Synthesis of new troglitazone derivatives: Anti-proliferative activity in breast cancer cell lines and preliminary toxicological study

European Journal of Medicinal Chemistry

Volumn 51, Issue , 2012, Pages 206-215

  Salamone, Stéphane ^a   Colin, Christelle ^b   Grillier Vuissoz, Isabelle ^b   Kuntz, Sandra ^b   Mazerbourg, Sabine ^b   Flament, Stéphane ^b   Martin, Hélne ^c   Richert, Lysiane ^c   Chapleur, Yves ^a   Boisbrun, Michel ^a  

^a NANCY UNIVERSITÉ   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITÉ DE FRANCHE COMTÉ   (France)

Author keywords

Breast cancer; Chromane; Hepatotoxicity; Troglitazone

Indexed keywords

5 [1 [4 (2,5,7,8 TETRAMETHYLCHROMAN 2 YLMETHOXY)PHENYL]METHYLIDENE]THIAZOLIDINE 2,4 DIONE; 8 TERT BUTOXYCARBONYLAMINOOCTANOIC ACID 2 [4 (2,4 DIOXOTHIAZOLIDINYLIDENEMETHYL)PHENOXYMETHYL] 2,5,7,8 TETRAMETHYLCHROMAN 6 YL ESTER; ANTINEOPLASTIC AGENT; TROGLITAZONE; TROGLITAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER RESISTANCE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIVER TOXICITY; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY TECHNIQUES, SYNTHETIC; CHROMANS; HEPATOCYTES; HUMANS; THIAZOLIDINEDIONES; TOXICITY TESTS;

EID: 84860285168     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.02.044     Document Type: Article

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