PEPT1 involved in the uptake and transepithelial transport of cefditoren in vivo and in vitro

European Journal of Pharmacology

Volumn 612, Issue 1-3, 2009, Pages 9-14

  Zhang, Qinghao ^a   Liu, Qi ^a   Wu, Jingjing ^a   Wang, Changyuan ^a   Peng, Jinyong ^a   Ma, Xiaochi ^a   Liu, Kexin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cefditoren; Clonidine; Glycylsarcosine; PEPT1

Indexed keywords

CEFDITOREN; CLONIDINE; GLYCYLSARCOSINE; PEPTIDE TRANSPORTER 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG EXCRETION; DRUG TRANSPORT; DRUG UPTAKE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMALL INTESTINE; URINARY EXCRETION;

ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CEPHALOSPORINS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; JEJUNUM; KIDNEY; KINETICS; MALE; MEMBRANE TRANSPORT PROTEINS; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; SYMPORTERS;

EID: 65549142790     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.03.081     Document Type: Article

References (21)

1. Berlioz F., Julien S., Tsocas A., Chariot J., Carbon C., Farinotti R., and Rozé C. Neural modulation of cephalexin intestinal absorption through the di- and tripeptide brush border transporter of rat jejunum in vivo. J. Pharmacol. Exp. Ther. 288 (1999) 1037-1044
2. Berlioz F., Maoret J.J., Paris H., Laburthe M., Farinotti R., and Rozé C. α2-Adrenergic receptors stimulate oligopeptide transport in a human intestinal cell line. J. Pharmacol. Exp. Ther. 294 (2000) 466-472
3. Fei Y.J., Kanai Y., Nussberger S., Ganapathy V., Leibach F.H., Romero M.F., Singh S.K., Boron W.F., and Hediger M.A. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature. 368 (1994) 563-566
4. Foltz M., Meyer A., Theis S., Demuth H.U., and Daniel H. A rapid in vitro screening for delivery of peptide-derived peptidase inhibitors as potential drug candidates via epithelial peptide transporters. J. Pharmacol. Exp. Ther. 310 (2004) 695-702
5. Ganapathy V., and Leibach F.H. Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with L-carnosine and glycyl-L-proline. J. Biol. Chem. 258 (1983) 14189-14192
6. Ganapathy M.E., Brandsch M., Prasad P.D., Ganapathy V., and Leibach F.H. Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J. Biol. Chem. 270 (1995) 25672-25677
7. Kameyama N., Arisawa S., Ueyama J., Kagota S., Shinozuka K., Hattori A., Tatsumi Y., Hayashi H., Takagi K., and Wakusawa S. Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes. Biochim. Biophys. Acta 1782 (2008) 355-360
8. Lennernäs H. Intestinal drug absorption and bioavailability: beyond involvement of single transport function. J. Pharm. Pharmacol. 55 (2003) 429-433
9. Lu H., and Klaassen C. Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents. Peptides 27 (2006) 850-857
10. Lundquist S., Renftel M., Brillault J., Fenart L., Cecchelli R., and Dehouck M.P. Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models. Pharm. Res. 19 (2002) 976-981
11. Nakakariya M., Shimada T., Irokawa M., Koibuchi H., Iwanaga T., Yabuuchi H., Maeda T., and Tamai I. Predominant contribution of rat organic anion transporting polypeptide-2 (Oatp2) to hepatic uptake of beta-lactam antibiotics. Pharm. Res. 25 (2008) 578-585
12. Nakakariya M., Shimada T., Irokawa M., Maeda T., and Tamai I. Identification and species similarity of OATP transporters responsible for hepatic uptake of beta-lactam antibiotics. Drug Metab. Pharmacokinetics. 23 (2008) 347-355
13. Rubio-Aliaga I., Frey I., Boll M., Groneberg D.A., Eichinger H.M., Balling R., and Daniel H. Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney. Mol. Cell. Biol. 23 (2003) 3247-3252
14. Shen H., Smith D.E., Yang T., Huang Y.G., Schnermann J.B., and Brosius III F.C. Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney. Am. J. Physiol. 276 (1999) F658-F665
15. Souli A., Chariot J., Voisin T., Presset O., Tsocas A., Balasubramaniam A., Laburthe M., and Rozé C. Several receptors mediate the antisecretory effect of peptide YY, neuropeptide Y, and pancreatic polypeptide on VIP-induced fluid secretion in the rat jejunum in vivo. Peptides. 18 (1997) 551-557
16. Spangler S.K., Jacobs M.R., and Appelbaum P.C. Time-kill studies on susceptibility of nine penicillin-susceptible and -resistant pneumococci to cefditoren compared with nine other beta-lactams. J. Antimicrob. Chemother. 39 (1997) 141-148
17. Suzuki H., and Sugiyama Y. Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition. Adv. Drug Deliv. Rev. 54 (2002) 1311-1331
18. Tavelin S., Gråsjö J., Taipalensuu J., Ocklind G., and Artursson P. Applications of epithelial cell culture in studies of drug transport. Methods Mol. Biol. 188 (2002) 233-272
19. Wellington K., and Curran M.P. Cefditoren pivoxil: a review of its use in the treatment of bacterial infections. Drugs. 64 (2004) 2597-2618
20. Wilson T.H., and Wiseman G. The use of sacs of everted small intestine for the study of transference of substances from the mucosal to the serosal surface. J. Physiol. 123 (1954) 116-125
21. Yang C.Y., Dantzig A.H., and Pidgeon C. Intestinal peptide transport systems and oral drug availability. Pharm. Res. 16 (1999) 1331-1343