메뉴 건너뛰기




Volumn 107, Issue 3, 2012, Pages 317-325

Antiviral therapy against chronic hepatitis B in Brazil: High rates of lamivudine resistance mutations and correlation with HBV genotypes

Author keywords

Antiviral drug resistance; HBV; Lamivudine; Therapy

Indexed keywords

ADENINE; ANTIVIRUS AGENT; DRUG DERIVATIVE; ENTECAVIR; GUANINE; LAMIVUDINE; PHOSPHONIC ACID DERIVATIVE; TENOFOVIR; VIRUS DNA;

EID: 84860250202     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/S0074-02762012000300005     Document Type: Article
Times cited : (12)

References (56)
  • 1
    • 3142733825 scopus 로고    scopus 로고
    • High proportion of subgroup A' (genotype A) among Brazilian isolates of hepatitis B virus
    • Araujo NM, Mello FC, Yoshida CF, Niel C, Gomes SA 2004. High proportion of subgroup A' (genotype A) among Brazilian isolates of hepatitis B virus. Arch Virol 149: 1383-1395.
    • (2004) Arch Virol , vol.149 , pp. 1383-1395
    • Araujo, N.M.1    Mello, F.C.2    Yoshida, C.F.3    Niel, C.4    Gomes, S.A.5
  • 3
    • 78349236621 scopus 로고    scopus 로고
    • Review of hepatitis B therapeutics
    • Bhattacharya D, Thio CL 2010. Review of hepatitis B therapeutics. Clin Infect Dis 51: 1201-1208.
    • (2010) Clin Infect Dis , vol.51 , pp. 1201-1208
    • Bhattacharya, D.1    Thio, C.L.2
  • 4
    • 37249001826 scopus 로고    scopus 로고
    • Lamivudine resistance and other mutations in the polyme-rase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case
    • Bottecchia M, Ikuta N, Niel C, Araujo NM, OKycia MR, Gomes SA 2008a. Lamivudine resistance and other mutations in the polyme-rase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case. J Gastroenterol Hepatol 23: 67-72.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 67-72
    • Bottecchia, M.1    Ikuta, N.2    Niel, C.3    Araujo, N.M.4    Okycia, M.R.5    Gomes, S.A.6
  • 5
    • 39149121860 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: Characterization of genotype G in Brazil
    • Bottecchia M, Souto FJ, O Kycia MR, Amendola M, Brandao CE, Niel C, Gomes SA 2008b. Hepatitis B virus genotypes and resistance mutations in patients under long term lamivudine therapy: characterization of genotype G in Brazil. BMC Microbiol 8: 11.
    • (2008) BMC Microbiol , vol.8 , pp. 11
    • Bottecchia, M.1    Souto, F.J.2    Okycia, M.R.3    Amendola, M.4    Brandao, C.E.5    Niel, C.6    Gomes, S.A.7
  • 6
    • 74049117607 scopus 로고    scopus 로고
    • Clinical relevance and public health significance of hepatitis B virus genomic variations
    • Cao GW 2009. Clinical relevance and public health significance of hepatitis B virus genomic variations. World J Gastroenterol 15: 5761-5769.
    • (2009) World J Gastroenterol , vol.15 , pp. 5761-5769
    • Cao, G.W.1
  • 7
    • 23444443850 scopus 로고    scopus 로고
    • Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: A longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline
    • Chu CM, Liaw YF 2005. Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline. J Hepatol 43: 411-417.
    • (2005) J Hepatol , vol.43 , pp. 411-417
    • Chu, C.M.1    Liaw, Y.F.2
  • 9
    • 0034879623 scopus 로고    scopus 로고
    • Efficacy and tolerability of long-term therapy using high lamivudine doses for the treatment of chronic hepatitis B
    • Da Silva LC, Pinho JR, Sitnik R, Da Fonseca LE, Carrilho FJ 2001. Efficacy and tolerability of long-term therapy using high lamivudine doses for the treatment of chronic hepatitis B. J Gastroenterol 36: 476-485.
