Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents

European Journal of Medicinal Chemistry

Volumn 51, Issue , 2012, Pages 277-285

  Ponaire, Sarah ^a   Zinglé, Catherine ^a   Tritsch, Denis ^a   Grosdemange Billiard, Catherine ^a   Rohmer, Michel ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Deoxyxylulose 5 phosphate reducto isomerase; Isoprenoid biosynthesis; Mycobacterium; Prodrug synthesis

Indexed keywords

ANTIMYCOBACTERIAL AGENT; DEOXYXYLULOSE PHOSPHATE REDUCTOISOMERASE INHIBITOR; DI(BENZYLOXOMETHYL) 4 [HYDROXY (METHYL)AMINO] 4 OXOBUTYLPHOSPHONATE; DI(BUTYLOXOMETHYL) 4 [HYDROXY (METHYL)AMINO] 4 OXOBUTYLPHOSPHONATE; DI(PIVALOYLOXOMETHYL) 4 [HYDROXY (METHYL)AMINO] 4 OXOBUTYLPHOSPHONATE; ISOMERASE INHIBITOR; PRODRUG; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; DRUG SYNTHESIS; GROWTH INHIBITION; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; REACTION ANALYSIS;

ALDOSE-KETOSE ISOMERASES; ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; FOSFOMYCIN; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MICROBIAL VIABILITY; MULTIENZYME COMPLEXES; MYCOBACTERIUM SMEGMATIS; OXAZINES; OXIDOREDUCTASES; PHOSPHONIC ACIDS; PRODRUGS; XANTHENES;

EID: 84860276356     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.02.031     Document Type: Article

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