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Volumn 2, Issue , 2012, Pages

Antihypertensives for combating dementia A perspective on candidate molecular mechanisms and population-based prevention

Author keywords

Alzheimer's disease; cerebrovascular disease; dementia; hypertension; prevention

Indexed keywords

ALPHA TOCOPHEROL; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; INDAPAMIDE; PERINDOPRIL;

EID: 84860307697     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2012.28     Document Type: Review
Times cited : (16)

References (111)
  • 2
    • 22844448780 scopus 로고    scopus 로고
    • Hypertension in adults across the age spectrum: Current outcomes and control in the community
    • DOI 10.1001/jama.294.4.466
    • Lloyd-Jones D, Evans J, Levy D. Hypertension in Adults across the age spectrum: Current outcomes and control in the community. JAMA 2005; 294: 466-472. (Pubitemid 41124179)
    • (2005) Journal of the American Medical Association , vol.294 , Issue.4 , pp. 466-472
    • Lloyd-Jones, D.M.1    Evans, J.C.2    Levy, D.3
  • 3
    • 34249697099 scopus 로고    scopus 로고
    • Forecasting the global burden of Alzheimer's disease
    • DOI 10.1016/j.jalz.2007.04.381, PII S155252600700475X
    • Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer's disease. Alzheimers Dement 2007; 3: 186-191. (Pubitemid 46825511)
    • (2007) Alzheimer's and Dementia , vol.3 , Issue.3 , pp. 186-191
    • Brookmeyer, R.1    Johnson, E.2    Ziegler-Graham, K.3    Arrighi, H.M.4
  • 5
  • 6
    • 46949106968 scopus 로고    scopus 로고
    • Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): A double-blind, placebo controlled trial
    • Peters R, Beckett N, Forette F, Tuomilehto J, Clarke R, Ritchie C et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): A double-blind, placebo controlled trial. Lancet Neurol 2008; 7: 683-689.
    • (2008) Lancet Neurol , vol.7 , pp. 683-689
    • Peters, R.1    Beckett, N.2    Forette, F.3    Tuomilehto, J.4    Clarke, R.5    Ritchie, C.6
  • 7
    • 14844291328 scopus 로고    scopus 로고
    • Does blood pressure lowering treatment prevents dementia or cognitive decline in patients with cardiovascular and cerebrovascular disease?
    • DOI 10.1016/j.jns.2004.11.020, Vascular Dementia Proceedings of the Third International Congress on Vascualr Dementia
    • Feigin V, Ratnasabapathy Y, Anderson C. Does blood pressure lowering treatment prevents dementia or cognitive decline in patients with cardiovascular and cerebrovascular disease? J Neurol Sci 2005; 229-230: 151-155. (Pubitemid 40341579)
    • (2005) Journal of the Neurological Sciences , vol.229-230 , pp. 151-155
    • Feigin, V.1    Ratnasabapathy, Y.2    Anderson, C.3
  • 8
    • 33745025248 scopus 로고    scopus 로고
    • The effects of blood pressure lowering on development of cognitive impairment and dementia in patients without apparent prior cerebrovascular disease
    • McGuinness B, Todd S, Passmore P, Bullock R. The effects of blood pressure lowering on development of cognitive impairment and dementia in patients without apparent prior cerebrovascular disease. Cochrane Database Syst Rev 2006; CD004034.
    • (2006) Cochrane Database Syst Rev
    • McGuinness, B.1    Todd, S.2    Passmore, P.3    Bullock, R.4
  • 9
    • 0033546910 scopus 로고    scopus 로고
    • Differentiation of vascular dementia from AD on neuropsychological tests
    • Looi JC, Sachdev PS. Differentiation of vascular dementia from AD on neuropsychological tests. Neurology 1999; 53: 670-678. (Pubitemid 29448284)
    • (1999) Neurology , vol.53 , Issue.4 , pp. 670-678
    • Looi, J.C.L.1    Sachdev, P.S.2
  • 12
    • 0007645406 scopus 로고    scopus 로고
    • Structural changes in the aged brain
    • In: Timiras P, Bittar E (eds). Jai Press: Greenwich
    • Dickson D. Structural Changes in the Aged Brain. In: Timiras P, Bittar E (eds). Advances in Cell Aging and Gerontology. Jai Press: Greenwich, 1997, pp 51-76.
    • (1997) Advances in Cell Aging and Gerontology. , pp. 51-76
    • Dickson, D.1
  • 14
    • 0035915621 scopus 로고    scopus 로고
    • Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales
    • Neuropathology Group Medical Research Council Cognitive Function and Aging Study. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS)
    • Neuropathology Group Medical Research Council Cognitive Function and Aging Study. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 2001; 357: 169-175.
    • (2001) Lancet , vol.357 , pp. 169-175
  • 15
    • 35748959415 scopus 로고    scopus 로고
    • Mixed brain pathologies account for most dementia cases in community-dwelling older persons
    • DOI 10.1212/01.wnl.0000271090.28148.24, PII 0000611420071211000005
    • Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 2007; 69: 2197-2204. (Pubitemid 350294674)
    • (2007) Neurology , vol.69 , Issue.24 , pp. 2197-2204
    • Schneider, J.A.1    Arvanitakis, Z.2    Bang, W.3    Bennett, D.A.4
  • 16
    • 70149097327 scopus 로고    scopus 로고
    • The neuropathology of probable Alzheimer disease and mild cognitive impairment
    • Schneider JA, Arvanitakis Z, Leurgans SE, Bennett DA. The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol 2009; 66: 200-208.
