Isoxazolidinyl polycyclic aromatic hydrocarbons as DNA-intercalating antitumor agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 129-136

  Rescifina, Antonio ^a   Chiacchio, Ugo ^a   Corsaro, Antonino ^a   Piperno, Anna ^b   Romeo, Roberto ^b  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

1,3 Dipolar cycloaddition; Antitumor agent; DNA intercalation; Docking; Isoxazolidine; Polycyclic aromatic hydrocarbon

Indexed keywords

1 [2 BENZYL 3 (9 PHENANTHRYL)ISOXAZOLIDIN 5 YL]METHANAMINE; 1 [2 METHYL 3 (PYREN 1 YL)ISOXAZOLIDIN 5 YL]METHANAMINE; 2 METHYL 3 (PYREN 1 YL)DIHYDRO 2H PYRROLO[3,4 D]ISOXAZOLE 4,6(3H,5H) DIONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ISOXAZOLIDINE DERIVATIVE; MITOXANTRONE; POLYCYCLIC AROMATIC HYDROCARBON; PROFLAVINE; TERT BUTYL [[2 BENZYL 3 (9 PHENANTHRYL)ISOXAZOLIDIN 5 YL]METHYL]CARBAMIC ACID; TERT BUTYL [[2 METHYL 3 (PYREN 1 YL)ISOXAZOLIDIN 5 YL]METHYL]CARBAMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CYCLOADDITION; CYTOTOXICITY; DRUG DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA; DRUG DESIGN; HUMANS; INTERCALATING AGENTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; POLYCYCLIC HYDROCARBONS, AROMATIC;

EID: 78650516922     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.10.023     Document Type: Article

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