-
1
-
-
0037383496
-
EASL International Consensus Conference on Hepatitis B. 13-14 September, 2002: Geneva, Switzerland. Consensus statement (short version)
-
EASL Jury. EASL International Consensus Conference on Hepatitis B. 13-14 September, 2002: Geneva, Switzerland. Consensus statement (short version). J Hepatol 38 (2003) 533-540
-
(2003)
J Hepatol
, vol.38
, pp. 533-540
-
-
EASL Jury1
-
2
-
-
0023933449
-
Hepatitis B virus. The major etiology of hepatocellular carcinoma
-
Beasley R.P. Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 61 (1988) 1942-1956
-
(1988)
Cancer
, vol.61
, pp. 1942-1956
-
-
Beasley, R.P.1
-
3
-
-
29944436855
-
Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
-
Chen C.J., Yang H.I., Su J., Jen C.L., You S.L., Lu S.N., Huang G.T., and Iloeje U.H. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 295 (2006) 65-73
-
(2006)
JAMA
, vol.295
, pp. 65-73
-
-
Chen, C.J.1
Yang, H.I.2
Su, J.3
Jen, C.L.4
You, S.L.5
Lu, S.N.6
Huang, G.T.7
Iloeje, U.H.8
-
4
-
-
33644858331
-
Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
-
Iloeje U.H., Yang H.I., Su J., Jen C.L., You S.L., and Chen C.J. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 130 (2006) 678-686
-
(2006)
Gastroenterology
, vol.130
, pp. 678-686
-
-
Iloeje, U.H.1
Yang, H.I.2
Su, J.3
Jen, C.L.4
You, S.L.5
Chen, C.J.6
-
5
-
-
54849440388
-
Week 48 HBV DNA and 5 years risk of resistance to adefovir dipivoxil (ADV) in patients with HBeAg-negative chronic hepatitis B (CHB) [poster LB-7]
-
Palm Springs, California, USA
-
Marcellin P., Hadziyannis S., Mondou E., Arterburn S., Borroto-Esoda K., Miller M.D., Frederick D., and Rousseau F. Week 48 HBV DNA and 5 years risk of resistance to adefovir dipivoxil (ADV) in patients with HBeAg-negative chronic hepatitis B (CHB) [poster LB-7]. 20th International Conference on Antirviral Research (ICAR) April 29-May 3 (2007), Palm Springs, California, USA
-
(2007)
20th International Conference on Antirviral Research (ICAR) April 29-May 3
-
-
Marcellin, P.1
Hadziyannis, S.2
Mondou, E.3
Arterburn, S.4
Borroto-Esoda, K.5
Miller, M.D.6
Frederick, D.7
Rousseau, F.8
-
6
-
-
33847667158
-
Telbivudine Globe Trial: maximal early HBV suppression is predictive of optimal two-year efficacy in nucleoside-treated hepatitis B patients [abstract]
-
112 Abstract
-
DiBisceglie A., Lai C.-L., Gane E., Chen Y.-C., Thongsawat S., Wang Y., Chen Y., Heathcote E.J., Zeuzem S., Rasenack J., et al. Telbivudine Globe Trial: maximal early HBV suppression is predictive of optimal two-year efficacy in nucleoside-treated hepatitis B patients [abstract]. Hepatology 44 (2006) 230A-231A 112 Abstract
-
(2006)
Hepatology
, vol.44
-
-
DiBisceglie, A.1
Lai, C.-L.2
Gane, E.3
Chen, Y.-C.4
Thongsawat, S.5
Wang, Y.6
Chen, Y.7
Heathcote, E.J.8
Zeuzem, S.9
Rasenack, J.10
-
7
-
-
34247194561
-
Management of hepatitis B: summary of a clinical research workshop
-
Hoofnagle J.H., Doo E., Liang T.J., Fleischer R., and Lok A.S. Management of hepatitis B: summary of a clinical research workshop. Hepatology 45 (2007) 1056-1075
-
(2007)
Hepatology
, vol.45
, pp. 1056-1075
-
-
Hoofnagle, J.H.1
Doo, E.2
Liang, T.J.3
Fleischer, R.4
Lok, A.S.5
-
8
-
-
34447259615
-
The natural history and treatment of chronic hepatitis B: a critical evaluation of standard treatment criteria and end points
-
Lai C.L., and Yuen M.F. The natural history and treatment of chronic hepatitis B: a critical evaluation of standard treatment criteria and end points. Ann Int Med 147 (2007) 5
-
(2007)
Ann Int Med
, vol.147
, pp. 5
-
-
Lai, C.L.1
Yuen, M.F.2
-
9
-
-
33746339209
-
A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: an update
-
Provides recent guidelines the selection of patients for CHB treatment and a description of therapies available at the time of publication (ETV, ADV, LAM and pegylated-interferon-α).
-
Keeffe E.B., Dieterich D.T., Han S.H., Jacobson I.M., Martin P., Schiff E.R., Tobias H., and Wright T.L. A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: an update. Clin Gastroenterol Hepatol 4 (2006) 936-962. Provides recent guidelines the selection of patients for CHB treatment and a description of therapies available at the time of publication (ETV, ADV, LAM and pegylated-interferon-α).
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 936-962
-
-
Keeffe, E.B.1
Dieterich, D.T.2
Han, S.H.3
Jacobson, I.M.4
Martin, P.5
Schiff, E.R.6
Tobias, H.7
Wright, T.L.8
-
10
-
-
33847701354
-
Chronic hepatitis B
-
The most recent AASLD treatment guidelines for CHB which summarize preferred treatment options for various CHB patient populations. Includes a clinical summary and recommendations for use of LAM, ADV, ETV, L-dT as well as interferon-based therapies.