    • (2009) Ann Neurol , vol.66 , pp. 200-208
    • Schneider, J.A.1    Arvanitakis, Z.2    Leurgans, S.E.3    Bennett, D.A.4
  • 18
  • 19
    • 80051551890 scopus 로고    scopus 로고
    • Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B
    • Lee JH, Kim SH, Kim GH, Seo SW, Park HK, Oh SJ et al. Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B. Neurology 2011; 77: 18-25.
    • (2011) Neurology , vol.77 , pp. 18-25
    • Lee, J.H.1    Kim, S.H.2    Kim, G.H.3    Seo, S.W.4    Park, H.K.5    Oh, S.J.6
  • 20
    • 70349334173 scopus 로고    scopus 로고
    • Treatment of vascular risk factors is associated with slower decline in Alzheimer disease
    • Deschaintre Y, Richard F, Leys D, Pasquier F. Treatment of vascular risk factors is associated with slower decline in Alzheimer disease. Neurology 2009; 73: 674-680.
    • (2009) Neurology , vol.73 , pp. 674-680
    • Deschaintre, Y.1    Richard, F.2    Leys, D.3    Pasquier, F.4
  • 21
    • 77952951906 scopus 로고    scopus 로고
    • Lowering midlife levels of systolic blood pressure as a public health strategy to reduce late-life dementia: Perspective from the Honolulu Heart Program/Honolulu Asia Aging Study
    • Launer LJ, Hughes T, Yu B, Masaki K, Petrovitch H, Ross GW et al. Lowering midlife levels of systolic blood pressure as a public health strategy to reduce late-life dementia: Perspective from the Honolulu Heart Program/Honolulu Asia Aging Study. Hypertension 2010; 55: 1352-1359.
    • (2010) Hypertension , vol.55 , pp. 1352-1359
    • Launer, L.J.1    Hughes, T.2    Yu, B.3    Masaki, K.4    Petrovitch, H.5    Ross, G.W.6
  • 22
    • 84860312540 scopus 로고    scopus 로고
    • Hemodynamic concepts of hypertension: From the Eindkessel model to large artery compliance and wave reflections
    • In: Birkenhager W, Robertson J, Zanchetti A (eds). Hypertension in the Twentieth Century: Concepts and Achievements, Elsevier: Amsterdam
    • Safar M. Hemodynamic concepts of hypertension: From the Eindkessel model to large artery compliance and wave reflections. In: Birkenhager W, Robertson J, Zanchetti A (eds). Handbook of Hypertension. Hypertension in the Twentieth Century: Concepts and Achievements, vol. 22, Elsevier: Amsterdam, 2004, pp 173-191.
    • (2004) Handbook of Hypertension , vol.22 , pp. 173-191
    • Safar, M.1
  • 23
    • 0026768128 scopus 로고
    • Micro-architecture and composition of artery walls: Relationship to location, diameter and the distribution of mechanical stress
    • Glagov S, Vito R, Giddens DP, Zarins CK. Micro-architecture and composition of artery walls: Relationship to location, diameter and the distribution of mechanical stress. J Hypertens Suppl 1992; 10: S101-S104.
    • (1992) J Hypertens Suppl , vol.10
    • Glagov, S.1    Vito, R.2    Giddens, D.P.3    Zarins, C.K.4
  • 25
    • 0016845955 scopus 로고
    • Is lowrenin hypertension a stage in the development of essential hypertension or a diagnostic entity?
    • Padfield PL, Brown JJ, Lever AF, Schalekamp MA, Beevers DG, Davies DL et al. Is lowrenin hypertension a stage in the development of essential hypertension or a diagnostic entity? Lancet 1975; 1: 548-550.
    • (1975) Lancet , vol.1 , pp. 548-550
    • Padfield, P.L.1    Brown, J.J.2    Lever, A.F.3    Schalekamp, M.A.4    Beevers, D.G.5    Davies, D.L.6
  • 26
    • 0141688134 scopus 로고    scopus 로고
    • Hypertension and cognitive function: Pathophysiologic effects of hypertension on the brain
    • Manolio TA, Olson J, Longstreth WT. Hypertension and cognitive function: Pathophysiologic effects of hypertension on the brain. Curr Hypertens Rep 2003; 5: 255-261. (Pubitemid 38914969)
    • (2003) Current Hypertension Reports , vol.5 , Issue.3 , pp. 255-261
    • Manolio, T.A.1    Olson, J.2    Longstreth Jr., W.T.3
  • 27
    • 0036484242 scopus 로고    scopus 로고
    • Small artery remodeling in hypertension
    • Mulvany MJ. Small artery remodeling in hypertension. Curr Hypertens Rep 2002; 4: 49-55.