    • (2001) J Gastroenterol , vol.36 , pp. 476-485
    • da Silva, L.C.1    Pinho, J.R.2    Sitnik, R.3    da Fonseca, L.E.4    Carrilho, F.J.5
  • 10
    • 77958189562 scopus 로고    scopus 로고
    • Mutation pattern of lamivudine resistance in relation to hepatitis B genotypes: Hepatitis B genotypes differ in their lamivudine resistance associated mutation pattern
    • Damerow H, Yuen L, Wiegand J, Walker C, Bock CT, Locarnini S, Tillmann HL 2010. Mutation pattern of lamivudine resistance in relation to hepatitis B genotypes: hepatitis B genotypes differ in their lamivudine resistance associated mutation pattern. J Med Virol 82: 1850-1858.
    • (2010) J Med Virol , vol.82 , pp. 1850-1858
    • Damerow, H.1    Yuen, L.2    Wiegand, J.3    Walker, C.4    Bock, C.T.5    Locarnini, S.6    Tillmann, H.L.7
  • 11
    • 54849417161 scopus 로고    scopus 로고
    • Therapy of chronic hepatitis B: Trends and developments
    • Delaney WET, Borroto-Esoda K 2008. Therapy of chronic hepatitis B: trends and developments. Curr Opin Pharmacol 8: 532-540.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 532-540
    • Delaney, W.E.T.1    Borroto-Esoda, K.2
  • 12
    • 54849146600 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Dienstag JL 2008. Hepatitis B virus infection. N Engl J Med 359: 1486-1500.
    • (2008) N Engl J Med , vol.359 , pp. 1486-1500
    • Dienstag, J.L.1
  • 14
    • 34748844767 scopus 로고    scopus 로고
    • Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug-resistant variants during lamivudine therapy: Analyses of the polymerase gene and full-length sequences
    • Enomoto M, Tamori A, Kohmoto MT, Morikawa H, Habu D, Sakaguchi H, Takeda T, Seki S, Kawada N, Shiomi S, Nishiguchi S 2007. Mutational patterns of hepatitis B virus genome and clinical outcomes after emergence of drug-resistant variants during lamivudine therapy: analyses of the polymerase gene and full-length sequences. J Med Virol 79: 1664-1670.
    • (2007) J Med Virol , vol.79 , pp. 1664-1670
    • Enomoto, M.1    Tamori, A.2    Kohmoto, M.T.3    Morikawa, H.4    Habu, D.5    Sakaguchi, H.6    Takeda, T.7    Seki, S.8    Kawada, N.9    Shiomi, S.10    Nishiguchi, S.11
  • 15
    • 21044453739 scopus 로고    scopus 로고
    • Response to interferon alfa is hepatitis B virus genotype dependent: Genotype A is more sensitive to interferon than genotype D
    • Erhardt A, Blondin D, Hauck K, Sagir A, Kohnle T, Heintges T, Haussinger D 2005. Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than genotype D. Gut 54: 1009-1013.
    • (2005) Gut , vol.54 , pp. 1009-1013
    • Erhardt, A.1    Blondin, D.2    Hauck, K.3    Sagir, A.4    Kohnle, T.5    Heintges, T.6    Haussinger, D.7
  • 16
    • 0032751727 scopus 로고    scopus 로고
    • Quantitation of hepatitis B viremia and emergence of YMDD variants in patients with chronic hepatitis B treated with lamivudine
    • Gauthier J, Bourne EJ, Lutz MW, Crowther LM, Dienstag JL, Brown NA, Condreay LD 1999. Quantitation of hepatitis B viremia and emergence of YMDD variants in patients with chronic hepatitis B treated with lamivudine. J Infect Dis 180: 1757-1762.
    • (1999) J Infect Dis , vol.180 , pp. 1757-1762
    • Gauthier, J.1    Bourne, E.J.2    Lutz, M.W.3    Crowther, L.M.4    Dienstag, J.L.5    Brown, N.A.6    Condreay, L.D.7
  • 17
    • 77954825079 scopus 로고    scopus 로고
    • Hepatitis B virus genotyping among chronic hepatitis B patients with resistance to treatment with lamivudine in the city of Ribeirão Preto, state of São Paulo
    • Haddad R, Martinelli Ade L, Uyemura SA, Yokosawa J 2010. Hepatitis B virus genotyping among chronic hepatitis B patients with resistance to treatment with lamivudine in the city of Ribeirão Preto, state of São Paulo. Rev Soc Bras Med Trop 43: 224-228.