-
Lok A.S., and McMahon B.J. Chronic hepatitis B. Hepatology 45 (2007) 507-539. The most recent AASLD treatment guidelines for CHB which summarize preferred treatment options for various CHB patient populations. Includes a clinical summary and recommendations for use of LAM, ADV, ETV, L-dT as well as interferon-based therapies.
-
(2007)
Hepatology
, vol.45
, pp. 507-539
-
-
Lok, A.S.1
McMahon, B.J.2
-
11
-
-
0033592764
-
Lamivudine as initial treatment for chronic hepatitis B in the United States
-
Dienstag J.L., Schiff E.R., Wright T.L., Perrillo R.P., Hann H.-W., Goodman Z., Crowther L., Condreay L.D., Woessner M., Rubin M., et al. Lamivudine as initial treatment for chronic hepatitis B in the United States. N Engl J Med 341 (1999) 1256-1263
-
(1999)
N Engl J Med
, vol.341
, pp. 1256-1263
-
-
Dienstag, J.L.1
Schiff, E.R.2
Wright, T.L.3
Perrillo, R.P.4
Hann, H.-W.5
Goodman, Z.6
Crowther, L.7
Condreay, L.D.8
Woessner, M.9
Rubin, M.10
-
12
-
-
0033012793
-
Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis B
-
Tassopoulos N.C., Volpes R., Pastore G., Heathcote J., Buti M., Goldin R.D., Hawley S., Barber J., Condreay L., Gray D.F., et al. Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis B. Hepatology 29 (1999) 889-896
-
(1999)
Hepatology
, vol.29
, pp. 889-896
-
-
Tassopoulos, N.C.1
Volpes, R.2
Pastore, G.3
Heathcote, J.4
Buti, M.5
Goldin, R.D.6
Hawley, S.7
Barber, J.8
Condreay, L.9
Gray, D.F.10
-
13
-
-
33644818518
-
A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
-
Chang T.-T., Gish R.G., de Man R., Gadano A., Sollano J., Chao Y.-C., Lok A.S., Han K.-H., Goodman Z., Zhu J., et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med 354 (2006) 1001-1110
-
(2006)
N Engl J Med
, vol.354
, pp. 1001-1110
-
-
Chang, T.-T.1
Gish, R.G.2
de Man, R.3
Gadano, A.4
Sollano, J.5
Chao, Y.-C.6
Lok, A.S.7
Han, K.-H.8
Goodman, Z.9
Zhu, J.10
-
14
-
-
37349120537
-
Telbivudine versus lamivudine in patients with chronic hepatitis B
-
Summarizes the results of the GLOBE study, the phase 3 registrational studies telbivudine in both HBeAg+ patients and HBeAg- patients. Telbivudine is studied using a head-to-head trial design with lamivudine which allows direct comparison of safety, efficacy and resistance.
-
Lai C.L., Gane E., Liaw Y.F., Hsu C.W., Thongsawat S., Wang Y., Chen Y., Heathcote E.J., Rasenack J., Bzowej N., et al. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med 357 (2007) 2576-2588. Summarizes the results of the GLOBE study, the phase 3 registrational studies telbivudine in both HBeAg+ patients and HBeAg- patients. Telbivudine is studied using a head-to-head trial design with lamivudine which allows direct comparison of safety, efficacy and resistance.
-
(2007)
N Engl J Med
, vol.357
, pp. 2576-2588
-
-
Lai, C.L.1
Gane, E.2
Liaw, Y.F.3
Hsu, C.W.4
Thongsawat, S.5
Wang, Y.6
Chen, Y.7
Heathcote, E.J.8
Rasenack, J.9
Bzowej, N.10
-
15
-
-
33644822860
-
Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B
-
Lai C.L., Shouval D., Lok A.S., Chang T.T., Cheinquer H., Goodman Z., DeHertogh D., Wilber R., Zink R.C., Cross A., et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med 354 (2006) 1011-1020
-
(2006)
N Engl J Med
, vol.354
, pp. 1011-1020
-
-
Lai, C.L.1
Shouval, D.2
Lok, A.S.3
Chang, T.T.4
Cheinquer, H.5
Goodman, Z.6
DeHertogh, D.7
Wilber, R.8
Zink, R.C.9
Cross, A.10
-
16
-
-
0003134396
-
Efficacy and safety of 5 years lamivudine treatment of Chinese patients with chronic hepatitis B
-
Abstract 187
-
Guan R., Lai C.L., Liaw Y.F., Lim S.G., and Lee C.M. Efficacy and safety of 5 years lamivudine treatment of Chinese patients with chronic hepatitis B. J Gastroenterol Hepatol 16 (2001) A60 Abstract 187
-
(2001)
J Gastroenterol Hepatol
, vol.16
-
-
Guan, R.1
Lai, C.L.2
Liaw, Y.F.3
Lim, S.G.4
Lee, C.M.5
-
17
-
-
0037468421
-
Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B
-
Marcellin P., Chang T.-T., Lim S.G., Tong M.J., Sievert W., Shiffman M.L., Jeffers L., Goodman Z., Wulfsohn M.S., Xiong S., et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med 348 (2003) 808-816
-
(2003)
N Engl J Med
, vol.348
, pp. 808-816
-
-
Marcellin, P.1
Chang, T.-T.2
Lim, S.G.3
Tong, M.J.4
Sievert, W.5
Shiffman, M.L.6
Jeffers, L.7
Goodman, Z.8
Wulfsohn, M.S.9
Xiong, S.10
-
18
-
-
0037468406
-
Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B
-
Hadziyannis S.J., Tassopoulos N., Heathcote E.J., Chang T.-T., Kitis G., Rizzetto M., Marcellin P., Lim S.G., Goodman Z., Wulfsohn M.S., et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B. N Engl J Med 348 (2003) 800-807
-
(2003)
N Engl J Med
, vol.348
, pp. 800-807
-
-
Hadziyannis, S.J.1
Tassopoulos, N.2
Heathcote, E.J.3
Chang, T.-T.4
Kitis, G.5
Rizzetto, M.6
Marcellin, P.7
Lim, S.G.8
Goodman, Z.9
Wulfsohn, M.S.10
-
19
-
-
39149122593
-
A randomized, double-blind comparison of tenofovir DF (TDF) versus adefovir dipivoxil (ADV) for the treatment of HBEAG-positive chronic hepatitis B (CHB): study GS-US-174-0103 [AASLD Abstracts]
-
This abstract and presentation at the 2007 AASLD meeting summarizes the 48 week safety, efficacy and resistance results of the phase 3 registrational studies for TDF. The study design provides a head-to-head comparison of TDF to ADV which demonstrates the superior efficacy of TDF.