    • (2002) Curr Hypertens Rep , vol.4 , pp. 49-55
    • Mulvany, M.J.1
  • 28
    • 0036134967 scopus 로고    scopus 로고
    • Hypertension and cerebrovascular diseases: A specific role of vascular protection for the prevention of dementia
    • Semplicini A, Maresca A, Sartori M, Calo L, Pessina AC. Hypertension and cerebrovascular diseases: A specific role of vascular protection for the prevention of dementia. J Cardiovasc Pharmacol 2001; 38(Suppl 2): S79-S82. (Pubitemid 34020563)
    • (2002) Journal of Cardiovascular Pharmacology , vol.38 , Issue.SUPPL. 2
    • Semplicini, A.1    Maresca, A.2    Sartori, M.3    Calo, L.4    Pessina, A.C.5
  • 30
    • 9444268676 scopus 로고    scopus 로고
    • Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people: The cardiovascular health study
    • Longstreth Jr WT, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke 1996; 27: 1274-1282. (Pubitemid 26286152)
    • (1996) Stroke , vol.27 , Issue.8 , pp. 1274-1282
    • Longstreth Jr., W.T.1    Manolio, T.A.2    Arnold, A.3    Burke, G.L.4    Bryan, N.5    Jungreis, C.A.6    Enright, P.L.7    O'Leary, D.8    Fried, L.9
  • 31
    • 0029018417 scopus 로고
    • The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review
    • Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke 1995; 26: 1293-1301.
    • (1995) Stroke , vol.26 , pp. 1293-1301
    • Pantoni, L.1    Garcia, J.H.2
  • 33
    • 0036128625 scopus 로고    scopus 로고
    • Neuropathology of white matter lesions in vascular cognitive impairment
    • DOI 10.1159/000049144
    • Englund E. Neuropathology of white matter lesions in vascular cognitive impairment. Cerebrovasc Dis 2002; 13(Suppl 2): 11-15. (Pubitemid 34233903)
    • (2002) Cerebrovascular Diseases , vol.13 , Issue.SUPPL. 2 , pp. 11-15
    • Englund, E.1
  • 35
  • 37
    • 66849126212 scopus 로고    scopus 로고
    • Severe cerebral white matter hyperintensities predict severe cognitive decline in patients with cerebrovascular disease history
    • Dufouil C, Godin O, Chalmers J, Coskun O, MacMahon S, Tzourio-Mazoyer N et al. Severe cerebral white matter hyperintensities predict severe cognitive decline in patients with cerebrovascular disease history. Stroke 2009; 40: 2219-2221.
    • (2009) Stroke , vol.40 , pp. 2219-2221
    • Dufouil, C.1    Godin, O.2    Chalmers, J.3    Coskun, O.4    MacMahon, S.5    Tzourio-Mazoyer, N.6
  • 38
    • 55149090311 scopus 로고    scopus 로고
    • Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia
    • van Straaten EC, Harvey D, Scheltens P, Barkhof F, Petersen RC, Thal LJ et al. Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia. J Neurol 2008; 255: 1302-1308.
    • (2008) J Neurol , vol.255 , pp. 1302-1308
    • Van Straaten, E.C.1    Harvey, D.2    Scheltens, P.3    Barkhof, F.4    Petersen, R.C.5    Thal, L.J.6
  • 39
  • 40
    • 0036284867 scopus 로고    scopus 로고
    • Silent cerebral microbleeds on T2*-weighted MRI: Correlation with stroke subtype, stroke recurrence, and leukoaraiosis
    • DOI 10.1161/01.STR.0000018012.65108.86
    • Kato H, Izumiyama M, Izumiyama K, Takahashi A, Itoyama Y. Silent cerebral microbleeds on T2*-weighted MRI: Correlation with stroke subtype, stroke recurrence, and leukoaraiosis. Stroke 2002; 33: 1536-1540. (Pubitemid 34619953)
    • (2002) Stroke , vol.33 , Issue.6 , pp. 1536-1540
    • Kato, H.1    Izumiyama, M.2    Izumiyama, K.3    Takahashi, A.4    Itoyama, Y.5
  • 41
    • 39349089972 scopus 로고    scopus 로고
    • Abnormal regional cerebral blood flow in cognitively normal elderly subjects with hypertension
    • DOI 10.1161/STROKEAHA.107.495457, PII 0000767020080200000024
    • Dai W, Lopez OL, Carmichael OT, Becker JT, Kuller LH, Gach HM. Abnormal regional cerebral blood flow in cognitively normal elderly subjects with hypertension. Stroke 2008; 39: 349-354. (Pubitemid 351619454)
    • (2008) Stroke , vol.39 , Issue.2 , pp. 349-354
    • Dai, W.1    Lopez, O.L.2    Carmichael, O.T.3    Becker, J.T.4    Kuller, L.H.5    Gach, H.M.6
  • 42
    • 0031302684 scopus 로고    scopus 로고
    • Staging of Alzheimer-related cortical destruction
    • Braak H, Braak E. Staging of Alzheimer-related cortical destruction. Int Psychogeriatr 1997; 9(Suppl 1): 257-261.
