The ligand specificity of the G-protein-coupled receptor GPR34

Biochemical Journal

Volumn 443, Issue 3, 2012, Pages 841-850

  Ritscher, Lars ^a   Engemaier, Eva ^a   Staübert, Claudia ^a   Liebscher, Ines ^a   Schmidt, Philipp ^a   Hermsdorf, Thomas ^a   Rom̈pler, Holger ^a   Schulz, Angela ^a   Schon̈eberg, Torsten ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Chimaeric receptor; Evolution; Mutagenesis; Orphan G protein coupled receptor (GPCR); Structure function relationship

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR GPR34; LYSOPHOSPHATIDYLSERINE; UNCLASSIFIED DRUG;

AGONIST; ARTICLE; CARP; CHICKEN; CHIMERA; HUMAN; MOUSE; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; XENOPUS; XENOPUS TROPICALIS; ZEBRA FISH;

CELLS, CULTURED; HUMANS; LIGANDS; LIKELIHOOD FUNCTIONS; RECEPTORS, LYSOPHOSPHOLIPID;

EID: 84860132296     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20112090     Document Type: Article

References (56)

1. Marchese, A., Sawzdargo, M., Nguyen, T., Cheng, R., Heng, H. H., Nowak, T., Im, D. S., Lynch, K. R., George, S. R. and O'Dowd, B. F. (1999) Discovery of three novel orphan G-protein-coupled receptors. Genomics 56, 12-21 (Pubitemid 29107199)
2. Schöneberg, T., Schulz, A., Grosse, R., Schade, R., Henklein, P., Schultz, G. and Gudermann, T. (1999) A novel subgroup of class I G-protein-coupled receptors. Biochim. Biophys. Acta 1446, 57-70 (Pubitemid 29299324)
3. Schöneberg, T., Hermsdorf, T., Engemaier, E., Engel, K., Liebscher, I., Thor, D., Zierau, K., Römpler, H. and Schulz, A. (2007) Structural and functional evolution of the P2Y12-like receptor group. Purinergic Signalling 3, 255-268
4. Foster, C. J., Prosser, D. M., Agans, J. M., Zhai, Y., Smith, M. D., Lachowicz, J. E., Zhang, F. L., Gustafson, E., Monsma, Jr, F. J., Wiekowski, M. T. et al. (2001) Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J. Clin. Invest. 107, 1591-1598 (Pubitemid 32574645)
5. Hollopeter, G., Jantzen, H. M., Vincent, D., Li, G., England, L., Ramakrishnan, V., Yang, R. B., Nurden, P., Nurden, A., Julius, D. and Conley, P. B. (2001) Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409, 202-207 (Pubitemid 32144286)
6. Tabata, K., Baba, K., Shiraishi, A., Ito, M. and Fujita, N. (2007) The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem. Biophys. Res. Commun. 363, 861-866 (Pubitemid 47516713)
7. Nonaka, Y., Hiramoto, T. and Fujita, N. (2005) Identification of endogenous surrogate ligands for human P2Y12 receptors by in silicoand in vitro methods. Biochem. Biophys. Res. Commun. 337, 281-288 (Pubitemid 41393791)
8. Sugo, T., Tachimoto, H., Chikatsu, T., Murakami, Y., Kikukawa, Y., Sato, S., Kikuchi, K., Nagi, T., Harada, M., Ogi, K. et al. (2006) Identification of a lysophosphatidylserine receptor on mast cells. Biochem. Biophys. Res. Commun. 341, 1078-1087 (Pubitemid 43221776)
9. Aoki, J., Nagai, Y., Hosono, H., Inoue, K. and Arai, H. (2002) Structure and function of phosphatidylserine-specific phospholipase A1. Biochim. Biophys. Acta 1582, 26-32
10. Park, K. S., Lee, H. Y., Kim, M. K., Shin, E. H., Jo, S. H., Kim, S. D., Im, D. S. and Bae, Y. S. (2006) Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins. Mol. Pharmacol. 69, 1066-1073
11. Bellini, F., Viola, G., Menegus, A. M., Toffano, G. and Bruni, A. (1990) Signalling mechanism in the lysophosphatidylserine-induced activation of mouse mast cells. Biochim. Biophys. Acta 1052, 216-220 (Pubitemid 20113185)
12. Park, K. S., Lee, H. Y., Kim, M. K., Shin, E. H. and Bae, Y. S. (2005) Lysophosphatidylserine stimulates leukemic cells but not normal leukocytes. Biochem. Biophys. Res. Commun. 333, 353-358 (Pubitemid 40848298)
13. Lee, S. Y., Lee, H. Y., Kim, S. D., Jo, S. H., Shim, J. W., Lee, H. J., Yun, J. and Bae, Y. S. (2008) Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells. Biochem. Biophys. Res. Commun. 374, 147-151
14. van der Kleij, D., Latz, E., Brouwers, J. F., Kruize, Y. C., Schmitz, M., Kurt-Jones, E. A., Espevik, T., de Jong, E. C., Kapsenberg, M. L., Golenbock, D. T. et al. (2002) A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J. Biol. Chem. 277, 48122-48129 (Pubitemid 35470760)