-
Heathcote E.J., Gane E., DeMan R., Lee S., Flisiak R., Manns M.P., Tchernev K., Kurdos O., Shiffman M., Sorbel J., et al. A randomized, double-blind comparison of tenofovir DF (TDF) versus adefovir dipivoxil (ADV) for the treatment of HBEAG-positive chronic hepatitis B (CHB): study GS-US-174-0103 [AASLD Abstracts]. Hepatology 46 (2007) 861A. This abstract and presentation at the 2007 AASLD meeting summarizes the 48 week safety, efficacy and resistance results of the phase 3 registrational studies for TDF. The study design provides a head-to-head comparison of TDF to ADV which demonstrates the superior efficacy of TDF.
-
(2007)
Hepatology
, vol.46
-
-
Heathcote, E.J.1
Gane, E.2
DeMan, R.3
Lee, S.4
Flisiak, R.5
Manns, M.P.6
Tchernev, K.7
Kurdos, O.8
Shiffman, M.9
Sorbel, J.10
-
20
-
-
54849442523
-
Entecavir (ETV) results in higher HBV-DNA reduction vs adefovir (ADV) in chronically infected HBeAg+ antiviral-naïve adults: 48 week results (E.A.R.L.Y. Study) [oral presentation 49]
-
Barcelona, Spain
-
Leung N., Peng C., Sollano J., Lesmana L., Yuen M.-F., Jeffers L., Hann H., Sherman M., Zhu J., Mencarini K., et al. Entecavir (ETV) results in higher HBV-DNA reduction vs adefovir (ADV) in chronically infected HBeAg+ antiviral-naïve adults: 48 week results (E.A.R.L.Y. Study) [oral presentation 49]. 42nd Annual Meeting of the European Association for the Study of the Liver April 11-15. Barcelona, Spain (2007)
-
(2007)
42nd Annual Meeting of the European Association for the Study of the Liver April 11-15
-
-
Leung, N.1
Peng, C.2
Sollano, J.3
Lesmana, L.4
Yuen, M.-F.5
Jeffers, L.6
Hann, H.7
Sherman, M.8
Zhu, J.9
Mencarini, K.10
-
21
-
-
54849421612
-
A randomized, double-blind, comparison of tenofovir DF (TDF) versus adefovir dipivoxil (ADV) for the treatment of HBeAg-negative chronic hepatitis B (CHB): study GS-US-174-0102 [oral presentation]
-
Boston, Mass, USA
-
Marcellin P., Buti M., Krastev Z., Germanidis G., Kaita K., Kotzev I., Buggisch P., Weilert F., Trinh H., Sorbel J., et al. A randomized, double-blind, comparison of tenofovir DF (TDF) versus adefovir dipivoxil (ADV) for the treatment of HBeAg-negative chronic hepatitis B (CHB): study GS-US-174-0102 [oral presentation]. 58th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) November 2-6. Boston, Mass, USA (2007)
-
(2007)
58th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) November 2-6
-
-
Marcellin, P.1
Buti, M.2
Krastev, Z.3
Germanidis, G.4
Kaita, K.5
Kotzev, I.6
Buggisch, P.7
Weilert, F.8
Trinh, H.9
Sorbel, J.10
-
22
-
-
33845671388
-
Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 Years
-
Summarizes the long-term safety, efficacy and resistance data for ADV in HBeAg- CHB by following patients completing a 96 week double blind phase 3 study on open-label therapy for an additional three years.
-
Hadziyannis S.J., Tassopoulos N.C., Heathcote E.J., Chang T.T., Kitis G., Rizzetto M., Marcellin P., Lim S.G., Goodman Z., Ma J., et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 Years. Gastroenterology 131 (2006) 1743-1751. Summarizes the long-term safety, efficacy and resistance data for ADV in HBeAg- CHB by following patients completing a 96 week double blind phase 3 study on open-label therapy for an additional three years.