    • (1997) Int Psychogeriatr , vol.9 , Issue.SUPPL. 1 , pp. 257-261
    • Braak, H.1    Braak, E.2
  • 44
    • 0842325638 scopus 로고    scopus 로고
    • White matter lesions and hippocampal atrophy in Alzheimer's disease
    • de Leeuw FE, Barkhof F, Scheltens P. White matter lesions and hippocampal atrophy in Alzheimer's disease. Neurology 2004; 62: 310-312. (Pubitemid 38167149)
    • (2004) Neurology , vol.62 , Issue.2 , pp. 310-312
    • De Leeuw, F.-E.1    Barkhof, F.2    Scheltens, P.3
  • 45
    • 24944486283 scopus 로고    scopus 로고
    • Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: The PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy
    • DOI 10.1161/CIRCULATIONAHA.104.501163
    • Dufouil C, Chalmers J, Coskun O, Besancon V, Bousser MG, Guillon P et al. Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: The PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy. Circulation 2005; 112: 1644-1650. (Pubitemid 41324527)
    • (2005) Circulation , vol.112 , Issue.11 , pp. 1644-1650
    • Dufouil, C.1    Chalmers, J.2    Coskun, O.3    Besancon, V.4    Bousser, M.-G.5    Guillon, P.6    MacMahon, S.7    Mazoyer, B.8    Neal, B.9    Woodward, M.10    Tzourio-Mazoyer, N.11    Tzourio, C.12
  • 46
    • 0038669268 scopus 로고    scopus 로고
    • Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease
    • DOI 10.1001/archinte.163.9.1069
    • Tzourio C, Anderson C, Chapman N, Woodward M, Neal B, MacMahon S et al. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med 2003; 163: 1069-1075. (Pubitemid 36548935)
    • (2003) Archives of Internal Medicine , vol.163 , Issue.9 , pp. 1069-1075
    • Tzourio, C.1    Anderson, C.2    Chapman, N.3    Woodward, M.4    Neal, B.5    MacMahon, S.6    Chalmers, J.7
  • 47
    • 77955014011 scopus 로고    scopus 로고
    • Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): A case-control study
    • O'Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): A case-control study. Lancet 2010; 376: 112-123.
    • (2010) Lancet , vol.376 , pp. 112-123
    • O'Donnell, M.J.1    Xavier, D.2    Liu, L.3    Zhang, H.4    Chin, S.L.5    Rao-Melacini, P.6
  • 50
    • 84860310243 scopus 로고    scopus 로고
    • Basics of alzheimer's disease prevention
    • Special Issue, (guest editor: Jack de la Torre
    • Special Issue 'Basics of Alzheimer's Disease Prevention'. J Alzheimer's Dis 2010; 20 (guest editor: Jack de la Torre).
    • (2010) J Alzheimer's Dis , pp. 20
  • 51
    • 0001909515 scopus 로고    scopus 로고
    • Vascular factors in alzheimer's disease
    • Special Issue
    • Special Issue 'Vascular Factors in Alzheimer's Disease'. Ann NY Acad Sci 2000; 903.
    • (2000) Ann NY Acad Sci , vol.903
  • 52
    • 0001909515 scopus 로고    scopus 로고
    • Vascular factors in Alzheimer's disease
    • Kalaria R, Ince P. Vascular factors in Alzheimer's disease. Ann NY Acad Sci 2000; 903.
    • (2000) Ann NY Acad Sci , vol.903
    • Kalaria, R.1    Ince, P.2
  • 53
    • 38049034539 scopus 로고    scopus 로고
    • Cerebral ischemia and Alzheimer's disease: The expression of amyloid-beta and apolipoprotein E in human hippocampus
    • Qi JP, Wu H, Yang Y, Wang DD, Chen YX, Gu YH et al. Cerebral ischemia and Alzheimer's disease: The expression of amyloid-beta and apolipoprotein E in human hippocampus. J Alzheimers Dis 2007; 12: 335-341.
    • (2007) J Alzheimers Dis , vol.12 , pp. 335-341
    • Qi, J.P.1    Wu, H.2    Yang, Y.3    Wang, D.D.4    Chen, Y.X.5    Gu, Y.H.6
  • 54
    • 0035070084 scopus 로고    scopus 로고
    • Expression and distribution of beta amyloid precursor protein and beta amyloid peptide in reactive astrocytes after transient middle cerebral artery occlusion
    • DOI 10.1007/s007010170109
    • Nihashi T, Inao S, Kajita Y, Kawai T, Sugimoto T, Niwa M et al. Expression and distribution of beta amyloid precursor protein and beta amyloid peptide in reactive astrocytes after transient middle cerebral artery occlusion. Acta Neurochir (Wien) 2001; 143: 287-295. (Pubitemid 32268603)
    • (2001) Acta Neurochirurgica , vol.143 , Issue.3 , pp. 287-295
    • Nihashi, T.1    Inao, S.2    Kajita, Y.3    Kawai, T.4    Sugimoto, T.5    Niwa, M.6    Kabeya, R.7    Hata, N.8    Hayashi, S.9    Yoshida, J.10
  • 55
    • 0031595553 scopus 로고    scopus 로고
    • 18-Amyloid precursor protein and β-amyloid peptide immunoreactivity in the rat brain after middle cerebral artery occlusion: Effect of age
    • Popa-Wagner A, Schroder E, Walker LC, Kessler C. Beta-amyloid precursor protein and ss-amyloid peptide immunoreactivity in the rat brain after middle cerebral artery occlusion: Effect of age. Stroke 1998; 29: 2196-2202. (Pubitemid 28443539)
    • (1998) Stroke , vol.29 , Issue.10 , pp. 2196-2202
    • Popa-Wagner, A.1    Schroder, E.2    Walker, L.C.3    Kessler, C.4
  • 56
    • 0028802605 scopus 로고
    • Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils
    • Hall ED, Oostveen JA, Dunn E, Carter DB. Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils. Exp Neurol 1995; 135: 17-27.
