Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative

Journal of Medicinal Chemistry

Volumn 52, Issue 19, 2009, Pages 5837-5863

  Iwashita, Masazumi ^a   Makide, Kumiko ^a,c,e   Nonomura, Taro ^a   Misumi, Yoshimasa ^a   Otani, Yuko ^a   Ishida, Mayuko ^b   Taguchi, Ryo ^b,d   Tsujimoto, Masafumi ^c   Aoki, Junken ^a,d,e   Arai, Hiroyuki ^a,d   Ohwada, Tomohiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c RIKEN   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOPHOSPHATIDYLSERINE; LYSOPHOSPHATIDYLTHREONINE; LYSOPHOSPHOLIPID; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ETHERIFICATION; HISTAMINE RELEASE; MALE; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL DEGRANULATION; GLYCEROPHOSPHOLIPIDS; HISTAMINE; INFLAMMATION MEDIATORS; LYSOPHOSPHOLIPIDS; MAST CELLS; MICE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE;

EID: 70349646890     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900598m     Document Type: Article

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