ATP citrate lyase inhibitors as novel cancer therapeutic agents

Recent Patents on Anti-Cancer Drug Discovery

Volumn 7, Issue 2, 2012, Pages 154-167

  Zu, Xu Yu ^a   Zhang, Qing Hai ^a   Liu, Jiang Hua ^a   Cao, Ren Xian ^a   Zhong, Jing ^a   Yi, Guang Hui ^a   Quan, Zhi Hua ^a   Pizzorno, Giuseppe ^b  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b DESERT RESEARCH INSTITUTE   (United States)

Author keywords

ACL inhibitors; ATP citrate lyase; Cancer therapy; Citrate; Lipogenesis; Small chemicals

Indexed keywords

2 HYDROXY N ARYLBENZENESULFONAMIDE; 2,3 BUTANEDIONE; 3 THIADICARBOXYLIC ACID; 3,3,14,14 TETRAMETHYLHEXADECANEDIOIC ACID; ADENOSINE TRIPHOSPHATE CITRATE LYASE; ADENOSINE TRIPHOSPHATE CITRATE LYASE INHIBITOR; ANTIMYCIN A1A; ANTIMYCIN A1B; ANTIMYCIN A2A; ANTINEOPLASTIC AGENT; CISPLATIN; CITRIC ACID DERIVATIVE; CITRININ; DEOXYCHOLIC ACID; DICARBOXYLIC ACID DERIVATIVE; GARCINIA EXTRACT; GLUTAMIC ACID; HYDROXYCITRIC ACID; METHIONINE SULFOXIMINE; METHOTREXATE; PHENYLGLYOXAL; PLANT EXTRACT; POLYCHLORINATED BIPHENYL DERIVATIVE; PURPURONE; RADICICOL; SB 201076; SB 204990; SUCCINIC ACID DERIVATIVE; THIOCTIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANADIC ACID;

ADENOCARCINOMA; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; BINDING AFFINITY; BIOENERGY; BLADDER CARCINOMA; CANCER INHIBITION; CANCER THERAPY; CARCINOGENESIS; CELL CYCLE ARREST; CHEMICAL MODIFICATION; CLINICAL TRIAL (TOPIC); COLON CARCINOMA; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG RESEARCH; DRUG SAFETY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME REGULATION; ENZYME STRUCTURE; GARCINIA; GLIOBLASTOMA; GLYCOLYSIS; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LEWIS CARCINOMA; LUNG CARCINOMA; MELANOMA; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION; SOLID TUMOR; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION; TRANSITIONAL CELL CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; ATP CITRATE (PRO-S)-LYASE; CITRIC ACID; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; LIPOGENESIS; MICE; NEOPLASMS; PATENTS AS TOPIC; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84860282413     PISSN: 15748928     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489212799972954     Document Type: Review

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