    • (1995) Exp Neurol , vol.135 , pp. 17-27
    • Hall, E.D.1    Oostveen, J.A.2    Dunn, E.3    Carter, D.B.4
  • 57
    • 64349114305 scopus 로고    scopus 로고
    • Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP
    • Li L, Zhang X, Yang D, Luo G, Chen S, Le W. Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP. Neurobiol Aging 2009; 30: 1091-1098.
    • (2009) Neurobiol Aging , vol.30 , pp. 1091-1098
    • Li, L.1    Zhang, X.2    Yang, D.3    Luo, G.4    Chen, S.5    Le, W.6
  • 59
    • 2142815707 scopus 로고    scopus 로고
    • Increased β-secretase activity and expression in rats following transient cerebral ischemia
    • DOI 10.1016/j.brainres.2003.09.086, PII S000689930400232X
    • Wen Y, Onyewuchi O, Yang S, Liu R, Simpkins JW. Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res 2004; 1009: 1-8. (Pubitemid 38553842)
    • (2004) Brain Research , vol.1009 , Issue.1-2 , pp. 1-8
    • Wen, Y.1    Onyewuchi, O.2    Yang, S.3    Liu, R.4    Simpkins, J.W.5
  • 60
    • 33750000602 scopus 로고    scopus 로고
    • Microvascular pathology in the aging human brain: Evidence that senile plaques are sites of microhaemorrhages
    • DOI 10.1016/j.neurobiolaging.2005.10.016, PII S0197458005003398
    • Cullen K, Kocsi Z, Stone J. Microvascular pathology in the aging human brain: Evidence that senile plaques are sites of microhaemorrhages. Neurobiol Aging 2006; 27: 1786-1796. (Pubitemid 44572582)
    • (2006) Neurobiology of Aging , vol.27 , Issue.12 , pp. 1786-1796
    • Cullen, K.M.1    Kocsi, Z.2    Stone, J.3
  • 61
    • 70449519969 scopus 로고    scopus 로고
    • Contribution of hypoxia to Alzheimer's disease: Is HIF-1alpha a mediator of neurodegeneration?
    • Ogunshola OO, Antoniou X. Contribution of hypoxia to Alzheimer's disease: Is HIF-1alpha a mediator of neurodegeneration? Cell Mol Life Sci 2009; 66: 3555-3563.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3555-3563
    • Ogunshola, O.O.1    Antoniou, X.2
  • 62
    • 55049095941 scopus 로고    scopus 로고
    • Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases
    • Ray M, Ruan J, Zhang W. Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases. Genome Biol 2008; 9: R148.
    • (2008) Genome Biol , vol.9
    • Ray, M.1    Ruan, J.2    Zhang, W.3
  • 63
    • 0029664414 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study
    • Myers RH, Schaefer EJ, Wilson PW, D'Agostino R, Ordovas JM, Espino A et al. Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study. Neurology 1996; 46: 673-677.
    • (1996) Neurology , vol.46 , pp. 673-677
    • Myers, R.H.1    Schaefer, E.J.2    Wilson, P.W.3    D'Agostino, R.4    Ordovas, J.M.5    Espino, A.6
  • 69
    • 22144451172 scopus 로고    scopus 로고
    • The age-dependent relation of blood pressure to cognitive function and dementia
    • DOI 10.1016/S1474-4422(05)70141-1, PII S1474442205701411
    • Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol 2005; 4: 487-499. (Pubitemid 40982459)
    • (2005) Lancet Neurology , vol.4 , Issue.8 , pp. 487-499
    • Qiu, C.1    Winblad, B.2    Fratiglioni, L.3
  • 73
    • 79959704345 scopus 로고    scopus 로고
    • Midlife and late-life blood pressure and dementia in Japanese elderly: The hisayama study
    • Ninomiya T, Ohara T, Hirakawa Y, Yoshida D, Doi Y, Hata J et al. Midlife and late-life blood pressure and dementia in Japanese elderly: The hisayama study. Hypertension 2011; 58: 22-28.
    • (2011) Hypertension , vol.58 , pp. 22-28
    • Ninomiya, T.1    Ohara, T.2    Hirakawa, Y.3    Yoshida, D.4    Doi, Y.5    Hata, J.6
  • 74
    • 0344837411 scopus 로고    scopus 로고
    • Association between dementia and midlife risk factors: The radiation effects research foundation Adult Health Study
    • DOI 10.1046/j.1532-5415.2003.51117.x
    • Yamada M, Kasagi F, Sasaki H, Masunari N, Mimori Y, Suzuki G. Association between dementia and midlife risk factors: The Radiation Effects Research Foundation Adult Health Study. J Am Geriatr Soc 2003; 51: 410-414. (Pubitemid 36348905)
    • (2003) Journal of the American Geriatrics Society , vol.51 , Issue.3 , pp. 410-414
    • Yamada, M.1    Kasagi, F.2    Sasaki, H.3    Masunari, N.4    Mimori, Y.5    Suzuki, G.6
  • 75
    • 80051547314 scopus 로고    scopus 로고
    • The association between blood pressure and incident alzheimer disease: A systematic review and meta-analysis
    • Power MC, Weuve J, Gagne JJ, McQueen MB, Viswanathan A, Blacker D. The Association Between Blood Pressure and Incident Alzheimer Disease: A Systematic Review and Meta-analysis. Epidemiology 2011; 22: 646-659.
