Rapid quantitative analysis of clarithromycin in rat plasma by UPLC-MS/MS after intravenous injection of the clarithromycin-loaded ultrafine PLGA nanoparticles

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 895-896, Issue , 2012, Pages 178-181

  Wang, Yu Jing ^a   Wu, Yi Ting ^a   Lin, Jia Yi ^a   Chu, Chih Hung ^b   Huang, Hsin Ying ^a   Wang, Yu Chao ^a   Chen, Jen Kun ^a   Yang, Chung Shi ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CHI NAN UNIVERSITY   (Taiwan)

Author keywords

SPE; Clarithromycin; Pharmacokinetics; Rat plasma; Ultrafine PLGA NP; UPLC MS MS

Indexed keywords

96-WELL; CLARITHROMYCIN; INTRAVENOUS ADMINISTRATION; INTRAVENOUS INJECTIONS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; PHARMACOKINETIC PROFILES; PHARMACOKINETIC STUDIES; PLGA NANOPARTICLES; POLYMERIC NANOPARTICLES; RAT PLASMA; SIDE EFFECT; SOLID-PHASE EXTRACTION; ULTRA HIGH PERFORMANCE; ULTRAFINE; UPLC-MS/MS;

BODY FLUIDS; DRUG INTERACTIONS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

NANOPARTICLES;

CLARITHROMYCIN; POLYGLACTIN; ROXITHROMYCIN;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENCAPSULATION; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLARITHROMYCIN; INJECTIONS, INTRAVENOUS; LACTIC ACID; LINEAR MODELS; MALE; NANOPARTICLES; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SOLID PHASE MICROEXTRACTION; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84860187207     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.03.022     Document Type: Article

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