Fermentation enhances the in vitro antioxidative effect of onion (Allium cepa) via an increase in quercetin content

Food and Chemical Toxicology

Volumn 50, Issue 6, 2012, Pages 2042-2048

  Yang, Eun Ju ^a   Kim, Sang In ^a,b   Park, Sang Yun ^a,b   Bang, Han Yeol ^a   Jeong, Ji Hye ^a   So, Jai Hyun ^b   Rhee, In Koo ^a   Song, Kyung Sik ^a  

^a Kyungpook National University   (South Korea)

^b Korea Promotion Institute for Traditional Medicine Industry   (South Korea)

Author keywords

Antioxidative effect; Aspergillus kawachii; Fermentation; Onion; Quercetin

Indexed keywords

ONION EXTRACT; QUERCETIN; QUERCETIN 3 DI O BETA DEXTRO GLUCOSIDE; QUERCETIN 3,4' DI O BETA DEXTRO GLUCOSIDE; QUERCETIN 4' DI O BETA DEXTRO GLUCOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPERGILLUS; ASPERGILLUS KAWACHII; BRAIN CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IN VITRO STUDY; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN;

ANIMALS; ANTIOXIDANTS; ASPERGILLUS; BACTERIA; BIPHENYL COMPOUNDS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FERMENTATION; FLAVONES; FOOD HANDLING; FREE RADICAL SCAVENGERS; HIPPOCAMPUS; MICE; NEUROPROTECTIVE AGENTS; ONIONS; PICRATES; PLANT EXTRACTS; QUERCETIN; SOLVENTS;

ALLIUM CEPA; ASPERGILLUS KAWACHII; FUNGI; GLYCINE MAX;

EID: 84860197018     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.03.065     Document Type: Article

References (31)

