8488 8494
24. I.J. MacDougall, and R. Griffith J. Mol. Graph. Model. 25 2006 146 157
25. R. Barbaro, L. Betti, M. Botta, F. Corelli, G. Giannaccini, L. Maccari, F. Manetti, G. Strappaghetti, and S. Corsano Bioorg. Med. Chem. 10 2002 361 369