-
(2006)
Gastroenterology
, vol.131
, pp. 1743-1751
-
-
Hadziyannis, S.J.1
Tassopoulos, N.C.2
Heathcote, E.J.3
Chang, T.T.4
Kitis, G.5
Rizzetto, M.6
Marcellin, P.7
Lim, S.G.8
Goodman, Z.9
Ma, J.10
-
23
-
-
33947427581
-
Adefovir dipivoxil for wait-listed and post-liver transplantation patients with lamivudine-resistant hepatitis B: final long-term results
-
Schiff E., Lai C.-L., Hadziyannis S., Neuhaus P., Terrault N., Colombo M., Tillmann H., Samuel D., Zeuzem S., Vileneuve J.-P., et al. Adefovir dipivoxil for wait-listed and post-liver transplantation patients with lamivudine-resistant hepatitis B: final long-term results. Liver Transpl 13 (2007) 349-360
-
(2007)
Liver Transpl
, vol.13
, pp. 349-360
-
-
Schiff, E.1
Lai, C.-L.2
Hadziyannis, S.3
Neuhaus, P.4
Terrault, N.5
Colombo, M.6
Tillmann, H.7
Samuel, D.8
Zeuzem, S.9
Vileneuve, J.-P.10
-
24
-
-
19944430573
-
Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients
-
Westland C.E., Yang H., Delaney IV W.E., Wulfsohn M., Lama N., Gibbs C.S., Miller M.D., Fry J., Brosgart C.L., Schiff E.R., et al. Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients. J Viral Hepatitis 12 (2005) 67-73
-
(2005)
J Viral Hepatitis
, vol.12
, pp. 67-73
-
-
Westland, C.E.1
Yang, H.2
Delaney IV, W.E.3
Wulfsohn, M.4
Lama, N.5
Gibbs, C.S.6
Miller, M.D.7
Fry, J.8
Brosgart, C.L.9
Schiff, E.R.10
-
25
-
-
28844480087
-
Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1
-
Benhamou Y., Thibault V., Vig P., Calvez V., Marcelin A.-G., Fievet M.-H., Currie G., Chang C.G., Biao L., Xiong S., et al. Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1. J Hepatol 44 (2006) 62-67
-
(2006)
J Hepatol
, vol.44
, pp. 62-67
-
-
Benhamou, Y.1
Thibault, V.2
Vig, P.3
Calvez, V.4
Marcelin, A.-G.5
Fievet, M.-H.6
Currie, G.7
Chang, C.G.8
Biao, L.9
Xiong, S.10
-
26
-
-
35648982926
-
Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients
-
Data from this large cohort of LAM-resistant patients shows that treatment intensification by adding ADV therapy to ongoing LAM therapy results in prolonged suppression of HBV DNA with very low risk of developing ADV-resistance mutations over three years.
-
Lampertico P., Vigano M., Manenti E., Iavarone M., Sablon E., and Colombo M. Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients. Gastroenterology 133 (2007) 1445-1451. Data from this large cohort of LAM-resistant patients shows that treatment intensification by adding ADV therapy to ongoing LAM therapy results in prolonged suppression of HBV DNA with very low risk of developing ADV-resistance mutations over three years.
-
(2007)
Gastroenterology
, vol.133
, pp. 1445-1451
-
-
Lampertico, P.1
Vigano, M.2
Manenti, E.3
Iavarone, M.4
Sablon, E.5
Colombo, M.6
-
27
-
-
26844500312
-
A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patients
-
Chang T.T., Gish R.G., Hadziyannis S.J., Cianciara J., Rizzetto M., Schiff E.R., Pastore G., Bacon B.R., Poynard T., Joshi S., et al. A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patients. Gastroenterology 129 (2005) 1198-1209
-
(2005)
Gastroenterology
, vol.129
, pp. 1198-1209
-
-
Chang, T.T.1
Gish, R.G.2
Hadziyannis, S.J.3
Cianciara, J.4
Rizzetto, M.5
Schiff, E.R.6
Pastore, G.7
Bacon, B.R.8
Poynard, T.9
Joshi, S.10
-
28
-
-
24044526915
-
Cross-resistance testing of next-generation nucleoside and nucleotide analogues against lamivudine-resistant HBV
-
Yang H., Qi X., Sabogal A., Miller M., Xiong S., and Delaney IV W.E. Cross-resistance testing of next-generation nucleoside and nucleotide analogues against lamivudine-resistant HBV. Antiv Ther 10 (2005) 625-633
-
(2005)
Antiv Ther
, vol.10
, pp. 625-633
-
-
Yang, H.1
Qi, X.2
Sabogal, A.3
Miller, M.4
Xiong, S.5
Delaney IV, W.E.6
-
29
-
-
33744531146
-
Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B
-
Sherman M., Yurdaydin C., Sollano J., Silva M., Liaw Y.F., Cianciara J., Boron-Kaczmarska A., Martin P., Goodman Z., Colonno R., et al. Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B. Gastroenterology 130 (2006) 2039-2049
-
(2006)
Gastroenterology
, vol.130
, pp. 2039-2049
-
-
Sherman, M.1
Yurdaydin, C.2
Sollano, J.3
Silva, M.4
Liaw, Y.F.5
Cianciara, J.6
Boron-Kaczmarska, A.7
Martin, P.8
Goodman, Z.9
Colonno, R.10
-
30
-
-
47149108478
-
Entecavir therapy for lamivudine-refractory chronic hepatitis B: improved virologic, biochemical, and serology outcomes through 96 weeks
-
Sherman M., Yurdaydin C., Simsek H., Silva M., Liaw Y.F., Rustgi V.K., Sette H., Tsai N., Tenney D.J., Vaughan J., et al. Entecavir therapy for lamivudine-refractory chronic hepatitis B: improved virologic, biochemical, and serology outcomes through 96 weeks. Hepatology 48 (2008) 99-108
-
(2008)
Hepatology
, vol.48
, pp. 99-108
-
-
Sherman, M.1
Yurdaydin, C.2
Simsek, H.3
Silva, M.4
Liaw, Y.F.5
Rustgi, V.K.6
Sette, H.7
Tsai, N.8
Tenney, D.J.9
Vaughan, J.10
-
31
-
-
35649020315
-
Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B
-
Summarizes the results of the phase 3 registrational studies for ETV in HBeAg+ patients through 96 weeks. ETV is studied using a head-to-head trial design with lamivudine which allows direct comparison of safety and efficacy. Also describes how patients either continued or discontinued ETV therapy at the end of 52 weeks based on classification as responders, non-responders, and virologic responders.
