Direct evidence of generation and accumulation of β-sheet-rich prion protein in scrapie-infected neuroblastoma cells with human IgG1 antibody specific for β-form prion protein

Journal of Biological Chemistry

Volumn 287, Issue 17, 2012, Pages 14023-14039

  Kubota, Toshiya ^a   Hamazoe, Yuta ^a   Hashiguchi, Shuhei ^a   Ishibashi, Daisuke ^b   Akasaka, Kazuyuki ^c   Nishida, Noriyuki ^b   Katamine, Shigeru ^b   Sakaguchi, Suehiro ^d   Kuroki, Ryota ^e   Nakashima, Toshihiro ^f   Sugimura, Kazuhisa ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c KINKI UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

^e JAPAN ATOMIC ENERGY AGENCY   (Japan)

^f Chemo Sero Therapeutic Research Institute   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC CELL DEATH; APOPTOTIC CELLS; BOUND AGGREGATES; CONFOCAL LASER MICROSCOPY; END-PRODUCTS; HUMAN ANTIBODIES; JACKSON; N-TERMINALS; NEUROBLASTOMA CELLS; PHAGE LIBRARIES; PRION PROPAGATION; PRION PROTEIN; SINGLE CHAINS;

AGGREGATES; ANTIBODIES; CELL DEATH; GRANULATION;

RECOMBINANT PROTEINS;

EPITOPE; IMMUNOGLOBULIN G1 ANTIBODY; PRION PROTEIN; PROTEINASE K; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL CELL CULTURE; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; APOPTOSIS; ARTICLE; BETA SHEET; BIOACCUMULATION; BIOPANNING; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EPITOPE MAPPING; MOUSE; NEUROBLASTOMA; NEUROBLASTOMA CELL; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; SCRAPIE;

ANIMALS; ANTIBODIES; CIRCULAR DICHROISM; GENETIC ENGINEERING; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; MICE; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, CONFOCAL; NEUROBLASTOMA; PEPTIDE LIBRARY; PRIONS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; SCRAPIE;

EID: 84859949974     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.318352     Document Type: Article

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