    • (2010) Rev Soc Bras Med Trop , vol.43 , pp. 224-228
    • Haddad, R.1    Martinelli Ade, L.2    Uyemura, S.A.3    Yokosawa, J.4
  • 19
    • 84984578737 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers
    • Kao JH, Chen PJ, Lai MY, Chen DS 2004. Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis B carriers. J Med Virol 72: 363-369.
    • (2004) J Med Virol , vol.72 , pp. 363-369
    • Kao, J.H.1    Chen, P.J.2    Lai, M.Y.3    Chen, D.S.4
  • 21
    • 14744299915 scopus 로고    scopus 로고
    • Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy
    • Kramvis A, Kew MC 2005. Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy. J Viral Hepat 12: 456-464.
    • (2005) J Viral Hepat , vol.12 , pp. 456-464
    • Kramvis, A.1    Kew, M.C.2
  • 24
    • 49949094294 scopus 로고    scopus 로고
    • Genetic variability of hepatitis B virus and response to antiviral therapy
    • Liu CJ, Kao JH 2008. Genetic variability of hepatitis B virus and response to antiviral therapy. Antivir Ther 13: 613-624.
    • (2008) Antivir Ther , vol.13 , pp. 613-624
    • Liu, C.J.1    Kao, J.H.2
  • 25
    • 33847701354 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • Lok AS, McMahon BJ 2007. Chronic hepatitis B. Hepatology 45: 507-539.
    • (2007) Hepatology , vol.45 , pp. 507-539
    • Lok, A.S.1    McMahon, B.J.2
  • 28
    • 0038276960 scopus 로고    scopus 로고
    • Serum HBV DNA as a marker of efficacy during therapy for chronic HBV infection: Analysis and review of the literature
    • Mommeja-Marin H, Mondou E, Blum MR, Rousseau F 2003. Serum HBV DNA as a marker of efficacy during therapy for chronic HBV infection: analysis and review of the literature. Hepatology 37: 1309-1319.
    • (2003) Hepatology , vol.37 , pp. 1309-1319
    • Mommeja-Marin, H.1    Mondou, E.2    Blum, M.R.3    Rousseau, F.4
  • 29
    • 0029841054 scopus 로고    scopus 로고
    • Sequence analysis of pre-S/S gene of hepatitis B virus strains of genotypes A, D and F isolated in Brazil
    • Moraes MT, Gomes SA, Niel C 1996. Sequence analysis of pre-S/S gene of hepatitis B virus strains of genotypes A, D and F isolated in Brazil. Arch Virol 141: 1767-1773.
    • (1996) Arch Virol , vol.141 , pp. 1767-1773
    • Moraes, M.T.1    Gomes, S.A.2    Niel, C.3
  • 30
    • 0032602521 scopus 로고    scopus 로고
    • A polymerase chain reaction-based assay to identify genotype F of hepatitis B virus
    • Moraes MT, Niel C, Gomes SA 1999. A polymerase chain reaction-based assay to identify genotype F of hepatitis B virus. Braz J Med Biol Res 32: 45-49.
    • (1999) Braz J Med Biol Res , vol.32 , pp. 45-49
    • Moraes, M.T.1    Niel, C.2    Gomes, S.A.3
  • 32
    • 0033761078 scopus 로고    scopus 로고
    • Early detection of viral resistance by determination of hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic hepatitis B
    • Nafa S, Ahmed S, Tavan D, Pichoud C, Berby F, Stuyver L, Johnson M, Merle P, Abidi H, Trepo C, Zoulim F 2000. Early detection of viral resistance by determination of hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic hepatitis B. Hepatology 32: 1078-1088.
