Cell cycle model to describe animal cell size variation and lag between cell number and biomass dynamics

Biotechnology and Bioengineering

Volumn 56, Issue 4, 1997, Pages 372-379

  Nielsen, Lars K ^a,b   Reid, Steven ^a   Greenfield, Paul F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Northwestern University   (United States)

Author keywords

Biomass dynamics; Cell cycle model; Cell number; Cell size variation; Lag phenomenon

Indexed keywords

BIOMASS; BIOSYNTHESIS; DNA; GROWTH KINETICS; PHYSIOLOGICAL MODELS;

CELL CYCLE MODEL; CELL SIZE VARIATION; LAG PHENOMENON;

ANIMAL CELL CULTURE;

ANIMAL CELL; ARTICLE; BIOMASS; CELL CULTURE; CELL CYCLE; CELL SIZE; DNA SYNTHESIS; GROWTH RATE; MIOSIS; MODEL; MOUSE; NONHUMAN;

EID: 0342601482     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19971120)56:4<372::AID-BIT3>3.0.CO;2-L     Document Type: Article

References (20)

1. Al-Rubeai, M., Emery, A. N., Chalder, S., Jan, D. C. 1992. Specific monoclonal antibody productivity and the cell cycle,Comparisons of batch, continuous and perfusion cultures. Cytotechnology 9: 85-97.
2. Cooper, S. 1991. Bacterial growth and division: Biochemistry and regulation of prokaryotic and eukaryotic division cycles. Academic Press, San Diego.
3. Dalili, M., Ollis, D. F. 1990. A flow-cytometric analysis of hybridoma growth and monoclonal antibody production. Biotechnol. Bioeng. 36: 64-73.
4. Eisen, M. 1979. Mathematical models in cell biology and cancer chemotherapy, pp. 73-121. Springer-Verlag, Berlin.
5. Frame, K. K., Hu, W.-S. 1990. Cell volume measurement as an estimation of mammalian cell biomass. Biotechnol. Bioeng. 36: 191-197.
6. Frame, K. K., Hu, W.-S. 1991. Kinetic study of hybridoma cell growth in continuous culture. I. A model for non-producing cells. Biotechnol. Bioeng. 37: 55-64.
7. Glacken, M. W., Huang, C., Sinskey, A. J. 1989. Mathematical descriptions of hybridoma culture kinetics: III. Simulation of fed-batch reactors. J. Biotechnol. 10: 39-66.
8. Kjeldgaard, N. O., Maaloe, O., Schaechter, M. 1958. The transition between different physiological states during balanced growth of Salmonella typhimurium. J. Gen. Microbiol. 19: 607-616.
9. Lloyd, D., Poole, R. K., Edwards, S. W. 1982. The cell division cycle, pp. 371-372. Academic Press, London.
10. Martens, D. E., de Gooijer, C. D., van der Velden-de Groot, C. A. M., Beuvery, E. C., Tramper, J. 1993. Effect of dilution rate on growth, productivity, cell cycle and size, and shear sensitivity of a hybridoma cell in a continuous culture. Biotechnol. Bioeng. 41: 429-439.
11. Newland, M., Kamal, M. N., Greenfield, P. F., Nielsen, L. K. 1994. Ammonia inhibition of hybridomas propagated in batch, fed-batch, and continuous culture. Biotechnol. Bioeng. 43: 434-438.
12. Nielsen, J., Villadsen, J. 1994. Bioreaction engineering principles, pp. 271-294. Plenum Press, New York.
13. Nielsen, L. K. 1995. Modelling hybridoma cultures. Ph.D thesis, University of Queensland, Brisbane, Queensland, Australia.
14. Park, S. H., Ryu, D. D. Y. 1994. Cell cycle kinetics and monoclonal antibody productivity of hybridoma cells during perfusion culture. Biotechnol. Bioeng. 44: 361-367.
15. Prescott, D. M. 1976. Reproduction of eukaryotic cells. Academic Press, New York.
16. Ramirez, O. T., Mutharasan, M. 1990. Cell cycle- and growth phase-dependent variations in size distribution, antibody productivity and oxygen demand in hybridoma cultures. Biotechnol. Bioeng. 36: 839-848.
17. Reid, S., Randerson, D. H., Greenfield, P. F. 1987. Amino acid determination in mammalian cell culture supernatants. Aust. J. Biotechnol. 1: 69-72.
18. Schaechter, M., Maaloe, O., Kjeldgaard, N. O. 1958. Dependency on medium and temperature of cell size and chemical composition during balanced growth of Salmonella typhimurium. J. Gen. Microbiol. 19: 592-606.
19. Smith, J. A., Martin, L. 1974. Regulation of cell proliferation, pp. 43-76. In: G. M. Pardilla, I. L. Cameron, and A. Zimmerman (eds.), Cell cycle controls. Academic Press, New York.
20. Tyson, J. J., Novak, B., Odell, G. M., Chen, K., Thron, C. D. 1996. Chemical kinetics theory: Understanding cell-cycle regulation. TiBSci. 21: 89-96.