-
Gish R.G., Lok A.S., Chang T.T., de Man R.A., Gadano A., Sollano J., Han K.H., Chao Y.C., Lee S.D., Harris M., et al. Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B. Gastroenterology 133 (2007) 1437-1444. Summarizes the results of the phase 3 registrational studies for ETV in HBeAg+ patients through 96 weeks. ETV is studied using a head-to-head trial design with lamivudine which allows direct comparison of safety and efficacy. Also describes how patients either continued or discontinued ETV therapy at the end of 52 weeks based on classification as responders, non-responders, and virologic responders.
-
(2007)
Gastroenterology
, vol.133
, pp. 1437-1444
-
-
Gish, R.G.1
Lok, A.S.2
Chang, T.T.3
de Man, R.A.4
Gadano, A.5
Sollano, J.6
Han, K.H.7
Chao, Y.C.8
Lee, S.D.9
Harris, M.10
-
32
-
-
45549103065
-
Entecavir at five years shows long-term maintenance of high genetic barrier to hepatitis B virus resistance [abstract]
-
Abstract OL-107. Abstract and presentation at 2008 APASL meeting summarizes the results of long-term ETV resistance surveillance in treatment-naive and lamivudine resistant patient populations.
-
Tenney D.J., Pokornowski K.A., Rose R.E., Baldick C.J., Eggers B.J., Fang J., Yang J.Y., Xu D., Brett-Smith L., Kreter B., et al. Entecavir at five years shows long-term maintenance of high genetic barrier to hepatitis B virus resistance [abstract]. Hepatol Int 2 (2008) S76-77 Abstract OL-107. Abstract and presentation at 2008 APASL meeting summarizes the results of long-term ETV resistance surveillance in treatment-naive and lamivudine resistant patient populations.
-
(2008)
Hepatol Int
, vol.2
-
-
Tenney, D.J.1
Pokornowski, K.A.2
Rose, R.E.3
Baldick, C.J.4
Eggers, B.J.5
Fang, J.6
Yang, J.Y.7
Xu, D.8
Brett-Smith, L.9
Kreter, B.10
-
33
-
-
43249116834
-
The anti-HIV activity of entecavir: a multicentre evaluation of lamivudine-experienced and lamivudine-naive patients
-
Sasadeusz J., Audsley J., Mijch A., Baden R., Caro J., Hunter H., Matthews G., McMahon M.A., Olender S.A., Siliciano R.F., et al. The anti-HIV activity of entecavir: a multicentre evaluation of lamivudine-experienced and lamivudine-naive patients. AIDS 22 (2008) 947-955
-
(2008)
AIDS
, vol.22
, pp. 947-955
-
-
Sasadeusz, J.1
Audsley, J.2
Mijch, A.3
Baden, R.4
Caro, J.5
Hunter, H.6
Matthews, G.7
McMahon, M.A.8
Olender, S.A.9
Siliciano, R.F.10
-
34
-
-
41949114325
-
Pre-steady-state kinetic studies establish entecavir 5′-triphosphate as a substrate for HIV-1 reverse transcriptase
-
Domaoal R.A., McMahon M., Thio C.L., Bailey C.M., Tirado-Rives J., Obikhod A., Detorio M., Rapp K.L., Siliciano R.F., Schinazi R.F., et al. Pre-steady-state kinetic studies establish entecavir 5′-triphosphate as a substrate for HIV-1 reverse transcriptase. J Biol Chem 283 (2008) 5452-5459
-
(2008)
J Biol Chem
, vol.283
, pp. 5452-5459
-
-
Domaoal, R.A.1
McMahon, M.2
Thio, C.L.3
Bailey, C.M.4
Tirado-Rives, J.5
Obikhod, A.6
Detorio, M.7
Rapp, K.L.8
Siliciano, R.F.9
Schinazi, R.F.10
-
35
-
-
54849408015
-
Tenofovir disoproxil fumarate (TDF) for the treatment of HBeAg-positive chronic hepatitis B: week 72 TDF data and week 24 adefovirdipivoxilswitch data (study 103) [oral presentation #1593]
-
Milan, Italy
-
Heathcote J., George J., Gordon S., Bronowicki J.-P., Sperl J., Williams R.R., Martin P., Beniowski M., Sorbel J., Anderson J., et al. Tenofovir disoproxil fumarate (TDF) for the treatment of HBeAg-positive chronic hepatitis B: week 72 TDF data and week 24 adefovirdipivoxilswitch data (study 103) [oral presentation #1593]. 43rd Annual Meeting of the European Association for the Study of the Liver (EASL) April 23-27. Milan, Italy (2008)
-
(2008)
43rd Annual Meeting of the European Association for the Study of the Liver (EASL) April 23-27
-
-
Heathcote, J.1
George, J.2
Gordon, S.3
Bronowicki, J.-P.4
Sperl, J.5
Williams, R.R.6
Martin, P.7
Beniowski, M.8
Sorbel, J.9
Anderson, J.10
-
36
-
-
54849417833
-
Tenofovir disoproxil fumarate (TDF) for the treatment of HBeAg-negative chronic hepatitis B: week 72 TDF data and week 24 adefovir dipivoxil switch data (study 102) [oral presentation #1602]
-
Milan, Italy
-