    • (2000) Hepatology , vol.32 , pp. 1078-1088
    • Nafa, S.1    Ahmed, S.2    Tavan, D.3    Pichoud, C.4    Berby, F.5    Stuyver, L.6    Johnson, M.7    Merle, P.8    Abidi, H.9    Trepo, C.10    Zoulim, F.11
  • 33
    • 0038700805 scopus 로고    scopus 로고
    • Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: A prospective study
    • Nakayoshi T, Maeshiro T, Nakasone H, Sakugawa H, Kinjo F, Orito E, Mizokami M 2003. Difference in prognosis between patients infected with hepatitis B virus with genotype B and those with genotype C in the Okinawa Islands: a prospective study. J Med Virol 70: 350-354.
    • (2003) J Med Virol , vol.70 , pp. 350-354
    • Nakayoshi, T.1    Maeshiro, T.2    Nakasone, H.3    Sakugawa, H.4    Kinjo, F.5    Orito, E.6    Mizokami, M.7
  • 35
    • 0035196637 scopus 로고    scopus 로고
    • A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group
    • Orito E, Mizokami M, Sakugawa H, Michitaka K, Ishikawa K, Ichida T, Okanoue T, Yotsuyanagi H, Iino S 2001. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group. Hepatology 33: 218-223.
    • (2001) Hepatology , vol.33 , pp. 218-223
    • Orito, E.1    Mizokami, M.2    Sakugawa, H.3    Michitaka, K.4    Ishikawa, K.5    Ichida, T.6    Okanoue, T.7    Yotsuyanagi, H.8    Iino, S.9
  • 36
    • 0036635609 scopus 로고    scopus 로고
    • Detection of HBV DNA using real time analysis
    • Pas SD, Niesters HG 2002. Detection of HBV DNA using real time analysis. J Clin Virol 25: 93-94.
    • (2002) J Clin Virol , vol.25 , pp. 93-94
    • Pas, S.D.1    Niesters, H.G.2
  • 37
    • 0025681070 scopus 로고
    • Factors influencing response to interferon in chronic hepatitis B: Implications for Asian and western populations
    • Perrillo RP 1990. Factors influencing response to interferon in chronic hepatitis B: implications for Asian and western populations. Hepatology 12: 1433-1435.
    • (1990) Hepatology , vol.12 , pp. 1433-1435
    • Perrillo, R.P.1
  • 39
    • 10444284909 scopus 로고    scopus 로고
    • Hepatitis B virus variants in an HIV-HBV co-infected patient at different periods of antiretroviral treatment with and without lamivudine
    • Santos EA, Sucupira MV, Arabe J, Gomes SA 2004. Hepatitis B virus variants in an HIV-HBV co-infected patient at different periods of antiretroviral treatment with and without lamivudine. BMC Infect Dis 4: 29.
    • (2004) BMC Infect Dis , vol.4 , pp. 29
    • Santos, E.A.1    Sucupira, M.V.2    Arabe, J.3    Gomes, S.A.4
  • 40
    • 41149084629 scopus 로고    scopus 로고
    • Hepatitis B virus escape mutants induced by antiviral therapy
    • Sheldon J, Soriano V 2008. Hepatitis B virus escape mutants induced by antiviral therapy. J Antimicrob Chemother 61: 766-768.
    • (2008) J Antimicrob Chemother , vol.61 , pp. 766-768
    • Sheldon, J.1    Soriano, V.2
  • 43
    • 33749658604 scopus 로고    scopus 로고
    • Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: High prevalence of occult infection and low frequency of lamivudine resistant mutations
    • Sucupira MVF, Mello FCA, Santos EA, Niel C, Rolla VC, Arabe J, Gomes SA 2006. Patterns of hepatitis B virus infection in Brazilian human immunodeficiency virus infected patients: high prevalence of occult infection and low frequency of lamivudine resistant mutations. Mem Inst Oswaldo Cruz 101: 655-660.
    • (2006) Mem Inst Oswaldo Cruz , vol.101 , pp. 655-660
    • Sucupira, M.V.F.1    Mello, F.C.A.2    Santos, E.A.3    Niel, C.4    Rolla, V.C.5    Arabe, J.6    Gomes, S.A.7
  • 45
    • 34547781750 scopus 로고    scopus 로고
    • MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0
    • Tamura K, Dudley J, Nei M, Kumar S 2007. MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24: 1596-1599.