    • (2011) Epidemiology , vol.22 , pp. 646-659
    • Power, M.C.1    Weuve, J.2    Gagne, J.J.3    McQueen, M.B.4    Viswanathan, A.5    Blacker, D.6
  • 77
    • 34547679439 scopus 로고    scopus 로고
    • Smoking as a risk factor for dementia and cognitive decline: A meta-analysis of prospective studies
    • DOI 10.1093/aje/kwm116
    • Anstey K, von Sanden C, Salim A, O'Kearney R. Smoking as a risk factor for dementia and cognitive decline: A meta-analysis of prospective studies. Am J Epidemiol 2007; 166: 367-378. (Pubitemid 47216800)
    • (2007) American Journal of Epidemiology , vol.166 , Issue.4 , pp. 367-378
    • Anstey, K.J.1    Von Sanden, C.2    Salim, A.3    O'Kearney, R.4
  • 78
    • 29044449855 scopus 로고    scopus 로고
    • Risk of dementia in diabetes mellitus: A systematic review
    • DOI 10.1016/S1474-4422(05)70284-2, PII S1474442205702842
    • Jan Biessels G, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: A systematic review. Lancet Neurol 2006; 5: 64-74. (Pubitemid 41790697)
    • (2006) Lancet Neurology , vol.5 , Issue.1 , pp. 64-74
    • Biessels, G.J.1    Staekenborg, S.2    Brunner, E.3    Brayne, C.4    Scheltens, P.5
  • 79
    • 79954996833 scopus 로고    scopus 로고
    • Body mass index in midlife and late-life as a risk factor for dementia: A meta-analysis of prospective studies
    • Anstey KJ, Cherbuin N, Budge M, Young J. Body mass index in midlife and late-life as a risk factor for dementia: A meta-analysis of prospective studies. Obes Rev 2011; 12: E426-e437.
    • (2011) Obes Rev , vol.12
    • Anstey, K.J.1    Cherbuin, N.2    Budge, M.3    Young, J.4
  • 80
    • 23844522541 scopus 로고    scopus 로고
    • Aggregation of vascular risk factors and risk of incident Alzheimer disease
    • DOI 10.1212/01.wnl.0000172914.08967.dc
    • Luchsinger J, Reitz C, Honig L, Tang M, Shea S, Mayeax R. Aggregation of vascular risk factors and risk of incident Alzheimer's disease. Neurology 2005; 65: 545-551. (Pubitemid 41170713)
    • (2005) Neurology , vol.65 , Issue.4 , pp. 545-551
    • Luchsinger, J.A.1    Reitz, C.2    Honig, L.S.3    Tang, M.-X.4    Shea, S.5    Mayeux, R.6
  • 81
    • 33746951395 scopus 로고    scopus 로고
    • Risk score for the prediction of dementia risk in 20 years among middle aged people: A longitudinal, population-based study
    • DOI 10.1016/S1474-4422(06)70537-3, PII S1474442206705373
    • Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. Risk score for the prediction of dementia risk in 20 years among middle aged people: A longitudinal, population-based study. Lancet Neurol 2006; 5: 735-741. (Pubitemid 44205512)
    • (2006) Lancet Neurology , vol.5 , Issue.9 , pp. 735-741
    • Kivipelto, M.1    Ngandu, T.2    Laatikainen, T.3    Winblad, B.4    Soininen, H.5    Tuomilehto, J.6
  • 84
    • 0029988543 scopus 로고    scopus 로고
    • Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's treatment trial of hypertension in older adults
    • Prince MJ, Bird AS, Blizard RA, Mann AH. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's trial of hypertension in older adults. BMJ 1996; 312: 801-805. (Pubitemid 26099297)
    • (1996) British Medical Journal , vol.312 , Issue.7034 , pp. 801-805
    • Prince, M.J.1    Bird, A.S.2    Blizard, R.A.3    Mann, A.H.4
  • 86
    • 0035156539 scopus 로고    scopus 로고
    • Dementia and disability outcomes in large hypertension trials: Lessons learned from the systolic hypertension in the elderly program (SHEP) trial
    • DOI 10.1093/aje/153.1.72
    • Di Bari M, Pahor M, Franse LV, Shorr RI,Wan JY, Ferrucci L et al. Dementia and disability outcomes in large hypertension trials: Lessons learned from the systolic hypertension in the elderly program (SHEP) trial. Am J Epidemiol 2001; 153: 72-78. (Pubitemid 32041899)
    • (2001) American Journal of Epidemiology , vol.153 , Issue.1 , pp. 72-78
    • Di Bari, M.1    Pahor, M.2    Franse, L.V.3    Shorr, R.I.4    Wan, J.Y.5    Ferrucci, L.6    Somes, G.W.7    Applegate, W.B.8
  • 87
    • 0036144363 scopus 로고    scopus 로고
    • The PROGRESS trial: Preventing strokes by lowering blood pressure in patients with cerebral ischemia. Emerging therapies: Critique of an important advance
    • van Gijn J. The PROGRESS Trial: Preventing strokes by lowering blood pressure in patients with cerebral ischemia. Emerging therapies: Critique of an important advance. Stroke 2002; 33: 319-320. (Pubitemid 34052237)
    • (2002) Stroke , vol.33 , Issue.1 , pp. 319-320
    • Van Gijn, J.1
  • 88
    • 0037432304 scopus 로고    scopus 로고
    • Prevention of heart failure in patients in the Heart Outcomes Prevention Evaluation (HOPE) study
    • DOI 10.1161/01.CIR.0000054165.93055.42
    • Arnold JM, Yusuf S, Young J, Mathew J, Johnstone D, Avezum A et al. Prevention of Heart Failure in Patients in the Heart Outcomes Prevention Evaluation (HOPE) Study. Circulation 2003; 107: 1284-1290. (Pubitemid 36314412)
    • (2003) Circulation , vol.107 , Issue.9 , pp. 1284-1290
    • Arnold, J.M.O.1    Yusuf, S.2    Young, J.3    Mathew, J.4    Johnstone, D.5    Avezum, A.6    Lonn, E.7    Pogue, J.8    Bosch, J.9
  • 89
    • 33144466666 scopus 로고    scopus 로고
    • When will dementia become a curable disease and Alzheimer's a forgotten word?