Marcellin P., Jacobson I., Habersetzer F., Senturk H., Andreone P., Moyes C., Horban A., Teuber G., Sorbel J., Anderson J., et al. Tenofovir disoproxil fumarate (TDF) for the treatment of HBeAg-negative chronic hepatitis B: week 72 TDF data and week 24 adefovir dipivoxil switch data (study 102) [oral presentation #1602]. 43rd Annual Meeting of the European Association for the Study of the Liver (EASL). Milan, Italy (2008)
-
(2008)
43rd Annual Meeting of the European Association for the Study of the Liver (EASL)
-
-
Marcellin, P.1
Jacobson, I.2
Habersetzer, F.3
Senturk, H.4
Andreone, P.5
Moyes, C.6
Horban, A.7
Teuber, G.8
Sorbel, J.9
Anderson, J.10
-
37
-
-
34249075512
-
In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents
-
Qi X., Xiong S., Yang H., Miller M., and Delaney IV W.E. In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents. Antiv Ther 12 (2007) 355-362
-
(2007)
Antiv Ther
, vol.12
, pp. 355-362
-
-
Qi, X.1
Xiong, S.2
Yang, H.3
Miller, M.4
Delaney IV, W.E.5
-
38
-
-
44149117971
-
Role of tenofovir in the treatment of chronic HBV infection
-
A comprehensive review of existing preclinical and clinical data regarding the use of TDF to treat CHB. Summarizes and comments on the results of many investigator sponsored studies of TDF use in lamivudine-resistant and HIV co-infected populations.
-
van Bömmel F., and Berg T. Role of tenofovir in the treatment of chronic HBV infection. Future Virol 3 (2008) 207-220. A comprehensive review of existing preclinical and clinical data regarding the use of TDF to treat CHB. Summarizes and comments on the results of many investigator sponsored studies of TDF use in lamivudine-resistant and HIV co-infected populations.
-
(2008)
Future Virol
, vol.3
, pp. 207-220
-
-
van Bömmel, F.1
Berg, T.2
-
39
-
-
0032499913
-
A one-year trial of lamivudine for chronic hepatitis B
-
Lai C.-L., Chien R.-N., Leung N.W.Y., Chang T.-T., Guan R., Tai D.-I., Ng K.-Y., Wu P.-C., Dent J.C., Barber J., et al. A one-year trial of lamivudine for chronic hepatitis B. N Engl J Med 339 (1998) 61-68
-
(1998)
N Engl J Med
, vol.339
, pp. 61-68
-
-
Lai, C.-L.1
Chien, R.-N.2
Leung, N.W.Y.3
Chang, T.-T.4
Guan, R.5
Tai, D.-I.6
Ng, K.-Y.7
Wu, P.-C.8
Dent, J.C.9
Barber, J.10
-
40
-
-
33846067615
-
Two-year results from the globe trial in patients with hepatitis B: greater clinical and antiviral efficacy for telbivudine (LDT) vs. lamivudine [abstract]
-
Abstract 291
-
Lai C.-L., Gane E., Hsu C.-W., Thongsawat S., Wang Y., Chen Y., Heathcote E.J., Rasenack J., Bzowej N., Naoumov N., et al. Two-year results from the globe trial in patients with hepatitis B: greater clinical and antiviral efficacy for telbivudine (LDT) vs. lamivudine [abstract]. Hepatology 4 (2006) 222A Abstract 291
-
(2006)
Hepatology
, vol.4
-
-
Lai, C.-L.1
Gane, E.2
Hsu, C.-W.3
Thongsawat, S.4
Wang, Y.5
Chen, Y.6
Heathcote, E.J.7
Rasenack, J.8
Bzowej, N.9
Naoumov, N.10
-
41
-
-
54849406611
-
Pre-existing antiviral resistance mutations among treatment-naive HBV patients can be detected by a sensitive line probe assay [poster]
-
Poster 688
-
Fung S.K., Mazzulli T., Sherman M., Popovic V., Ramos M., and Sablon E. Pre-existing antiviral resistance mutations among treatment-naive HBV patients can be detected by a sensitive line probe assay [poster]. J Hepatol 2 (2008) S256 Poster 688
-
(2008)
J Hepatol
, vol.2
-
-
Fung, S.K.1
Mazzulli, T.2
Sherman, M.3
Popovic, V.4
Ramos, M.5
Sablon, E.6
-
42
-
-
35449001647
-
Antiviral-resistant hepatitis B virus: can we prevent this monster from growing?
-
This review provides an insightful overview of molecular and clinical aspects of drug resistance and includes thoughts on which therapies can be used to rescue first line treatment-failure and prospects for avoiding and managing drug resistance in the future.
-
Zoulim F., Buti M., and Lok A.S. Antiviral-resistant hepatitis B virus: can we prevent this monster from growing?. J Viral Hepat 14 Suppl. 1 (2007) 29-36. This review provides an insightful overview of molecular and clinical aspects of drug resistance and includes thoughts on which therapies can be used to rescue first line treatment-failure and prospects for avoiding and managing drug resistance in the future.
