Dementia and disability outcomes in large hypertension trials: Lessons learned from the systolic hypertension in the elderly program (SHEP) trial

American Journal of Epidemiology

Volumn 153, Issue 1, 2001, Pages 72-78

  Di Bari, Mauro ^a   Pahor, Marco ^b   Franse, Lonneke V ^c   Shorr, Ronald I ^c   Wan, Jim Y ^c   Ferrucci, Luigi ^d   Somes, Grant W ^c   Applegate, William B ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^d Geriatric Department   (Italy)

Author keywords

Bias (epidemiology); Clinical trials; Dementia; Disability evaluation; Hypertension

Indexed keywords

ADULT; AGED; AGING; ARTICLE; CARDIOVASCULAR RESPONSE; DEMENTIA; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PHYSICAL DISABILITY; PREDICTION; QUALITY OF LIFE; RISK ASSESSMENT; SYSTOLIC BLOOD PRESSURE; UTILIZATION REVIEW;

AGED; ANTIHYPERTENSIVE AGENTS; ATENOLOL; BIAS (EPIDEMIOLOGY); CHLORTHALIDONE; DEMENTIA; DISABLED PERSONS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERTENSION; INCIDENCE; MULTICENTER STUDIES; PATIENT DROPOUTS; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS; RESERPINE; TREATMENT OUTCOME;

EID: 0035156539     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/aje/153.1.72     Document Type: Article

References (34)

1. Disability in older adults: Evidence regarding significance, etiology, and risk
2. Dementia is the major cause of functional dependence in the elderly: 3-year follow-up data from a population-based study
3. Progressive versus catastrophic disability: A longitudinal view of the disablement process
4. Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled
5. Instruments for the functional assessment of older patients
6. Prevention of stroke by antihypertensive drag treatment in older persons with isolated systolic hypertension Final results of the Systolic Hypertension in the Elderly Program (SHEP)
7. Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension)
8. MRC trial of treatment of mild hypertension: Principal results
9. Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis
10. The relationship between blood pressure and dementia: A review
11. Pathogenesis of vascular dementia: The possible role of hypertension
12. Hypertension is related to cognitive impairment: A 20-year follow-up of 999 men
13. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's trial of hypertension in older adults
14. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial
15. Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the Systolic Hypertension in the Elderly Program
16. Prevention of dementia: Syst-Eur trial
17. Unidimensional and multidimensional approaches to the differentiation of depression and dementia in the elderly
18. Assessing depressive symptoms in five psychiatric populations: A validation study
19. The Framingham Disability Study: II. Physical disability among the aging
20. The assessment of social networks and social support in the elderly
21. Cognitive decline in an elderly population - A two wave study of change
22. Assessing risk for the onset of functional dependence among older adults: The role of physical performance
23. Association of stroke with dementia, cognitive impairment, and functional disability in the very old: A population-based study
24. Handicap in stroke survivors
25. Congestive heart failure and cognitive impairment in an older population
26. Variable effect of comorbidity on the association of chronic cardiac failure with disability in community-dwelling older persons
27. Clinical trials in the elderly
28. The exclusion of the elderly and women from clinical trials in acute myocardial infarction
29. Methods for the analysis of informatively censored longitudinal data
30. Estimation and comparison of rates of change in longitudinal studies with informative drop-outs
31. Recruitment of elderly volunteers for a multicenter clinical trial: The SHEP pilot study
32. Random versus volunteer selection for a community-based study
33. Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study
34. Executive dyscontrol: An important factor affecting the level of care received by older retirees