    • DOI 10.1016/j.jalz.2005.12.004, PII S1552526005005224
    • Khachaturian ZS. When will dementia become a curable disease and Alzheimer's a forgotten word? Alzheimers Dement 2006; 2: 1. (Pubitemid 43264478)
    • (2006) Alzheimer's and Dementia , vol.2 , Issue.1 , pp. 1
    • Khachaturian, Z.S.1
  • 90
    • 66149154667 scopus 로고    scopus 로고
    • Duration of antihypertensive drug use and risk of dementia: A prospective cohort study
    • Haag MD, Hofman A, Koudstaal PJ, Breteler MM, Stricker BH. Duration of antihypertensive drug use and risk of dementia: A prospective cohort study. Neurology 2009; 72: 1727-1734.
    • (2009) Neurology , vol.72 , pp. 1727-1734
    • Haag, M.D.1    Hofman, A.2    Koudstaal, P.J.3    Breteler, M.M.4    Stricker, B.H.5
  • 91
    • 32844467861 scopus 로고    scopus 로고
    • Neuroprotective effect of calcium channel blocker against retinal ganglion cell damage under hypoxia
    • DOI 10.1016/j.brainres.2005.11.072, PII S0006899305016859
    • Yamada H, Chen YN, Aihara M, Araie M. Neuroprotective effect of calcium channel blocker against retinal ganglion cell damage under hypoxia. Brain Res 2006; 1071: 75-80. (Pubitemid 43255477)
    • (2006) Brain Research , vol.1071 , Issue.1 , pp. 75-80
    • Yamada, H.1    Chen, Y.-N.2    Aihara, M.3    Araie, M.4
  • 93
    • 0033780304 scopus 로고    scopus 로고
    • Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia
    • Korenkov AI, Pahnke J, Frei K, Warzok R, Schroeder HW, Frick R et al. Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia. Neurosurg Rev 2000; 23: 145-150.
    • (2000) Neurosurg Rev , vol.23 , pp. 145-150
    • Korenkov, A.I.1    Pahnke, J.2    Frei, K.3    Warzok, R.4    Schroeder, H.W.5    Frick, R.6
  • 94
    • 0023625565 scopus 로고
    • Effect of a calcium channel blocker on the development of ischemic neuron damage in sector CA1 of the horn of Ammon in Mongolian gerbils
    • Mossakowski MJ, Gadamski R. Effect of a calcium channel blocker on the development of ischemic neuron damage in sector CA1 of the horn of Ammon in Mongolian gerbils]. Neuropatol Pol 1987; 25: 439-450.
    • (1987) Neuropatol Pol , vol.25 , pp. 439-450
    • Mossakowski, M.J.1    Gadamski, R.2
  • 95
    • 78651471865 scopus 로고    scopus 로고
    • Spontaneously hypertensive rat neuroanatomy: Applications to pharmacological research
    • Amenta F, Tayebati SK, Tomassoni D. Spontaneously hypertensive rat neuroanatomy: Applications to pharmacological research. Ital J Anat Embryol 2010; 115: 13-17.
    • (2010) Ital J Anat Embryol , vol.115 , pp. 13-17
    • Amenta, F.1    Tayebati, S.K.2    Tomassoni, D.3
  • 96
    • 0035129947 scopus 로고    scopus 로고
    • Effect of nicardipine treatment on the expression of neurofilament 200 KDa immunoreactivity in the brain of spontaneously hypertensive rats
    • DOI 10.1081/CEH-100001204
    • Sabbatini M, Mignini F, Venarucci D, Vega JA, Amenta F. Effect of nicardipine treatment on the expression of neurofilament 200 KDa immunoreactivity in the brain of spontaneously hypertensive rats. Clin Exp Hypertens 2001; 23: 127-141. (Pubitemid 32183263)
    • (2001) Clinical and Experimental Hypertension , vol.23 , Issue.1-2 , pp. 127-141
    • Sabbatini, M.1    Mignini, F.2    Venarucci, D.3    Vega, J.A.4    Amenta, F.5
  • 97
    • 50249135503 scopus 로고    scopus 로고
    • Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
    • Bezprozvanny I, Mattson MP. Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci 2008; 31: 454-463.