1. Ahn J., Lee H., Kim S., Park J., Ha T. The anti-obesity effect quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem. Biophys. Res. Commun. 2008, 373:545-549.
2. Benz C.C., Yau C. Ageing, oxidative stress and cancer: paradigms in parallax. Nat. Rev. Cancer 2008, 8:875-879.
3. Cevallos-Casals B.A., Cisneros-Zevallos L.J. Stoichiometric and kinetic studies of phenolic antioxidants from Andean purple corn and red-fleshed sweet potato. J. Agric. Food Chem. 2003, 51:3313-3319.
4. Chen J.C., Ho F.M., Pei-Dawn L.C., Chen C.P., Jeng K.C., Hsu H.B., Lee S.T., Wen T.W., Lin W.W. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of Ikappa B kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur. J. Pharmacol. 2005, 521:9-20.
5. Choe E., Min D.B. Chemistry and reactions of reactive oxygen species in foods. Crit. Rev. Food Sci. 2006, 46:1-22.
6. Chung D.M., Chung Y.C., Maeng P.J., Chun H.K. Regioselective deglycosylation of onion quercetin glucosides by Saccharomyces serevisiae. Biotechnol. Lett. 2011, 33:783-786.
7. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993, 262:689-695.
8. Do H.J. Purification and characterization of Aspergillus usamii D5 isolated from traditional fermented food, Thesis for the degree of Master 2003, Kyungpook National University, Daegu, Korea.
9. Fekete A., Vizi E.S., Kovacs K.J., Lendvai B., Zelles T. Layer-specific differences in reactive oxygen species levels after oxygen-glucose deprivation in acute hippocampal slices. Free Radical Bio. Med. 2008, 44:1010-1022.
10. Fernandez J., Reyes R., Ponce H., Oropeza M., VanCalsteren M., Jankowski C., Campos M.G. Isoquercitrin from Argemone platyceras inhibits carbachol and leukotriene D4-induced contraction in guinea-pig airways. Eur. J. Pharmacol. 2005, 522:108-115.
11. Fossen T., Pedersen A.T., Andersen Ø.M. Flavonoids from red onion (Allium cepa). Phytochemistry 1998, 47:281-285.
12. Graf B., Milbury A.P.E., Blumberg J.B. Flavonols, flavones, flavanones, and human health: Epidemiological evidence. J. Med. Food 2005, 8:281-290.
13. Greenwood S.M., Connolly C.N. Dendritic and mitochondrial changes during glutamate toxicity. Neuropharmacology 2007, 53:891-898.
14. Halliwell B., Rafter J., Jenner A. Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?. Am. J. Clin. Nutr. 2005, 81:268S-276S.
15. Hollman P.C., van Trijp J., Buysman M.N., van der Gaag M., Mengelers M.J., de Vrise J., Katan M.B. Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett. 1997, 418:152-156.
16. Houghton P., Howes M.J. Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease. Neurosignals 2005, 14:6-22.
17. Jeon K.S., Hwang I.K., Ji G.E. Assay of β-glucosidase activity of Bifidobacteria and the hydrolysis of isoflavone glucosides by Bifidobacterium sp. Int-57 in soymilk fermentation. J. Microbiol. Biotechnol. 2002, 12:8-13.
18. Jeon S.Y., Kim E.K., Kwak H.M., Kim J.Y., Lim J.H., Cheng S.K., Song K.S. Changes in chemical composition and biological activities of Oriental crude drugs by food processing techniques (II) - Changes in paeonol contents in roasted Mountan Cortex. Kor. J. Pharmacogn. 2004, 35:388-392.
19. Khan N., Afaq F., Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid. Redox Sign. 2008, 10:475-510.
20. Kim S.I., Kim J.E., So J.H., Rhee I.K., Chung S.K., Lee K.B., Yoo Y.C. Changes in chemical composition and biological activities Oriental crude drugs by food processing techniques (I) - Changes in liquiritigenin contents in licorice extract treated by the crude enzyme extract from Aspergillus kawachii. Kor. J. Pharmacogn. 2004, 35:309-314.
21. Kiviranta J., Huovinen K., Hiltunen R. Variation in phenolic substances in onion. Acta Pharmaceutica Fennica 1988, 97:67-72.
22. Kwak H.M., Kim J.Y., Lim J.H., Chung S.K., Kwon S.H., Jeong H.H., Hur J.M., Song K.S. Changes in chemical composition and biological activities of Oriental crude drugs by food processing techniques (III) - Changes of 5-HMF contents from roasted Asparagi Tuber. Kor. J. Pharmacogn. 2005, 36:235-239.
23. Lee C.Y., Kim K.H., Hur S.Y., Heo J.H., Choi M.H., Rhee S.K., Kim C.H. Enzymatic synthesis of ascorbic acid fructoside by transfructosylation using levan fructotransferase. J. Microbiol. Biotechnol. 2006, 16:64-67.
24. Manach C., Morand C., Crespy V., Cemigne C., Texier O., Reqerat F., Remesy C. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett. 1998, 426:331-336.
25. Oh S.J., Kim O., Lee J.S., Kim J.A., Kim M.R., Choi H.S., Shim J.H., Kang K.W., Kim Y.C. Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells. Food Chem. Toxicol. 2010, 48:3227-3234.
26. Olsson M.E., Gustavsson K.E., Vågen I.M. Quercetin and isorhamnetin in sweet and red cultivars of onion (Allium cepa L.) at harvest, after field curing, heat treatment, and storage. J. Agric. Food Chem. 2010, 58:2323-2330.
27. Rice Evans C., Miller N.J., Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Bio. Med. 1996, 20:933-956.
28. Torres-Piedra M., Ortiz-Andrade R., Villalobos-Molina R., Singh N., Medina-Franco J.L., Webster S.P., Binnie M., Navarrete-Vazquez G., Estrada-Soto S. A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition. Eur. J. Med. Chem. 2010, 45:2606-2612.
29. Wettasinghe M., Shahidi F. Scavenging of reactive-oxygen species and DPPH free radicals by extracts of borage and evening primrose meals. Food Chem. 2000, 70:17-26.
30. Yoshiki Y., Kahara T., Okubo K., Sakabe T., Yamasaki T. Superoxide- and 1,1-diphenyl-2-pycrylhydrazyl radical scavenging activities of soyasaponin β related to gallic acid. Biosci. Biotechnol. Biochem. 2001, 65:2162-2165.
31. Zou Y., Chang S.K.C., Gu Y., Qian S.Y. Antioxidant activity and phenolic compositions of lentil (Lens culinaris var. Morton) extract and its fractions. J. Agric. Food Chem. 2011, 59:2268-2276.