    • (2007) Mol Biol Evol , vol.24 , pp. 1596-1599
    • Tamura, K.1    Dudley, J.2    Nei, M.3    Kumar, S.4
  • 47
    • 0027968068 scopus 로고
    • CLUSTALW: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, Gibson TJ 1994. CLUSTALW: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22: 4673-4680.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 48
    • 34447255407 scopus 로고    scopus 로고
    • The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro
    • Warner N, Locarnini S, Kuiper M, Bartholomeusz A, Ayres A, Yuen L, Shaw T 2007. The L80I substitution in the reverse transcriptase domain of the hepatitis B virus polymerase is associated with lamivudine resistance and enhanced viral replication in vitro. Antimicrob Agents Chemother 51: 2285-2292.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2285-2292
    • Warner, N.1    Locarnini, S.2    Kuiper, M.3    Bartholomeusz, A.4    Ayres, A.5    Yuen, L.6    Shaw, T.7
  • 49
    • 1642337523 scopus 로고    scopus 로고
    • WHO - World Health Organization, [homepage on the Internet], [revised 2008 August; cited 2011 april 5]. Available from
    • WHO - World Health Organization 2008. [homepage on the Internet]. Hepatitis B [revised 2008 August; cited 2011 april 5]. Available from: who.int/mediacentre/factsheets/fs204/en/.
    • (2008) Hepatitis B
  • 50
    • 77958187991 scopus 로고    scopus 로고
    • Management of chronic hepatitis B: Status and challenges beyond treatment guidelines
    • Wiegand J, van Bömmel F, Berg T 2010. Management of chronic hepatitis B: status and challenges beyond treatment guidelines. Semin Liver Dis 30: 361-377.
    • (2010) Semin Liver Dis , vol.30 , pp. 361-377
    • Wiegand, J.1    van Bömmel, F.2    Berg, T.3
  • 51
    • 0027378724 scopus 로고
    • Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis
    • Wong DK, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J 1993. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A meta-analysis. Ann Intern Med 119: 312-323.
    • (1993) Ann Intern Med , vol.119 , pp. 312-323
    • Wong, D.K.1    Cheung, A.M.2    O'Rourke, K.3    Naylor, C.D.4    Detsky, A.S.5    Heathcote, J.6
  • 52
    • 59549105956 scopus 로고    scopus 로고
    • Genetic variability of hepatitis B virus and response to antiviral treatments: Searching for a bigger picture
    • Yuen LK, Locarnini SA 2009. Genetic variability of hepatitis B virus and response to antiviral treatments: searching for a bigger picture. J Hepatol 50: 445-448.
    • (2009) J Hepatol , vol.50 , pp. 445-448
    • Yuen, L.K.1    Locarnini, S.A.2
  • 53
    • 79952324747 scopus 로고    scopus 로고
    • Comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: A systematic review
    • Zhao SS, Tang LH, Dai XH, Wang W, Zhou RR, Chen LZ, Fan XG 2011. Comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: a systematic review. Virol J 8: 111.
    • (2011) Virol J , vol.8 , pp. 111
    • Zhao, S.S.1    Tang, L.H.2    Dai, X.H.3    Wang, W.4    Zhou, R.R.5    Chen, L.Z.6    Fan, X.G.7
  • 55
    • 0035942013 scopus 로고    scopus 로고
    • 20-fold increase in risk of lamivudine resistance in hepatitis B virus subtype adw
    • Zollner B, Petersen J, Schroter M, Laufs R, Schoder V, Feucht HH 2001. 20-fold increase in risk of lamivudine resistance in hepatitis B virus subtype adw. Lancet 357: 934-935.
    • (2001) Lancet , vol.357 , pp. 934-935
    • Zollner, B.1    Petersen, J.2    Schroter, M.3    Laufs, R.4    Schoder, V.5    Feucht, H.H.6
  • 56
    • 70350095437 scopus 로고    scopus 로고
    • Hepatitis B virus resistance to nucleos(t)ide analogues
    • Zoulim F, Locarnini S 2009. Hepatitis B virus resistance to nucleos(t)ide analogues. Gastroenterology 137: 1593-1608.
    • (2009) Gastroenterology , vol.137 , pp. 1593-1608
    • Zoulim, F.1    Locarnini, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.