    • (2008) Trends Neurosci , vol.31 , pp. 454-463
    • Bezprozvanny, I.1    Mattson, M.P.2
  • 98
    • 0026825733 scopus 로고
    • The five-five, ten-ten plan for Alzheimer's disease
    • discussion 199
    • Khachaturian Z. The five-five, ten-ten plan for Alzheimer's disease. Neurobiol Aging 1992; 13: 197-198; discussion 199.
    • (1992) Neurobiol Aging , vol.13 , pp. 197-198
    • Khachaturian, Z.1
  • 99
    • 0026570528 scopus 로고
    • Rydel RE. beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992; 12: 376-389.
    • (1992) J Neurosci , vol.12 , pp. 376-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5
  • 101
    • 20444496481 scopus 로고    scopus 로고
    • Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
    • DOI 10.1074/jbc.M500997200
    • Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem 2005; 280: 17294-17300. (Pubitemid 41389198)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.17 , pp. 17294-17300
    • Demuro, A.1    Mina, E.2    Kayed, R.3    Milton, S.C.4    Parker, I.5    Glabe, C.G.6
  • 102
    • 0025513769 scopus 로고
    • Neuronal protection correlates with prevention of calcium-calmodulin binding in rats
    • Grotta JC, Picone CM, Dedman JR, Rhoades HM, Strong RA, Earls RM et al. Neuronal protection correlates with prevention of calcium-calmodulin binding in rats. Stroke 1990; 21(11 Suppl): III28-III31.
    • (1990) Stroke , vol.21 , Issue.11 SUPPL.
    • Grotta, J.C.1    Picone, C.M.2    Dedman, J.R.3    Rhoades, H.M.4    Strong, R.A.5    Earls, R.M.6
  • 103
    • 0026608995 scopus 로고
    • Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons
    • Randall RD, Thayer SA. Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J Neurosci 1992; 12: 1882-1895.
    • (1992) J Neurosci , vol.12 , pp. 1882-1895
    • Randall, R.D.1    Thayer, S.A.2
  • 105
    • 49149124343 scopus 로고    scopus 로고
    • Amyloidbeta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I et al. Amyloidbeta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008; 14: 837-842.
    • (2008) Nat Med , vol.14 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5    Smith, I.6
  • 106
    • 79952977933 scopus 로고    scopus 로고
    • Angiotensin IIinhibiting drugs have no effect on intraneuronal Abeta or oligomeric Abeta levels in a triple transgenic mouse model of Alzheimer's disease
    • Ferrington L, Miners JS, Palmer LE, Bond SM, Povey JE, Kelly PA et al. Angiotensin IIinhibiting drugs have no effect on intraneuronal Abeta or oligomeric Abeta levels in a triple transgenic mouse model of Alzheimer's disease. Am J Transl Res 2011; 3: 197-208.
    • (2011) Am J Transl Res , vol.3 , pp. 197-208
    • Ferrington, L.1    Miners, J.S.2    Palmer, L.E.3    Bond, S.M.4    Povey, J.E.5    Kelly, P.A.6
  • 107
    • 66149096646 scopus 로고    scopus 로고
    • Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons
    • Hoffman LB, Schmeidler J, Lesser GT, Beeri MS, Purohit DP, Grossman HT et al. Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons. Neurology 2009; 72: 1720-1726.
    • (2009) Neurology , vol.72 , pp. 1720-1726
    • Hoffman, L.B.1    Schmeidler, J.2    Lesser, G.T.3    Beeri, M.S.4    Purohit, D.P.5    Grossman, H.T.6
  • 108
    • 28044448943 scopus 로고    scopus 로고
    • Pericapillary haem-rich deposits: Evidence for microhaemorrhages in aging human cerebral cortex
    • DOI 10.1038/sj.jcbfm.9600155, PII 9600155
    • Cullen K, Stone J. Vascular relationships of heam-rich deposits in the aging cerebral cortex. J Cereb Blood Flow Metab 2005; 25: 1656-1667. (Pubitemid 41683176)
    • (2005) Journal of Cerebral Blood Flow and Metabolism , vol.25 , Issue.12 , pp. 1656-1667
    • Cullen, K.M.1    Kocsi, Z.2    Stone, J.3
  • 109
    • 0345276568 scopus 로고    scopus 로고
    • Synaptic pathology in Alzheimer's disease: A review of ultrastructural studies
    • DOI 10.1016/j.neurobiolaging.2003.08.002
    • Scheff SW, Price DA. Synaptic pathology in Alzheimer's disease: A review of ultrastructural studies. Neurobiol Aging 2003; 24: 1029-1046. (Pubitemid 37487881)
    • (2003) Neurobiology of Aging , vol.24 , Issue.8 , pp. 1029-1046
    • Scheff, S.W.1    Price, D.A.2
  • 110
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R et al. Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30: 572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6
  • 111
    • 0034603601 scopus 로고    scopus 로고
    • Soluble β-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway
    • DOI 10.1016/S0197-4580(99)00111-6, PII S0197458099001116
    • Paris D, Town T, Mori T, Parker TA, Humphrey J, Mullan M. Soluble beta-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway. Neurobiol Aging 2000; 21: 183-197. (Pubitemid 30387077)
    • (2000) Neurobiology of Aging , vol.21 , Issue.2 , pp. 183-197
    • Paris, D.1    Town, T.2    Mori, T.3    Parker, T.A.4    Humphrey, J.5    Mullan, M.6


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