15. Schulz, A. and Schöneberg, T. (2003) The structural evolution of a P2Y-like G-protein-coupled receptor. J. Biol. Chem. 278, 35531-35541 (Pubitemid 37102325)
16. Liebscher, I., Muller, U., Teupser, D., Engemaier, E., Engel, K. M., Ritscher, L., Thor, D., Sangkuhl, K., Ricken, A., Wurm, A. et al. (2011) Altered immune response in mice deficient for the G protein-coupled receptor GPR34. J. Biol. Chem. 286, 2101-2110
17. Bedard, A., Tremblay, P., Chernomoretz, A. and Vallieres, L. (2007) Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation. Glia 55, 777-789 (Pubitemid 46787189)
18. Engemaier, E., Römpler, H., Schöneberg, T. and Schulz, A. (2006) Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34. Genomics 87, 254-264 (Pubitemid 43117446)
19. Novak, A., Akasaka, T., Manske, M., Gupta, M., Witzig, T., Dyer, M.J.S., Dogan, A., Remstein, E. and Ansell, S. (2008) Elevated expression of GPR34 and its association with a novel translocation T(X;14)(p11;q32) involving IGHS and GPR34 in MALT lymphoma., 50th ASH Annual Meeting and Exposition, San Francisco, CA, U.S.A., 6-9 December 2008, Poster 2251
20. Wlodarska, I., Tousseyn, T., De Leval, L., Ferreiro, J., Urbankova, H., Michaux, L., Dierickx, D., Wolter, P., Vandenberghe, P., Marynen, P. et al. (2009) Novel T(X;14)(p11.4;q32.33) resulting in upregulation of gpr34 and activation of the NFκB pathway is recurrent in malt lymphomas. Haematologica 2009, Berlin, Germany, 4-7 June 2009, 94[suppl.2]:271 abs. 0666
21. Vissinga, C., Hensley, K. and Kirchner, J. (2009) GPR34 is not required for mast cell degranulation induced by IgE or lysophosphatidyl-L-serine. J. Immunol. 182
22. Yin, H., Chu, A., Li, W., Wang, B., Shelton, F., Otero, F., Nguyen, D. G., Caldwell, J. S. and Chen, Y. A. (2009) Lipid G protein-coupled receptor ligand identification using β-arrestin PathHunter assay. J. Biol. Chem. 284, 12328-12338
23. Iwashita, M., Makide, K., Nonomura, T., Misumi, Y., Otani, Y., Ishida, M., Taguchi, R., Tsujimoto, M., Aoki, J., Arai, H. and Ohwada, T. (2009) Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative. J. Med. Chem. 52, 5837-5863
24. Mumberg, D., Muller, R. and Funk, M. (1995) Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156, 119-122
25. Okayama, H. and Berg, P. (1983) A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells. Mol. Cell. Biol. 3, 280-289 (Pubitemid 13122390)
26. Boselt, I., Rompler, H., Hermsdorf, T., Thor, D., Busch, W., Schulz, A. and Schoneberg, T. (2009) Involvement of the V2 vasopressin receptor in adaptation to limited water supply. PLoS ONE 4, e5573
27. Thor, D., Schulz, A., Hermsdorf, T. and Schöneberg, T. (2008) Generation of an agonistic binding site for blockers of the M3 muscarinic acetylcholine receptor. Biochem. J. 412, 103-112 (Pubitemid 351678340)
28. Berridge, M. J. (1983) Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem. J. 212, 849-858
29. Salomon, Y., Londos, C. and Rodbell, M. (1974) A highly sensitive adenylate cyclase assay. Anal. Biochem. 58, 541-548
30. Schroder, R., Janssen, N., Schmidt, J., Kebig, A., Merten, N., Hennen, S., Muller, A., Blattermann, S., Mohr-Andra, M., Zahn, S. et al. (2010) Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements. Nat. Biotechnol. 28, 943-949
31. Schoneberg, T., Schulz, A., Biebermann, H., Gruters, A., Grimm, T., Hubschmann, K., Filler, G., Gudermann, T. and Schultz, G. (1998) V2 vasopressin receptor dysfunction in nephrogenic diabetes insipidus caused by different molecular mechanisms. Hum. Mutat. 12, 196-205 (Pubitemid 28384591)
32. Rompler, H., Yu, H. T., Arnold, A., Orth, A. and Schoneberg, T. (2006) Functional consequences of naturally occurring DRY motif variants in the mammalian chemoattractant receptor GPR33. Genomics 87, 724-732 (Pubitemid 43792497)
33. Ballesteros, J. A. and Weinstein, H. (1995) Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors. Methods Neurosci. 25, 366-428
34. Thompson, J. D., Higgins, D. G. and Gibson, T. J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22, 4673-4680 (Pubitemid 24354800)
35. Tamura, K., Dudley, J., Nei, M. and Kumar, S. (2007) MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0. Mol. Biol. Evol. 24, 1596-1599 (Pubitemid 47236692)
36. Saitou, N. and Nei, M. (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 4, 406-425