-
(2007)
J Viral Hepat
, vol.14
, Issue.SUPPL. 1
, pp. 29-36
-
-
Zoulim, F.1
Buti, M.2
Lok, A.S.3
-
43
-
-
0346243783
-
Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient
-
Villeneuve J.-P., Durantel D., Durantel S., Westland C., Xiong S., Brosgart C.L., Gibbs C.S., Parvaz P., Werle B., Trepo C., et al. Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient. J Hepatol 39 (2003) 1085-1089
-
(2003)
J Hepatol
, vol.39
, pp. 1085-1089
-
-
Villeneuve, J.-P.1
Durantel, D.2
Durantel, S.3
Westland, C.4
Xiong, S.5
Brosgart, C.L.6
Gibbs, C.S.7
Parvaz, P.8
Werle, B.9
Trepo, C.10
-
44
-
-
30344449469
-
Virologic response and resistance to adefovir in patients with chronic hepatitis B
-
Fung S.K., Chae H.B., Fontana R.J., Conjeevaram H., Marrero J., Oberhelman K., Hussain M., and Lok A.S. Virologic response and resistance to adefovir in patients with chronic hepatitis B. J Hepatol 44 (2006) 283-290
-
(2006)
J Hepatol
, vol.44
, pp. 283-290
-
-
Fung, S.K.1
Chae, H.B.2
Fontana, R.J.3
Conjeevaram, H.4
Marrero, J.5
Oberhelman, K.6
Hussain, M.7
Lok, A.S.8
-
45
-
-
48249153623
-
Entecavir: a rescue therapy for chronic hepatitis B patients with a limited virological response to adefovir? [abstract]
-
Abstract 951
-
Reijnders J., De Man R.A., Pas S.D., Schutten M., and Janssen H.L. Entecavir: a rescue therapy for chronic hepatitis B patients with a limited virological response to adefovir? [abstract]. Hepatology 46 (2007) 660A Abstract 951
-
(2007)
Hepatology
, vol.46
-
-
Reijnders, J.1
De Man, R.A.2
Pas, S.D.3
Schutten, M.4
Janssen, H.L.5
-
46
-
-
54249162685
-
Tenofovir disoproxil fumarate (TDF) versus emtricitabine plus TDF for Treatment of chronic hepatitis B (CHB) in subjects with persistent viral replication receiving adefovir dipivoxil (ADV) [Abstract #76].
-
Berg T., Moller B., Trinh H., Chan S., Marcellin P., Suarez E., Snow-Lampart A., Frederick D., Oldach D., Sorbel J., et al. Tenofovir disoproxil fumarate (TDF) versus emtricitabine plus TDF for Treatment of chronic hepatitis B (CHB) in subjects with persistent viral replication receiving adefovir dipivoxil (ADV) [Abstract #76]. J Hepatol 48 (2008) S34
-
(2008)
J Hepatol
, vol.48
-
-
Berg, T.1
Moller, B.2
Trinh, H.3
Chan, S.4
Marcellin, P.5
Suarez, E.6
Snow-Lampart, A.7
Frederick, D.8
Oldach, D.9
Sorbel, J.10
-
47
-
-
54849410487
-
First multicenter evaluation of the efficacy of Tenofovir in nucleos(t)ide analog experienced patients with HBV monoinfection [oral presentation]
-
Boston, MA
-
van Bommel F., de Man R.A., Erhardt A., Huppe D., Stein K., Buggisch P., Bocher W., Sarrazin C., Wedemeyer H., Trojan J., et al. First multicenter evaluation of the efficacy of Tenofovir in nucleos(t)ide analog experienced patients with HBV monoinfection [oral presentation]. 58th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) November 2-6. Boston, MA (2007)
-
(2007)
58th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) November 2-6
-
-
van Bommel, F.1
de Man, R.A.2
Erhardt, A.3
Huppe, D.4
Stein, K.5
Buggisch, P.6
Bocher, W.7
Sarrazin, C.8
Wedemeyer, H.9
Trojan, J.10
-
48
-
-
39149096847
-
Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations
-
Tan J., Degertekin B., Wong S.N., Husain M., Oberhelman K., and Lok A.S. Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations. J Hepatol 48 (2008) 391-398
-
(2008)
J Hepatol
, vol.48
, pp. 391-398
-
-
Tan, J.1
Degertekin, B.2
Wong, S.N.3
Husain, M.4
Oberhelman, K.5
Lok, A.S.6
-
49
-
-
36749040378
-
Hepatitis B virus polymerase variants associated with entecavir drug resistance in treatment-naive patients
-
Jardi R., Rodriguez-Frias F., Schaper M., Ruiz G., Elefsiniotis I., Esteban R., and Buti M. Hepatitis B virus polymerase variants associated with entecavir drug resistance in treatment-naive patients. J Viral Hepat 14 (2007) 835-840
-
(2007)
J Viral Hepat
, vol.14
, pp. 835-840
-
-
Jardi, R.1
Rodriguez-Frias, F.2
Schaper, M.3
Ruiz, G.4
Elefsiniotis, I.5
Esteban, R.6
Buti, M.7
-
50
-
-
33846785216
-
Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient
-
Villet S., Ollivet A., Pichoud C., Barraud L., Villeneuve J.P., Trepo C., and Zoulim F. Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient. J Hepatol 46 (2007) 531-538
-
(2007)
J Hepatol
, vol.46
, pp. 531-538
-
-
Villet, S.1
Ollivet, A.2
Pichoud, C.3
Barraud, L.4
Villeneuve, J.P.5
Trepo, C.6
Zoulim, F.7
-
51