37. Tamura, K., Nei, M. and Kumar, S. (2004) Prospects for inferring very large phylogenies by using the neighbor-joining method. Proc. Natl. Acad. Sci. U.S.A. 101, 11030-11035 (Pubitemid 38989579)
38. Felsenstein, J. (1985) Confidence-limits on phylogenies - an approach using the bootstrap. Evolution 39, 783-791
39. Yang, Z. (2007) PAML 4: phylogenetic analysis by maximum likelihood. Mol. Biol. Evol. 24, 1586-1591
40. Yang, Z. (1998) Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution. Mol. Biol. Evol. 15, 568-573
41. Yang, Z. and Nielsen, R. (2002) Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages. Mol. Biol. Evol. 19, 908-917 (Pubitemid 34602960)
42. Zhang, J., Nielsen, R. and Yang, Z. (2005) Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level. Mol. Biol. Evol. 22, 2472-2479 (Pubitemid 41661383)
43. Murphy, W. J., Pevzner, P. A. and O'Brien, S. J. (2004) Mammalian phylogenomics comes of age. Trends Genet. 20, 631-639 (Pubitemid 39441282)
44. Bininda-Emonds, O. R., Cardillo, M., Jones, K. E., MacPhee, R. D., Beck, R. M., Grenyer, R., Price, S. A., Vos, R. A., Gittleman, J. L. and Purvis, A. (2007) The delayed rise of present-day mammals. Nature 446, 507-512 (Pubitemid 46514725)
45. Farias, I. P., Orti, G., Sampaio, I., Schneider, H. and Meyer, A. (1999) Mitochondrial DNA phylogeny of the family Cichlidae: monophyly and fast molecular evolution of the neotropical assemblage. J. Mol. Evol. 48, 703-711 (Pubitemid 29287960)
46. Sparks, J. S. and Smith, W. L. (2004) Phylogeny and biogeography of the Malagasy and Australasian rainbowfishes (Teleostei: Melanotaenioidei): Gondwanan vicariance and evolution in freshwater. Mol. Phylogenet. Evol. 33, 719-734 (Pubitemid 39444510)
47. Kawahara, R., Miya, M., Mabuchi, K., Lavoue, S., Inoue, J. G., Satoh, T. P., Kawaguchi, A. and Nishida, M. (2008) Interrelationships of the 11 gasterosteiform families (sticklebacks, pipefishes, and their relatives): a new perspective based on whole mitogenome sequences from 75 higher teleosts. Mol. Phylogenet. Evol. 46, 224-236 (Pubitemid 350267212)
48. Chiba, S. N., Iwatsuki, Y., Yoshino, T. and Hanzawa, N. (2009) Comprehensive phylogeny of the family Sparidae (Perciformes: Teleostei) inferred from mitochondrial gene analyses. Genes Genet. Syst. 84, 153-170
49. Tang, K. L., Berendzen, P. B., Wiley, E. O., Morrissey, J. F., Winterbottom, R. and Johnson, G. D. (1999) The phylogenetic relationships of the suborder Acanthuroidei (Teleostei: Perciformes) based on molecular and morphological evidence. Mol. Phylogenet. Evol. 11, 415-425 (Pubitemid 129499279)
50. Farias, I. P., Orti, G., Sampaio, I., Schneider, H. and Meyer, A. (2001) The cytochrome b gene as a phylogenetic marker: the limits of resolution for analyzing relationships among cichlid fishes. J. Mol. Evol. 53, 89-103 (Pubitemid 32652634)
51. Dettai, A. and Lecointre, G. (2005) Further support for the clades obtained by multiple molecular phylogenies in the acanthomorph bush. C. R. Biol. 328, 674-689 (Pubitemid 40903701)
52. Thacker, C. E. and Roje, D. M. (2009) Phylogeny of cardinalfishes (Teleostei: Gobiiformes: Apogonidae) and the evolution of visceral bioluminescence. Mol. Phylogenet. Evol. 52, 735-745
53. He, S., Mayden, R. L., Wang, X., Wang, W., Tang, K. L., Chen, W. J. and Chen, Y. (2008) Molecular phylogenetics of the family Cyprinidae (Actinopterygii: Cypriniformes) as evidenced by sequence variation in the first intron of S7 ribosomal protein-coding gene: further evidence from a nuclear gene of the systematic chaos in the family. Mol. Phylogenet. Evol. 46, 818-829
54. Azuma, Y., Kumazawa, Y., Miya, M., Mabuchi, K. and Nishida, M. (2008) Mitogenomic evaluation of the historical biogeography of cichlids toward reliable dating of teleostean divergences. BMC Evol. Biol. 8, 215
55. Staubert, C., Boselt, I., Bohnekamp, J., Rompler, H., Enard, W. and Schoneberg, T. (2010) Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS ONE 5, e11133
56. Kleinau, G., Pratzka, J., Nurnberg, D., Gruters, A., Fuhrer-Sakel, D., Krude, H., Kohrle, J., Schoneberg, T. and Biebermann, H. (2011) Differential modulation of β-adrenergic receptor signaling by trace amine-associated receptor 1 agonists. PLoS ONE 6, e27073