-
-
4344627233
-
Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine
-
Tenney D.J., Levine S.M., Rose R.E., Walsh A.W., Weinheimer S.P., Discotto L., Plym M., Pokornowski K., Yu C.F., Angus P., et al. Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine. Antimicrob Agents Chemother 48 (2004) 3498-3507
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 3498-3507
-
-
Tenney, D.J.1
Levine, S.M.2
Rose, R.E.3
Walsh, A.W.4
Weinheimer, S.P.5
Discotto, L.6
Plym, M.7
Pokornowski, K.8
Yu, C.F.9
Angus, P.10
-
52
-
-
52749088340
-
Selection of an entecavir-resistant mutant despite prolonged hepatitis B virus DNA suppression, in a chronic hepatitis B patient with preexistent lamivudine resistance: successful rescue therapy with tenofovir
-
Leemans W.F., Niesters H.G., van der Eijk A.A., Janssen H.L., Schalm S.W., and de Man R.A. Selection of an entecavir-resistant mutant despite prolonged hepatitis B virus DNA suppression, in a chronic hepatitis B patient with preexistent lamivudine resistance: successful rescue therapy with tenofovir. Eur J Gastroenterol Hepatol 20 (2008) 773-777
-
(2008)
Eur J Gastroenterol Hepatol
, vol.20
, pp. 773-777
-
-
Leemans, W.F.1
Niesters, H.G.2
van der Eijk, A.A.3
Janssen, H.L.4
Schalm, S.W.5
de Man, R.A.6
-
53
-
-
40849091053
-
Lamivudine compared with lamivudine and adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B
-
Sung J.J., Lai J.Y., Zeuzem S., Chow W.C., Heathcote E.J., Perrillo R.P., Brosgart C.L., Woessner M.A., Scott S.A., Gray D.F., et al. Lamivudine compared with lamivudine and adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B. J Hepatol 48 (2008) 728-735
-
(2008)
J Hepatol
, vol.48
, pp. 728-735
-
-
Sung, J.J.1
Lai, J.Y.2
Zeuzem, S.3
Chow, W.C.4
Heathcote, E.J.5
Perrillo, R.P.6
Brosgart, C.L.7
Woessner, M.A.8
Scott, S.A.9
Gray, D.F.10
-
54
-
-
40849132370
-
96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B
-
Hui C.K., Zhang H.Y., Bowden S., Locarnini S., Luk J.M., Leung K.W., Yueng Y.H., Wong A., Rousseau F., Yuen K.Y., et al. 96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B. J Hepatol 48 (2008) 714-720
-
(2008)
J Hepatol
, vol.48
, pp. 714-720
-
-
Hui, C.K.1
Zhang, H.Y.2
Bowden, S.3
Locarnini, S.4
Luk, J.M.5
Leung, K.W.6
Yueng, Y.H.7
Wong, A.8
Rousseau, F.9
Yuen, K.Y.10
-
55
-
-
23244453590
-
A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B
-
Lai C.L., Leung N., Teo E.K., Tong M., Wong F., Hann H.W., Han S., Poynard T., Myers M., Chao G., et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology 129 (2005) 528-536
-
(2005)
Gastroenterology
, vol.129
, pp. 528-536
-
-
Lai, C.L.1
Leung, N.2
Teo, E.K.3
Tong, M.4
Wong, F.5
Hann, H.W.6
Han, S.7
Poynard, T.8
Myers, M.9
Chao, G.10
-
56
-
-
0034090544
-
Selection of multiresistant hepatitis B virus during sequential nucleoside-analogue therapy
-
Mutimer D., Pillay D., Cook P., Ratcliffe D., O'Donnell K., Dowling D., Shaw J., Elias E., and Cane P.A. Selection of multiresistant hepatitis B virus during sequential nucleoside-analogue therapy. J Infect Dis 181 (2000) 713-716
-
(2000)
J Infect Dis
, vol.181
, pp. 713-716
-
-
Mutimer, D.1
Pillay, D.2
Cook, P.3
Ratcliffe, D.4
O'Donnell, K.5
Dowling, D.6
Shaw, J.7
Elias, E.8
Cane, P.A.9
-
57
-
-
33847709539
-
Adding-on versus switching-to adefovir therapy in lamivudine-resistant HBeAg-negative chronic hepatitis B
-
Rapti I., Dimou E., Mitsoula P., and Hadziyannis S.J. Adding-on versus switching-to adefovir therapy in lamivudine-resistant HBeAg-negative chronic hepatitis B. Hepatology 45 (2007) 307-313
-
(2007)
Hepatology
, vol.45
, pp. 307-313
-
-
Rapti, I.1
Dimou, E.2
Mitsoula, P.3
Hadziyannis, S.J.4
-
58
-
-
34848898749
-
Entecavir (ETV) results in higher HBV-DNA reduction vs adefovir (ADV) in chronically infected HBeAg(+) antiviral-naive adults: 48 week results (E.A.R.L.Y. Study) [Abstract 49]
-
Leung N., Peng C., Sollano J., Lesmana L., Yuen M., Jeffers L., Hann H., Sherman M., Zhu J., and Mencarini K. Entecavir (ETV) results in higher HBV-DNA reduction vs adefovir (ADV) in chronically infected HBeAg(+) antiviral-naive adults: 48 week results (E.A.R.L.Y. Study) [Abstract 49]. J Hepatol 46 (2007) S24
-
(2007)
J Hepatol
, vol.46
-
-
Leung, N.1
Peng, C.2
Sollano, J.3
Lesmana, L.4
Yuen, M.5
Jeffers, L.6
Hann, H.7
Sherman, M.8
Zhu, J.9
Mencarini, K.10
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